Di Jiang
@dijiang319.bsky.social
Senior editor @science.org. Molecular biology, #DNA, #RNA, #gene regulation, #epigenetics, nuclear biology, #chromatin biology, 3D #genome, #synbio, #CRISPR and gene editing, other bacterial immune systems, and #AI in all these
🧬🔬🎥 @science.org Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries | Science www.science.org/doi/10.1126/...
Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries
Eukaryotic gene expression is orchestrated by RNA polymerases (RNAPI, II, and III) and associated factors, yet their real-time dynamics remain obscure. Using single-molecule tracking in living yeast, ...
www.science.org
February 6, 2026 at 12:14 AM
🧬🔬🎥 @science.org Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries | Science www.science.org/doi/10.1126/...
🧬🌉Online @science.org Programmable genome editing in human cells using RNA-guided bridge recombinases | Science www.science.org/doi/10.1126/...
Programmable genome editing in human cells using RNA-guided bridge recombinases
Site-specific insertion of gene-sized DNA fragments remains an unmet need in the genome editing field. IS110-family serine recombinases have recently been shown to mediate programmable DNA recombinati...
www.science.org
February 6, 2026 at 12:12 AM
🧬🌉Online @science.org Programmable genome editing in human cells using RNA-guided bridge recombinases | Science www.science.org/doi/10.1126/...
🧬Appearing today @science.org a Review - From sequence to function: Bridging single-molecule kinetics and molecular diversity | Science 🔬https://www.science.org/doi/10.1126/science.adv4503
From sequence to function: Bridging single-molecule kinetics and molecular diversity
Biological function is fundamentally determined by nucleic acid and protein sequence. Beyond encoding genetic information, nucleic acids also display complex physicochemical parameters that shape stru...
www.science.org
January 29, 2026 at 7:44 PM
🧬Appearing today @science.org a Review - From sequence to function: Bridging single-molecule kinetics and molecular diversity | Science 🔬https://www.science.org/doi/10.1126/science.adv4503
🧬🔬@science.org A genetically encoded device for #transcriptome storage in mammalian cells | Science www.science.org/doi/10.1126/... @broadinstitute.org
A genetically encoded device for transcriptome storage in mammalian cells
Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and s...
www.science.org
January 15, 2026 at 8:31 PM
🧬🔬@science.org A genetically encoded device for #transcriptome storage in mammalian cells | Science www.science.org/doi/10.1126/... @broadinstitute.org
@science.org Deep contrastive learning enables genome-wide virtual screening | Science www.science.org/doi/10.1126/...
Deep contrastive learning enables genome-wide virtual screening
Recent breakthroughs in protein structure prediction have opened new avenues for genome-wide drug discovery, yet existing virtual screening methods remain computationally prohibitive. We present DrugC...
www.science.org
January 9, 2026 at 6:55 PM
@science.org Deep contrastive learning enables genome-wide virtual screening | Science www.science.org/doi/10.1126/...
🌱🍁🌻 #plantscience in 2025 @science.org 🎍🌽🌸👇
At the end of 2024 I did a chronological round up of all the #plantscience in @science.org that year.
So how did 2025 pan out? This year, I’m grouping papers thematically instead of chronologically so read on to find out what exciting plant science came out over the last 12 months. (1/22)
So how did 2025 pan out? This year, I’m grouping papers thematically instead of chronologically so read on to find out what exciting plant science came out over the last 12 months. (1/22)
January 3, 2026 at 12:26 AM
🌱🍁🌻 #plantscience in 2025 @science.org 🎍🌽🌸👇
🧬 @science.org A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform | Science www.science.org/doi/10.1126/... @ckadoch.bsky.social @danafarber.bsky.social @harvardmed.bsky.social @broadinstitute.org @hhmi-science.bsky.social 🔬 #chromatin #transcription #cancer 🧫
A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform
Mammalian SWI/SNF chromatin remodeling complexes modulate DNA accessibility and gene expression; however, their genomic targeting mechanisms remain incompletely understood. Here, we identify SWIFT (SW...
www.science.org
January 1, 2026 at 7:53 PM
🧬 @science.org A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform | Science www.science.org/doi/10.1126/... @ckadoch.bsky.social @danafarber.bsky.social @harvardmed.bsky.social @broadinstitute.org @hhmi-science.bsky.social 🔬 #chromatin #transcription #cancer 🧫
@science.org Multistep genomics on single cells and live cultures in subnanoliter capsules | Science www.science.org/doi/10.1126/...
Multistep genomics on single cells and live cultures in subnanoliter capsules
Single-cell sequencing methods uncover natural and induced variation between cells. Many functional genomic methods, however, require multiple steps that cannot yet be scaled to high throughput, inclu...
www.science.org
December 19, 2025 at 10:32 PM
@science.org Multistep genomics on single cells and live cultures in subnanoliter capsules | Science www.science.org/doi/10.1126/...
@science.org Chromatin buffers torsional stress during transcription | Science www.science.org/doi/10.1126/...
Chromatin buffers torsional stress during transcription
During eukaryotic transcription, Pol II must overcome nucleosome obstacles and, because of DNA’s helical structure, must also rotate relative to DNA, generating torsional stress. However, there is lim...
www.science.org
December 19, 2025 at 10:31 PM
@science.org Chromatin buffers torsional stress during transcription | Science www.science.org/doi/10.1126/...
🧬🔬@science.org #Chromothripsis and ecDNA initiated by N4BP2 nuclease fragmentation of cytoplasm-exposed chromosomes | Science www.science.org/doi/10.1126/...
Chromothripsis and ecDNA initiated by N4BP2 nuclease fragmentation of cytoplasm-exposed chromosomes
Genome instability, including chromothripsis, is a hallmark of cancer. Cancer cells frequently contain micronuclei—small, nucleus-like structures formed by chromosome missegregation—that are susceptib...
www.science.org
December 12, 2025 at 10:07 PM
🧬🔬@science.org #Chromothripsis and ecDNA initiated by N4BP2 nuclease fragmentation of cytoplasm-exposed chromosomes | Science www.science.org/doi/10.1126/...
@science.org🧬High-fidelity human chromosome transfer and elimination | Science www.science.org/doi/10.1126/... @wellcometrust.bsky.social @mrclmb.bsky.social
High-fidelity human chromosome transfer and elimination
The synthesis of human genomes and other gigabase-scale genomes will require new strategies. Here, we realized key steps in our pipeline for building synthetic human chromosomes. We established: (i) t...
www.science.org
December 6, 2025 at 4:11 AM
@science.org🧬High-fidelity human chromosome transfer and elimination | Science www.science.org/doi/10.1126/... @wellcometrust.bsky.social @mrclmb.bsky.social
@science.org🧬Cohesin guides homology search during DNA repair using loops and sister chromatid linkages | Science www.science.org/doi/10.1126/... @fedeteloni.bsky.social @danielgerlich.bsky.social et al.
Cohesin guides homology search during DNA repair using loops and sister chromatid linkages
Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequenc...
www.science.org
December 5, 2025 at 8:50 PM
@science.org🧬Cohesin guides homology search during DNA repair using loops and sister chromatid linkages | Science www.science.org/doi/10.1126/... @fedeteloni.bsky.social @danielgerlich.bsky.social et al.
@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.
Multiscale structure of chromatin condensates explains phase separation and material properties
The structure and interaction networks of molecules within biomolecular condensates are poorly understood. Using cryo–electron tomography and molecular dynamics simulations, we elucidated the structur...
www.science.org
December 5, 2025 at 5:24 AM
@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.
🦠🐝🧬🐳This short blog shares many interesting facts about our magazine that I didn’t know before @science.org 📰🖼️⚛️⚗️🔭🧪🔬The evolving face of Science | Science | AAAS www.science.org/content/blog...
The evolving face of Science
Inspired by the redesign, our Design Managing Editor reviews covers across the course of Science’s 145-year legacy.
www.science.org
October 25, 2025 at 6:08 PM
🦠🐝🧬🐳This short blog shares many interesting facts about our magazine that I didn’t know before @science.org 📰🖼️⚛️⚗️🔭🧪🔬The evolving face of Science | Science | AAAS www.science.org/content/blog...
@science.org 🧬🔬🐛🔭🌊🌳🧫🐳
A reminder that @science.org is a learned society journal, owned & published by the non-profit @aaas.org. It's green open access, with no article processing fees for authors - compatible with all major funder mandates. All subscription revenue is reinvested in science, not paid to shareholders.
🔭⚛️🧪
🔭⚛️🧪
October 25, 2025 at 3:12 PM
@science.org 🧬🔬🐛🔭🌊🌳🧫🐳
🧬🔬🦠🧫🧪@science.org Escherichia coli with a 57-codon genetic code | Science www.science.org/doi/10.1126/...
October 23, 2025 at 9:51 PM
🧬🔬🦠🧫🧪@science.org Escherichia coli with a 57-codon genetic code | Science www.science.org/doi/10.1126/...
This study @science.org finds what appears to be the long-lost RNA subunit of C. elegans telomerase. The TERC RNA is encoded within an intron of a germline-upregulated gene, nmy-2🪱🔬🧬Nematode telomerase RNA hitchhikes on introns of germline–up-regulated genes | Science www.science.org/doi/10.1126/...
October 23, 2025 at 9:38 PM
This study @science.org finds what appears to be the long-lost RNA subunit of C. elegans telomerase. The TERC RNA is encoded within an intron of a germline-upregulated gene, nmy-2🪱🔬🧬Nematode telomerase RNA hitchhikes on introns of germline–up-regulated genes | Science www.science.org/doi/10.1126/...
@science.org High-resolution spatial mapping of cell state and lineage dynamics in vivo with PEtracer | Science www.science.org/doi/10.1126/... @lukekoblan.bsky.social @weissmanlab.bsky.social @zhuanglab.bsky.social @whiteheadinstitute.bsky.social et al.
October 16, 2025 at 7:07 PM
@science.org High-resolution spatial mapping of cell state and lineage dynamics in vivo with PEtracer | Science www.science.org/doi/10.1126/... @lukekoblan.bsky.social @weissmanlab.bsky.social @zhuanglab.bsky.social @whiteheadinstitute.bsky.social et al.
Last week @science.org mRNA initiation and termination are spatially coordinated | Science www.science.org/doi/10.1126/... from @anafiszbein.bsky.social @athmapai.bsky.social et al.
October 13, 2025 at 2:03 AM
Last week @science.org mRNA initiation and termination are spatially coordinated | Science www.science.org/doi/10.1126/... from @anafiszbein.bsky.social @athmapai.bsky.social et al.
@science.org ATP-dependent remodeling of #chromatin #condensates reveals distinct #mesoscale outcomes | Science www.science.org/doi/10.1126/...
October 13, 2025 at 1:50 AM
@science.org ATP-dependent remodeling of #chromatin #condensates reveals distinct #mesoscale outcomes | Science www.science.org/doi/10.1126/...
🧬🌉Online @science.org Megabase-scale human #genome rearrangement with programmable bridge recombinases | Science www.science.org/doi/10.1126/...
Megabase-scale human genome rearrangement with programmable bridge recombinases
Bridge recombinases are naturally occurring RNA-guided DNA recombinases that we previously demonstrated can programmably insert, excise, and invert DNA in vitro and in Escherichia coli. In this study,...
www.science.org
September 29, 2025 at 10:01 PM
🧬🌉Online @science.org Megabase-scale human #genome rearrangement with programmable bridge recombinases | Science www.science.org/doi/10.1126/...
@science.org Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS #immunity | Science www.science.org/doi/10.1126/... ❄️🔬🧬🦠🧫
September 29, 2025 at 5:46 AM
@science.org Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS #immunity | Science www.science.org/doi/10.1126/... ❄️🔬🧬🦠🧫
This week @science.org Dual #transposon sequencing profiles the #genetic interaction landscape in #bacteria | Science www.science.org/doi/10.1126/... 🦠🔬🧫🧬
Dual transposon sequencing profiles the genetic interaction landscape in bacteria
Gene redundancy complicates systematic characterization of gene function as single-gene deletions may not produce discernible phenotypes. We report dual transposon sequencing (dual Tn-seq), a platform...
www.science.org
September 26, 2025 at 7:01 PM
This week @science.org Dual #transposon sequencing profiles the #genetic interaction landscape in #bacteria | Science www.science.org/doi/10.1126/... 🦠🔬🧫🧬
@science.org🧬🔬Functional maps of a #genomic locus reveal confinement of an enhancer by its target #gene | Science www.science.org/doi/10.1126/...
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...
www.science.org
September 22, 2025 at 7:43 PM
@science.org🧬🔬Functional maps of a #genomic locus reveal confinement of an enhancer by its target #gene | Science www.science.org/doi/10.1126/...
@science.org🧬🔬Kinetic organization of the #genome revealed by ultraresolution multiscale live #imaging | Science www.science.org/doi/10.1126/...
Kinetic organization of the genome revealed by ultraresolution multiscale live imaging
Genome function requires regulated genome motion. However, tools to directly observe this motion in vivo have been limited in coverage and resolution. Here we introduce an approach to tile mammalian c...
www.science.org
September 22, 2025 at 7:43 PM
@science.org🧬🔬Kinetic organization of the #genome revealed by ultraresolution multiscale live #imaging | Science www.science.org/doi/10.1126/...