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natcardiovascres.nature.com
Nature Cardiovascular Research
@natcardiovascres.nature.com
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Online-only Nature Research journal that publishes basic, translational, clinical and public health research in cardiac, vascular and blood biology.
https://www.nature.com/natcardiovascres/
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natcardiovascres.nature.com
Big thanks to the Science Ministry of Serbia and our speakers, Drs. Knoblich, Guilliatt, Stewart, & Turco, and Profs. Radisic, Hedtrich, Clevers, Vunjak-Novakovic, Trayanova, Lütolf, Heilshorn, Dvir, Cho & Singh for the great event!

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December 19, 2025 at 2:44 PM
natcardiovascres.nature.com
❤️Our December issue is out❤️Read about a method to measure mitochondrial membrane potential in intact hearts, gene therapy for myocardial infarction, genetic association between thromboembolism and long COVID, and more.

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Image: Bethany Vukomanovic. Cover design: Bethany Vukomanovic Genetic insights into long COVID Human genetic analyses show that thromboembolism-related variants are associated with an increased risk of long COVID, suggesting shared pathogenic pathways and implicating the thrombin receptor PAR-1 as a potential contributor. (see Schuermans et al.)
December 17, 2025 at 5:00 PM
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❤️Our November issue is out❤️Read about an imaging method that combines cardiac electrophysiology with 3D structural heart reconstruction, a targeted glycophagy ATG8 therapy reversing diabetic heart disease, and more.

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Image: Leonardo Sacconi, Institute of Clinical Physiology. Cover design: Bethany Vukomanovic Cardiac fibrosis and arrhythmia Three-dimensional structural reconstruction of entire cleared mouse ventricles from a diseased heart acquired using mesoSPIM tomography. Myocardium is visualized by fluorescence (gray), and fibrosis is detected via scattered light (red) (see Giardini et al.).
November 13, 2025 at 1:50 PM
natcardiovascres.nature.com
❤️Our October issue is out❤️Read about the RNA editing enzyme ADAR1 regulating atherosclerosis progression, PGC-1α and cardiac adaptation to exercise training, the role of LYVE1-macrophages in heart regeneration and peripheral artery disease, and more.
Image: ScienceBrush Design. Cover design: Bethany Vukomanovic; RNA editing in atherosclerosis: Weldy et al. show that expression of the RNA-editing enzyme ADAR1 in smooth muscle cells regulates activation of the double-stranded RNA sensor MDA5, in a new model of atherosclerosis.
October 15, 2025 at 2:41 PM
natcardiovascres.nature.com
❤️Our September issue is out❤️Discover how primary cilia regulate valve development, a human ocular outflow on-chip, regional and sex-specific transcriptional programs in the aorta and more!
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Image: Kathryn Berg. Cover design: Bethany Vukomanovic
September 23, 2025 at 12:16 PM
natcardiovascres.nature.com
❤️Our August issue is out❤️Discover how premenstrual disorders increase cardiovascular risk, a new diagnostic deep learning model for hypertrophic cardiomyopathy, the relationship between membrane cholesterol accessibility and vascular leakage, and more!
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Image: Heart and uterus image: Viarshyla Hanna / Alamy Stock Photo. Cover design: Bethany Vukomanovic
August 13, 2025 at 4:49 PM
natcardiovascres.nature.com
❤️Our July issue is out❤️Discover an Angiopoietin-TIE2-dependent circuit promoting venous malformations, complex disease modelling in cardiac organoids, regulation of cardiac homeostasis by methyonil tRNA synthetase, and more!

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July 15, 2025 at 4:11 PM
natcardiovascres.nature.com
❤️Our June issue is out❤️Read about the insight from the LILACS trial on T-cell regulation in cardiology, empagliflozin’s role in protecting the kidney and preventing heart failure in the EMPACT-MI trial, and more!
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Image: Georgios Rovas, École Polytechnique Fédérale de Lausanne, 2025. Cover design: Bethany Vukomanovic
June 23, 2025 at 3:55 PM
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❤️Our May issue is out❤️Read our three articles focused on atherosclerosis, describing TLO-like structures within plaques, FDX1’s protective role, and how gut microbiota-derived bile acids suppress platelet activation, and more!
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Image credit: Deqiang Kong, Yue Wang and Tianxing Yan. Cover design: Bethany Vukomanovic
May 19, 2025 at 1:27 PM
natcardiovascres.nature.com
❤️Our April issue is out❤️ Read about sex differences in atherosclerosis revealed by single-cell sequencing, how cardiac motion can be generated from electrocardiogram readings, the cardiac side effects of targeting immune checkpoint regulators, and more!

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Image: Atherosclerosis vessel: KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty; background: nobeastsofierce Science / Alamy Stock Photo. Cover design: Bethany Vukomanovic
April 15, 2025 at 12:42 PM
natcardiovascres.nature.com
Research| Sukhavasi et al. reveal sex-specific differences in carotid stenosis. Deep single-cell sequencing shows distinct phenotypes in smooth muscle cells: osteogenic in females and chondrocytic in males, highlighting potential therapeutic targets.
A schematic illustrating the key stages and components of the overall study design.
April 11, 2025 at 4:09 PM
natcardiovascres.nature.com
Research| Li, Ni, Wang et al. identify CD248+ fibroblasts as key players in cardiac fibrosis, promoting fibroblast-T cell interactions. Disrupting CD248-mediated pathways shows promise in reducing fibrosis and improving heart function.

👉https://rdcu.be/efPj0
a, UMAP of fibroblast subpopulations from different spatial positions of mouse hearts subjected to sham and MI (sham, 3 days and 28 days after infarction). n = 3 in each scRNA-seq group. b, Top marker genes expressed in each fibroblast subpopulation. c, Proportion of each fibroblast subpopulation in cardiac infarcted and remote zones at 3 days and 28 days after infarction. d, GO analysis of Cd248/Ackr3 F9 subset. e, Violin plots reflecting the Cd248 expression level in each fibroblast subpopulation (n = 15 animals). f, Violin plots reflecting the expression level of Cd248 in infarcted and remote zones at 3 days and 28 days after infarction with sham as control (n = 3 animals).
March 31, 2025 at 2:37 PM