Tony Cesare
@thecesarelab.bsky.social
Head of the Genome Integrity Unit, Children's Medical Research Institute. Professor, University of Sydney.
Delighted to host @cellpress.bsky.social editor Ilaria Carnevale today at @cmri.bsky.social for a seminar and meetings with our trainees and lab heads.
Ilaria was Lead Editor at @cp-trendscellbio.bsky.social and now leads Trends Open.
Welcome to Australia, Ilaria. Thank you for visiting CMRI.
Ilaria was Lead Editor at @cp-trendscellbio.bsky.social and now leads Trends Open.
Welcome to Australia, Ilaria. Thank you for visiting CMRI.
February 17, 2026 at 10:54 PM
Delighted to host @cellpress.bsky.social editor Ilaria Carnevale today at @cmri.bsky.social for a seminar and meetings with our trainees and lab heads.
Ilaria was Lead Editor at @cp-trendscellbio.bsky.social and now leads Trends Open.
Welcome to Australia, Ilaria. Thank you for visiting CMRI.
Ilaria was Lead Editor at @cp-trendscellbio.bsky.social and now leads Trends Open.
Welcome to Australia, Ilaria. Thank you for visiting CMRI.
2026 @cmri.bsky.social seminar series starts today!
12:00 pm: Angelica Lau, Program Manager (Health), Cicada Innovations. www.cicadainnovations.com
Angelica will share how Cicada, Australia’s leading deep-tech incubator, supports researchers in translating lab discoveries into real-world impact.
12:00 pm: Angelica Lau, Program Manager (Health), Cicada Innovations. www.cicadainnovations.com
Angelica will share how Cicada, Australia’s leading deep-tech incubator, supports researchers in translating lab discoveries into real-world impact.
Cicada Innovations
Cicada Innovations is Australia's leading incubator for startups and scaleups working on deep tech science and engineering innovations.
www.cicadainnovations.com
February 4, 2026 at 12:32 AM
2026 @cmri.bsky.social seminar series starts today!
12:00 pm: Angelica Lau, Program Manager (Health), Cicada Innovations. www.cicadainnovations.com
Angelica will share how Cicada, Australia’s leading deep-tech incubator, supports researchers in translating lab discoveries into real-world impact.
12:00 pm: Angelica Lau, Program Manager (Health), Cicada Innovations. www.cicadainnovations.com
Angelica will share how Cicada, Australia’s leading deep-tech incubator, supports researchers in translating lab discoveries into real-world impact.
1/Delighted to be part of a team from @cmri.bsky.social, @sydney.edu.au, the University of Wollongong, and SVI (Melbourne) awarded a $5M NHMRC Synergy Grant to explore: “A mechanistic approach to developing precision therapies for ALT-dependent cancers.”
www.nhmrc.gov.au/funding/find...
www.nhmrc.gov.au/funding/find...
January 12, 2026 at 1:50 AM
1/Delighted to be part of a team from @cmri.bsky.social, @sydney.edu.au, the University of Wollongong, and SVI (Melbourne) awarded a $5M NHMRC Synergy Grant to explore: “A mechanistic approach to developing precision therapies for ALT-dependent cancers.”
www.nhmrc.gov.au/funding/find...
www.nhmrc.gov.au/funding/find...
If I may be allowed a moment of fatherly pride.
Huge congratulations to Maddy Cesare on being selected for the New South Wales team competing at the Australian Youth Women’s Baseball Championship ⚾️🇦🇺
A big achievement, especially in her first year of eligibility.
Baseball is awesome.
Huge congratulations to Maddy Cesare on being selected for the New South Wales team competing at the Australian Youth Women’s Baseball Championship ⚾️🇦🇺
A big achievement, especially in her first year of eligibility.
Baseball is awesome.
December 18, 2025 at 10:33 AM
If I may be allowed a moment of fatherly pride.
Huge congratulations to Maddy Cesare on being selected for the New South Wales team competing at the Australian Youth Women’s Baseball Championship ⚾️🇦🇺
A big achievement, especially in her first year of eligibility.
Baseball is awesome.
Huge congratulations to Maddy Cesare on being selected for the New South Wales team competing at the Australian Youth Women’s Baseball Championship ⚾️🇦🇺
A big achievement, especially in her first year of eligibility.
Baseball is awesome.
1/I’m proud to that our NHMRC Ideas Grant was successful and will support ongoing research in how DNA repair influences cancer cell fate.
This project builds on pioneering work by @szmyd-radoslaw.bsky.social and @radoncdocgee.bsky.social, supported by @cmri.bsky.social and @sydney.edu.au
This project builds on pioneering work by @szmyd-radoslaw.bsky.social and @radoncdocgee.bsky.social, supported by @cmri.bsky.social and @sydney.edu.au
We are grateful to the National Health and Medical Research Council for granting four of our scientists highly sought after Ideas Grants. https://www.cmrijeansforgenes.org.au/news/cmri-researchers-awarded-four-nhmrc-grants
Tony Cesare
Tony Cesare
December 18, 2025 at 6:45 AM
1/I’m proud to that our NHMRC Ideas Grant was successful and will support ongoing research in how DNA repair influences cancer cell fate.
This project builds on pioneering work by @szmyd-radoslaw.bsky.social and @radoncdocgee.bsky.social, supported by @cmri.bsky.social and @sydney.edu.au
This project builds on pioneering work by @szmyd-radoslaw.bsky.social and @radoncdocgee.bsky.social, supported by @cmri.bsky.social and @sydney.edu.au
Reposted by Tony Cesare
We are grateful to the National Health and Medical Research Council for granting four of our scientists highly sought after Ideas Grants. https://www.cmrijeansforgenes.org.au/news/cmri-researchers-awarded-four-nhmrc-grants
Tony Cesare
Tony Cesare
December 18, 2025 at 5:38 AM
We are grateful to the National Health and Medical Research Council for granting four of our scientists highly sought after Ideas Grants. https://www.cmrijeansforgenes.org.au/news/cmri-researchers-awarded-four-nhmrc-grants
Tony Cesare
Tony Cesare
New @natcomms.nature.com paper today from Tracy Bryan's lab @cmri.bsky.social: "Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase".
Happy our lab could play a small part.
Congrats Tracy, Ash Harman, Noa Lamm and the whole team.
www.nature.com/articles/s41...
Happy our lab could play a small part.
Congrats Tracy, Ash Harman, Noa Lamm and the whole team.
www.nature.com/articles/s41...
Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase - Nature Communications
Telomerase recruitment to telomeres is a tightly regulated process which is stimulated by replication stress. Here, the authors identify that nuclear filamentous actin is important for interaction bet...
www.nature.com
December 3, 2025 at 12:19 AM
New @natcomms.nature.com paper today from Tracy Bryan's lab @cmri.bsky.social: "Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase".
Happy our lab could play a small part.
Congrats Tracy, Ash Harman, Noa Lamm and the whole team.
www.nature.com/articles/s41...
Happy our lab could play a small part.
Congrats Tracy, Ash Harman, Noa Lamm and the whole team.
www.nature.com/articles/s41...
One name appears on an award, but it truly reflects the collective effort of an exceptionally talented team. All credit to @radoncdocgee.bsky.social, @szmyd-radoslaw.bsky.social, @drmelaniew.bsky.social, @annagmanjon.bsky.social, Lucy French, Sienna Casolin, Scott Page, & our awesome collaborators.
Huge congratulations to Professor Tony Cesare, winner of the University of Sydney’s 2025 Makers and Shapers Award for Outstanding Research. @sydney.edu.au @thecesarelab.bsky.social
November 27, 2025 at 5:41 AM
One name appears on an award, but it truly reflects the collective effort of an exceptionally talented team. All credit to @radoncdocgee.bsky.social, @szmyd-radoslaw.bsky.social, @drmelaniew.bsky.social, @annagmanjon.bsky.social, Lucy French, Sienna Casolin, Scott Page, & our awesome collaborators.
Thank you @karimmekhail.bsky.social, @chiololab.bsky.social, and @altmeyerlab.bsky.social for organising @fusionconf.bsky.social #SGO25.
Exciting science at a fantastic venue!
Exciting science at a fantastic venue!
November 3, 2025 at 11:53 AM
Thank you @karimmekhail.bsky.social, @chiololab.bsky.social, and @altmeyerlab.bsky.social for organising @fusionconf.bsky.social #SGO25.
Exciting science at a fantastic venue!
Exciting science at a fantastic venue!
Delighted to be in beautiful Riviera Maya Mexico 🇲🇽 for @fusionconf.bsky.social #SGO25.
www.fusion-conferences.com/conference/188
www.fusion-conferences.com/conference/188
October 31, 2025 at 4:10 PM
Delighted to be in beautiful Riviera Maya Mexico 🇲🇽 for @fusionconf.bsky.social #SGO25.
www.fusion-conferences.com/conference/188
www.fusion-conferences.com/conference/188
The first preprint from Noa Lamm’s team @cmri.bsky.social is now available: Anillin-dependent actin assembly at PML nuclear bodies protects genome stability
www.biorxiv.org/content/10.1...
Delighted our lab could play a role supporting Noa’s vision on this project.
www.biorxiv.org/content/10.1...
Delighted our lab could play a role supporting Noa’s vision on this project.
| bioRxiv
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
October 31, 2025 at 4:03 PM
The first preprint from Noa Lamm’s team @cmri.bsky.social is now available: Anillin-dependent actin assembly at PML nuclear bodies protects genome stability
www.biorxiv.org/content/10.1...
Delighted our lab could play a role supporting Noa’s vision on this project.
www.biorxiv.org/content/10.1...
Delighted our lab could play a role supporting Noa’s vision on this project.
Grateful that our lab was successful in two Australian Research Council Discovery Project grants last week.
I’m the sole CI on one, while @hildapickett.bsky.social and Cesare-lab post-doc @scientistkate.bsky.social are CIs on the other. Both projects explore genome stability in human cells
I’m the sole CI on one, while @hildapickett.bsky.social and Cesare-lab post-doc @scientistkate.bsky.social are CIs on the other. Both projects explore genome stability in human cells
October 31, 2025 at 3:35 PM
Grateful that our lab was successful in two Australian Research Council Discovery Project grants last week.
I’m the sole CI on one, while @hildapickett.bsky.social and Cesare-lab post-doc @scientistkate.bsky.social are CIs on the other. Both projects explore genome stability in human cells
I’m the sole CI on one, while @hildapickett.bsky.social and Cesare-lab post-doc @scientistkate.bsky.social are CIs on the other. Both projects explore genome stability in human cells
The Cesare Lab had an excellent time at the Australian Cell Cycle, DNA Repair & Telomere Meeting in Melbourne.
australiancellcycle.org
A huge thank you to @genomestability.bsky.social and all the organisers for putting together such a fantastic and inspiring meeting.
We're looking forward to 2027!
australiancellcycle.org
A huge thank you to @genomestability.bsky.social and all the organisers for putting together such a fantastic and inspiring meeting.
We're looking forward to 2027!
October 22, 2025 at 11:55 PM
The Cesare Lab had an excellent time at the Australian Cell Cycle, DNA Repair & Telomere Meeting in Melbourne.
australiancellcycle.org
A huge thank you to @genomestability.bsky.social and all the organisers for putting together such a fantastic and inspiring meeting.
We're looking forward to 2027!
australiancellcycle.org
A huge thank you to @genomestability.bsky.social and all the organisers for putting together such a fantastic and inspiring meeting.
We're looking forward to 2027!
Delighted to be hosting Simon Boulton (@boultonlab.bsky.social) today for seminar at @cmri.bsky.social.
Simon will present “Making T-loops to solve the end-protection problem”, sharing recent advances from his lab on how cells safeguard their chromosome ends.
Simon will present “Making T-loops to solve the end-protection problem”, sharing recent advances from his lab on how cells safeguard their chromosome ends.
October 22, 2025 at 11:38 PM
Delighted to be hosting Simon Boulton (@boultonlab.bsky.social) today for seminar at @cmri.bsky.social.
Simon will present “Making T-loops to solve the end-protection problem”, sharing recent advances from his lab on how cells safeguard their chromosome ends.
Simon will present “Making T-loops to solve the end-protection problem”, sharing recent advances from his lab on how cells safeguard their chromosome ends.
Sharon Cantor (@cantorlab.bsky.social) is visiting @cmri.bsky.social tomorrow (Friday 17 October) to present her seminar -- "Defining and Targeting BRCAness".
If you’re in the area, stop by the CMRI Seminar Room at 12:30 PM for what will be an excellent talk!
If you’re in the area, stop by the CMRI Seminar Room at 12:30 PM for what will be an excellent talk!
October 16, 2025 at 6:07 AM
Sharon Cantor (@cantorlab.bsky.social) is visiting @cmri.bsky.social tomorrow (Friday 17 October) to present her seminar -- "Defining and Targeting BRCAness".
If you’re in the area, stop by the CMRI Seminar Room at 12:30 PM for what will be an excellent talk!
If you’re in the area, stop by the CMRI Seminar Room at 12:30 PM for what will be an excellent talk!
Happy that @drmelaniew.bsky.social and I could play a small role in this lovely work led by @ssegurabayona.bsky.social. Please do give the preprint a look.
🚀 New preprint alert!
We uncover SLFN11 as a molecular gatekeeper that restricts alternative lengthening of telomeres (ALT) by sensing telomere-associated replication stress and triggering apoptosis.
📄 Read the manuscript here: www.biorxiv.org/content/10.1...
We uncover SLFN11 as a molecular gatekeeper that restricts alternative lengthening of telomeres (ALT) by sensing telomere-associated replication stress and triggering apoptosis.
📄 Read the manuscript here: www.biorxiv.org/content/10.1...
SLFN11 restricts escape from telomere crisis to prevent alternative lengthening of telomeres
The tRNA nuclease SLFN11 is epigenetically silenced in ~50% of treatment-naive tumours and is the strongest predictor of chemoresistance but why it is frequently inactivated in cancer is unknown. To a...
www.biorxiv.org
September 11, 2025 at 8:35 AM
Happy that @drmelaniew.bsky.social and I could play a small role in this lovely work led by @ssegurabayona.bsky.social. Please do give the preprint a look.
Reposted by Tony Cesare
📢Deadline extended!
Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25
Final slots ➡️https://bit.ly/3JJzYR4
Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25
Final slots ➡️https://bit.ly/3JJzYR4
September 2, 2025 at 2:38 PM
📢Deadline extended!
Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25
Final slots ➡️https://bit.ly/3JJzYR4
Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25
Final slots ➡️https://bit.ly/3JJzYR4
A shout out to lab member @szmyd-radoslaw.bsky.social for his recent recognition by @sydney.edu.au. Well earned Radek!
We’re proud of our researcher Dr Radek Szmyd who has received a 2025 University of Sydney Faculty of Medicine and Health Mid-Career Research Outstanding Publication Award - for Radek’s extraordinary work to understand why cancer cells die in different ways following radiotherapy.
August 6, 2025 at 12:55 AM
A shout out to lab member @szmyd-radoslaw.bsky.social for his recent recognition by @sydney.edu.au. Well earned Radek!
Reposted by Tony Cesare
We’re proud of our researcher Dr Radek Szmyd who has received a 2025 University of Sydney Faculty of Medicine and Health Mid-Career Research Outstanding Publication Award - for Radek’s extraordinary work to understand why cancer cells die in different ways following radiotherapy.
July 17, 2025 at 6:59 AM
We’re proud of our researcher Dr Radek Szmyd who has received a 2025 University of Sydney Faculty of Medicine and Health Mid-Career Research Outstanding Publication Award - for Radek’s extraordinary work to understand why cancer cells die in different ways following radiotherapy.
New from us in @natrevmcb.nature.com -- @szmyd-radoslaw.bsky.social & @radoncdocgee.bsky.social explore how DNA repair actively shapes cancer cell fate following DNA damage, reframing repair as both a protective process & a driver of treatment response and cell death. www.nature.com/articles/s41...
DNA-repair-driven cell death compels us to rethink cancer therapies - Nature Reviews Molecular Cell Biology
Emerging evidence suggests that, following genotoxic therapy, it is the repair of DNA double-strand breaks, rather than the damage itself, that frequently drives cancer cell death.
www.nature.com
August 4, 2025 at 5:48 AM
New from us in @natrevmcb.nature.com -- @szmyd-radoslaw.bsky.social & @radoncdocgee.bsky.social explore how DNA repair actively shapes cancer cell fate following DNA damage, reframing repair as both a protective process & a driver of treatment response and cell death. www.nature.com/articles/s41...
DNA replication and Cryo-EM star Jacob Lewis is visiting @cmri.bsky.social today to present seminar. If you happen to be in Westmead, talk is 12:30 pm local time. See you there.
June 20, 2025 at 1:54 AM
DNA replication and Cryo-EM star Jacob Lewis is visiting @cmri.bsky.social today to present seminar. If you happen to be in Westmead, talk is 12:30 pm local time. See you there.
Excited to speak at the Hunter Meeting next week, alongside @cmri.bsky.social colleagues Pragathi Masamsetti (postdoc with Patrick Tam, proud Cesare lab alum) and Pengyi Yang (Head, Computational Systems Biology Unit). Looking forward to great science and good company.
www.huntermeeting.org.au
www.huntermeeting.org.au
Hunter Meeting 2025
www.huntermeeting.org.au
May 27, 2025 at 1:56 AM
Excited to speak at the Hunter Meeting next week, alongside @cmri.bsky.social colleagues Pragathi Masamsetti (postdoc with Patrick Tam, proud Cesare lab alum) and Pengyi Yang (Head, Computational Systems Biology Unit). Looking forward to great science and good company.
www.huntermeeting.org.au
www.huntermeeting.org.au
If you happen to be the the Oz Single Cell Conference this week in Sydney, check out @scientistkate.bsky.social's talk on Friday.
Kate is a joint postdoc w/@piptaberlay.bsky.social and will present her work on 3D Genome architecture and replication stress.
www.ozsinglecell.com
Kate is a joint postdoc w/@piptaberlay.bsky.social and will present her work on 3D Genome architecture and replication stress.
www.ozsinglecell.com
Home | acpc
www.ozsinglecell.com
May 19, 2025 at 11:26 PM
If you happen to be the the Oz Single Cell Conference this week in Sydney, check out @scientistkate.bsky.social's talk on Friday.
Kate is a joint postdoc w/@piptaberlay.bsky.social and will present her work on 3D Genome architecture and replication stress.
www.ozsinglecell.com
Kate is a joint postdoc w/@piptaberlay.bsky.social and will present her work on 3D Genome architecture and replication stress.
www.ozsinglecell.com
ACCM 2025! The Cesare lab will be there in force. Come join us in Melbourne for 3 days of amazing science.
I'm super excited to announce that registrations are now open for the 19th Australian Cell Cycle, DNA Repair and Telomere Workshop. Awesome international speaker line-up, with plenty of locals being invited! Book now to secure your earlybird rate. www.australiancellcycle.org
May 15, 2025 at 12:36 PM
ACCM 2025! The Cesare lab will be there in force. Come join us in Melbourne for 3 days of amazing science.
Reposted by Tony Cesare
I'm super excited to announce that registrations are now open for the 19th Australian Cell Cycle, DNA Repair and Telomere Workshop. Awesome international speaker line-up, with plenty of locals being invited! Book now to secure your earlybird rate. www.australiancellcycle.org
May 15, 2025 at 5:48 AM
I'm super excited to announce that registrations are now open for the 19th Australian Cell Cycle, DNA Repair and Telomere Workshop. Awesome international speaker line-up, with plenty of locals being invited! Book now to secure your earlybird rate. www.australiancellcycle.org