Prof Deepak Modi
@drdeepaknmodi.bsky.social
Faculty at ICMR-NIRRCH 🇮🇳 Developmental biologist, embryo implantation, placentation and sex determination
We also develop organ on chip and organoids models of ♀️ rep tract and placenta
#womenshealth #gender #hoxgenes
🏳️🌈
We also develop organ on chip and organoids models of ♀️ rep tract and placenta
#womenshealth #gender #hoxgenes
🏳️🌈
Pinned
HOXA10-TWIST2 antagonism drives partial epithelial-to-mesenchymal transition for embryo implantation - Cell Death Discovery
Cell Death Discovery - HOXA10-TWIST2 antagonism drives partial epithelial-to-mesenchymal transition for embryo implantation
www.nature.com
Thrilled to share our discovery on the genetic switch that creates a hybrid EMT state for embryo implantation.
This work has broad implications as it explains control of physiologic EMT in adult tissues and it also shows that HOX genes have bifunctional roles
www.nature.com/articles/s41...
This work has broad implications as it explains control of physiologic EMT in adult tissues and it also shows that HOX genes have bifunctional roles
www.nature.com/articles/s41...
2 new studies from the lab show that early pregnancy needs inflammation but only briefly. When uterine inflammation does not activate in time, implantation fails and if prolongs pregnancy is lost.
Links
doi.org/10.1093/reprod…
doi.org/10.1016/j.lfs.���
Super proud of my team
Links
doi.org/10.1093/reprod…
doi.org/10.1016/j.lfs.���
Super proud of my team
February 5, 2026 at 2:36 AM
2 new studies from the lab show that early pregnancy needs inflammation but only briefly. When uterine inflammation does not activate in time, implantation fails and if prolongs pregnancy is lost.
Links
doi.org/10.1093/reprod…
doi.org/10.1016/j.lfs.���
Super proud of my team
Links
doi.org/10.1093/reprod…
doi.org/10.1016/j.lfs.���
Super proud of my team
Republic Day Greetings
January 26, 2026 at 7:56 AM
Republic Day Greetings
Reposted by Prof Deepak Modi
The IBEX Knowledge-Base is setting a new standard for reproducibility in #immunofluorescence imaging: open, community-driven, and with ‘exceptional’ evidence of its utility.
It’s now up to the community to contribute to its growth.
🔗 buff.ly/klv0TSF
It’s now up to the community to contribute to its growth.
🔗 buff.ly/klv0TSF
January 25, 2026 at 11:01 AM
The IBEX Knowledge-Base is setting a new standard for reproducibility in #immunofluorescence imaging: open, community-driven, and with ‘exceptional’ evidence of its utility.
It’s now up to the community to contribute to its growth.
🔗 buff.ly/klv0TSF
It’s now up to the community to contribute to its growth.
🔗 buff.ly/klv0TSF
Regulation of embryonic ploidy by meiotic recombination.. expected ? Unexpected?
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Common variation in meiosis genes shapes human recombination and aneuploidy - Nature
Analysis of data from pre-implantation genetic testing sheds light on the genetic basis of meiotic-origin aneuploidy, the leading cause of human pregnancy loss, identifying common genetic variants ass...
www.nature.com
January 25, 2026 at 3:52 PM
Regulation of embryonic ploidy by meiotic recombination.. expected ? Unexpected?
www.nature.com/articles/s41...
www.nature.com/articles/s41...
WHO statement on notification of withdrawal of the United States share.google/nfdhuCJAQrzW...
WHO statement on notification of withdrawal of the United States
WHO regrets the United States’ notification of withdrawal from WHO – a decision that makes both the United States and the world less safe. The notification of withdrawal raises issues that will be con...
share.google
January 25, 2026 at 3:41 PM
WHO statement on notification of withdrawal of the United States share.google/nfdhuCJAQrzW...
Elated to share the publication of our paper on how HOXA10 controls NLRP3 to drive #hybridEMT and pyroptosis for embryo implantation
#Inflamation #pregnancy #reproduction
academic.oup.com/reproduction...
#Inflamation #pregnancy #reproduction
academic.oup.com/reproduction...
Loss of HOXA10 activates NLRP3 for epithelial plasticity and pyroptosis in endometrium during embryo implantation
In briefA successful pregnancy begins with embryo implantation, but how the embryo breaks through the endometrial lining is not understood. Here, we uncove
academic.oup.com
January 20, 2026 at 12:45 AM
Elated to share the publication of our paper on how HOXA10 controls NLRP3 to drive #hybridEMT and pyroptosis for embryo implantation
#Inflamation #pregnancy #reproduction
academic.oup.com/reproduction...
#Inflamation #pregnancy #reproduction
academic.oup.com/reproduction...
Reposted by Prof Deepak Modi
Woolly Rhino was not experiencing population decline prior to its rapid extinction ~14,000 years ago, based on DNA recovered from mummified wolf stomach in Siberian permafrost. Instead, extinction likely due to rapid environmental change.
🧪🌎🧬🖥️ #EvoSky #Genomics
pmc.ncbi.nlm.nih.gov/articles/PMC...
🧪🌎🧬🖥️ #EvoSky #Genomics
pmc.ncbi.nlm.nih.gov/articles/PMC...
Genome Shows no Recent Inbreeding in Near-Extinction Woolly Rhinoceros Sample Found in Ancient Wolf's Stomach
Using temporarily spaced high-coverage ancient genomes, we can assess population decline prior to extinction. However, finding suitable ancient remains for recovering this type of data is challenging. Here, we sequenced a high-coverage genome from ...
pmc.ncbi.nlm.nih.gov
January 17, 2026 at 1:33 AM
Woolly Rhino was not experiencing population decline prior to its rapid extinction ~14,000 years ago, based on DNA recovered from mummified wolf stomach in Siberian permafrost. Instead, extinction likely due to rapid environmental change.
🧪🌎🧬🖥️ #EvoSky #Genomics
pmc.ncbi.nlm.nih.gov/articles/PMC...
🧪🌎🧬🖥️ #EvoSky #Genomics
pmc.ncbi.nlm.nih.gov/articles/PMC...
Reposted by Prof Deepak Modi
Tylenol during pregnancy is safe without increased risk of autism, ADHD, or intellectual disability of offspring
A new review of the evidence just out
www.thelancet.com/journals/lan...
A new review of the evidence just out
www.thelancet.com/journals/lan...
January 16, 2026 at 11:43 PM
Tylenol during pregnancy is safe without increased risk of autism, ADHD, or intellectual disability of offspring
A new review of the evidence just out
www.thelancet.com/journals/lan...
A new review of the evidence just out
www.thelancet.com/journals/lan...
The serenity of the city called Bhubaneswar
January 15, 2026 at 7:36 AM
The serenity of the city called Bhubaneswar
Reposted by Prof Deepak Modi
Interested in the biophysics of organoids? We just published a review in Dev Cell—take a look! dlvr.it/TPyTb8 #Organoids #Biophysics
Biophysics of organoids
In this review, Weichselberger, Moore et al. discuss how physics-based approaches
illuminate organoid development and homeostasis by integrating mechanical, chemical,
and informational processes. They...
dlvr.it
January 6, 2026 at 10:27 AM
Interested in the biophysics of organoids? We just published a review in Dev Cell—take a look! dlvr.it/TPyTb8 #Organoids #Biophysics
Reposted by Prof Deepak Modi
All-in-one Single-Cell Proteomic Analysis of Protein Alterations in Human Oocytes Undergoing in Vitro Aging https://www.biorxiv.org/content/10.64898/2026.01.05.697813v1
January 6, 2026 at 6:30 PM
All-in-one Single-Cell Proteomic Analysis of Protein Alterations in Human Oocytes Undergoing in Vitro Aging https://www.biorxiv.org/content/10.64898/2026.01.05.697813v1
Indias position statement on the use of niPGT for clincial use is published in JHRS and covered by the media
#ivf #fertilityclinic
#embryo
#genetics
www.ndtv.com/health/india...
#ivf #fertilityclinic
#embryo
#genetics
www.ndtv.com/health/india...
www.ndtv.com
January 4, 2026 at 5:34 PM
Indias position statement on the use of niPGT for clincial use is published in JHRS and covered by the media
#ivf #fertilityclinic
#embryo
#genetics
www.ndtv.com/health/india...
#ivf #fertilityclinic
#embryo
#genetics
www.ndtv.com/health/india...
The year 2026 opens with a bang
Thrilled to share the publication from the lab showing that an inflammation is essential for embryo implantation
#fertility #miscarriage #uterus #infertility
www.sciencedirect.com/science/arti...
Thrilled to share the publication from the lab showing that an inflammation is essential for embryo implantation
#fertility #miscarriage #uterus #infertility
www.sciencedirect.com/science/arti...
Temporal control of decidual inflammation by HOXA10 is essential for implantation and its dysregulation is associated with early pregnancy loss
Successful implantation requires tightly regulated endometrial inflammation. While initial inflammatory signaling is essential for implantation, persi…
www.sciencedirect.com
January 1, 2026 at 7:05 PM
The year 2026 opens with a bang
Thrilled to share the publication from the lab showing that an inflammation is essential for embryo implantation
#fertility #miscarriage #uterus #infertility
www.sciencedirect.com/science/arti...
Thrilled to share the publication from the lab showing that an inflammation is essential for embryo implantation
#fertility #miscarriage #uterus #infertility
www.sciencedirect.com/science/arti...
The year closes with a key policy paper.
India issues its position statement on non-invasive PGT (niPGT). Based on available data of 3000 embryos an expert review panel concludes that niPGT is not ready for clinical use for embryo selection.
journals.lww.com/jhrs/fulltex...
India issues its position statement on non-invasive PGT (niPGT). Based on available data of 3000 embryos an expert review panel concludes that niPGT is not ready for clinical use for embryo selection.
journals.lww.com/jhrs/fulltex...
journals.lww.com
December 29, 2025 at 5:53 AM
The year closes with a key policy paper.
India issues its position statement on non-invasive PGT (niPGT). Based on available data of 3000 embryos an expert review panel concludes that niPGT is not ready for clinical use for embryo selection.
journals.lww.com/jhrs/fulltex...
India issues its position statement on non-invasive PGT (niPGT). Based on available data of 3000 embryos an expert review panel concludes that niPGT is not ready for clinical use for embryo selection.
journals.lww.com/jhrs/fulltex...
Techniques, methods papers and software papers are bound to be higher on scoreboards and there are no prizes for guessing that. For which direction the science is moving .. ideal would be to look at highly cited original papers and look at field normalised citations.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Exclusive: the most-cited papers of the twenty-first century
A Nature analysis reveals the 25 highest-cited papers published this century and explores why they are breaking records.
www.nature.com
December 27, 2025 at 7:26 AM
Techniques, methods papers and software papers are bound to be higher on scoreboards and there are no prizes for guessing that. For which direction the science is moving .. ideal would be to look at highly cited original papers and look at field normalised citations.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
The sun kissed evening.
Chasing the sun across the horizon. Watching the world trade its gold for midnight sapphire at 30,000 feet. There’s a certain kind of magic between sun, clouds and the sky.
#WindowSeatViews
#DuskTillDawn
#SkyAesthetic
#GoldenHourMagic
#HorizonLines
Chasing the sun across the horizon. Watching the world trade its gold for midnight sapphire at 30,000 feet. There’s a certain kind of magic between sun, clouds and the sky.
#WindowSeatViews
#DuskTillDawn
#SkyAesthetic
#GoldenHourMagic
#HorizonLines
December 21, 2025 at 6:52 AM
The sun kissed evening.
Chasing the sun across the horizon. Watching the world trade its gold for midnight sapphire at 30,000 feet. There’s a certain kind of magic between sun, clouds and the sky.
#WindowSeatViews
#DuskTillDawn
#SkyAesthetic
#GoldenHourMagic
#HorizonLines
Chasing the sun across the horizon. Watching the world trade its gold for midnight sapphire at 30,000 feet. There’s a certain kind of magic between sun, clouds and the sky.
#WindowSeatViews
#DuskTillDawn
#SkyAesthetic
#GoldenHourMagic
#HorizonLines
Fantastic insights on how replication stress drives cell differentiation by Osvaldo Contreras at the joint meeting of the #InSDB and International Society of Differentiation #ISD joint meeting at #IISER_BERHAMPUR
@osvaldoics.bsky.social
#INSDBISD2025
@osvaldoics.bsky.social
#INSDBISD2025
December 15, 2025 at 5:29 AM
Fantastic insights on how replication stress drives cell differentiation by Osvaldo Contreras at the joint meeting of the #InSDB and International Society of Differentiation #ISD joint meeting at #IISER_BERHAMPUR
@osvaldoics.bsky.social
#INSDBISD2025
@osvaldoics.bsky.social
#INSDBISD2025
This is just is just the tip of the iceberg ... Much more mess is around
December 14, 2025 at 1:22 PM
This is just is just the tip of the iceberg ... Much more mess is around
Elected at the executive council of Society for Reproductive Biology and Comparative Endocrinology #SRBCE
Looking forward to ser6ve the society and taking Indian science to the international map
Looking forward to ser6ve the society and taking Indian science to the international map
December 13, 2025 at 3:56 PM
Elected at the executive council of Society for Reproductive Biology and Comparative Endocrinology #SRBCE
Looking forward to ser6ve the society and taking Indian science to the international map
Looking forward to ser6ve the society and taking Indian science to the international map
Batch 1 and batch 2 to off to IISER Bherampur for the coveted and much awaited meeting of the Indian Society of Developmental Biologist #InSDB 2025
Excited to present our groups work on embryo implantation and placental organ on chip and placentoids models
Excited to present our groups work on embryo implantation and placental organ on chip and placentoids models
December 13, 2025 at 7:56 AM
Batch 1 and batch 2 to off to IISER Bherampur for the coveted and much awaited meeting of the Indian Society of Developmental Biologist #InSDB 2025
Excited to present our groups work on embryo implantation and placental organ on chip and placentoids models
Excited to present our groups work on embryo implantation and placental organ on chip and placentoids models
Some beautiful insights into the genomics of #Preterm births. Key SNPs in the maternal genome are strongly associated with Preterm delivery in the Indian population. Dr Arindam Mitra BRIC-NIBMG at #ReproNext2025 #SRBCE2025 #prematurity
December 11, 2025 at 12:56 PM
Some beautiful insights into the genomics of #Preterm births. Key SNPs in the maternal genome are strongly associated with Preterm delivery in the Indian population. Dr Arindam Mitra BRIC-NIBMG at #ReproNext2025 #SRBCE2025 #prematurity
A phenomenal keynote address by #padmashree Dr Neerja Bhatla on cervical cancer screening and prevention at the #ReproNext2025 and 42nd annual meeting of #SRBCEn2025
December 11, 2025 at 12:02 PM
A phenomenal keynote address by #padmashree Dr Neerja Bhatla on cervical cancer screening and prevention at the #ReproNext2025 and 42nd annual meeting of #SRBCEn2025
The inauguration of ReproNext 2025 begins
It's also the 42nd annual meeting of SRBCE
#ReproNext2025 #SRBCE2025
It's also the 42nd annual meeting of SRBCE
#ReproNext2025 #SRBCE2025
December 11, 2025 at 11:54 AM
The inauguration of ReproNext 2025 begins
It's also the 42nd annual meeting of SRBCE
#ReproNext2025 #SRBCE2025
It's also the 42nd annual meeting of SRBCE
#ReproNext2025 #SRBCE2025