Osvaldo Contreras
@osvaldoics.bsky.social
Cell Identity + Cell Cycle Networks + Chromatin Dynamics & DevEvo in Human Development 🧬 @UNSWMedicine | #MyoTwitter 📝 @Prelights #eLifeAmbassador
Pinned
OpenEMMU: A versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics
Biochemistry; Cell biology; Developmental biology; Computational bioinformatics
www.cell.com
Thrilled to share our new paper: "OpenEMMU: A versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics"!
We've developed a new resource that make this crucial research more accessible, accurate, powerful and low-cost.
www.cell.com/iscience/ful...
We've developed a new resource that make this crucial research more accessible, accurate, powerful and low-cost.
www.cell.com/iscience/ful...
Reposted by Osvaldo Contreras
In vivo differentiation of embryonic cells devoid of key reprogramming factors
In vivo differentiation of embryonic cells devoid of key reprogramming factors
Youlten, Miao et al. use zebrafish transplantation to understand the fate of cells lacking pluripotency factors Nanog, Pou5f3, and Sox19b (NPS) in developmental reprogramming and cell identity establishment. They found that NPS are required for proper cell identity for most, but not all, lineages, likely through nuclear and cytoplasmic reprogramming.
dlvr.it
November 12, 2025 at 8:50 PM
In vivo differentiation of embryonic cells devoid of key reprogramming factors
Reposted by Osvaldo Contreras
One week left to register! Join the Editors-in-Chief of Differentiation on November 14 at 12:00 p.m. Central for a virtual seminar with Pavani P. Perera on the enteric nervous system, evolution, and cave fish. Register for free: https://bit.ly/4oaU71P
Topic: https://bit.ly/478UZhu
Topic: https://bit.ly/478UZhu
November 7, 2025 at 7:49 PM
One week left to register! Join the Editors-in-Chief of Differentiation on November 14 at 12:00 p.m. Central for a virtual seminar with Pavani P. Perera on the enteric nervous system, evolution, and cave fish. Register for free: https://bit.ly/4oaU71P
Topic: https://bit.ly/478UZhu
Topic: https://bit.ly/478UZhu
Reposted by Osvaldo Contreras
Save the date! @isscr.org, @alleninstitute.org & @socdevbio.bsky.social are collaborating to present a 3-day scientific symposium led by early-career scientists. The Stem Cell & Developmental Biology Early Career Symposium will be held September 23-25, 2026 in Seattle, WA. Learn more: bit.ly/4p98dkv
November 13, 2025 at 5:20 PM
Save the date! @isscr.org, @alleninstitute.org & @socdevbio.bsky.social are collaborating to present a 3-day scientific symposium led by early-career scientists. The Stem Cell & Developmental Biology Early Career Symposium will be held September 23-25, 2026 in Seattle, WA. Learn more: bit.ly/4p98dkv
Reposted by Osvaldo Contreras
Catch up on the recordings from our October #DevPres webinar on development across scales. View the presentations from @osvaldoics.bsky.social and @yinanwan.bsky.social.
thenode.biologists.com/catch-up-on-...
thenode.biologists.com/catch-up-on-...
Catch up on Development presents… webinar on development across scales - the Node
Our October webinar featured two early-career researchers working on development across scales. Here, we share the talks from Osvaldo Contreras (Victor
thenode.biologists.com
November 12, 2025 at 10:13 AM
Catch up on the recordings from our October #DevPres webinar on development across scales. View the presentations from @osvaldoics.bsky.social and @yinanwan.bsky.social.
thenode.biologists.com/catch-up-on-...
thenode.biologists.com/catch-up-on-...
Reposted by Osvaldo Contreras
Transitions is the newest in our series of stem cell conversations. Launched by Ritika Saxena, Jarmon Lees and @osvaldoics.bsky.social we explore project and career transitions. All the parts needed for successful science that don't make it to the bench. For Aussie scientists, but all welcome.
October 19, 2025 at 10:11 PM
Transitions is the newest in our series of stem cell conversations. Launched by Ritika Saxena, Jarmon Lees and @osvaldoics.bsky.social we explore project and career transitions. All the parts needed for successful science that don't make it to the bench. For Aussie scientists, but all welcome.
Reposted by Osvaldo Contreras
We are celebrating 5 years of the Australia stem cell conversation! Hosted by @unimelb.bsky.social and @asscr.bsky.social the stem cell conversation is a weekly 30min virtual seminar series organised by EMCR for EMCR.
Join the first 'transitions' episode Leadership through Service: 11am AEST Wed.
Join the first 'transitions' episode Leadership through Service: 11am AEST Wed.
October 19, 2025 at 10:05 PM
We are celebrating 5 years of the Australia stem cell conversation! Hosted by @unimelb.bsky.social and @asscr.bsky.social the stem cell conversation is a weekly 30min virtual seminar series organised by EMCR for EMCR.
Join the first 'transitions' episode Leadership through Service: 11am AEST Wed.
Join the first 'transitions' episode Leadership through Service: 11am AEST Wed.
Join us 15 October to hear from two early-career researchers, @osvaldoics.bsky.social & Yinan Wan, working on development across scales.
Chaired by @dev-journal.bsky.social Executive Editor @amjeve.bsky.social.
📅 15 October, 09:00 BST (UTC+1)
Register here: us02web.zoom.us/webinar/regi...
Chaired by @dev-journal.bsky.social Executive Editor @amjeve.bsky.social.
📅 15 October, 09:00 BST (UTC+1)
Register here: us02web.zoom.us/webinar/regi...
September 30, 2025 at 11:36 AM
Remarkable conference organized by @asbmbaus.bsky.social up in Brisbane at the University of Queensland.
I was invited to present my latest work as a Keynote Speaker for the Multi-Sonic’s session, and so many thanks for selecting me!
Truly an honour!
I was invited to present my latest work as a Keynote Speaker for the Multi-Sonic’s session, and so many thanks for selecting me!
Truly an honour!
September 30, 2025 at 1:13 AM
Remarkable conference organized by @asbmbaus.bsky.social up in Brisbane at the University of Queensland.
I was invited to present my latest work as a Keynote Speaker for the Multi-Sonic’s session, and so many thanks for selecting me!
Truly an honour!
I was invited to present my latest work as a Keynote Speaker for the Multi-Sonic’s session, and so many thanks for selecting me!
Truly an honour!
Reposted by Osvaldo Contreras
SAVE THE DATE! Join us for the 2025 @anzscdb.bsky.social
NSW Branch Cell & Developmental Biology Symposium at the Garvan Institute @garvaninstitute.bsky.social on Wed 5 Nov 2025. Keynote speakers include Dougall Norris, @katequinlan.bsky.social, Silvia Velasco and @ryanlister.bsky.social 🔬🧠🧫
NSW Branch Cell & Developmental Biology Symposium at the Garvan Institute @garvaninstitute.bsky.social on Wed 5 Nov 2025. Keynote speakers include Dougall Norris, @katequinlan.bsky.social, Silvia Velasco and @ryanlister.bsky.social 🔬🧠🧫
September 19, 2025 at 7:29 AM
SAVE THE DATE! Join us for the 2025 @anzscdb.bsky.social
NSW Branch Cell & Developmental Biology Symposium at the Garvan Institute @garvaninstitute.bsky.social on Wed 5 Nov 2025. Keynote speakers include Dougall Norris, @katequinlan.bsky.social, Silvia Velasco and @ryanlister.bsky.social 🔬🧠🧫
NSW Branch Cell & Developmental Biology Symposium at the Garvan Institute @garvaninstitute.bsky.social on Wed 5 Nov 2025. Keynote speakers include Dougall Norris, @katequinlan.bsky.social, Silvia Velasco and @ryanlister.bsky.social 🔬🧠🧫
Honored to present at @ramacgenomics.bsky.social @unsw.edu.au next Tuesday.😃
Some exciting #SingleCell events with #ParseBio coming up this month at @ramacgenomics.bsky.social 🧬
9 Sept: SPLiT-Seq Tech Showcase Seminar 🔗 tinyurl.com/bddc5zc3
15 Sept: Application deadline for discounted Parse Evercode WT Mini v3 Kit promotion 🔗 tinyurl.com/yc84zmfm
📩 ramaciotti@unsw.edu.au
9 Sept: SPLiT-Seq Tech Showcase Seminar 🔗 tinyurl.com/bddc5zc3
15 Sept: Application deadline for discounted Parse Evercode WT Mini v3 Kit promotion 🔗 tinyurl.com/yc84zmfm
📩 ramaciotti@unsw.edu.au
September 5, 2025 at 3:55 AM
Honored to present at @ramacgenomics.bsky.social @unsw.edu.au next Tuesday.😃
Reposted by Osvaldo Contreras
Don't miss @osvaldoics.bsky.social in the flesh next Tuesday in Sydney
Some exciting #SingleCell events with #ParseBio coming up this month at @ramacgenomics.bsky.social 🧬
9 Sept: SPLiT-Seq Tech Showcase Seminar 🔗 tinyurl.com/bddc5zc3
15 Sept: Application deadline for discounted Parse Evercode WT Mini v3 Kit promotion 🔗 tinyurl.com/yc84zmfm
📩 ramaciotti@unsw.edu.au
9 Sept: SPLiT-Seq Tech Showcase Seminar 🔗 tinyurl.com/bddc5zc3
15 Sept: Application deadline for discounted Parse Evercode WT Mini v3 Kit promotion 🔗 tinyurl.com/yc84zmfm
📩 ramaciotti@unsw.edu.au
September 5, 2025 at 1:00 AM
Don't miss @osvaldoics.bsky.social in the flesh next Tuesday in Sydney
Reposted by Osvaldo Contreras
We're proud to share Dr Osvaldo Contreras has been awarded a Scale Biosciences Core Lab Grant, from @garvaninstitute.bsky.social Genomics Platform, Scale Biosciences, and Integrated Sciences to further his research into the origins of congenital heart disease that affects one in 100 babies.
September 1, 2025 at 12:49 AM
We're proud to share Dr Osvaldo Contreras has been awarded a Scale Biosciences Core Lab Grant, from @garvaninstitute.bsky.social Genomics Platform, Scale Biosciences, and Integrated Sciences to further his research into the origins of congenital heart disease that affects one in 100 babies.
Thrilled to share our new paper: "OpenEMMU: A versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics"!
We've developed a new resource that make this crucial research more accessible, accurate, powerful and low-cost.
www.cell.com/iscience/ful...
We've developed a new resource that make this crucial research more accessible, accurate, powerful and low-cost.
www.cell.com/iscience/ful...
OpenEMMU: A versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics
Biochemistry; Cell biology; Developmental biology; Computational bioinformatics
www.cell.com
September 2, 2025 at 9:44 PM
Thrilled to share our new paper: "OpenEMMU: A versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics"!
We've developed a new resource that make this crucial research more accessible, accurate, powerful and low-cost.
www.cell.com/iscience/ful...
We've developed a new resource that make this crucial research more accessible, accurate, powerful and low-cost.
www.cell.com/iscience/ful...
Reposted by Osvaldo Contreras
1/n Very excited to share our recent paper published on
@ScienceAdvances
where we dissect the gene regulatory landscape guiding mouse sex determination!
science.org/doi/10.1126/...
A huge well done to @IsabelleStevant.genomic.social.ap.brid.gy, Meshi and Elisheva who spearhead this project!
@ScienceAdvances
where we dissect the gene regulatory landscape guiding mouse sex determination!
science.org/doi/10.1126/...
A huge well done to @IsabelleStevant.genomic.social.ap.brid.gy, Meshi and Elisheva who spearhead this project!
The gene regulatory landscape driving mouse gonadal supporting cell differentiation
Multiomics analysis revealed the regulatory elements and transcription factors responsible for gonadal sex determination.
science.org
July 27, 2025 at 6:04 AM
1/n Very excited to share our recent paper published on
@ScienceAdvances
where we dissect the gene regulatory landscape guiding mouse sex determination!
science.org/doi/10.1126/...
A huge well done to @IsabelleStevant.genomic.social.ap.brid.gy, Meshi and Elisheva who spearhead this project!
@ScienceAdvances
where we dissect the gene regulatory landscape guiding mouse sex determination!
science.org/doi/10.1126/...
A huge well done to @IsabelleStevant.genomic.social.ap.brid.gy, Meshi and Elisheva who spearhead this project!
Reposted by Osvaldo Contreras
If you love Daniocell, but wish it could generate analyses specific to YOUR genes & cell types of interest, check out DaniocellDesktop - a new point-and-click app for Mac and Windows that enables reanalysis of the Daniocell data without programming: daniocell.nichd.nih.gov/desktop/ (1/4)
June 13, 2025 at 2:30 PM
If you love Daniocell, but wish it could generate analyses specific to YOUR genes & cell types of interest, check out DaniocellDesktop - a new point-and-click app for Mac and Windows that enables reanalysis of the Daniocell data without programming: daniocell.nichd.nih.gov/desktop/ (1/4)
What’s potentially the first multi-omics study out there? Find it below.
This represents a major step forward into what’s later defined as personalised medicine.
Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes: Cell
www.cell.com/cell/fulltex...
This represents a major step forward into what’s later defined as personalised medicine.
Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes: Cell
www.cell.com/cell/fulltex...
Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes
A personalized medicine pilot study samples a patient's transcriptome, proteome, and
metabolome multiple times over the course of 14 months and integrates this information
with whole-genome sequence d...
www.cell.com
June 4, 2025 at 11:22 PM
What’s potentially the first multi-omics study out there? Find it below.
This represents a major step forward into what’s later defined as personalised medicine.
Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes: Cell
www.cell.com/cell/fulltex...
This represents a major step forward into what’s later defined as personalised medicine.
Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes: Cell
www.cell.com/cell/fulltex...
So happy about presenting our Pan-Omics work next week!🎉
Thanks for the invite👨🏽🔬🙏🏽❤️
Thanks for the invite👨🏽🔬🙏🏽❤️
May 8, 2025 at 11:30 PM
So happy about presenting our Pan-Omics work next week!🎉
Thanks for the invite👨🏽🔬🙏🏽❤️
Thanks for the invite👨🏽🔬🙏🏽❤️
📢 Today!
National Stem Cell Conversations
🔬 Regulation of Patterning
Qi Zhang: "Molecular mechanisms of epigenetic regulation"
Adrienne Sullivan: "Early GATA3 activity mediates lineage commitment and patterning in human gastrulation"
📅 Wednesday, 7th May 2025 ⏰ Time: 11:00 AM - 11:30 AM AEST
National Stem Cell Conversations
🔬 Regulation of Patterning
Qi Zhang: "Molecular mechanisms of epigenetic regulation"
Adrienne Sullivan: "Early GATA3 activity mediates lineage commitment and patterning in human gastrulation"
📅 Wednesday, 7th May 2025 ⏰ Time: 11:00 AM - 11:30 AM AEST
May 6, 2025 at 11:27 PM
📢 Today!
National Stem Cell Conversations
🔬 Regulation of Patterning
Qi Zhang: "Molecular mechanisms of epigenetic regulation"
Adrienne Sullivan: "Early GATA3 activity mediates lineage commitment and patterning in human gastrulation"
📅 Wednesday, 7th May 2025 ⏰ Time: 11:00 AM - 11:30 AM AEST
National Stem Cell Conversations
🔬 Regulation of Patterning
Qi Zhang: "Molecular mechanisms of epigenetic regulation"
Adrienne Sullivan: "Early GATA3 activity mediates lineage commitment and patterning in human gastrulation"
📅 Wednesday, 7th May 2025 ⏰ Time: 11:00 AM - 11:30 AM AEST
FACS-assisted separation of cells for untargeted proteomics. Working with 10,000 cells per experiment to reveal the proteome of these, using low-input omics👨🏽🔬🔭
Thanks to all who make our research possible 🙏🏽✨
@victorchang.edu.au
@garvaninstitute.bsky.social
Thanks to all who make our research possible 🙏🏽✨
@victorchang.edu.au
@garvaninstitute.bsky.social
April 10, 2025 at 4:35 AM
FACS-assisted separation of cells for untargeted proteomics. Working with 10,000 cells per experiment to reveal the proteome of these, using low-input omics👨🏽🔬🔭
Thanks to all who make our research possible 🙏🏽✨
@victorchang.edu.au
@garvaninstitute.bsky.social
Thanks to all who make our research possible 🙏🏽✨
@victorchang.edu.au
@garvaninstitute.bsky.social
A Piece of Art!
A simple 2.5% Agarose gel with so much information in it.
Fundamental science blows my mind, always 🤯❤️
A simple 2.5% Agarose gel with so much information in it.
Fundamental science blows my mind, always 🤯❤️
March 17, 2025 at 1:23 AM
A Piece of Art!
A simple 2.5% Agarose gel with so much information in it.
Fundamental science blows my mind, always 🤯❤️
A simple 2.5% Agarose gel with so much information in it.
Fundamental science blows my mind, always 🤯❤️
Third paper submitted of the year 🎉
Extremely grateful to my team and colleagues for the daily fundamental discoveries that pave the way for impact and translation 🙏🏽
Fingers crossed for their consideration and smooth revisions
Extremely grateful to my team and colleagues for the daily fundamental discoveries that pave the way for impact and translation 🙏🏽
Fingers crossed for their consideration and smooth revisions
February 28, 2025 at 7:50 AM
Third paper submitted of the year 🎉
Extremely grateful to my team and colleagues for the daily fundamental discoveries that pave the way for impact and translation 🙏🏽
Fingers crossed for their consideration and smooth revisions
Extremely grateful to my team and colleagues for the daily fundamental discoveries that pave the way for impact and translation 🙏🏽
Fingers crossed for their consideration and smooth revisions
Reposted by Osvaldo Contreras
🚀 Open Science can’t wait! I’m thrilled to share our latest preprint: 𝐎𝐩𝐞𝐧𝐄𝐌𝐌𝐔!
🔬 𝐎𝐩𝐞𝐧𝐄𝐌𝐌𝐔: A versatile, open-source EdU multiplexing methodology for understanding DNA replication and cell cycle dynamics
🔗 Read the preprint here: biorxiv.org/content/10.1...
#OpenEMMU #DNAReplication #CellCycle
🔬 𝐎𝐩𝐞𝐧𝐄𝐌𝐌𝐔: A versatile, open-source EdU multiplexing methodology for understanding DNA replication and cell cycle dynamics
🔗 Read the preprint here: biorxiv.org/content/10.1...
#OpenEMMU #DNAReplication #CellCycle
OpenEMMU: a versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics
5-Ethynyl-2’-deoxyuridine (EdU) has transformed DNA replication and cell cycle analyses through fast and efficient click chemistry detection. However, commercial EdU kits are expensive, contain propri...
biorxiv.org
January 22, 2025 at 3:30 AM
🚀 Open Science can’t wait! I’m thrilled to share our latest preprint: 𝐎𝐩𝐞𝐧𝐄𝐌𝐌𝐔!
🔬 𝐎𝐩𝐞𝐧𝐄𝐌𝐌𝐔: A versatile, open-source EdU multiplexing methodology for understanding DNA replication and cell cycle dynamics
🔗 Read the preprint here: biorxiv.org/content/10.1...
#OpenEMMU #DNAReplication #CellCycle
🔬 𝐎𝐩𝐞𝐧𝐄𝐌𝐌𝐔: A versatile, open-source EdU multiplexing methodology for understanding DNA replication and cell cycle dynamics
🔗 Read the preprint here: biorxiv.org/content/10.1...
#OpenEMMU #DNAReplication #CellCycle