Nonia Pariente
@npariente.bsky.social
Editor in Chief of the #NonProfit, #OpenAccess journal @plosbiology.org Former Chief Editor of Nature Microbiology.
#Virologist. #Feminist. #Spaniard in the UK. #Galician. #European always.
Views my own.
https://orcid.org/0000-0002-3666-5683
#Virologist. #Feminist. #Spaniard in the UK. #Galician. #European always.
Views my own.
https://orcid.org/0000-0002-3666-5683
Pinned
Nonia Pariente
@npariente.bsky.social
· Nov 22
Hi Bluesky! 👋
Dipping my toes here given the dumpsterfire over at X. I am Editor in Chief of #PLOSBiology, interested in all things #science.
#virologist, passionate about #OpenScience & making #publication process constructive & transparent.
I look forward to rebuilding community here!
Dipping my toes here given the dumpsterfire over at X. I am Editor in Chief of #PLOSBiology, interested in all things #science.
#virologist, passionate about #OpenScience & making #publication process constructive & transparent.
I look forward to rebuilding community here!
Reposted by Nonia Pariente
Eye-opening article on Russia’s low-level war on Europe by recruiting ‘single-use agents’. Inside Russia’s Secret Campaign of Sabotage in Europe www.newyorker.com/magazine/202...
Inside Russia’s Secret Campaign of Sabotage in Europe
How Russian military intelligence is recruiting young people online to carry out espionage, arson, and other attacks across the Continent.
www.newyorker.com
February 15, 2026 at 6:10 PM
Eye-opening article on Russia’s low-level war on Europe by recruiting ‘single-use agents’. Inside Russia’s Secret Campaign of Sabotage in Europe www.newyorker.com/magazine/202...
Reposted by Nonia Pariente
How do diverse synapses relate spatially to whole-brain dynamics? @misicbata.bsky.social &co map ~1 billion synaptic puncta from a single mouse brain onto #hemodynamic features, revealing links between #synapse features, #brain networks & synaptic engagement @plosbiology.org 🧪 plos.io/4rmeef6
February 13, 2026 at 1:55 PM
How do diverse synapses relate spatially to whole-brain dynamics? @misicbata.bsky.social &co map ~1 billion synaptic puncta from a single mouse brain onto #hemodynamic features, revealing links between #synapse features, #brain networks & synaptic engagement @plosbiology.org 🧪 plos.io/4rmeef6
Reposted by Nonia Pariente
Regardless, I am very looking forward to a few days in the one place I still think of as home, despite not having lived there since the fall of 1996 (God I am old!)
February 12, 2026 at 7:56 PM
Regardless, I am very looking forward to a few days in the one place I still think of as home, despite not having lived there since the fall of 1996 (God I am old!)
Regardless, I am very looking forward to a few days in the one place I still think of as home, despite not having lived there since the fall of 1996 (God I am old!)
February 12, 2026 at 7:56 PM
Regardless, I am very looking forward to a few days in the one place I still think of as home, despite not having lived there since the fall of 1996 (God I am old!)
How your email will find me tomorrow and next week
February 12, 2026 at 7:03 PM
How your email will find me tomorrow and next week
Reposted by Nonia Pariente
😎 paper alert!
Nice work from the Laub lab showing that binding to ring structures made by different phage defense proteins activates RNAse to inhibits translation and phage infection. It needs to be in a 24-meric ring structure to cut.
🧪#microsky
Nice work from the Laub lab showing that binding to ring structures made by different phage defense proteins activates RNAse to inhibits translation and phage infection. It needs to be in a 24-meric ring structure to cut.
🧪#microsky
February 6, 2026 at 9:50 AM
😎 paper alert!
Nice work from the Laub lab showing that binding to ring structures made by different phage defense proteins activates RNAse to inhibits translation and phage infection. It needs to be in a 24-meric ring structure to cut.
🧪#microsky
Nice work from the Laub lab showing that binding to ring structures made by different phage defense proteins activates RNAse to inhibits translation and phage infection. It needs to be in a 24-meric ring structure to cut.
🧪#microsky
😎 paper alert!
Nice work from the Laub lab showing that binding to ring structures made by different phage defense proteins activates RNAse to inhibits translation and phage infection. It needs to be in a 24-meric ring structure to cut.
🧪#microsky
Nice work from the Laub lab showing that binding to ring structures made by different phage defense proteins activates RNAse to inhibits translation and phage infection. It needs to be in a 24-meric ring structure to cut.
🧪#microsky
February 6, 2026 at 9:50 AM
😎 paper alert!
Nice work from the Laub lab showing that binding to ring structures made by different phage defense proteins activates RNAse to inhibits translation and phage infection. It needs to be in a 24-meric ring structure to cut.
🧪#microsky
Nice work from the Laub lab showing that binding to ring structures made by different phage defense proteins activates RNAse to inhibits translation and phage infection. It needs to be in a 24-meric ring structure to cut.
🧪#microsky
Reposted by Nonia Pariente
The James Chen lab does it again!
PI(3,5)P2 identified as the molecular glue that mediates STING oligomerization upon cGAMP binding, necessary for downstream signaling
😎 work!
🧪
PI(3,5)P2 identified as the molecular glue that mediates STING oligomerization upon cGAMP binding, necessary for downstream signaling
😎 work!
🧪
Nature research paper: PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling
go.nature.com/4klvMp1
go.nature.com/4klvMp1
PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling - Nature
Phosphatidylinositol 3,5-bisphosphate is a ligand of STING and, together with cGAMP, induces STING activation and innate immune responses.
go.nature.com
February 5, 2026 at 9:10 AM
The James Chen lab does it again!
PI(3,5)P2 identified as the molecular glue that mediates STING oligomerization upon cGAMP binding, necessary for downstream signaling
😎 work!
🧪
PI(3,5)P2 identified as the molecular glue that mediates STING oligomerization upon cGAMP binding, necessary for downstream signaling
😎 work!
🧪
The James Chen lab does it again!
PI(3,5)P2 identified as the molecular glue that mediates STING oligomerization upon cGAMP binding, necessary for downstream signaling
😎 work!
🧪
PI(3,5)P2 identified as the molecular glue that mediates STING oligomerization upon cGAMP binding, necessary for downstream signaling
😎 work!
🧪
Nature research paper: PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling
go.nature.com/4klvMp1
go.nature.com/4klvMp1
PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling - Nature
Phosphatidylinositol 3,5-bisphosphate is a ligand of STING and, together with cGAMP, induces STING activation and innate immune responses.
go.nature.com
February 5, 2026 at 9:10 AM
The James Chen lab does it again!
PI(3,5)P2 identified as the molecular glue that mediates STING oligomerization upon cGAMP binding, necessary for downstream signaling
😎 work!
🧪
PI(3,5)P2 identified as the molecular glue that mediates STING oligomerization upon cGAMP binding, necessary for downstream signaling
😎 work!
🧪
Reposted by Nonia Pariente
The hometown newspaper that I read as a teenager through Watergate and Vietnam and made me crave the life of a reporter is now being butchered by a billionaire who had $75 million to bribe and flatter a president and his wife but nothing to save journalism, an bulwark of the republic itself. Got it.
February 4, 2026 at 4:25 PM
The hometown newspaper that I read as a teenager through Watergate and Vietnam and made me crave the life of a reporter is now being butchered by a billionaire who had $75 million to bribe and flatter a president and his wife but nothing to save journalism, an bulwark of the republic itself. Got it.
Reposted by Nonia Pariente
In their Perspective, Nicole Chapman and Hongbo Chi advocate for the use of systems biology approaches in #immunometabolism research as discovery tools for new therapeutic targets.
plos.io/4aR959z
plos.io/4aR959z
Multi-omics and perturbation screens as discovery tools in immunometabolism
Metabolic regulation of immune function is a complex and dynamic process. This Perspective highlights how systems biology approaches, including multi-omics profiling and perturbomics screening, are be...
plos.io
February 3, 2026 at 10:36 AM
In their Perspective, Nicole Chapman and Hongbo Chi advocate for the use of systems biology approaches in #immunometabolism research as discovery tools for new therapeutic targets.
plos.io/4aR959z
plos.io/4aR959z
Reposted by Nonia Pariente
In his Essay, Yun Sok Lee investigates the process of metaflammation, the chronic low-grade inflammatory response that occurs in metabolic diseases such as obesity and type 2 diabetes, exploring how systemic changes in #metabolism can affect tissue-resident immune cells plos.io/4sOCOqh
Immunometabolism in obesity: Understanding the beneficial and detrimental roles of inflammation
Chronic low-grade metabolic inflammation (known as metaflammation) drives insulin resistance and metabolic dysfunction in obesity. This Essay discusses the immunometabolic mechanisms underlying metafl...
plos.io
February 3, 2026 at 10:36 AM
In his Essay, Yun Sok Lee investigates the process of metaflammation, the chronic low-grade inflammatory response that occurs in metabolic diseases such as obesity and type 2 diabetes, exploring how systemic changes in #metabolism can affect tissue-resident immune cells plos.io/4sOCOqh
Reposted by Nonia Pariente
In their Essay, Griffin Gowdy and Alice Prince look at the role of immunometabolites in both driving and combating bacterial infections, with a focus on #pathogens that infect the lungs plos.io/4jpVnNb
How do immunometabolites shape bacterial infections?
Metabolites generated by both host and pathogen have a major impact on the severity and outcomes of infection. This Essay investigates how the study of immunometabolism has yielded insight into the mo...
plos.io
February 3, 2026 at 10:36 AM
In their Essay, Griffin Gowdy and Alice Prince look at the role of immunometabolites in both driving and combating bacterial infections, with a focus on #pathogens that infect the lungs plos.io/4jpVnNb
Reposted by Nonia Pariente
Finally, on a more holistic level, Guang Sheng Ling and colleagues suggest a two-pronged approach to targeting #immunometabolism therapeutically through pharmaceutical and lifestyle interventions, with a focus on #cancer plos.io/4jNASKk
Targeting immunometabolism in cancer through pharmacological and lifestyle interventions
Immunometabolism is often disrupted in diseases such as cancer, suggesting it could be useful target for therapy. This Essay explores the potential for incorporating both lifestyle changes and drug th...
plos.io
February 3, 2026 at 10:36 AM
Finally, on a more holistic level, Guang Sheng Ling and colleagues suggest a two-pronged approach to targeting #immunometabolism therapeutically through pharmaceutical and lifestyle interventions, with a focus on #cancer plos.io/4jNASKk
Reposted by Nonia Pariente
Senior Editor Lucas Smith discusses his hopes for the field of #immunometabolism in his blog post plos.io/4qd5EOo
February 3, 2026 at 10:36 AM
Senior Editor Lucas Smith discusses his hopes for the field of #immunometabolism in his blog post plos.io/4qd5EOo
Reposted by Nonia Pariente
First, our Collection Editor Claudio Mauro introduces the theme for the Collection and his vision for the future of #immunometabolism research in his Editorial
plos.io/4qTmEu1
plos.io/4qTmEu1
February 3, 2026 at 10:36 AM
First, our Collection Editor Claudio Mauro introduces the theme for the Collection and his vision for the future of #immunometabolism research in his Editorial
plos.io/4qTmEu1
plos.io/4qTmEu1
Our latest collection of commentary and Essays is devoted to #immunometabolism, highlighting how molecular & cellular mechanisms impact tissue and organismal functions, as well as the therapeutic potential of manipulating immunometabolism
#cancer #aging #metabolism #inflammation
🧪
@plosbiology.org
#cancer #aging #metabolism #inflammation
🧪
@plosbiology.org
PLOS Biology is proud to present our new collection of comment and opinionated review articles on the many facets of #immunometabolism!
🧪 #immunosky #immunology #metabolism
plos.io/4c5z6Cn
See 🧵⬇️ for more details
🧪 #immunosky #immunology #metabolism
plos.io/4c5z6Cn
See 🧵⬇️ for more details
The many facets of immunometabolism
This Collection of articles aims to shine a light on the many facets of immunometabolism, highlighting how molecular and cellular mechanisms impact diverse tissue and organismal functions and the exci...
plos.io
February 4, 2026 at 6:10 PM
Our latest collection of commentary and Essays is devoted to #immunometabolism, highlighting how molecular & cellular mechanisms impact tissue and organismal functions, as well as the therapeutic potential of manipulating immunometabolism
#cancer #aging #metabolism #inflammation
🧪
@plosbiology.org
#cancer #aging #metabolism #inflammation
🧪
@plosbiology.org
Reposted by Nonia Pariente
Why are there such big differences between the sexes when it comes to immune responses? This Essay looks at what further research is required to fully determine sex-differential mechanisms in #immunity.🧪 #immunosky
Knowledge gaps and research priorities to understand sex differences in immunity
Immunity differs profoundly according to biological sex, leading to sex differences in autoimmunity, infections, cancer and responses to immunotherapy and vaccines. This Essay explores the major…
plos.io
February 3, 2026 at 2:05 PM
Why are there such big differences between the sexes when it comes to immune responses? This Essay looks at what further research is required to fully determine sex-differential mechanisms in #immunity.🧪 #immunosky
Reposted by Nonia Pariente
Fungi can become drug-resistant without changing their DNA. They just... turn off the gene. And turn it back on when the drug's gone. This is wild and concerning for treating infections like mucormycosis (50-90% mortality). From Joe Heitman's group at @duke-university.bsky.social.
#Antifungal resistance is a global threat, but epigenetic mechanisms drive rapid, reversible adaptation in fungi. This study shows that #RNAi or #heterochromatin driven #epimutations transiently silence the gene fkbA to confer FK506 #tacrolimus resistance in #Mucor @plosbiology.org 🧪 plos.io/4qdttWc
February 3, 2026 at 2:17 PM
Fungi can become drug-resistant without changing their DNA. They just... turn off the gene. And turn it back on when the drug's gone. This is wild and concerning for treating infections like mucormycosis (50-90% mortality). From Joe Heitman's group at @duke-university.bsky.social.
Reposted by Nonia Pariente
#Antifungal resistance is a global threat, but epigenetic mechanisms drive rapid, reversible adaptation in fungi. This study shows that #RNAi or #heterochromatin driven #epimutations transiently silence the gene fkbA to confer FK506 #tacrolimus resistance in #Mucor @plosbiology.org 🧪 plos.io/4qdttWc
February 3, 2026 at 5:30 PM
#Antifungal resistance is a global threat, but epigenetic mechanisms drive rapid, reversible adaptation in fungi. This study shows that #RNAi or #heterochromatin driven #epimutations transiently silence the gene fkbA to confer FK506 #tacrolimus resistance in #Mucor @plosbiology.org 🧪 plos.io/4qdttWc
There are clear sex differences in immunity, but we don't understand them well.
Here Katie Flanagan and Sabra Klein discuss the state of the field and research priorities to advance our understanding and better prevent and treat disease in everyone
@plosbiology.org #Immunosky
🧪
Here Katie Flanagan and Sabra Klein discuss the state of the field and research priorities to advance our understanding and better prevent and treat disease in everyone
@plosbiology.org #Immunosky
🧪
Why are there such big differences between the sexes when it comes to immune responses? This Essay looks at what further research is required to fully determine sex-differential mechanisms in #immunity.🧪 #immunosky
Knowledge gaps and research priorities to understand sex differences in immunity
Immunity differs profoundly according to biological sex, leading to sex differences in autoimmunity, infections, cancer and responses to immunotherapy and vaccines. This Essay explores the major…
plos.io
February 4, 2026 at 6:05 PM
There are clear sex differences in immunity, but we don't understand them well.
Here Katie Flanagan and Sabra Klein discuss the state of the field and research priorities to advance our understanding and better prevent and treat disease in everyone
@plosbiology.org #Immunosky
🧪
Here Katie Flanagan and Sabra Klein discuss the state of the field and research priorities to advance our understanding and better prevent and treat disease in everyone
@plosbiology.org #Immunosky
🧪
Reposted by Nonia Pariente
Oviposition is crucial for #insect fitness and is a target for #PestControl. This study reveals that two #KainateReceptors in regulate #oviposition preference & egg-laying quantity in the fruit pest #Bactrocera dorsalis, and identifies relevant inhibitors @plosbiology.org 🧪 plos.io/4c6HgdK
February 4, 2026 at 8:55 AM
Oviposition is crucial for #insect fitness and is a target for #PestControl. This study reveals that two #KainateReceptors in regulate #oviposition preference & egg-laying quantity in the fruit pest #Bactrocera dorsalis, and identifies relevant inhibitors @plosbiology.org 🧪 plos.io/4c6HgdK
Reposted by Nonia Pariente
#Azole resistance in #Candida albicans poses a growing threat, and is linked to #StressResponse. @annaselmecki.bsky.social &co show that mutations in the oxidative stress TF Cap1 promote #DrugResistance while exposing a lethal vulnerability at high azole doses @plosbiology.org 🧪 plos.io/4rOrfOz
February 4, 2026 at 1:55 PM
#Azole resistance in #Candida albicans poses a growing threat, and is linked to #StressResponse. @annaselmecki.bsky.social &co show that mutations in the oxidative stress TF Cap1 promote #DrugResistance while exposing a lethal vulnerability at high azole doses @plosbiology.org 🧪 plos.io/4rOrfOz
Reposted by Nonia Pariente
The #vaginal #microbiome is shaped by bacterial access to specific nutritional resources. This study uses a resource-based model & clinical data to identify key ecological mechanisms underlying #microbiota composition & potential #BacterialVaginosis interventions @plosbiology.org 🧪 plos.io/3NY2ssu
February 4, 2026 at 5:25 PM
The #vaginal #microbiome is shaped by bacterial access to specific nutritional resources. This study uses a resource-based model & clinical data to identify key ecological mechanisms underlying #microbiota composition & potential #BacterialVaginosis interventions @plosbiology.org 🧪 plos.io/3NY2ssu
#HIV-1 Vpr always reminds me of my postdoc times in the Chen lab!
HIV-1 induces #DNADamageResponse via Vpr, but does this affect the viral cycle? This study shows that Vpr-driven #DNA damage promotes epigenetic remodeling & transcriptional programs to enhance #HIV1 transcription & latency reactivation, with therapeutic potential @plosbiology.org 🧪 plos.io/4c9wVhe
February 4, 2026 at 6:01 PM
#HIV-1 Vpr always reminds me of my postdoc times in the Chen lab!