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singhlab.bsky.social
SinghLab@SNIoE
@singhlab.bsky.social
850 followers 1.2K following 61 posts
Regenerative & Stress Biology Lab, Shiv Nadar University, Delhi-NCR, India
Regenerative Plasticity | Zebrafish | In vivo Fluorescent Imaging | Liver Regeneration | Starvation Response | Alcoholic Liver Disease
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singhlab.bsky.social
SinghLab@SNIoE @singhlab.bsky.social · Jun 6
🚨 Just out in Nature Communications:
Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish
We challenge old assumptions on liver regeneration!
🔗 nature.com/articles/s41...
🧵(1/8)
Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish - Nature Communications
During partial liver injury in growing zebrafish, cholangiocytes regenerate hepatocytes through transdifferentiation, revealing a stage-specific regeneration mechanism regulated by mTORC1 signaling.
nature.com
singhlab.bsky.social
As part of the Faculty Development Program at Shiv Nadar University , received these 10 commandments for faculty. This is the best advice I have seen, and certainly hits the nail on the head. Especially about focusing and getting the first study out early on.
July 31, 2025 at 10:59 AM
singhlab.bsky.social
🚨 Just out in Nature Communications:
Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish
We challenge old assumptions on liver regeneration!
🔗 nature.com/articles/s41...
🧵(1/8)
Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish - Nature Communications
During partial liver injury in growing zebrafish, cholangiocytes regenerate hepatocytes through transdifferentiation, revealing a stage-specific regeneration mechanism regulated by mTORC1 signaling.
nature.com
June 6, 2025 at 11:39 AM
Reposted by SinghLab@SNIoE
simoesfilipa.bsky.social
🫀Job alert 🧬 come and be our colleague! Join a BBSRC-funded consortium aiming to understand how the human heart develops - you will be contributing multimodal single cell & spatial transcriptomics data using zebrafish and human cardiac organoids as models. Learn more: www.heartdevelopment.org (1/4)
CellTalk HHD | Human Heart Development Research
CellTalk-Human Heart Development is a BBSRC funded consortium established to find out more about how cells come together to build the heart as it grows inside the womb.
www.heartdevelopment.org
May 16, 2025 at 10:10 AM
singhlab.bsky.social
Pleased to have contributed commentary to this recent article by Maria Bolevich for Interesting Engineering, which explores the science of tissue #regeneration and its potential applications in medicine.
Read the full article here: interestingengineering.com/health/body-...
Why the body's natural regeneration isn't enough to stop chronic disease
From skin renewal to liver repair, the body is rebuilding itself. Scientists are now uncovering why some organs heal and others don’t.
interestingengineering.com
June 2, 2025 at 3:15 AM
singhlab.bsky.social
We just posted our new preprint, spearheaded by Garnik Hovhannisyan in collaboration with Esteban Gurzov Lab! biorxiv.org/content/10.1... #zebrafish #liverregeneration #DevBio #LineageTracing
CellCousin2: An Optimized System for Partial Ablation and Tracing of Regenerative Lineages
Regeneration can rely on multiple cellular sources, including stem cells, self-duplicating cells, and transdifferentiating cells. A central question in regenerative biology is how these distinct linea...
biorxiv.org
May 28, 2025 at 3:18 PM
singhlab.bsky.social
Stunning 3D fluorescent images of the human #tooth and the first cellular/molecular map of tooth #decay! Hoang Thai Ha from Nicolas Baeyens Lab nails it with tissue clearing + imaging.
www.biorxiv.org/content/10.1...
May 16, 2025 at 6:16 PM
Reposted by SinghLab@SNIoE
yhcarolyang.bsky.social
Interested in understanding how neural-pancreas interplay contributes to blood sugar control? We have an exciting PhD project to study galanin regulation of pancreatic #islet hormone secretion in live #zebrafish

www.exeter.ac.uk/research/ins...
May 14, 2025 at 1:49 PM
singhlab.bsky.social
Liver regeneration after killing part of the liver! In this image, the same liver from same #zebrafish is imaged before (left) and after (right) regeneration. The newly born liver cells are in blue.

Project led by @selifeski.bsky.social
May 14, 2025 at 6:53 PM
singhlab.bsky.social
We celebrated a big milestone in our lab: our first #Undergrad intern presented her work at lab meeting! She helped develop two new #liver #injury models, and is on her way to becoming a fantastic scientist. Thanks to PhD student Garnik for mentoring her so well! 👏🧪 #TeamScience
May 3, 2025 at 6:33 AM
singhlab.bsky.social
Whole mount EdU staining of 5 day old #zebrafish.
April 12, 2025 at 5:34 PM
singhlab.bsky.social
I'm excited to share that I will join School of Natural Sciences, Shiv Nadar University as an Associate Professor! Looking forward to working with amazing students and being part of a thriving research community.
April 8, 2025 at 7:26 AM
Reposted by SinghLab@SNIoE
zebrafishrock.bsky.social
Come help us build an inclusive community, for those finterested! Did they mention it’s FREE?!? 🧪
izfs.bsky.social International Zebrafish Society @izfs.bsky.social · Mar 5
The first IZFS and ZDMS joint webinar promoting global awareness about our varied backgrounds and experiences in science takes place tomorrow, March 6th at 10am EST! Featuring speaker Dr. Rachel Brewster, you will not want to miss this! Register here today: forms.gle/5uWMpdspRhtz...
Joint DEI session IZFS/ZDMS
Does this form look suspicious? Report
forms.gle
March 5, 2025 at 5:35 PM
singhlab.bsky.social
Delighted to receive FOXO Transcription Factors edited by Dr. Wolfgang Link! FOXO genes are key in stress response & metabolism. Inés Garteizgogeascoa Suñer details a knock-in #zebrafish foxo1a reporter: pubmed.ncbi.nlm.nih.gov/39565585/ Check out the book for key advances!
March 3, 2025 at 9:16 AM
singhlab.bsky.social
Had a great time meeting the students at Freedom Employability Academy (FEA:
feaindia.org ) today! Inspiring to see their enthusiasm and growth. Excited to support their journey towards meaningful careers! #Mentorship #Education
February 12, 2025 at 3:08 PM
Reposted by SinghLab@SNIoE
wehnerlab.bsky.social
We demonstrate that this biphasic regulation limits the neutrophil-driven acute inflammatory phase, preventing chronic inflammation, fostering a lesion environment with mechano-structural properties conducive to regeneration.
January 27, 2025 at 7:17 PM
Reposted by SinghLab@SNIoE
wehnerlab.bsky.social
Excited to share the latest work from our lab: www.biorxiv.org/content/10.1...
Biphasic inflammation control by dedifferentiated fibroblasts enables axon regeneration after spinal cord injury in zebrafish
Fibrosis and persistent inflammation are interconnected processes that inhibit axon regeneration in the mammalian central nervous system (CNS). In zebrafish, by contrast, fibroblast-derived extracellu...
www.biorxiv.org
January 27, 2025 at 7:17 PM
Reposted by SinghLab@SNIoE
wehnerlab.bsky.social
Fantastic collaboration with the labs of Sven Falk, @singhlab.bsky.social, Jochen Guck, @franzelab.bsky.social, Kanwarpal Singh, and Federico Marini. @fau.de @mpi-scienceoflight.bsky.social Johannes Gutenberg University University of Cambridge @iribhm.bsky.social, @mcmasteruniversity.bsky.social
January 27, 2025 at 7:17 PM
Reposted by SinghLab@SNIoE
valetornini.bsky.social
We are openly recruiting at all levels at the Tornini Lab at the University of California, Los Angeles (UCLA)!
Please share with your networks. For more information, please check the info below, visit www.torninilab.org, or email me directly at vtornini at ucla dot edu. Thank you in advance!
Open recruitment for the Tornini Lab Department of Integrative Biology and Physiology & Institute for Society and Genetics Hispanic Serving Institution Infrastructure Initiative University of California, Los Angeles (UCLA) www.torninilab.org We are a new developmental, cell, and molecular biology lab interested in understanding the genetics of vertebrate neurodevelopment. We use genome engineering, single-cell technologies, behavioral analyses, pharmacological profiling, confocal imaging, genomics, and computational biology using the vertebrate zebrafish (Danio rerio) system and other models (like sea lamprey) for evolutionary studies. Our work is driven by curiosity, independence and teamwork, fun, a sense of urgency, and a desire to understand how networks of genes regulate brain and organismal development. This work can help us better understand basic mechanisms of what happens in human developmental disorders or diseases and can inform novel therapeutic strategies. We are recruiting across all levels. Our lab works in multiple complementary areas (please see below). We’re looking to match motivated people with what motivates them in a supportive and engaging environment. We are recruiting staff research scientists (1-2 years after undergrad+), graduate students (open rotation positions), postdocs, and other positions as relevant. While multiple of our projects are already funded, we strongly support candidates to identify and apply for your own fellowships/grants with the full mentorship and resources of the lab. Like our research? Think you might be a good fit? Consider joining us! For more information, please visit our website, the next page, or contact Val at: vtornini at ucla dot edu UCLA is an equal opportunity employer. Novel micropeptides in vertebrate neurodevelopment Using zebrafish models, we ask: what are these proteins; what are their functions in neurodevelopment; what are other “ignored” or “dark proteome” genes we are missing; and what can they reveal about human neurodevelopmental disorders or diseases? Chromatin regulators in vertebrate development and behavior A growing group of evolutionarily conserved chromatin regulators have been identified as genes linked with neurodevelopmental disorders, such as autism. In many cases, patients may struggle with co-occurring conditions that impact daily life in childhood and adulthood, including seizures, sleeplessness or sleep disruptions, and autoimmune disruptions. How do these genes work to establish and maintain neural cell types during development, and in turn shape circuits during early critical periods, including interactions with the environment, to establish organismal physiological processes? Non-neuronal regulation during development and aging Non-neuronal cell types, including oligodendrocytes and microglia, have emerged as key players in shaping neurodevelopment and into adulthood. How are the cellular, molecular, and physiological dynamics of these cell types in developing and aging brains affected in mutant genetic models linked to neurodevelopmental disorders? Can we target these cells to modulate neural dysregulation and resulting behaviors in these mutant models? Evolution of vertebrate brain cell states We seek to understand the principles of how novel genes co-evolve with the emergence of neural cell types found only in vertebrates. We use cross-species genomics and functional approaches with the jawless vertebrate model, sea lamprey, to elucidate the roles of vertebrate-specific genes on the gene regulatory networks. Bioethics, neuroethics, and genetics We seek to integrate evidence-based methods throughout our projects to investigate and address bioethical considerations in this research domain.
December 9, 2024 at 8:48 PM
Reposted by SinghLab@SNIoE
sdeoliveira.bsky.social
Our debut here 🥰

Non-invasive intravital imaging of wound in skin epithelium of a juvenille zebrafish fed with a High-Cholesterol diet (HCD) versus a Normal Diet (ND)

Zebrafish is an outstanding model to study how diet and metabolic disease impact neutrophils

Keep following us, spread the word!
November 8, 2024 at 8:46 PM
Reposted by SinghLab@SNIoE
o-andersson-lab.bsky.social
Fancy joining our lab? apply here for a PhD student position, (DM me for potential postdoc opportunities)
www.uu.se/en/about-uu/...
PhD student in regeneration of insulin-producing beta-cells in diabetes models - Uppsala University
PhD student in regeneration of insulin-producing beta-cells in diabetes models, Institutionen för medicinsk cellbiologi, Uppsala University
www.uu.se
January 14, 2025 at 10:52 AM
Reposted by SinghLab@SNIoE
o-andersson-lab.bsky.social
Check out our preprint about liver regeneration, showing hepatic duct heterogeneity and cell plasticity using lineage tracing and single-cell transcriptomics. @zebrafishrock.bsky.social @biorxivpreprint.bsky.social @the-node.bsky.social
www.biorxiv.org/content/10.1...
January 10, 2025 at 11:07 AM
singhlab.bsky.social
Excited to share our latest work on #liver #regeneration in @biorxiv-devbio.bsky.social ! We uncover how cholangiocytes contribute to hepatocyte regeneration, even in the presence of spared hepatocytes, using our novel CellCousin model in #zebrafish: www.biorxiv.org/content/10.1... 🐟✨ A 🧵👇 (1/12)
Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish
The liver's regenerative ability depends on injury extent. Minor injuries are repaired by hepatocyte self-duplication, while severe damage triggers cholangiocyte involvement in hepatocyte recovery. Th...
www.biorxiv.org
January 10, 2025 at 7:57 AM
Reposted by SinghLab@SNIoE
slavov-n.bsky.social
5,562 proteins were found to have tissue-specific enrichment across 32 human tissues.

The majority of them (3,088) are enriched at the protein but not RNA level.

The brain hosts the largest number of proteins that are only enriched at the protein level but not RNA level.
January 8, 2025 at 12:29 PM
singhlab.bsky.social
What shapes the #immune profile of organs? Study from Ninov Lab #CRTD, led by Nadeem, find that developmental #celldeath define the immune cells of the pancreatic #islet in #zebrafish ! 🎉👏 Read more @embojournal.bsky.social : embopress.org/doi/full/10.... #Diabetes
Developmental beta-cell death orchestrates the islet’s inflammatory milieu by regulating immune system crosstalk | The EMBO Journal
imageimageDuring islet development, beta-cell death, rather than proliferation alone, regulates beta-cell mass and shapes the immune environment. This process triggers immune system crosstalk, influen...
embopress.org
January 7, 2025 at 9:26 AM
Reposted by SinghLab@SNIoE
pdcampbell.bsky.social
We are looking to hire at all levels - undergrads, research technicians, graduate students, postdocs. Experience with zebrafish, induced pluripotent stem cell models, molecular genetic approaches, imaging, or programming is desirable but not required.
January 6, 2025 at 5:54 PM