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eLife
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The funder-researcher collaboration and open-access publisher for research in the life and biomedical sciences.

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We’re pleased to announce our Trained Immunity Focus Issue 🎉

With original research and reviews spanning history, current state and future directions of trained immunity, explore today:
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Findings reveal how TGF-beta signalling keeps the brain’s blood vessels healthy.

Disrupting this in brain blood vessels disrupts retinal development and triggers immune cell invasion, revealing its role in maintaining vascular–immune balance in the CNS.
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November 11, 2025 at 11:01 AM
The pathogenic bacteria Shigella avoids detection inside host cells by degrading RNF213, the protein responsible for sensing the presence of intracellular pathogens.

Read more in the eLife Insight Article: buff.ly/1mIc6m0
November 10, 2025 at 11:28 PM
Chromosomes: Exploring a crossroads in the ageing process

New Insight Article explains experiments on yeast show that the nuclear pore complex has a central role in the loss of chromosomes associated with ageing.
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November 10, 2025 at 9:02 PM
With a score of 85, this article is in the top 5% of all research outputs scored by @altmetric.com!

It even featured in @scienceofthetimes.bsky.social's podcast: elife.altmetric.com/details/1744...

Take a look: elife.altmetric.com/details/1744...

Look out for Altmetric badges on eLife articles 🏆
November 10, 2025 at 5:10 PM
The sex factor

Ants have been using the same mechanism to determine their sex for over 100 million years of evolution.
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November 10, 2025 at 11:44 AM
Reposted by eLife
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Two rainforest butterflies have evolved to look more alike, likely to confuse shared predators. But why don’t they get confused themselves?

To avoid mating with the wrong species, they’ve cleverly evolved distinct scents.
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November 9, 2025 at 12:05 AM
The peach aphid is one of the most harmful pests worldwide. So far, controlling them mainly relies on chemical pesticides that lead to pollution and resistance. A plant byproduct called betulin promises a new green alternative.
Green pesticides for aphid control
The secondary plant metabolite betulin shows potential for development as a green insecticide.
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November 9, 2025 at 11:28 PM
For most of us, our physical and mental abilities decline as we age.

Scientists are examining tool use, a technically challenging activity, to learn how ageing affects our close relatives, chimpanzees, something we know very little about.
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November 9, 2025 at 11:01 AM
Innate immunity was long thought to be devoid of immunological memory until a landmark study a decade ago.

Our new Focus Issue curates reviews and research in the field of Trained Immunity.
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November 9, 2025 at 9:21 AM
Two rainforest butterflies have evolved to look more alike, likely to confuse shared predators. But why don’t they get confused themselves?

To avoid mating with the wrong species, they’ve cleverly evolved distinct scents.
buff.ly/fxVrlCI
November 8, 2025 at 11:44 PM
Looking for a home for your genetics or genomics preprint?

We review research from the genetic basis of health and disease to epigenetics.

Learn how preprints are changing the way research is shared at eLife and submit today: buff.ly/n9ml5Am
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The eLife Model: Submit your research
In January 2023, we switched to a new way of publishing where all papers reviewed by eLife are published as Reviewed Preprints.
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November 8, 2025 at 2:59 PM
Meet Owen Ouyang, the newest member of the @ecr_life editorial team! 🎉

A PhD student studying viral evolution, Owen’s passionate about mentorship and supporting early-career researchers.

Get to know him 👇
ecrlife.org/getting-to-k...
November 8, 2025 at 11:01 AM
Findings reveal how TGF-beta signalling keeps the brain’s blood vessels healthy.

Disrupting this in brain blood vessels disrupts retinal development and triggers immune cell invasion, revealing its role in maintaining vascular–immune balance in the CNS.
buff.ly/1mIc6m0
November 7, 2025 at 9:02 PM
The concept of immunological memory has expanded since a landmark study on innate immunity a decade ago. Now, we’re sharing a new Focus Issue on Trained Immunity.

From its history to its future directions, read the latest reviews and research.
buff.ly/OoqVRjM
November 7, 2025 at 2:59 PM
Reposted by eLife
Final version now out in @elife.bsky.social: Heterozygosity at a conserved candidate sex determination locus is associated with female development in the clonal raider ant (Ooceraea biroi) doi.org/10.7554/eLif...
Heterozygosity at a conserved candidate sex determination locus is associated with female development in the clonal raider ant (Ooceraea biroi)
A complementary sex determination locus is conserved in ants and dates back to approximately 112 million years ago.
doi.org
November 6, 2025 at 7:53 PM
Reposted by eLife
Blood Suppl-eye: Loss of TGF-β in blood vessel endothelial cells as a model of retinal & neurological diseases

📷 Yanshu Wang et al @hopkinsmedicine.bsky.social
in @elife.bsky.social

➡️ bpod.org.uk/archive/2025... with Lux Fatimathas
November 7, 2025 at 10:43 AM
Reposted by eLife
Nouvelle publication de Joséphine Ledamoisel (ISYEB / CRC), Christine Andraud (CRC), @vincentdebat.bsky.social, Violaine Llaurens du @crc-recherche.bsky.social et de l'@isyeb.mnhn.fr & al. dans @elife.bsky.social
Finally out in Elife @elife.bsky.social : well done @joledamoisel.bsky.social ! Convergent iridescence and divergent chemical signals in sympatric sister-species of Amazonian butterflies doi.org/10.7554/eLif...
November 7, 2025 at 8:16 AM
Lifestyles shape genome size and gene content in fungal pathogens.
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November 7, 2025 at 9:21 AM
By comparing differently tuned glomeruli, this work shows that the brain uses different circuit layouts for specialised vs general smells, offering new insight into how odour meaning is encoded.
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November 6, 2025 at 11:28 PM
1/ Want to try your hand at science communication but don’t know where to start?

We put together seven tried and tested tips for communicating preprinted research with suggestions and resources that can help you on social media and beyond! #SciComm

🔗 buff.ly/1jesQg5
November 6, 2025 at 9:03 PM
The gut-brain connection

Glia cells mediate cytokine signalling between the gut and the brain, linking sleep to inflammation in the gut.
The gut-brain connection
Glia cells mediate cytokine signaling between the gut and the brain, linking sleep to inflammation in the gut.
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November 6, 2025 at 2:44 PM
Reposted by eLife
Research into wild chimpanzees’ changing tool use suggests evolutionary origins of Alzheimer’s disease and related disorders #URochesterResearch by Dr. Dora Biro of @uor-braincogsci.bsky.social

via @elife.bsky.social ➡️ elifesciences.org/articles/105...
Wild chimpanzees show human-like cognitive decline with age
Research into changing tool use by wild chimpanzees suggests evolutionary origins of Alzheimer’s disease and related disorders.
www.rochester.edu
November 4, 2025 at 8:31 PM
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Did you know open science can empower you and your research community?

@elife.bsky.social share how to get started, overcome barriers, and join a global community of researchers practising open science.

Watch the webinar here: elifesciences.org/inside-elife...

#OpenScience #OpenAccess #PhDSky
New to open science?

💡 Revisit our introductory webinar exploring what it means, why it matters, and how it can benefit researchers and the public alike.

📝 Watch on our YouTube 👇
Webinar Report: An introduction to open science
Watch back as our speakers introduce and discuss the importance of open science.
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November 5, 2025 at 11:08 AM
Reposted by eLife
My first paper as a first author is officially out 🎉 @elife.bsky.social

We show that the iridescent colour of Morphos 🦋 tends to converge in sympatry while their chemical signals diverge, illustrating the constrasting effect natural and sexual selection on trait evolution.

doi.org/10.7554/eLif...
Convergent iridescence and divergent chemical signals in sympatric sister-species of Amazonian butterflies
Ecological interactions exert contrasting evolutionary pressures on sympatric Morpho butterflies, promoting convergence in iridescence but divergence in chemical cues, illustrating how ecological inte...
doi.org
November 6, 2025 at 8:55 AM
Reposted by eLife
Finally out in Elife @elife.bsky.social : well done @joledamoisel.bsky.social ! Convergent iridescence and divergent chemical signals in sympatric sister-species of Amazonian butterflies doi.org/10.7554/eLif...
November 6, 2025 at 9:47 AM