Nature Cardiovascular Research
@natcardiovascres.nature.com
Online-only Nature Research journal that publishes basic, translational, clinical and public health research in cardiac, vascular and blood biology.
https://www.nature.com/natcardiovascres/
https://www.nature.com/natcardiovascres/
Research | Neo et al. map blood emergence from three hemogenic endothelial (HE) populations biased toward distinct blood fates. HE primed for stem progenitors shows elevated chromatin and RNA splicing gene expression and greater isoform diversity.
doi.org/10.1038/s441...
rdcu.be/eQxPN
doi.org/10.1038/s441...
rdcu.be/eQxPN
doi.org
November 18, 2025 at 12:46 PM
Research | Neo et al. map blood emergence from three hemogenic endothelial (HE) populations biased toward distinct blood fates. HE primed for stem progenitors shows elevated chromatin and RNA splicing gene expression and greater isoform diversity.
doi.org/10.1038/s441...
rdcu.be/eQxPN
doi.org/10.1038/s441...
rdcu.be/eQxPN
❤️Our November issue is out❤️Read about an imaging method that combines cardiac electrophysiology with 3D structural heart reconstruction, a targeted glycophagy ATG8 therapy reversing diabetic heart disease, and more.
www.nature.com/natcardiovas...
www.nature.com/natcardiovas...
November 13, 2025 at 1:50 PM
❤️Our November issue is out❤️Read about an imaging method that combines cardiac electrophysiology with 3D structural heart reconstruction, a targeted glycophagy ATG8 therapy reversing diabetic heart disease, and more.
www.nature.com/natcardiovas...
www.nature.com/natcardiovas...
Research | Chan et al. generate a high-resolution spatiotemporal atlas of healing hearts and reveal cellular networks of lesion repair, including macrophage-fibroblast interactions that control late-stage fibrosis.
doi.org/10.1038/s441...
rdcu.be/ePzs6
doi.org/10.1038/s441...
rdcu.be/ePzs6
Spatiotemporal dynamics of the cardioimmune niche during lesion repair - Nature Cardiovascular Research
Chan et al. generate a high-resolution spatiotemporal atlas of healing hearts and reveal cellular networks of lesion repair, including macrophage–fibroblast interactions that control late-stage fibros...
doi.org
November 12, 2025 at 2:22 PM
Research | Chan et al. generate a high-resolution spatiotemporal atlas of healing hearts and reveal cellular networks of lesion repair, including macrophage-fibroblast interactions that control late-stage fibrosis.
doi.org/10.1038/s441...
rdcu.be/ePzs6
doi.org/10.1038/s441...
rdcu.be/ePzs6
Research | Chen, Wang, Zhong and colleagues show that females derive greater cardiovascular benefits from guideline-recommended levels of physical activity and require less activity than males to see their beneficial effects.
doi.org/10.1038/s441...
rdcu.be/ePoLS
doi.org/10.1038/s441...
rdcu.be/ePoLS
Sex differences in the association of wearable accelerometer-derived physical activity with coronary heart disease incidence and mortality - Nature Cardiovascular Research
Chen, Wang, Zhong and colleagues show that females derive greater cardiovascular benefits from guideline-recommended levels of physical activity and require less activity than males to see their benef...
doi.org
November 11, 2025 at 3:37 PM
Research | Chen, Wang, Zhong and colleagues show that females derive greater cardiovascular benefits from guideline-recommended levels of physical activity and require less activity than males to see their beneficial effects.
doi.org/10.1038/s441...
rdcu.be/ePoLS
doi.org/10.1038/s441...
rdcu.be/ePoLS
Research | Tan et al. identify PRDM16 as a key repressor of fibrotic switching in smooth muscle cells and show that its downregulation in atherosclerosis drives smooth muscle cells toward a synthetic fate, promoting fibrous plaques.
doi.org/10.1038/s441...
rdcu.be/eOBP0
doi.org/10.1038/s441...
rdcu.be/eOBP0
PRDM16 regulates smooth muscle cell identity and atherosclerotic plaque composition - Nature Cardiovascular Research
Tan et al. identify PRDM16 as a key repressor of fibrotic switching in smooth muscle cells and show that its downregulation in atherosclerosis drives smooth muscle cells toward a synthetic fate, promo...
doi.org
November 6, 2025 at 3:35 PM
Research | Tan et al. identify PRDM16 as a key repressor of fibrotic switching in smooth muscle cells and show that its downregulation in atherosclerosis drives smooth muscle cells toward a synthetic fate, promoting fibrous plaques.
doi.org/10.1038/s441...
rdcu.be/eOBP0
doi.org/10.1038/s441...
rdcu.be/eOBP0
Research | Lin, Geng et al. identify a non-canonical AHR pathway that is activated by canonical AHR inhibitors, promoting the proliferation of quiescent endothelial cells with potential applications in cell therapy.
doi.org/10.1038/s441...
rdcu.be/eOoxB
doi.org/10.1038/s441...
rdcu.be/eOoxB
A non-canonical aryl hydrocarbon receptor pathway authorizes and safeguards clinical-scale expansion of functional human endothelial cells - Nature Cardiovascular Research
Lin, Geng and colleagues identify a non-canonical AHR pathway that is activated by canonical AHR inhibitors, promoting the proliferation of quiescent endothelial cells with potential applications in c...
doi.org
November 5, 2025 at 1:32 PM
Research | Lin, Geng et al. identify a non-canonical AHR pathway that is activated by canonical AHR inhibitors, promoting the proliferation of quiescent endothelial cells with potential applications in cell therapy.
doi.org/10.1038/s441...
rdcu.be/eOoxB
doi.org/10.1038/s441...
rdcu.be/eOoxB
Research | Amiad Pavlov, Heffler et al. demonstrate that stress transmitted to the cardiomyocyte nucleus by the microtubule cage drives LMNA-associated cardiomyopathy and may represent a promising therapeutic target.
doi.org/10.1038/s441...
rdcu.be/eOeTA
doi.org/10.1038/s441...
rdcu.be/eOeTA
Microtubule forces drive nuclear damage in LMNA cardiomyopathy - Nature Cardiovascular Research
Amiad Pavlov, Heffler, et al. demonstrate that stress transmitted to the cardiomyocyte nucleus by the microtubule cage drives LMNA-associated cardiomyopathy and may represent a promising therapeutic t...
doi.org
November 4, 2025 at 2:56 PM
Research | Amiad Pavlov, Heffler et al. demonstrate that stress transmitted to the cardiomyocyte nucleus by the microtubule cage drives LMNA-associated cardiomyopathy and may represent a promising therapeutic target.
doi.org/10.1038/s441...
rdcu.be/eOeTA
doi.org/10.1038/s441...
rdcu.be/eOeTA
Research | Yamazoe et al. show that B-cell derived autoantibodies contribute to the development of atrial fibrillation, suggesting that targeting the humoral immune response may represent a viable therapeutic approach.
doi.org/10.1038/s441...
rdcu.be/eNFJV
doi.org/10.1038/s441...
rdcu.be/eNFJV
B cells promote atrial fibrillation via autoantibodies - Nature Cardiovascular Research
Yamazoe et al. show that B cell-derived autoantibodies contribute to the development of atrial fibrillation, suggesting that targeting the humoral immune response may represent a viable therapeutic ap...
doi.org
October 31, 2025 at 1:43 PM
Research | Yamazoe et al. show that B-cell derived autoantibodies contribute to the development of atrial fibrillation, suggesting that targeting the humoral immune response may represent a viable therapeutic approach.
doi.org/10.1038/s441...
rdcu.be/eNFJV
doi.org/10.1038/s441...
rdcu.be/eNFJV
Research | Mulholland et al. identify progenitor exhausted T cells, expressing intermediate levels of PD1, as a prominent source of pro-inflammatory cytokines in the murine atherosclerotic aorta and potential cellular targets.
doi.org/10.1038/s441...
rdcu.be/eL2nN
doi.org/10.1038/s441...
rdcu.be/eL2nN
Progenitor exhausted PD-1+ T cells are cellular targets of immune checkpoint inhibition in atherosclerosis - Nature Cardiovascular Research
Mulholland et al. identify progenitor exhausted T cells, expressing intermediate levels of PD-1 (PD-1int), as a prominent source of pro-inflammatory cytokines in the murine atherosclerotic aorta and p...
doi.org
October 21, 2025 at 1:53 PM
Research | Mulholland et al. identify progenitor exhausted T cells, expressing intermediate levels of PD1, as a prominent source of pro-inflammatory cytokines in the murine atherosclerotic aorta and potential cellular targets.
doi.org/10.1038/s441...
rdcu.be/eL2nN
doi.org/10.1038/s441...
rdcu.be/eL2nN
❤️Our October issue is out❤️Read about the RNA editing enzyme ADAR1 regulating atherosclerosis progression, PGC-1α and cardiac adaptation to exercise training, the role of LYVE1-macrophages in heart regeneration and peripheral artery disease, and more.
October 15, 2025 at 2:41 PM
❤️Our October issue is out❤️Read about the RNA editing enzyme ADAR1 regulating atherosclerosis progression, PGC-1α and cardiac adaptation to exercise training, the role of LYVE1-macrophages in heart regeneration and peripheral artery disease, and more.
Research | Barbera et al. identify and map genetic variants that alter the characteristics of vascular smooth muscle cells and contribute to the risk of coronary artery disease.
doi.org/10.1038/s441...
rdcu.be/eKY2S
doi.org/10.1038/s441...
rdcu.be/eKY2S
Client Challenge
doi.org
October 14, 2025 at 2:43 PM
Research | Barbera et al. identify and map genetic variants that alter the characteristics of vascular smooth muscle cells and contribute to the risk of coronary artery disease.
doi.org/10.1038/s441...
rdcu.be/eKY2S
doi.org/10.1038/s441...
rdcu.be/eKY2S
Research | Giardini et al. present an imaging method that combines measurements of cardiac electrophysiology with high-resolution 3D structural reconstructions and detects electrical coupling between cardiomyocytes and non-myocytes in murine hearts.
doi.org/10.1038/s441...
rdcu.be/eKNZT
doi.org/10.1038/s441...
rdcu.be/eKNZT
Client Challenge
doi.org
October 13, 2025 at 3:40 PM
Research | Giardini et al. present an imaging method that combines measurements of cardiac electrophysiology with high-resolution 3D structural reconstructions and detects electrical coupling between cardiomyocytes and non-myocytes in murine hearts.
doi.org/10.1038/s441...
rdcu.be/eKNZT
doi.org/10.1038/s441...
rdcu.be/eKNZT
Research | Wünnemann et al. generate a subcellular resolution spatial map of the murine heart after myocardial infarction, revealing that immune cells can infiltrate the organ through the endocardium.
doi.org/10.1038/s441...
rdcu.be/eKnDf
doi.org/10.1038/s441...
rdcu.be/eKnDf
Spatial multiomics of acute myocardial infarction reveals immune cell infiltration through the endocardium - Nature Cardiovascular Research
Wünnemann et al. generate a subcellular resolution spatial map of the murine heart after myocardial infarction, revealing that immune cells can infiltrate the organ through the endocardium.
doi.org
October 10, 2025 at 1:50 PM
Research | Wünnemann et al. generate a subcellular resolution spatial map of the murine heart after myocardial infarction, revealing that immune cells can infiltrate the organ through the endocardium.
doi.org/10.1038/s441...
rdcu.be/eKnDf
doi.org/10.1038/s441...
rdcu.be/eKnDf
Research | Boccella, Yu and colleagues reveal that the transmembrane protein ANTXR1 regulates post-infarction fibrotic remodelling, and its inhibition blocks collagen turnover and improves heart function.
doi.org/10.1038/s441...
rdcu.be/eKcfF
doi.org/10.1038/s441...
rdcu.be/eKcfF
ANTXR1 blockade enhances cardiac function in preclinical models of heart failure - Nature Cardiovascular Research
Boccella, Yu and colleagues reveal that the transmembrane protein ANTXR1 regulates post-infarction fibrotic remodeling, and its inhibition blocks collagen turnover and improves heart function.
doi.org
October 9, 2025 at 3:24 PM
Research | Boccella, Yu and colleagues reveal that the transmembrane protein ANTXR1 regulates post-infarction fibrotic remodelling, and its inhibition blocks collagen turnover and improves heart function.
doi.org/10.1038/s441...
rdcu.be/eKcfF
doi.org/10.1038/s441...
rdcu.be/eKcfF
Research | Lekkos et al. show that a metabolic switch towards oxidative phosphorylation is required for cardiomyocyte re-differentiation and heart regeneration after injury in fish.
doi.org/10.1038/s441...
rdcu.be/eJ3sB
doi.org/10.1038/s441...
rdcu.be/eJ3sB
Oxidative phosphorylation is required for cardiomyocyte re-differentiation and long-term fish heart regeneration - Nature Cardiovascular Research
Lekkos et al. show that a metabolic switch toward oxidative phosphorylation is required for cardiomyocyte re-differentiation and heart regeneration after injury in fish.
doi.org
October 8, 2025 at 3:43 PM
Research | Lekkos et al. show that a metabolic switch towards oxidative phosphorylation is required for cardiomyocyte re-differentiation and heart regeneration after injury in fish.
doi.org/10.1038/s441...
rdcu.be/eJ3sB
doi.org/10.1038/s441...
rdcu.be/eJ3sB
Research | Deficiency of GAPARAPL1 impairs diastolic function in diabetic mice. This effect can be reversed by gene delivery of the gene encoding GABARAPL1 in diabetic mice and in human organoids of type 2 diabetes.
@DelbridgeLab
doi.org/10.1038/s441...
rdcu.be/eJSl7
@DelbridgeLab
doi.org/10.1038/s441...
rdcu.be/eJSl7
Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues - Nature Cardiovascular Research
Mellor et al. report that deficiency of GABARAPL1, an ATG8-specific linking protein, impairs diastolic function in diabetic mice. This effect can be reversed by gene delivery of the gene encoding GABARAPL1 in diabetic mice and a human organoid model of type 2 diabetes.
doi.org
October 7, 2025 at 3:08 PM
Research | Deficiency of GAPARAPL1 impairs diastolic function in diabetic mice. This effect can be reversed by gene delivery of the gene encoding GABARAPL1 in diabetic mice and in human organoids of type 2 diabetes.
@DelbridgeLab
doi.org/10.1038/s441...
rdcu.be/eJSl7
@DelbridgeLab
doi.org/10.1038/s441...
rdcu.be/eJSl7
❤️Our September issue is out❤️Discover how primary cilia regulate valve development, a human ocular outflow on-chip, regional and sex-specific transcriptional programs in the aorta and more!
www.nature.com/natcardiovas...
www.nature.com/natcardiovas...
September 23, 2025 at 12:16 PM
❤️Our September issue is out❤️Discover how primary cilia regulate valve development, a human ocular outflow on-chip, regional and sex-specific transcriptional programs in the aorta and more!
www.nature.com/natcardiovas...
www.nature.com/natcardiovas...
Our chief editor, Vesna Todorovic, and associate editor Andrea Tavosanis are attending the #ESCCongress in Madrid! Get in touch if you would like to learn more about the journal or discuss your work
August 29, 2025 at 12:40 PM
Our chief editor, Vesna Todorovic, and associate editor Andrea Tavosanis are attending the #ESCCongress in Madrid! Get in touch if you would like to learn more about the journal or discuss your work
Research | Watanabe et al. show that cytopathic hypoxia, through the upregulation of COX2 and secretory PLA2, stabilises HIF-1a, contributing to impaired mitochondrial respiration and reduced cardiac contraction in septic cardiomyopathy.
doi.org/10.1038/s441...
doi.org/10.1038/s441...
Excessive HIF-1α driven by phospholipid metabolism causes septic cardiomyopathy through cytopathic hypoxia - Nature Cardiovascular Research
Watanabe et al. show that cytopathic hypoxia, through upregulation of COX2 and secretory PLA2, stabilizes HIF-1α, contributing to impaired mitochondrial respiration and reduced cardiac contraction in ...
doi.org
August 19, 2025 at 5:22 PM
Research | Watanabe et al. show that cytopathic hypoxia, through the upregulation of COX2 and secretory PLA2, stabilises HIF-1a, contributing to impaired mitochondrial respiration and reduced cardiac contraction in septic cardiomyopathy.
doi.org/10.1038/s441...
doi.org/10.1038/s441...
❤️Our August issue is out❤️Discover how premenstrual disorders increase cardiovascular risk, a new diagnostic deep learning model for hypertrophic cardiomyopathy, the relationship between membrane cholesterol accessibility and vascular leakage, and more!
www.nature.com/natcardiovas...
www.nature.com/natcardiovas...
August 13, 2025 at 4:49 PM
❤️Our August issue is out❤️Discover how premenstrual disorders increase cardiovascular risk, a new diagnostic deep learning model for hypertrophic cardiomyopathy, the relationship between membrane cholesterol accessibility and vascular leakage, and more!
www.nature.com/natcardiovas...
www.nature.com/natcardiovas...
Zheng et al. generate a triple phospho-ablation mouse model to show that RyR2 phosphorylation at canonical sites is dispensable for chronotropy and inotropy, but required for electrical stability during adrenergic stimulation.
rdcu.be/eArYg
doi.org/10.1038/s441...
rdcu.be/eArYg
doi.org/10.1038/s441...
Preventing the phosphorylation of RyR2 at canonical sites reduces Ca2+ leak and promotes arrhythmia by reactivating the INa current
Nature Cardiovascular Research - Zheng et al. generated a mouse model of phospho-ablation in all canonical ryanodine receptor 2 (RyR2) phosphorylation sites. They show that RyR2 phosphorylation at...
rdcu.be
August 12, 2025 at 4:44 PM
Zheng et al. generate a triple phospho-ablation mouse model to show that RyR2 phosphorylation at canonical sites is dispensable for chronotropy and inotropy, but required for electrical stability during adrenergic stimulation.
rdcu.be/eArYg
doi.org/10.1038/s441...
rdcu.be/eArYg
doi.org/10.1038/s441...
Ding, Y., Chen, J., Liu, S. et al show that tetraspanin regulates the level of accessible cholesterol on endothelial cells via OSBP/ORP-mediated transport to balance Cdc42 and RhoA activities and influence vascular inflammation.
rdcu.be/eym4W
rdcu.be/eym4W
Tetraspanin-enriched membrane domains regulate vascular leakage by altering membrane cholesterol accessibility to balance antagonistic GTPases
Nature Cardiovascular Research - By regulating the level of accessible cholesterol on endothelial cells via OSBP/ORP-mediated transport, tetraspanin tunes the balance of Cdc42 and RhoA activities...
rdcu.be
July 29, 2025 at 3:57 PM
Ding, Y., Chen, J., Liu, S. et al show that tetraspanin regulates the level of accessible cholesterol on endothelial cells via OSBP/ORP-mediated transport to balance Cdc42 and RhoA activities and influence vascular inflammation.
rdcu.be/eym4W
rdcu.be/eym4W
Research | Sangha, Dhingra et al. develop and validate a deep learning model to diagnose hypertrophic cardiomyopathy from electrocardiographic images, demonstrating its effectiveness across multiple 12-lead layouts.
rdcu.be/exm9t
rdcu.be/exm9t
Identification of hypertrophic cardiomyopathy on electrocardiographic images with deep learning - Nature Cardiovascular Research
Sangha, Dhingra et al. develop and validate a deep learning model to diagnose hypertrophic cardiomyopathy from electrocardiographic images, demonstrating its effectiveness across multiple 12-lead layo...
doi.org
July 22, 2025 at 4:02 PM
Research | Sangha, Dhingra et al. develop and validate a deep learning model to diagnose hypertrophic cardiomyopathy from electrocardiographic images, demonstrating its effectiveness across multiple 12-lead layouts.
rdcu.be/exm9t
rdcu.be/exm9t
Research| Chou et al. demonstrate that activation of the thrombin receptor PAR1 in the lung lymphatic vasculature augments lung lymphatic drainage in models of lung injury.
rdcu.be/ewDHm
rdcu.be/ewDHm
The thrombin receptor PAR1 orchestrates changes in lymphatic endothelial cell junction morphology to augment lymphatic drainage during lung injury - Nature Cardiovascular Research
Chou et al. demonstrate that activation of the thrombin receptor protease-activated receptor 1 in the lung lymphatic vasculature mediates morphological changes in lymphatic endothelial cell junctions ...
doi.org
July 17, 2025 at 3:51 PM
Research| Chou et al. demonstrate that activation of the thrombin receptor PAR1 in the lung lymphatic vasculature augments lung lymphatic drainage in models of lung injury.
rdcu.be/ewDHm
rdcu.be/ewDHm
❤️Our July issue is out❤️Discover an Angiopoietin-TIE2-dependent circuit promoting venous malformations, complex disease modelling in cardiac organoids, regulation of cardiac homeostasis by methyonil tRNA synthetase, and more!
www.nature.com/natcardiovas...
www.nature.com/natcardiovas...
July 15, 2025 at 4:11 PM
❤️Our July issue is out❤️Discover an Angiopoietin-TIE2-dependent circuit promoting venous malformations, complex disease modelling in cardiac organoids, regulation of cardiac homeostasis by methyonil tRNA synthetase, and more!
www.nature.com/natcardiovas...
www.nature.com/natcardiovas...