eLife
LightNews LightNews
banner
elife.bsky.social
eLife
@elife.bsky.social
17K followers 53 following 1.7K posts
The funder-researcher collaboration and open-access publisher for research in the life and biomedical sciences.

Follow @eLifeCommunity.bsky.social
Posts Replies Media Videos
elife.bsky.social
By comparing how people with and without borderline personality disorder play a simple social game, Joe Barnby uncovered how this core human ability can go awry, and what that reveals about all of us.

Read the interview for Inside Discovery: buff.ly/CKx4k5c
November 14, 2025 at 9:02 PM
elife.bsky.social
⛓️ October’s most-read Structural Biology paper challenges textbook views of synapses, revealing a complex ‘synaptoplasm’ instead of a dense post-synaptic layer: buff.ly/rAvREVV

Have a paper people should see? See what our Editors look for: buff.ly/NjxVKFB
November 14, 2025 at 2:59 PM
elife.bsky.social
Migration of cell populations is a fundamental process in morphogenesis and disease. Researchers have identified a novel form of collective mesenchymal cell migration during chick gastrulation, where cells self-organise into a dynamic meshwork structure.
buff.ly/JDp0rUo
November 14, 2025 at 9:21 AM
elife.bsky.social
Septins and the exocyst complex work together to guide membrane trafficking during cell division in fission yeast, revealing one of the most conserved functions of septins in exocytosis.
buff.ly/rkEfQZY
November 13, 2025 at 11:28 PM
elife.bsky.social
Hybridisation breaks species barriers in long-term coevolution of a cyanobacterial population.
buff.ly/EaJskBA
Hybridization between previously isolated lineages is main source of diversity within the population.
November 13, 2025 at 9:02 PM
elife.bsky.social
2/ The 'fundamental' rating is taken from our eLife Assessment.

Written by editors and reviewers, they summarise the work's significance and strength of evidence, providing a more nuanced alternative to journal-level metrics for research assessment.
elifesciences.org/about/elife-...
eLife Assessment This fundamental work provides novel insights into the blood flow-dependent mechanisms of neuronal migration and the role of Ghrelin signaling in the adult brain. The authors present convincing evidence that newborn rostral migratory stream (RMS) neurons are closely situated alongside blood vessels, preferentially along arterioles, and that migratory speed is correlated with blood flow. They also provide evidence (in vitro and some in vivo) that Ghrelin from blood is involved in augmenting RMS neuron migration speed.
November 13, 2025 at 2:44 PM
elife.bsky.social
1/ New ‘fundamental’ study shows that neuronal migration depends on blood flow in the adult mammalian brain.
elifesciences.org/articles/995...
November 13, 2025 at 2:44 PM
elife.bsky.social
Lifestyles shape genome size and gene content in fungal pathogens.
buff.ly/tec1Tds
Genomic traits associated with pathogenicity.
November 12, 2025 at 11:28 PM
elife.bsky.social
Evidence from 14 research funding programmes confirms that early winners tend to keep winning (Matthew effect). But the idea that an early setback makes you stronger later doesn’t replicate widely.
buff.ly/UEtcRd4
eLife Assessment This important study reports the results of efforts to replicate two phenomena of significant interest to early-career scientists and scientific policymakers: the Matthew effect and the early-career setback effect. Several previous studies of these effects have focused on early-career researchers with grant proposals that fell just below or just above a funding threshold. Those just above the threshold were more likely to be successful when they applied for funding later in the career (an example of the well-known Matthew effect), while those just below were more likely to go on to have stronger publication records (the early-career setback effect). In this study the Matthew effect was found to be robust across funders, and to generalize from those close to the funding threshold to the whole population. The early-career setback effect was not robust across funders and did not generalize to the whole population. The evidence reported is convincing.
November 12, 2025 at 4:15 PM
elife.bsky.social
Kinesin-1-driven microtubule sliding helps pancreatic β cells reorganise their cytoskeleton in response to glucose.
buff.ly/r3BlzFj
November 12, 2025 at 11:01 AM
elife.bsky.social
💭 In the first interview for Inside Discovery, @joebarnby.com discusses how deeply human questions about our social world can be explored through elegant, technical science.

Read the full conversation: buff.ly/CKx4k5c
November 11, 2025 at 4:11 PM
elife.bsky.social
Findings reveal how TGF-beta signalling keeps the brain’s blood vessels healthy.

Disrupting this in brain blood vessels disrupts retinal development and triggers immune cell invasion, revealing its role in maintaining vascular–immune balance in the CNS.
buff.ly/8XiArvq
November 11, 2025 at 11:01 AM
elife.bsky.social
The pathogenic bacteria Shigella avoids detection inside host cells by degrading RNF213, the protein responsible for sensing the presence of intracellular pathogens.

Read more in the eLife Insight Article: buff.ly/1mIc6m0
November 10, 2025 at 11:28 PM
elife.bsky.social
Chromosomes: Exploring a crossroads in the ageing process

New Insight Article explains experiments on yeast show that the nuclear pore complex has a central role in the loss of chromosomes associated with ageing.
buff.ly/HcP8nib
November 10, 2025 at 9:02 PM
elife.bsky.social
With a score of 85, this article is in the top 5% of all research outputs scored by @altmetric.com!

It even featured in @scienceofthetimes.bsky.social's podcast: elife.altmetric.com/details/1744...

Take a look: elife.altmetric.com/details/1744...

Look out for Altmetric badges on eLife articles 🏆
November 10, 2025 at 5:10 PM
elife.bsky.social
For most of us, our physical and mental abilities decline as we age.

Scientists are examining tool use, a technically challenging activity, to learn how ageing affects our close relatives, chimpanzees, something we know very little about.
buff.ly/Tzuw7q2
November 9, 2025 at 11:01 AM
elife.bsky.social
Two rainforest butterflies have evolved to look more alike, likely to confuse shared predators. But why don’t they get confused themselves?

To avoid mating with the wrong species, they’ve cleverly evolved distinct scents.
buff.ly/fxVrlCI
November 8, 2025 at 11:44 PM
elife.bsky.social
Findings reveal how TGF-beta signalling keeps the brain’s blood vessels healthy.

Disrupting this in brain blood vessels disrupts retinal development and triggers immune cell invasion, revealing its role in maintaining vascular–immune balance in the CNS.
buff.ly/1mIc6m0
November 7, 2025 at 9:02 PM
elife.bsky.social
Lifestyles shape genome size and gene content in fungal pathogens.
buff.ly/tec1Tds
Genomic traits associated with pathogenicity.
November 7, 2025 at 9:21 AM
elife.bsky.social
By comparing differently tuned glomeruli, this work shows that the brain uses different circuit layouts for specialised vs general smells, offering new insight into how odour meaning is encoded.
buff.ly/XDmo4Ue
November 6, 2025 at 11:28 PM
elife.bsky.social
1/ Want to try your hand at science communication but don’t know where to start?

We put together seven tried and tested tips for communicating preprinted research with suggestions and resources that can help you on social media and beyond! #SciComm

🔗 buff.ly/1jesQg5
November 6, 2025 at 9:03 PM
elife.bsky.social
Evidence from 14 research funding programmes confirms that early winners tend to keep winning (Matthew effect). But the idea that an early setback makes you stronger later doesn’t replicate widely.
buff.ly/UEtcRd4
eLife Assessment This important study reports the results of efforts to replicate two phenomena of significant interest to early-career scientists and scientific policymakers: the Matthew effect and the early-career setback effect. Several previous studies of these effects have focused on early-career researchers with grant proposals that fell just below or just above a funding threshold. Those just above the threshold were more likely to be successful when they applied for funding later in the career (an example of the well-known Matthew effect), while those just below were more likely to go on to have stronger publication records (the early-career setback effect). In this study the Matthew effect was found to be robust across funders, and to generalize from those close to the funding threshold to the whole population. The early-career setback effect was not robust across funders and did not generalize to the whole population. The evidence reported is convincing.
November 5, 2025 at 11:28 PM
elife.bsky.social
We’re pleased to announce our Trained Immunity Focus Issue 🎉

With original research and reviews spanning history, current state and future directions of trained immunity, explore today:
buff.ly/OoqVRjM
Trained Immunity. a new focus issue. explore the collection
November 5, 2025 at 3:12 PM
elife.bsky.social
Kinematics and morphology reveal how mammals descend trees safely, showing posture and movement strategies that suggest early upright behaviours in ancestral primates.
buff.ly/59o59R8
Strategies of descent on vertical supports of various diameters by species.
November 3, 2025 at 11:28 PM
elife.bsky.social
Help us challenge the traditional publishing system.

Find out why you should send your research to eLife: buff.ly/MJy9rBE
Faster, fairer, and even more open. join us in the future of publishing
November 3, 2025 at 9:01 PM