Long-read sequencing has ushered in a new era in genomics, enabling the exploration of genomic and epigenomic landscapes at single-molecule resolution and within complex regions previously inaccessible to short-read sequencing. Fiber-seq (single-molecule chromatin fiber sequencing) enables the decoding of chromatin fiber architectures at single-molecule resolution. At its core, this method treats nuclei or permeabilized cells with an exogenous nonspecific DNA N6-adenine methyltransferase (m6A-MTase) to label accessible adenines with m6A, thereby creating a ‘stencil’ of where proteins are bound along the DNA.

Peng et al. identify a class of non-aromatic, chorismate-derived compounds, abundant in the roots of Arabidopsis thaliana. These compounds are made by a biosynthetic gene cluster comprising five adjac...

Alt: “Wait never mind”

Pyrethrins are powerful natural insecticides traditionally extracted from the flowers of Tanacetum cinerariifolium. While effective and environmentally friendly, their agricultural production is limit...