Di Jiang
@dijiang319.bsky.social
Senior editor @science.org. Molecular biology, #DNA, #RNA, #gene regulation, #epigenetics, nuclear biology, #chromatin biology, 3D #genome, #synbio, #CRISPR and gene editing, other bacterial immune systems, and #AI in all these
🦠🐝🧬🐳This short blog shares many interesting facts about our magazine that I didn’t know before @science.org 📰🖼️⚛️⚗️🔭🧪🔬The evolving face of Science | Science | AAAS www.science.org/content/blog...
The evolving face of Science
Inspired by the redesign, our Design Managing Editor reviews covers across the course of Science’s 145-year legacy.
www.science.org
October 25, 2025 at 6:08 PM
🦠🐝🧬🐳This short blog shares many interesting facts about our magazine that I didn’t know before @science.org 📰🖼️⚛️⚗️🔭🧪🔬The evolving face of Science | Science | AAAS www.science.org/content/blog...
@science.org 🧬🔬🐛🔭🌊🌳🧫🐳
A reminder that @science.org is a learned society journal, owned & published by the non-profit @aaas.org. It's green open access, with no article processing fees for authors - compatible with all major funder mandates. All subscription revenue is reinvested in science, not paid to shareholders.
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October 25, 2025 at 3:12 PM
@science.org 🧬🔬🐛🔭🌊🌳🧫🐳
🧬🔬🦠🧫🧪@science.org Escherichia coli with a 57-codon genetic code | Science www.science.org/doi/10.1126/...
October 23, 2025 at 9:51 PM
🧬🔬🦠🧫🧪@science.org Escherichia coli with a 57-codon genetic code | Science www.science.org/doi/10.1126/...
This study @science.org finds what appears to be the long-lost RNA subunit of C. elegans telomerase. The TERC RNA is encoded within an intron of a germline-upregulated gene, nmy-2🪱🔬🧬Nematode telomerase RNA hitchhikes on introns of germline–up-regulated genes | Science www.science.org/doi/10.1126/...
October 23, 2025 at 9:38 PM
This study @science.org finds what appears to be the long-lost RNA subunit of C. elegans telomerase. The TERC RNA is encoded within an intron of a germline-upregulated gene, nmy-2🪱🔬🧬Nematode telomerase RNA hitchhikes on introns of germline–up-regulated genes | Science www.science.org/doi/10.1126/...
@science.org High-resolution spatial mapping of cell state and lineage dynamics in vivo with PEtracer | Science www.science.org/doi/10.1126/... @lukekoblan.bsky.social @weissmanlab.bsky.social @zhuanglab.bsky.social @whiteheadinstitute.bsky.social et al.
October 16, 2025 at 7:07 PM
@science.org High-resolution spatial mapping of cell state and lineage dynamics in vivo with PEtracer | Science www.science.org/doi/10.1126/... @lukekoblan.bsky.social @weissmanlab.bsky.social @zhuanglab.bsky.social @whiteheadinstitute.bsky.social et al.
Last week @science.org mRNA initiation and termination are spatially coordinated | Science www.science.org/doi/10.1126/... from @anafiszbein.bsky.social @athmapai.bsky.social et al.
October 13, 2025 at 2:03 AM
Last week @science.org mRNA initiation and termination are spatially coordinated | Science www.science.org/doi/10.1126/... from @anafiszbein.bsky.social @athmapai.bsky.social et al.
@science.org ATP-dependent remodeling of #chromatin #condensates reveals distinct #mesoscale outcomes | Science www.science.org/doi/10.1126/...
October 13, 2025 at 1:50 AM
@science.org ATP-dependent remodeling of #chromatin #condensates reveals distinct #mesoscale outcomes | Science www.science.org/doi/10.1126/...
🧬🌉Online @science.org Megabase-scale human #genome rearrangement with programmable bridge recombinases | Science www.science.org/doi/10.1126/...
Megabase-scale human genome rearrangement with programmable bridge recombinases
Bridge recombinases are naturally occurring RNA-guided DNA recombinases that we previously demonstrated can programmably insert, excise, and invert DNA in vitro and in Escherichia coli. In this study,...
www.science.org
September 29, 2025 at 10:01 PM
🧬🌉Online @science.org Megabase-scale human #genome rearrangement with programmable bridge recombinases | Science www.science.org/doi/10.1126/...
@science.org Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS #immunity | Science www.science.org/doi/10.1126/... ❄️🔬🧬🦠🧫
September 29, 2025 at 5:46 AM
@science.org Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS #immunity | Science www.science.org/doi/10.1126/... ❄️🔬🧬🦠🧫
This week @science.org Dual #transposon sequencing profiles the #genetic interaction landscape in #bacteria | Science www.science.org/doi/10.1126/... 🦠🔬🧫🧬
Dual transposon sequencing profiles the genetic interaction landscape in bacteria
Gene redundancy complicates systematic characterization of gene function as single-gene deletions may not produce discernible phenotypes. We report dual transposon sequencing (dual Tn-seq), a platform...
www.science.org
September 26, 2025 at 7:01 PM
This week @science.org Dual #transposon sequencing profiles the #genetic interaction landscape in #bacteria | Science www.science.org/doi/10.1126/... 🦠🔬🧫🧬
@science.org🧬🔬Functional maps of a #genomic locus reveal confinement of an enhancer by its target #gene | Science www.science.org/doi/10.1126/...
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...
www.science.org
September 22, 2025 at 7:43 PM
@science.org🧬🔬Functional maps of a #genomic locus reveal confinement of an enhancer by its target #gene | Science www.science.org/doi/10.1126/...
@science.org🧬🔬Kinetic organization of the #genome revealed by ultraresolution multiscale live #imaging | Science www.science.org/doi/10.1126/...
Kinetic organization of the genome revealed by ultraresolution multiscale live imaging
Genome function requires regulated genome motion. However, tools to directly observe this motion in vivo have been limited in coverage and resolution. Here we introduce an approach to tile mammalian c...
www.science.org
September 22, 2025 at 7:43 PM
@science.org🧬🔬Kinetic organization of the #genome revealed by ultraresolution multiscale live #imaging | Science www.science.org/doi/10.1126/...
@science.org ⤵️challenges prevailing notion—repressor and activator act by distinct mechanisms: repressors block via steric hindrance/activators enable Pol II binding to promoter🧬
E. coli transcription factors regulate promoter activity by a universal, homeostatic mechanism | Science bit.ly/adv2064
E. coli transcription factors regulate promoter activity by a universal, homeostatic mechanism | Science bit.ly/adv2064
September 12, 2025 at 4:55 PM
@science.org ⤵️challenges prevailing notion—repressor and activator act by distinct mechanisms: repressors block via steric hindrance/activators enable Pol II binding to promoter🧬
E. coli transcription factors regulate promoter activity by a universal, homeostatic mechanism | Science bit.ly/adv2064
E. coli transcription factors regulate promoter activity by a universal, homeostatic mechanism | Science bit.ly/adv2064
@science.org Zincore-coregulator dedicated to zinc🖐️ TFs essential in development www.science.org/doi/10.1126/...
@rborza.bsky.social @sgregoricchio.bsky.social @amazouzi.bsky.social @zwartlab.bsky.social @lindersimon.bsky.social @tassosperrakis.bsky.social @thijnbrummel.bsky.social + al.
@rborza.bsky.social @sgregoricchio.bsky.social @amazouzi.bsky.social @zwartlab.bsky.social @lindersimon.bsky.social @tassosperrakis.bsky.social @thijnbrummel.bsky.social + al.
July 8, 2025 at 1:11 AM
@science.org Zincore-coregulator dedicated to zinc🖐️ TFs essential in development www.science.org/doi/10.1126/...
@rborza.bsky.social @sgregoricchio.bsky.social @amazouzi.bsky.social @zwartlab.bsky.social @lindersimon.bsky.social @tassosperrakis.bsky.social @thijnbrummel.bsky.social + al.
@rborza.bsky.social @sgregoricchio.bsky.social @amazouzi.bsky.social @zwartlab.bsky.social @lindersimon.bsky.social @tassosperrakis.bsky.social @thijnbrummel.bsky.social + al.
❄️🔬@science.org Structural basis of BAX pore formation | Science www.science.org/doi/10.1126/...
#CryoEM #apoptosis #mitochondria #BAX
#CryoEM #apoptosis #mitochondria #BAX
June 27, 2025 at 4:33 AM
❄️🔬@science.org Structural basis of BAX pore formation | Science www.science.org/doi/10.1126/...
#CryoEM #apoptosis #mitochondria #BAX
#CryoEM #apoptosis #mitochondria #BAX
@science.org Mechanism of release factor–mediated peptidyl-tRNA hydrolysis on the ribosome | Science www.science.org/doi/10.1126/...
#ribosome #RNA #hydrolysis
#ribosome #RNA #hydrolysis
June 25, 2025 at 5:44 AM
@science.org Mechanism of release factor–mediated peptidyl-tRNA hydrolysis on the ribosome | Science www.science.org/doi/10.1126/...
#ribosome #RNA #hydrolysis
#ribosome #RNA #hydrolysis
🧬🧪 @science.org RNA transcripts regulate G-quadruplex landscapes through G-loop formation | Science www.science.org/doi/10.1126/... @puckknipscheer.bsky.social @simonelsasser.bsky.social + al. @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social #DNA #RNA #genome #G-quadruplex #G-loop
RNA transcripts regulate G-quadruplex landscapes through G-loop formation
G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...
www.science.org
June 16, 2025 at 5:36 AM
🧬🧪 @science.org RNA transcripts regulate G-quadruplex landscapes through G-loop formation | Science www.science.org/doi/10.1126/... @puckknipscheer.bsky.social @simonelsasser.bsky.social + al. @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social #DNA #RNA #genome #G-quadruplex #G-loop
❄️🔬🧬🦠🧫 Disassembly activates Retron-Septu for antiphage defense | Science www.science.org/doi/10.1126/... @rti-umasschan.bsky.social #RNA #DNA #retrons #microbiology #phage #immunity #phagesky #MicroSky
June 16, 2025 at 5:31 AM
❄️🔬🧬🦠🧫 Disassembly activates Retron-Septu for antiphage defense | Science www.science.org/doi/10.1126/... @rti-umasschan.bsky.social #RNA #DNA #retrons #microbiology #phage #immunity #phagesky #MicroSky
🐦🦃🦉🦆🦢🦅🦜🕊️🐔🐤🦚🐥I like this week's cover @science.org
Arctic bird nesting traces back to the Cretaceous | Science www.science.org/doi/10.1126/...
#Paleontology #Evolution #Bird #Bluesky #Arctic #Cretaceous #Ecosystems
Arctic bird nesting traces back to the Cretaceous | Science www.science.org/doi/10.1126/...
#Paleontology #Evolution #Bird #Bluesky #Arctic #Cretaceous #Ecosystems
May 29, 2025 at 7:11 PM
🐦🦃🦉🦆🦢🦅🦜🕊️🐔🐤🦚🐥I like this week's cover @science.org
Arctic bird nesting traces back to the Cretaceous | Science www.science.org/doi/10.1126/...
#Paleontology #Evolution #Bird #Bluesky #Arctic #Cretaceous #Ecosystems
Arctic bird nesting traces back to the Cretaceous | Science www.science.org/doi/10.1126/...
#Paleontology #Evolution #Bird #Bluesky #Arctic #Cretaceous #Ecosystems
🧬@science.org CTC1-STN1-TEN1 controls DNA break repair pathway choice via DNA end resection blockade | Science www.science.org/doi/10.1126/... @chowdhurylab.bsky.social @michelleswift.bsky.social + al.
#DNARepair
#DNARepair
CTC1-STN1-TEN1 controls DNA break repair pathway choice via DNA end resection blockade
Antagonistic activities of the 53BP1 axis and the tumor suppressor BRCA1-BARD1 determine whether DNA double-strand breaks (DSBs) are repaired by end joining or homologous recombination. We show that t...
www.science.org
May 29, 2025 at 6:38 PM
🧬@science.org CTC1-STN1-TEN1 controls DNA break repair pathway choice via DNA end resection blockade | Science www.science.org/doi/10.1126/... @chowdhurylab.bsky.social @michelleswift.bsky.social + al.
#DNARepair
#DNARepair
🧬@science.org ASB7 is a negative regulator of H3K9me3 homeostasis | Science www.science.org/doi/10.1126/...
#epigenetics #chromatin #genetics #histone
#epigenetics #chromatin #genetics #histone
ASB7 is a negative regulator of H3K9me3 homeostasis
The maintenance of H3K9me3 involves the recognition of pre-existing modifications by HP1, which recruits methyltransferase SUV39H1 to methylate the adjacent newly incorporated histones, thereby establ...
www.science.org
May 29, 2025 at 6:30 PM
🧬@science.org ASB7 is a negative regulator of H3K9me3 homeostasis | Science www.science.org/doi/10.1126/...
#epigenetics #chromatin #genetics #histone
#epigenetics #chromatin #genetics #histone
@science.org Expansion in situ genome sequencing links nuclear abnormalities to aberrant chromatin regulation | Science www.science.org/doi/10.1126/...
@jbuenrostro.bsky.social @eboyden3.bsky.social + al @broadinstitute.org @harvard.edu
#ExIGS #Chromatin #Lamin #Progeria #Aging #ExpansionMicroscopy
@jbuenrostro.bsky.social @eboyden3.bsky.social + al @broadinstitute.org @harvard.edu
#ExIGS #Chromatin #Lamin #Progeria #Aging #ExpansionMicroscopy
Expansion in situ genome sequencing links nuclear abnormalities to aberrant chromatin regulation
Microscopy and genomics are used to characterize cell function, but approaches to connect the two types of information are lacking, particularly at subnuclear resolution. Here, we describe expansion i...
www.science.org
May 29, 2025 at 6:24 PM
@science.org Expansion in situ genome sequencing links nuclear abnormalities to aberrant chromatin regulation | Science www.science.org/doi/10.1126/...
@jbuenrostro.bsky.social @eboyden3.bsky.social + al @broadinstitute.org @harvard.edu
#ExIGS #Chromatin #Lamin #Progeria #Aging #ExpansionMicroscopy
@jbuenrostro.bsky.social @eboyden3.bsky.social + al @broadinstitute.org @harvard.edu
#ExIGS #Chromatin #Lamin #Progeria #Aging #ExpansionMicroscopy
🧬💊 @science.org Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase | Science www.science.org/doi/10.1126/...
@sternberglab.bsky.social @isaacwitte.bsky.social eitzingersimon.bsky.social + al. #CRISPR #Medicine #Science #Evolution #Genome #evoCAST
@sternberglab.bsky.social @isaacwitte.bsky.social eitzingersimon.bsky.social + al. #CRISPR #Medicine #Science #Evolution #Genome #evoCAST
May 17, 2025 at 7:50 PM
🧬💊 @science.org Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase | Science www.science.org/doi/10.1126/...
@sternberglab.bsky.social @isaacwitte.bsky.social eitzingersimon.bsky.social + al. #CRISPR #Medicine #Science #Evolution #Genome #evoCAST
@sternberglab.bsky.social @isaacwitte.bsky.social eitzingersimon.bsky.social + al. #CRISPR #Medicine #Science #Evolution #Genome #evoCAST
🔬🧬🍄 @science.org Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi | Science www.science.org/doi/10.1126/...
@ubcbotany.bsky.social
#fungi #fungisky #mycology #genetics #chromosome #nucleus #DNA #evolution #genome #biodiversity
@ubcbotany.bsky.social
#fungi #fungisky #mycology #genetics #chromosome #nucleus #DNA #evolution #genome #biodiversity
May 17, 2025 at 7:34 PM
🔬🧬🍄 @science.org Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi | Science www.science.org/doi/10.1126/...
@ubcbotany.bsky.social
#fungi #fungisky #mycology #genetics #chromosome #nucleus #DNA #evolution #genome #biodiversity
@ubcbotany.bsky.social
#fungi #fungisky #mycology #genetics #chromosome #nucleus #DNA #evolution #genome #biodiversity