Buzz Baum
@buzzbaum.bsky.social
In search of a platform that widens and deepens our understanding of the world. Less re-posting, more reading. Listening more, talking less. My opinions are my own. Some of them aren’t even mine.
Reposted by Buzz Baum
Another Asgard paper to digest over breakfast! www.biorxiv.org/content/10.1...
November 10, 2025 at 9:21 AM
Another Asgard paper to digest over breakfast! www.biorxiv.org/content/10.1...
Reposted by Buzz Baum
How to become a "hot RNA" 🌡️? The answers were kindly provided by hyperthermophilic archaea: rRNA modifications are key! Check out this new publication presenting pan-modification profiling of the epitranscriptome. www.cell.com/cell/fulltex.... (1/3)
Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome
Pan-Mod-seq enables systematic, multi-modification mapping of rRNA across life. Applying
it to diverse organisms reveals that hyperthermophiles dynamically install stabilizing
modifications to support...
www.cell.com
October 27, 2025 at 1:19 PM
How to become a "hot RNA" 🌡️? The answers were kindly provided by hyperthermophilic archaea: rRNA modifications are key! Check out this new publication presenting pan-modification profiling of the epitranscriptome. www.cell.com/cell/fulltex.... (1/3)
Reposted by Buzz Baum
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
October 28, 2025 at 3:07 PM
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Reposted by Buzz Baum
Was a wild journey also with @magdalechowska.bsky.social @joeparham19.bsky.social @iainrichard.bsky.social @emaguilarpine.bsky.social @archaeal.bsky.social Heimdallarchaeia are beautiful!
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 11:36 AM
Was a wild journey also with @magdalechowska.bsky.social @joeparham19.bsky.social @iainrichard.bsky.social @emaguilarpine.bsky.social @archaeal.bsky.social Heimdallarchaeia are beautiful!
Reposted by Buzz Baum
And just when you thought things were settling down, the enigmatic Asgard archaea have another surprise in store! Cell cycle/life cycle stage-specific internal compartments with almost no eukaryote-derived clues as to how they might function.
Beautiful tomography and microscopy - congrats all 🤩
Beautiful tomography and microscopy - congrats all 🤩
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:56 AM
And just when you thought things were settling down, the enigmatic Asgard archaea have another surprise in store! Cell cycle/life cycle stage-specific internal compartments with almost no eukaryote-derived clues as to how they might function.
Beautiful tomography and microscopy - congrats all 🤩
Beautiful tomography and microscopy - congrats all 🤩
Reposted by Buzz Baum
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Just read this great quote from one of my scientific heroes: Franklin Harold: ‘The way of science is for the best of our achievements to endure in substance but lose their individuality, like raindrops falling into a pond.’
November 7, 2025 at 10:38 AM
Just read this great quote from one of my scientific heroes: Franklin Harold: ‘The way of science is for the best of our achievements to endure in substance but lose their individuality, like raindrops falling into a pond.’
See who I found in Uruguay
November 7, 2025 at 10:32 AM
See who I found in Uruguay
Fraser and Andriko! Your hard work has borne fruit.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:26 AM
Fraser and Andriko! Your hard work has borne fruit.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
LMB PhD studentship available in the Baum lab to use informatics to infer cell structure from genomic data in collaboration with the brilliant Tom Williams. If you write to me and I don’t reply - try again - the spam filter is hungry…
October 2, 2025 at 9:04 AM
LMB PhD studentship available in the Baum lab to use informatics to infer cell structure from genomic data in collaboration with the brilliant Tom Williams. If you write to me and I don’t reply - try again - the spam filter is hungry…
Turing discusses possibility of cloning a human from a single skin cell in 1950 in a little aside
July 14, 2025 at 7:54 PM
Turing discusses possibility of cloning a human from a single skin cell in 1950 in a little aside
Reposted by Buzz Baum
Today! FREE.
Not sure what to do this Saturday in London? Come to the UCL Festival of Stuff! Fun and wonder, and head-scratchingly interesting for all the family: www.instituteofmaking.org.uk/events/view/...
June 21, 2025 at 9:38 AM
Today! FREE.
Reposted by Buzz Baum
The mechanics of a continuous self-assembling surface-layer aids cell division in an archaeon
out in @pnas.org
Tight collaboration with Sherman Foo, Alice Cezanne and @buzzbaum.bsky.social, Sulfolobus cryo-ET from @idocaspy.bsky.social
www.pnas.org/doi/10.1073/...
out in @pnas.org
Tight collaboration with Sherman Foo, Alice Cezanne and @buzzbaum.bsky.social, Sulfolobus cryo-ET from @idocaspy.bsky.social
www.pnas.org/doi/10.1073/...
A self-assembling surface layer flattens the cytokinetic furrow to aid cell division in an archaeon | PNAS
The surface layer or “S-layer” is a two-dimensional lattice of proteins that coats
a wide range of archaea and bacteria in place of a cell wall or ...
www.pnas.org
June 19, 2025 at 2:06 PM
The mechanics of a continuous self-assembling surface-layer aids cell division in an archaeon
out in @pnas.org
Tight collaboration with Sherman Foo, Alice Cezanne and @buzzbaum.bsky.social, Sulfolobus cryo-ET from @idocaspy.bsky.social
www.pnas.org/doi/10.1073/...
out in @pnas.org
Tight collaboration with Sherman Foo, Alice Cezanne and @buzzbaum.bsky.social, Sulfolobus cryo-ET from @idocaspy.bsky.social
www.pnas.org/doi/10.1073/...
Reposted by Buzz Baum
We are excited to share our preprint describing how Sulfolobus cells coordinate DNA segregation with cell division! In eukaryotes this type of regulation involves checkpoints and CDK-cyclins. But how does this work in archaea? This is the question we ask in our paper: www.biorxiv.org/content/10.1...
Temporal and spatial coordination of DNA segregation and cell division in an archaeon.
Cells must coordinate DNA segregation with cytokinesis to ensure that each daughter cell inherits a complete genome. Here, we explore how DNA segregation and division are mechanistically coupled in ar...
www.biorxiv.org
May 29, 2025 at 3:36 PM
We are excited to share our preprint describing how Sulfolobus cells coordinate DNA segregation with cell division! In eukaryotes this type of regulation involves checkpoints and CDK-cyclins. But how does this work in archaea? This is the question we ask in our paper: www.biorxiv.org/content/10.1...
Reposted by Buzz Baum
What a year for the cell biology of archaeal chromosome segregation! 🧬 @joeparham19.bsky.social and @buzzbaum.bsky.social now add pieces to the SegAB puzzle by connecting it with cell division
We are excited to share our preprint describing how Sulfolobus cells coordinate DNA segregation with cell division! In eukaryotes this type of regulation involves checkpoints and CDK-cyclins. But how does this work in archaea? This is the question we ask in our paper: www.biorxiv.org/content/10.1...
Temporal and spatial coordination of DNA segregation and cell division in an archaeon.
Cells must coordinate DNA segregation with cytokinesis to ensure that each daughter cell inherits a complete genome. Here, we explore how DNA segregation and division are mechanistically coupled in ar...
www.biorxiv.org
May 29, 2025 at 3:55 PM
What a year for the cell biology of archaeal chromosome segregation! 🧬 @joeparham19.bsky.social and @buzzbaum.bsky.social now add pieces to the SegAB puzzle by connecting it with cell division
Reposted by Buzz Baum
Join us at Cheltenham Science Festival in June. I am doing events on the science of coffee, meteorites, cocktails and nappies. Yes something for everyone including babies. www.cheltenhamfestivals.org/festivals/sc...
May 20, 2025 at 8:16 AM
Join us at Cheltenham Science Festival in June. I am doing events on the science of coffee, meteorites, cocktails and nappies. Yes something for everyone including babies. www.cheltenhamfestivals.org/festivals/sc...
In 1997, Arafat invited my father to Gaza. He asked if the PA knew he was Jewish and a Zionist. Yes, they said, but they needed better training for paediatricians. So my father went, believing that to save a child is to save a world. How horrified he would be to hear the IDF has killed 15000. Stop!
May 19, 2025 at 5:59 AM
In 1997, Arafat invited my father to Gaza. He asked if the PA knew he was Jewish and a Zionist. Yes, they said, but they needed better training for paediatricians. So my father went, believing that to save a child is to save a world. How horrified he would be to hear the IDF has killed 15000. Stop!
Reposted by Buzz Baum
Sign ups for the fall Barcelona multicellularity meeting are now up- come join us!
meetings.embo.org/event/25-mul...
meetings.embo.org/event/25-mul...
Evolution and origins of multicellularity across the tree of life
The study of the origins and evolution of multicellularity in different lineages has recently captured the attention of many research groups and is fueling the generation of numerous innovative resea…
meetings.embo.org
April 18, 2025 at 2:28 PM
Sign ups for the fall Barcelona multicellularity meeting are now up- come join us!
meetings.embo.org/event/25-mul...
meetings.embo.org/event/25-mul...
Excited to announce the Molecular Biology of Archaea (MBoA) 2026!
Join us in Cambridge, UK, from 6–10 July 2026 for the only international meeting dedicated to Archaea.
Join us in Cambridge, UK, from 6–10 July 2026 for the only international meeting dedicated to Archaea.
April 18, 2025 at 1:56 PM
Excited to announce the Molecular Biology of Archaea (MBoA) 2026!
Join us in Cambridge, UK, from 6–10 July 2026 for the only international meeting dedicated to Archaea.
Join us in Cambridge, UK, from 6–10 July 2026 for the only international meeting dedicated to Archaea.
With a heavy heart I have decided not to attend a meeting in the US this June. I can’t act as if things are normal when science, universities, dissent & truth are all under threat. And I feel I can’t attend when there are scientists who are not able to travel to the US without fear of arrest.
April 11, 2025 at 8:05 PM
With a heavy heart I have decided not to attend a meeting in the US this June. I can’t act as if things are normal when science, universities, dissent & truth are all under threat. And I feel I can’t attend when there are scientists who are not able to travel to the US without fear of arrest.
A question! My team recently stopped working in flies. But there are lots of fly genes we know have cool cytoskeletal phenotypes (from RNAi screens and follow up work) which I think would be great to follow up. What is the best way to encourage others to take a fresh look at them?
January 18, 2024 at 10:01 AM
A question! My team recently stopped working in flies. But there are lots of fly genes we know have cool cytoskeletal phenotypes (from RNAi screens and follow up work) which I think would be great to follow up. What is the best way to encourage others to take a fresh look at them?
Thanks to Gordon and Betty Moore for funding fundamental research to better understand our planet:
www.moore.org/article-deta...
www.moore.org/article-deta...
www.moore.org/article-deta...
www.moore.org/article-deta...
January 4, 2024 at 5:16 PM
Thanks to Gordon and Betty Moore for funding fundamental research to better understand our planet:
www.moore.org/article-deta...
www.moore.org/article-deta...
www.moore.org/article-deta...
www.moore.org/article-deta...
Gaugin discovers the joys of ‘archaea’
December 27, 2023 at 4:30 PM
Gaugin discovers the joys of ‘archaea’
Reposted by Buzz Baum
This scientific meeting looks amazing!
December 21, 2023 at 2:30 PM
This scientific meeting looks amazing!