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natcardiovascres.nature.com
Nature Cardiovascular Research
@natcardiovascres.nature.com
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Online-only Nature Research journal that publishes basic, translational, clinical and public health research in cardiac, vascular and blood biology.
https://www.nature.com/natcardiovascres/
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natcardiovascres.nature.com
21/01/2026
❤️Our January issue is out❤️Read about pathogenic mechanism of mutated ribosomal protein PRL3L, identification of cardiac progenitor lineage linked to congenital heart disease, multimodal vision graph for drug repurposing, and more.

www.nature.com/natcardiovas...
Image: Martin Dominguez, Drexel University, Irfan Kathiriya, University of California, San Francisco. Cover design: Bethany Vukomanovic TBX5 sets boundaries for a healthy heart Kathiriya et al. identify a Tbx5 + /Mef2cAHF + cardiac progenitor lineage that demarcates the interventricular septum during development, and changes in this lineage contribute to congenital heart defects in mice. (see Kathiriya et al.)
January 21, 2026 at 4:35 PM
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Research | Kathiriya et al identify a cardiac Tbx5+/Mef2cAHF+progenitor lineage that bisects the intraventricular septum during the development and show that alterations in this lineage lead to congenital heart disease.

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A disrupted compartment boundary underlies abnormal cardiac patterning and congenital heart defects - Nature Cardiovascular Research
Kathiriya et al. identify a cardiac progenitor lineage with expression of Tbx5 and anterior heart field-specific expression of Mef2c that bisects the intraventricular septum during development and sho...
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January 19, 2026 at 9:30 AM
natcardiovascres.nature.com
Big thanks to the Science Ministry of Serbia and our speakers, Drs. Knoblich, Guilliatt, Stewart, & Turco, and Profs. Radisic, Hedtrich, Clevers, Vunjak-Novakovic, Trayanova, Lütolf, Heilshorn, Dvir, Cho & Singh for the great event!

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December 19, 2025 at 2:44 PM
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❤️Our December issue is out❤️Read about a method to measure mitochondrial membrane potential in intact hearts, gene therapy for myocardial infarction, genetic association between thromboembolism and long COVID, and more.

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Image: Bethany Vukomanovic. Cover design: Bethany Vukomanovic Genetic insights into long COVID Human genetic analyses show that thromboembolism-related variants are associated with an increased risk of long COVID, suggesting shared pathogenic pathways and implicating the thrombin receptor PAR-1 as a potential contributor. (see Schuermans et al.)
December 17, 2025 at 5:00 PM
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Research | Neo et al. map blood emergence from three hemogenic endothelial (HE) populations biased toward distinct blood fates. HE primed for stem progenitors shows elevated chromatin and RNA splicing gene expression and greater isoform diversity.

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November 18, 2025 at 12:46 PM
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❤️Our November issue is out❤️Read about an imaging method that combines cardiac electrophysiology with 3D structural heart reconstruction, a targeted glycophagy ATG8 therapy reversing diabetic heart disease, and more.

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Image: Leonardo Sacconi, Institute of Clinical Physiology. Cover design: Bethany Vukomanovic Cardiac fibrosis and arrhythmia Three-dimensional structural reconstruction of entire cleared mouse ventricles from a diseased heart acquired using mesoSPIM tomography. Myocardium is visualized by fluorescence (gray), and fibrosis is detected via scattered light (red) (see Giardini et al.).
November 13, 2025 at 1:50 PM
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Research | Chan et al. generate a high-resolution spatiotemporal atlas of healing hearts and reveal cellular networks of lesion repair, including macrophage-fibroblast interactions that control late-stage fibrosis.

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Spatiotemporal dynamics of the cardioimmune niche during lesion repair - Nature Cardiovascular Research
Chan et al. generate a high-resolution spatiotemporal atlas of healing hearts and reveal cellular networks of lesion repair, including macrophage–fibroblast interactions that control late-stage fibros...
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November 12, 2025 at 2:22 PM
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Research | Chen, Wang, Zhong and colleagues show that females derive greater cardiovascular benefits from guideline-recommended levels of physical activity and require less activity than males to see their beneficial effects.

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Sex differences in the association of wearable accelerometer-derived physical activity with coronary heart disease incidence and mortality - Nature Cardiovascular Research
Chen, Wang, Zhong and colleagues show that females derive greater cardiovascular benefits from guideline-recommended levels of physical activity and require less activity than males to see their benef...
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November 11, 2025 at 3:37 PM
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Research | Tan et al. identify PRDM16 as a key repressor of fibrotic switching in smooth muscle cells and show that its downregulation in atherosclerosis drives smooth muscle cells toward a synthetic fate, promoting fibrous plaques.

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PRDM16 regulates smooth muscle cell identity and atherosclerotic plaque composition - Nature Cardiovascular Research
Tan et al. identify PRDM16 as a key repressor of fibrotic switching in smooth muscle cells and show that its downregulation in atherosclerosis drives smooth muscle cells toward a synthetic fate, promo...
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November 6, 2025 at 3:35 PM
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Research | Lin, Geng et al. identify a non-canonical AHR pathway that is activated by canonical AHR inhibitors, promoting the proliferation of quiescent endothelial cells with potential applications in cell therapy.

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A non-canonical aryl hydrocarbon receptor pathway authorizes and safeguards clinical-scale expansion of functional human endothelial cells - Nature Cardiovascular Research
Lin, Geng and colleagues identify a non-canonical AHR pathway that is activated by canonical AHR inhibitors, promoting the proliferation of quiescent endothelial cells with potential applications in c...
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November 5, 2025 at 1:32 PM
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Research | Amiad Pavlov, Heffler et al. demonstrate that stress transmitted to the cardiomyocyte nucleus by the microtubule cage drives LMNA-associated cardiomyopathy and may represent a promising therapeutic target.

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Microtubule forces drive nuclear damage in LMNA cardiomyopathy - Nature Cardiovascular Research
Amiad Pavlov, Heffler, et al. demonstrate that stress transmitted to the cardiomyocyte nucleus by the microtubule cage drives LMNA-associated cardiomyopathy and may represent a promising therapeutic t...
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November 4, 2025 at 2:56 PM
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Research | Yamazoe et al. show that B-cell derived autoantibodies contribute to the development of atrial fibrillation, suggesting that targeting the humoral immune response may represent a viable therapeutic approach.

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B cells promote atrial fibrillation via autoantibodies - Nature Cardiovascular Research
Yamazoe et al. show that B cell-derived autoantibodies contribute to the development of atrial fibrillation, suggesting that targeting the humoral immune response may represent a viable therapeutic ap...
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October 31, 2025 at 1:43 PM
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Research | Mulholland et al. identify progenitor exhausted T cells, expressing intermediate levels of PD1, as a prominent source of pro-inflammatory cytokines in the murine atherosclerotic aorta and potential cellular targets.

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Progenitor exhausted PD-1+ T cells are cellular targets of immune checkpoint inhibition in atherosclerosis - Nature Cardiovascular Research
Mulholland et al. identify progenitor exhausted T cells, expressing intermediate levels of PD-1 (PD-1int), as a prominent source of pro-inflammatory cytokines in the murine atherosclerotic aorta and p...
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October 21, 2025 at 1:53 PM
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❤️Our October issue is out❤️Read about the RNA editing enzyme ADAR1 regulating atherosclerosis progression, PGC-1α and cardiac adaptation to exercise training, the role of LYVE1-macrophages in heart regeneration and peripheral artery disease, and more.
Image: ScienceBrush Design. Cover design: Bethany Vukomanovic; RNA editing in atherosclerosis: Weldy et al. show that expression of the RNA-editing enzyme ADAR1 in smooth muscle cells regulates activation of the double-stranded RNA sensor MDA5, in a new model of atherosclerosis.
October 15, 2025 at 2:41 PM
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Research | Barbera et al. identify and map genetic variants that alter the characteristics of vascular smooth muscle cells and contribute to the risk of coronary artery disease.

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October 14, 2025 at 2:43 PM
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Research | Giardini et al. present an imaging method that combines measurements of cardiac electrophysiology with high-resolution 3D structural reconstructions and detects electrical coupling between cardiomyocytes and non-myocytes in murine hearts.

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October 13, 2025 at 3:40 PM
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Research | Wünnemann et al. generate a subcellular resolution spatial map of the murine heart after myocardial infarction, revealing that immune cells can infiltrate the organ through the endocardium.

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Spatial multiomics of acute myocardial infarction reveals immune cell infiltration through the endocardium - Nature Cardiovascular Research
Wünnemann et al. generate a subcellular resolution spatial map of the murine heart after myocardial infarction, revealing that immune cells can infiltrate the organ through the endocardium.
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October 10, 2025 at 1:50 PM
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Research | Boccella, Yu and colleagues reveal that the transmembrane protein ANTXR1 regulates post-infarction fibrotic remodelling, and its inhibition blocks collagen turnover and improves heart function.

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ANTXR1 blockade enhances cardiac function in preclinical models of heart failure - Nature Cardiovascular Research
Boccella, Yu and colleagues reveal that the transmembrane protein ANTXR1 regulates post-infarction fibrotic remodeling, and its inhibition blocks collagen turnover and improves heart function.
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October 9, 2025 at 3:24 PM
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Research | Lekkos et al. show that a metabolic switch towards oxidative phosphorylation is required for cardiomyocyte re-differentiation and heart regeneration after injury in fish.
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Oxidative phosphorylation is required for cardiomyocyte re-differentiation and long-term fish heart regeneration - Nature Cardiovascular Research
Lekkos et al. show that a metabolic switch toward oxidative phosphorylation is required for cardiomyocyte re-differentiation and heart regeneration after injury in fish.
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October 8, 2025 at 3:43 PM
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Research | Deficiency of GAPARAPL1 impairs diastolic function in diabetic mice. This effect can be reversed by gene delivery of the gene encoding GABARAPL1 in diabetic mice and in human organoids of type 2 diabetes.
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Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues - Nature Cardiovascular Research
Mellor et al. report that deficiency of GABARAPL1, an ATG8-specific linking protein, impairs diastolic function in diabetic mice. This effect can be reversed by gene delivery of the gene encoding GABARAPL1 in diabetic mice and a human organoid model of type 2 diabetes.
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October 7, 2025 at 3:08 PM
natcardiovascres.nature.com
❤️Our September issue is out❤️Discover how primary cilia regulate valve development, a human ocular outflow on-chip, regional and sex-specific transcriptional programs in the aorta and more!
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Image: Kathryn Berg. Cover design: Bethany Vukomanovic
September 23, 2025 at 12:16 PM
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Our chief editor, Vesna Todorovic, and associate editor Andrea Tavosanis are attending the #ESCCongress in Madrid! Get in touch if you would like to learn more about the journal or discuss your work
August 29, 2025 at 12:40 PM
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Research | Watanabe et al. show that cytopathic hypoxia, through the upregulation of COX2 and secretory PLA2, stabilises HIF-1a, contributing to impaired mitochondrial respiration and reduced cardiac contraction in septic cardiomyopathy.
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Excessive HIF-1α driven by phospholipid metabolism causes septic cardiomyopathy through cytopathic hypoxia - Nature Cardiovascular Research
Watanabe et al. show that cytopathic hypoxia, through upregulation of COX2 and secretory PLA2, stabilizes HIF-1α, contributing to impaired mitochondrial respiration and reduced cardiac contraction in ...
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August 19, 2025 at 5:22 PM
natcardiovascres.nature.com
❤️Our August issue is out❤️Discover how premenstrual disorders increase cardiovascular risk, a new diagnostic deep learning model for hypertrophic cardiomyopathy, the relationship between membrane cholesterol accessibility and vascular leakage, and more!
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Image: Heart and uterus image: Viarshyla Hanna / Alamy Stock Photo. Cover design: Bethany Vukomanovic
August 13, 2025 at 4:49 PM
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Zheng et al. generate a triple phospho-ablation mouse model to show that RyR2 phosphorylation at canonical sites is dispensable for chronotropy and inotropy, but required for electrical stability during adrenergic stimulation.
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Preventing the phosphorylation of RyR2 at canonical sites reduces Ca2+ leak and promotes arrhythmia by reactivating the INa current
Nature Cardiovascular Research - Zheng et al. generated a mouse model of phospho-ablation in all canonical ryanodine receptor 2 (RyR2) phosphorylation sites. They show that RyR2 phosphorylation at...
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August 12, 2025 at 4:44 PM