Osvaldo Contreras
@osvaldoics.bsky.social
Cell Identity + Cell Cycle Networks + Chromatin Dynamics & DevEvo in Human Development 🧬 @UNSWMedicine | #MyoTwitter 📝 @Prelights #eLifeAmbassador
Pinned
I’m back here to share our new pre-print! 🔬 🧬 😃
Proteo-transcriptomics and morphometrics of teleost cardiac cells define regulatory networks and exercise-induced cardiomyocyte hypertrophy and hyperplasia
Flow cytometry+Imaging+RNA-seq+Proteomics
Preprint available on bioRxiv [link in comments]
Proteo-transcriptomics and morphometrics of teleost cardiac cells define regulatory networks and exercise-induced cardiomyocyte hypertrophy and hyperplasia
Flow cytometry+Imaging+RNA-seq+Proteomics
Preprint available on bioRxiv [link in comments]
Reposted by Osvaldo Contreras
ICYMI
🔗: www.biorxiv.org/content/10.6...
🔗: www.biorxiv.org/content/10.6...
I’m back here to share our new pre-print! 🔬 🧬 😃
Proteo-transcriptomics and morphometrics of teleost cardiac cells define regulatory networks and exercise-induced cardiomyocyte hypertrophy and hyperplasia
Flow cytometry+Imaging+RNA-seq+Proteomics
Preprint available on bioRxiv [link in comments]
Proteo-transcriptomics and morphometrics of teleost cardiac cells define regulatory networks and exercise-induced cardiomyocyte hypertrophy and hyperplasia
Flow cytometry+Imaging+RNA-seq+Proteomics
Preprint available on bioRxiv [link in comments]
January 21, 2026 at 10:08 AM
ICYMI
🔗: www.biorxiv.org/content/10.6...
🔗: www.biorxiv.org/content/10.6...
I’m back here to share our new pre-print! 🔬 🧬 😃
Proteo-transcriptomics and morphometrics of teleost cardiac cells define regulatory networks and exercise-induced cardiomyocyte hypertrophy and hyperplasia
Flow cytometry+Imaging+RNA-seq+Proteomics
Preprint available on bioRxiv [link in comments]
Proteo-transcriptomics and morphometrics of teleost cardiac cells define regulatory networks and exercise-induced cardiomyocyte hypertrophy and hyperplasia
Flow cytometry+Imaging+RNA-seq+Proteomics
Preprint available on bioRxiv [link in comments]
January 18, 2026 at 10:44 PM
I’m back here to share our new pre-print! 🔬 🧬 😃
Proteo-transcriptomics and morphometrics of teleost cardiac cells define regulatory networks and exercise-induced cardiomyocyte hypertrophy and hyperplasia
Flow cytometry+Imaging+RNA-seq+Proteomics
Preprint available on bioRxiv [link in comments]
Proteo-transcriptomics and morphometrics of teleost cardiac cells define regulatory networks and exercise-induced cardiomyocyte hypertrophy and hyperplasia
Flow cytometry+Imaging+RNA-seq+Proteomics
Preprint available on bioRxiv [link in comments]
Reposted by Osvaldo Contreras
Fantastic insights on how replication stress drives cell differentiation by Osvaldo Contreras at the joint meeting of the #InSDB and International Society of Differentiation #ISD joint meeting at #IISER_BERHAMPUR
@osvaldoics.bsky.social
#INSDBISD2025
@osvaldoics.bsky.social
#INSDBISD2025
December 15, 2025 at 5:29 AM
Fantastic insights on how replication stress drives cell differentiation by Osvaldo Contreras at the joint meeting of the #InSDB and International Society of Differentiation #ISD joint meeting at #IISER_BERHAMPUR
@osvaldoics.bsky.social
#INSDBISD2025
@osvaldoics.bsky.social
#INSDBISD2025
Reposted by Osvaldo Contreras
Star #Scientist @osvaldoics.bsky.socia is uncovering how hearts grow - and what goes wrong when they don’t. He's mapping the molecular ‘blueprint’ of heart cells to uncover the mechanisms that could one day help damaged hearts repair themselves:
Star Scientist - Dr Osvaldo Contreras
The Institute's Dr Osvaldo Contreras's work could one day help children born with heart defects and adults facing heart failure live longer, healthier…
www.victorchang.edu.au
December 10, 2025 at 4:10 AM
Star #Scientist @osvaldoics.bsky.socia is uncovering how hearts grow - and what goes wrong when they don’t. He's mapping the molecular ‘blueprint’ of heart cells to uncover the mechanisms that could one day help damaged hearts repair themselves:
Thank you for the highlight @ishr-aus.bsky.social 🙏🏼❤️
For our next #ECIExcellence2025 nomination we have Osvaldo from @victorchang.edu.au! We asked for 2 but received a long list of achievements in 2025 🤩
What a stellar year Osvaldo!
What a stellar year Osvaldo!
December 3, 2025 at 10:47 PM
Thank you for the highlight @ishr-aus.bsky.social 🙏🏼❤️
Reposted by Osvaldo Contreras
New @natcomms.nature.com paper today from Tracy Bryan's lab @cmri.bsky.social: "Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase".
Happy our lab could play a small part.
Congrats Tracy, Ash Harman, Noa Lamm and the whole team.
www.nature.com/articles/s41...
Happy our lab could play a small part.
Congrats Tracy, Ash Harman, Noa Lamm and the whole team.
www.nature.com/articles/s41...
Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase - Nature Communications
Telomerase recruitment to telomeres is a tightly regulated process which is stimulated by replication stress. Here, the authors identify that nuclear filamentous actin is important for interaction bet...
www.nature.com
December 3, 2025 at 12:19 AM
New @natcomms.nature.com paper today from Tracy Bryan's lab @cmri.bsky.social: "Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase".
Happy our lab could play a small part.
Congrats Tracy, Ash Harman, Noa Lamm and the whole team.
www.nature.com/articles/s41...
Happy our lab could play a small part.
Congrats Tracy, Ash Harman, Noa Lamm and the whole team.
www.nature.com/articles/s41...
Reposted by Osvaldo Contreras
💡Dr Osvaldo Contreras’s funds will allow for open access publication of “OpenEMMU: A versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics” in iScience.
December 3, 2025 at 10:26 PM
💡Dr Osvaldo Contreras’s funds will allow for open access publication of “OpenEMMU: A versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics” in iScience.
Reposted by Osvaldo Contreras
“There were some cells in there that were very messed up”
In a technological tour-de-force, researchers have sequenced the whole genomes of more than 100 individual cells from one 74-year-old man
go.nature.com/44yj4MN
In a technological tour-de-force, researchers have sequenced the whole genomes of more than 100 individual cells from one 74-year-old man
go.nature.com/44yj4MN
We are all mosaics: vast genetic diversity found between cells in a single person
Technical advances allow researchers to trace the genetic changes that occur over time.
go.nature.com
November 26, 2025 at 9:28 AM
“There were some cells in there that were very messed up”
In a technological tour-de-force, researchers have sequenced the whole genomes of more than 100 individual cells from one 74-year-old man
go.nature.com/44yj4MN
In a technological tour-de-force, researchers have sequenced the whole genomes of more than 100 individual cells from one 74-year-old man
go.nature.com/44yj4MN
Reposted by Osvaldo Contreras
In vivo differentiation of embryonic cells devoid of key reprogramming factors
In vivo differentiation of embryonic cells devoid of key reprogramming factors
Youlten, Miao et al. use zebrafish transplantation to understand the fate of cells lacking pluripotency factors Nanog, Pou5f3, and Sox19b (NPS) in developmental reprogramming and cell identity establishment. They found that NPS are required for proper cell identity for most, but not all, lineages, likely through nuclear and cytoplasmic reprogramming.
dlvr.it
November 12, 2025 at 8:50 PM
In vivo differentiation of embryonic cells devoid of key reprogramming factors
Reposted by Osvaldo Contreras
One week left to register! Join the Editors-in-Chief of Differentiation on November 14 at 12:00 p.m. Central for a virtual seminar with Pavani P. Perera on the enteric nervous system, evolution, and cave fish. Register for free: https://bit.ly/4oaU71P
Topic: https://bit.ly/478UZhu
Topic: https://bit.ly/478UZhu
November 7, 2025 at 7:49 PM
One week left to register! Join the Editors-in-Chief of Differentiation on November 14 at 12:00 p.m. Central for a virtual seminar with Pavani P. Perera on the enteric nervous system, evolution, and cave fish. Register for free: https://bit.ly/4oaU71P
Topic: https://bit.ly/478UZhu
Topic: https://bit.ly/478UZhu
Reposted by Osvaldo Contreras
Save the date! @isscr.org, @alleninstitute.org & @socdevbio.bsky.social are collaborating to present a 3-day scientific symposium led by early-career scientists. The Stem Cell & Developmental Biology Early Career Symposium will be held September 23-25, 2026 in Seattle, WA. Learn more: bit.ly/4p98dkv
November 13, 2025 at 5:20 PM
Save the date! @isscr.org, @alleninstitute.org & @socdevbio.bsky.social are collaborating to present a 3-day scientific symposium led by early-career scientists. The Stem Cell & Developmental Biology Early Career Symposium will be held September 23-25, 2026 in Seattle, WA. Learn more: bit.ly/4p98dkv
Reposted by Osvaldo Contreras
Catch up on the recordings from our October #DevPres webinar on development across scales. View the presentations from @osvaldoics.bsky.social and @yinanwan.bsky.social.
thenode.biologists.com/catch-up-on-...
thenode.biologists.com/catch-up-on-...
Catch up on Development presents… webinar on development across scales - the Node
Our October webinar featured two early-career researchers working on development across scales. Here, we share the talks from Osvaldo Contreras (Victor
thenode.biologists.com
November 12, 2025 at 10:13 AM
Catch up on the recordings from our October #DevPres webinar on development across scales. View the presentations from @osvaldoics.bsky.social and @yinanwan.bsky.social.
thenode.biologists.com/catch-up-on-...
thenode.biologists.com/catch-up-on-...
Reposted by Osvaldo Contreras
Transitions is the newest in our series of stem cell conversations. Launched by Ritika Saxena, Jarmon Lees and @osvaldoics.bsky.social we explore project and career transitions. All the parts needed for successful science that don't make it to the bench. For Aussie scientists, but all welcome.
October 19, 2025 at 10:11 PM
Transitions is the newest in our series of stem cell conversations. Launched by Ritika Saxena, Jarmon Lees and @osvaldoics.bsky.social we explore project and career transitions. All the parts needed for successful science that don't make it to the bench. For Aussie scientists, but all welcome.
Reposted by Osvaldo Contreras
We are celebrating 5 years of the Australia stem cell conversation! Hosted by @unimelb.bsky.social and @asscr.bsky.social the stem cell conversation is a weekly 30min virtual seminar series organised by EMCR for EMCR.
Join the first 'transitions' episode Leadership through Service: 11am AEST Wed.
Join the first 'transitions' episode Leadership through Service: 11am AEST Wed.
October 19, 2025 at 10:05 PM
We are celebrating 5 years of the Australia stem cell conversation! Hosted by @unimelb.bsky.social and @asscr.bsky.social the stem cell conversation is a weekly 30min virtual seminar series organised by EMCR for EMCR.
Join the first 'transitions' episode Leadership through Service: 11am AEST Wed.
Join the first 'transitions' episode Leadership through Service: 11am AEST Wed.
Join us 15 October to hear from two early-career researchers, @osvaldoics.bsky.social & Yinan Wan, working on development across scales.
Chaired by @dev-journal.bsky.social Executive Editor @amjeve.bsky.social.
📅 15 October, 09:00 BST (UTC+1)
Register here: us02web.zoom.us/webinar/regi...
Chaired by @dev-journal.bsky.social Executive Editor @amjeve.bsky.social.
📅 15 October, 09:00 BST (UTC+1)
Register here: us02web.zoom.us/webinar/regi...
September 30, 2025 at 11:36 AM
Remarkable conference organized by @asbmbaus.bsky.social up in Brisbane at the University of Queensland.
I was invited to present my latest work as a Keynote Speaker for the Multi-Sonic’s session, and so many thanks for selecting me!
Truly an honour!
I was invited to present my latest work as a Keynote Speaker for the Multi-Sonic’s session, and so many thanks for selecting me!
Truly an honour!
September 30, 2025 at 1:13 AM
Remarkable conference organized by @asbmbaus.bsky.social up in Brisbane at the University of Queensland.
I was invited to present my latest work as a Keynote Speaker for the Multi-Sonic’s session, and so many thanks for selecting me!
Truly an honour!
I was invited to present my latest work as a Keynote Speaker for the Multi-Sonic’s session, and so many thanks for selecting me!
Truly an honour!
Reposted by Osvaldo Contreras
SAVE THE DATE! Join us for the 2025 @anzscdb.bsky.social
NSW Branch Cell & Developmental Biology Symposium at the Garvan Institute @garvaninstitute.bsky.social on Wed 5 Nov 2025. Keynote speakers include Dougall Norris, @katequinlan.bsky.social, Silvia Velasco and @ryanlister.bsky.social 🔬🧠🧫
NSW Branch Cell & Developmental Biology Symposium at the Garvan Institute @garvaninstitute.bsky.social on Wed 5 Nov 2025. Keynote speakers include Dougall Norris, @katequinlan.bsky.social, Silvia Velasco and @ryanlister.bsky.social 🔬🧠🧫
September 19, 2025 at 7:29 AM
SAVE THE DATE! Join us for the 2025 @anzscdb.bsky.social
NSW Branch Cell & Developmental Biology Symposium at the Garvan Institute @garvaninstitute.bsky.social on Wed 5 Nov 2025. Keynote speakers include Dougall Norris, @katequinlan.bsky.social, Silvia Velasco and @ryanlister.bsky.social 🔬🧠🧫
NSW Branch Cell & Developmental Biology Symposium at the Garvan Institute @garvaninstitute.bsky.social on Wed 5 Nov 2025. Keynote speakers include Dougall Norris, @katequinlan.bsky.social, Silvia Velasco and @ryanlister.bsky.social 🔬🧠🧫
Honored to present at @ramacgenomics.bsky.social @unsw.edu.au next Tuesday.😃
Some exciting #SingleCell events with #ParseBio coming up this month at @ramacgenomics.bsky.social 🧬
9 Sept: SPLiT-Seq Tech Showcase Seminar 🔗 tinyurl.com/bddc5zc3
15 Sept: Application deadline for discounted Parse Evercode WT Mini v3 Kit promotion 🔗 tinyurl.com/yc84zmfm
📩 ramaciotti@unsw.edu.au
9 Sept: SPLiT-Seq Tech Showcase Seminar 🔗 tinyurl.com/bddc5zc3
15 Sept: Application deadline for discounted Parse Evercode WT Mini v3 Kit promotion 🔗 tinyurl.com/yc84zmfm
📩 ramaciotti@unsw.edu.au
September 5, 2025 at 3:55 AM
Honored to present at @ramacgenomics.bsky.social @unsw.edu.au next Tuesday.😃
Reposted by Osvaldo Contreras
Don't miss @osvaldoics.bsky.social in the flesh next Tuesday in Sydney
Some exciting #SingleCell events with #ParseBio coming up this month at @ramacgenomics.bsky.social 🧬
9 Sept: SPLiT-Seq Tech Showcase Seminar 🔗 tinyurl.com/bddc5zc3
15 Sept: Application deadline for discounted Parse Evercode WT Mini v3 Kit promotion 🔗 tinyurl.com/yc84zmfm
📩 ramaciotti@unsw.edu.au
9 Sept: SPLiT-Seq Tech Showcase Seminar 🔗 tinyurl.com/bddc5zc3
15 Sept: Application deadline for discounted Parse Evercode WT Mini v3 Kit promotion 🔗 tinyurl.com/yc84zmfm
📩 ramaciotti@unsw.edu.au
September 5, 2025 at 1:00 AM
Don't miss @osvaldoics.bsky.social in the flesh next Tuesday in Sydney
Reposted by Osvaldo Contreras
We're proud to share Dr Osvaldo Contreras has been awarded a Scale Biosciences Core Lab Grant, from @garvaninstitute.bsky.social Genomics Platform, Scale Biosciences, and Integrated Sciences to further his research into the origins of congenital heart disease that affects one in 100 babies.
September 1, 2025 at 12:49 AM
We're proud to share Dr Osvaldo Contreras has been awarded a Scale Biosciences Core Lab Grant, from @garvaninstitute.bsky.social Genomics Platform, Scale Biosciences, and Integrated Sciences to further his research into the origins of congenital heart disease that affects one in 100 babies.
Thrilled to share our new paper: "OpenEMMU: A versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics"!
We've developed a new resource that make this crucial research more accessible, accurate, powerful and low-cost.
www.cell.com/iscience/ful...
We've developed a new resource that make this crucial research more accessible, accurate, powerful and low-cost.
www.cell.com/iscience/ful...
OpenEMMU: A versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics
Biochemistry; Cell biology; Developmental biology; Computational bioinformatics
www.cell.com
September 2, 2025 at 9:44 PM
Thrilled to share our new paper: "OpenEMMU: A versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics"!
We've developed a new resource that make this crucial research more accessible, accurate, powerful and low-cost.
www.cell.com/iscience/ful...
We've developed a new resource that make this crucial research more accessible, accurate, powerful and low-cost.
www.cell.com/iscience/ful...
Reposted by Osvaldo Contreras
1/n Very excited to share our recent paper published on
@ScienceAdvances
where we dissect the gene regulatory landscape guiding mouse sex determination!
science.org/doi/10.1126/...
A huge well done to @IsabelleStevant.genomic.social.ap.brid.gy, Meshi and Elisheva who spearhead this project!
@ScienceAdvances
where we dissect the gene regulatory landscape guiding mouse sex determination!
science.org/doi/10.1126/...
A huge well done to @IsabelleStevant.genomic.social.ap.brid.gy, Meshi and Elisheva who spearhead this project!
The gene regulatory landscape driving mouse gonadal supporting cell differentiation
Multiomics analysis revealed the regulatory elements and transcription factors responsible for gonadal sex determination.
science.org
July 27, 2025 at 6:04 AM
1/n Very excited to share our recent paper published on
@ScienceAdvances
where we dissect the gene regulatory landscape guiding mouse sex determination!
science.org/doi/10.1126/...
A huge well done to @IsabelleStevant.genomic.social.ap.brid.gy, Meshi and Elisheva who spearhead this project!
@ScienceAdvances
where we dissect the gene regulatory landscape guiding mouse sex determination!
science.org/doi/10.1126/...
A huge well done to @IsabelleStevant.genomic.social.ap.brid.gy, Meshi and Elisheva who spearhead this project!
Reposted by Osvaldo Contreras
If you love Daniocell, but wish it could generate analyses specific to YOUR genes & cell types of interest, check out DaniocellDesktop - a new point-and-click app for Mac and Windows that enables reanalysis of the Daniocell data without programming: daniocell.nichd.nih.gov/desktop/ (1/4)
June 13, 2025 at 2:30 PM
If you love Daniocell, but wish it could generate analyses specific to YOUR genes & cell types of interest, check out DaniocellDesktop - a new point-and-click app for Mac and Windows that enables reanalysis of the Daniocell data without programming: daniocell.nichd.nih.gov/desktop/ (1/4)
What’s potentially the first multi-omics study out there? Find it below.
This represents a major step forward into what’s later defined as personalised medicine.
Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes: Cell
www.cell.com/cell/fulltex...
This represents a major step forward into what’s later defined as personalised medicine.
Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes: Cell
www.cell.com/cell/fulltex...
Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes
A personalized medicine pilot study samples a patient's transcriptome, proteome, and
metabolome multiple times over the course of 14 months and integrates this information
with whole-genome sequence d...
www.cell.com
June 4, 2025 at 11:22 PM
What’s potentially the first multi-omics study out there? Find it below.
This represents a major step forward into what’s later defined as personalised medicine.
Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes: Cell
www.cell.com/cell/fulltex...
This represents a major step forward into what’s later defined as personalised medicine.
Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes: Cell
www.cell.com/cell/fulltex...