Tony Cesare
@thecesarelab.bsky.social
Head of the Genome Integrity Unit, Children's Medical Research Institute. Professor, University of Sydney.
Thank you @karimmekhail.bsky.social, @chiololab.bsky.social, and @altmeyerlab.bsky.social for organising @fusionconf.bsky.social #SGO25.
Exciting science at a fantastic venue!
Exciting science at a fantastic venue!
November 3, 2025 at 11:53 AM
Thank you @karimmekhail.bsky.social, @chiololab.bsky.social, and @altmeyerlab.bsky.social for organising @fusionconf.bsky.social #SGO25.
Exciting science at a fantastic venue!
Exciting science at a fantastic venue!
Delighted to be in beautiful Riviera Maya Mexico 🇲🇽 for @fusionconf.bsky.social #SGO25.
www.fusion-conferences.com/conference/188
www.fusion-conferences.com/conference/188
October 31, 2025 at 4:10 PM
Delighted to be in beautiful Riviera Maya Mexico 🇲🇽 for @fusionconf.bsky.social #SGO25.
www.fusion-conferences.com/conference/188
www.fusion-conferences.com/conference/188
The first preprint from Noa Lamm’s team @cmri.bsky.social is now available: Anillin-dependent actin assembly at PML nuclear bodies protects genome stability
www.biorxiv.org/content/10.1...
Delighted our lab could play a role supporting Noa’s vision on this project.
www.biorxiv.org/content/10.1...
Delighted our lab could play a role supporting Noa’s vision on this project.
| bioRxiv
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
October 31, 2025 at 4:03 PM
The first preprint from Noa Lamm’s team @cmri.bsky.social is now available: Anillin-dependent actin assembly at PML nuclear bodies protects genome stability
www.biorxiv.org/content/10.1...
Delighted our lab could play a role supporting Noa’s vision on this project.
www.biorxiv.org/content/10.1...
Delighted our lab could play a role supporting Noa’s vision on this project.
Grateful that our lab was successful in two Australian Research Council Discovery Project grants last week.
I’m the sole CI on one, while @hildapickett.bsky.social and Cesare-lab post-doc @scientistkate.bsky.social are CIs on the other. Both projects explore genome stability in human cells
I’m the sole CI on one, while @hildapickett.bsky.social and Cesare-lab post-doc @scientistkate.bsky.social are CIs on the other. Both projects explore genome stability in human cells
October 31, 2025 at 3:35 PM
Grateful that our lab was successful in two Australian Research Council Discovery Project grants last week.
I’m the sole CI on one, while @hildapickett.bsky.social and Cesare-lab post-doc @scientistkate.bsky.social are CIs on the other. Both projects explore genome stability in human cells
I’m the sole CI on one, while @hildapickett.bsky.social and Cesare-lab post-doc @scientistkate.bsky.social are CIs on the other. Both projects explore genome stability in human cells
The Cesare Lab had an excellent time at the Australian Cell Cycle, DNA Repair & Telomere Meeting in Melbourne.
australiancellcycle.org
A huge thank you to @genomestability.bsky.social and all the organisers for putting together such a fantastic and inspiring meeting.
We're looking forward to 2027!
australiancellcycle.org
A huge thank you to @genomestability.bsky.social and all the organisers for putting together such a fantastic and inspiring meeting.
We're looking forward to 2027!
October 22, 2025 at 11:55 PM
The Cesare Lab had an excellent time at the Australian Cell Cycle, DNA Repair & Telomere Meeting in Melbourne.
australiancellcycle.org
A huge thank you to @genomestability.bsky.social and all the organisers for putting together such a fantastic and inspiring meeting.
We're looking forward to 2027!
australiancellcycle.org
A huge thank you to @genomestability.bsky.social and all the organisers for putting together such a fantastic and inspiring meeting.
We're looking forward to 2027!
Delighted to be hosting Simon Boulton (@boultonlab.bsky.social) today for seminar at @cmri.bsky.social.
Simon will present “Making T-loops to solve the end-protection problem”, sharing recent advances from his lab on how cells safeguard their chromosome ends.
Simon will present “Making T-loops to solve the end-protection problem”, sharing recent advances from his lab on how cells safeguard their chromosome ends.
October 22, 2025 at 11:38 PM
Delighted to be hosting Simon Boulton (@boultonlab.bsky.social) today for seminar at @cmri.bsky.social.
Simon will present “Making T-loops to solve the end-protection problem”, sharing recent advances from his lab on how cells safeguard their chromosome ends.
Simon will present “Making T-loops to solve the end-protection problem”, sharing recent advances from his lab on how cells safeguard their chromosome ends.
Sharon Cantor (@cantorlab.bsky.social) is visiting @cmri.bsky.social tomorrow (Friday 17 October) to present her seminar -- "Defining and Targeting BRCAness".
If you’re in the area, stop by the CMRI Seminar Room at 12:30 PM for what will be an excellent talk!
If you’re in the area, stop by the CMRI Seminar Room at 12:30 PM for what will be an excellent talk!
October 16, 2025 at 6:07 AM
Sharon Cantor (@cantorlab.bsky.social) is visiting @cmri.bsky.social tomorrow (Friday 17 October) to present her seminar -- "Defining and Targeting BRCAness".
If you’re in the area, stop by the CMRI Seminar Room at 12:30 PM for what will be an excellent talk!
If you’re in the area, stop by the CMRI Seminar Room at 12:30 PM for what will be an excellent talk!
Happy that @drmelaniew.bsky.social and I could play a small role in this lovely work led by @ssegurabayona.bsky.social. Please do give the preprint a look.
🚀 New preprint alert!
We uncover SLFN11 as a molecular gatekeeper that restricts alternative lengthening of telomeres (ALT) by sensing telomere-associated replication stress and triggering apoptosis.
📄 Read the manuscript here: www.biorxiv.org/content/10.1...
We uncover SLFN11 as a molecular gatekeeper that restricts alternative lengthening of telomeres (ALT) by sensing telomere-associated replication stress and triggering apoptosis.
📄 Read the manuscript here: www.biorxiv.org/content/10.1...
SLFN11 restricts escape from telomere crisis to prevent alternative lengthening of telomeres
The tRNA nuclease SLFN11 is epigenetically silenced in ~50% of treatment-naive tumours and is the strongest predictor of chemoresistance but why it is frequently inactivated in cancer is unknown. To a...
www.biorxiv.org
September 11, 2025 at 8:35 AM
Happy that @drmelaniew.bsky.social and I could play a small role in this lovely work led by @ssegurabayona.bsky.social. Please do give the preprint a look.
Reposted by Tony Cesare
📢Deadline extended!
Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25
Final slots ➡️https://bit.ly/3JJzYR4
Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25
Final slots ➡️https://bit.ly/3JJzYR4
September 2, 2025 at 2:38 PM
📢Deadline extended!
Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25
Final slots ➡️https://bit.ly/3JJzYR4
Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25
Final slots ➡️https://bit.ly/3JJzYR4
A shout out to lab member @szmyd-radoslaw.bsky.social for his recent recognition by @sydney.edu.au. Well earned Radek!
We’re proud of our researcher Dr Radek Szmyd who has received a 2025 University of Sydney Faculty of Medicine and Health Mid-Career Research Outstanding Publication Award - for Radek’s extraordinary work to understand why cancer cells die in different ways following radiotherapy.
August 6, 2025 at 12:55 AM
A shout out to lab member @szmyd-radoslaw.bsky.social for his recent recognition by @sydney.edu.au. Well earned Radek!
Reposted by Tony Cesare
We’re proud of our researcher Dr Radek Szmyd who has received a 2025 University of Sydney Faculty of Medicine and Health Mid-Career Research Outstanding Publication Award - for Radek’s extraordinary work to understand why cancer cells die in different ways following radiotherapy.
July 17, 2025 at 6:59 AM
We’re proud of our researcher Dr Radek Szmyd who has received a 2025 University of Sydney Faculty of Medicine and Health Mid-Career Research Outstanding Publication Award - for Radek’s extraordinary work to understand why cancer cells die in different ways following radiotherapy.
New from us in @natrevmcb.nature.com -- @szmyd-radoslaw.bsky.social & @radoncdocgee.bsky.social explore how DNA repair actively shapes cancer cell fate following DNA damage, reframing repair as both a protective process & a driver of treatment response and cell death. www.nature.com/articles/s41...
DNA-repair-driven cell death compels us to rethink cancer therapies - Nature Reviews Molecular Cell Biology
Emerging evidence suggests that, following genotoxic therapy, it is the repair of DNA double-strand breaks, rather than the damage itself, that frequently drives cancer cell death.
www.nature.com
August 4, 2025 at 5:48 AM
New from us in @natrevmcb.nature.com -- @szmyd-radoslaw.bsky.social & @radoncdocgee.bsky.social explore how DNA repair actively shapes cancer cell fate following DNA damage, reframing repair as both a protective process & a driver of treatment response and cell death. www.nature.com/articles/s41...
DNA replication and Cryo-EM star Jacob Lewis is visiting @cmri.bsky.social today to present seminar. If you happen to be in Westmead, talk is 12:30 pm local time. See you there.
June 20, 2025 at 1:54 AM
DNA replication and Cryo-EM star Jacob Lewis is visiting @cmri.bsky.social today to present seminar. If you happen to be in Westmead, talk is 12:30 pm local time. See you there.
Excited to speak at the Hunter Meeting next week, alongside @cmri.bsky.social colleagues Pragathi Masamsetti (postdoc with Patrick Tam, proud Cesare lab alum) and Pengyi Yang (Head, Computational Systems Biology Unit). Looking forward to great science and good company.
www.huntermeeting.org.au
www.huntermeeting.org.au
Hunter Meeting 2025
www.huntermeeting.org.au
May 27, 2025 at 1:56 AM
Excited to speak at the Hunter Meeting next week, alongside @cmri.bsky.social colleagues Pragathi Masamsetti (postdoc with Patrick Tam, proud Cesare lab alum) and Pengyi Yang (Head, Computational Systems Biology Unit). Looking forward to great science and good company.
www.huntermeeting.org.au
www.huntermeeting.org.au
If you happen to be the the Oz Single Cell Conference this week in Sydney, check out @scientistkate.bsky.social's talk on Friday.
Kate is a joint postdoc w/@piptaberlay.bsky.social and will present her work on 3D Genome architecture and replication stress.
www.ozsinglecell.com
Kate is a joint postdoc w/@piptaberlay.bsky.social and will present her work on 3D Genome architecture and replication stress.
www.ozsinglecell.com
Home | acpc
www.ozsinglecell.com
May 19, 2025 at 11:26 PM
If you happen to be the the Oz Single Cell Conference this week in Sydney, check out @scientistkate.bsky.social's talk on Friday.
Kate is a joint postdoc w/@piptaberlay.bsky.social and will present her work on 3D Genome architecture and replication stress.
www.ozsinglecell.com
Kate is a joint postdoc w/@piptaberlay.bsky.social and will present her work on 3D Genome architecture and replication stress.
www.ozsinglecell.com
ACCM 2025! The Cesare lab will be there in force. Come join us in Melbourne for 3 days of amazing science.
I'm super excited to announce that registrations are now open for the 19th Australian Cell Cycle, DNA Repair and Telomere Workshop. Awesome international speaker line-up, with plenty of locals being invited! Book now to secure your earlybird rate. www.australiancellcycle.org
May 15, 2025 at 12:36 PM
ACCM 2025! The Cesare lab will be there in force. Come join us in Melbourne for 3 days of amazing science.
Reposted by Tony Cesare
I'm super excited to announce that registrations are now open for the 19th Australian Cell Cycle, DNA Repair and Telomere Workshop. Awesome international speaker line-up, with plenty of locals being invited! Book now to secure your earlybird rate. www.australiancellcycle.org
May 15, 2025 at 5:48 AM
I'm super excited to announce that registrations are now open for the 19th Australian Cell Cycle, DNA Repair and Telomere Workshop. Awesome international speaker line-up, with plenty of locals being invited! Book now to secure your earlybird rate. www.australiancellcycle.org
Fantastic opportunity in Melbourne.
www.wehi.edu.au/careers/make...
WEHI is looking for new lab heads! New and experienced lab heads welcome. Check out the ad, consider applying and share. We’re a collaborative bunch, in Australia, with fabulous technology, great colleagues at a values-driven organisation. @wehi-research.bsky.social
WEHI is looking for new lab heads! New and experienced lab heads welcome. Check out the ad, consider applying and share. We’re a collaborative bunch, in Australia, with fabulous technology, great colleagues at a values-driven organisation. @wehi-research.bsky.social
Make your future Melbourne | WEHI
Lead the next wave of biomedical discovery
www.wehi.edu.au
May 14, 2025 at 11:55 AM
Fantastic opportunity in Melbourne.
Hosting Lee Wong from @monashuniversity.bsky.social tomorrow to present her seminar: "Onco-histone mutations in paediatric high-grade glioma: molecular mechanisms and implications for therapy." If you are around @cmri.bsky.social tomorrow at 12:30, come by for a great talk.
May 8, 2025 at 1:32 AM
Hosting Lee Wong from @monashuniversity.bsky.social tomorrow to present her seminar: "Onco-histone mutations in paediatric high-grade glioma: molecular mechanisms and implications for therapy." If you are around @cmri.bsky.social tomorrow at 12:30, come by for a great talk.
@genomestability.bsky.social (Andrew Deans) will be @cmri.bsky.social tomorrow to present seminar at 12:30; "The Multifaceted Role of FANCM enzyme in DNA Repair and Cancer Therapy". If you are in the area, please do come by for a great talk.
April 10, 2025 at 5:23 AM
@genomestability.bsky.social (Andrew Deans) will be @cmri.bsky.social tomorrow to present seminar at 12:30; "The Multifaceted Role of FANCM enzyme in DNA Repair and Cancer Therapy". If you are in the area, please do come by for a great talk.
My and @telomerase-cmri.bsky.social’s annual attempt to bring a little bit of college baseketball culture down under.
Go Tar Heels!
Go Tar Heels!
March 20, 2025 at 10:17 PM
My and @telomerase-cmri.bsky.social’s annual attempt to bring a little bit of college baseketball culture down under.
Go Tar Heels!
Go Tar Heels!
Reposted by Tony Cesare
🚀 New Paper Alert! Our latest @natrevmcb.bsky.social explores how nuclear and genome organization drive DNA double-strand break repair! 🧬
📖 Free access: rdcu.be/edViW
Please 🔄 ❤️
📖 Free access: rdcu.be/edViW
Please 🔄 ❤️
Nuclear and genome dynamics underlying DNA double-strand break repair
Nature Reviews Molecular Cell Biology - Changes in nuclear and genome organization promote the repair of DNA double-strand breaks and genome stability. Processes that are involved include the...
rdcu.be
March 18, 2025 at 1:49 PM
🚀 New Paper Alert! Our latest @natrevmcb.bsky.social explores how nuclear and genome organization drive DNA double-strand break repair! 🧬
📖 Free access: rdcu.be/edViW
Please 🔄 ❤️
📖 Free access: rdcu.be/edViW
Please 🔄 ❤️
Reposted by Tony Cesare
🧵 1/10 Excited to share our latest study in @naturecomms.bsky.social
"A CPC-shelterin-BTR axis regulates mitotic telomere deprotection" t.co/VypPsLBJCR
"A CPC-shelterin-BTR axis regulates mitotic telomere deprotection" t.co/VypPsLBJCR
A CPC-shelterin-BTR axis regulates mitotic telomere deprotection
Nature Communications - Here the authors reveal how telomeres signal mitotic stress. A key protein network alters their structure exposing telomere ends to signal mitotic stress, ultimately...
rdcu.be
March 17, 2025 at 12:49 PM
🧵 1/10 Excited to share our latest study in @naturecomms.bsky.social
"A CPC-shelterin-BTR axis regulates mitotic telomere deprotection" t.co/VypPsLBJCR
"A CPC-shelterin-BTR axis regulates mitotic telomere deprotection" t.co/VypPsLBJCR
1/Out today in @naturecomms.bsky.social,
“A CPC-shelterin-BTR axis regulates mitotic telomere deprotection”.
Here we identify the mechanism that unwinds telomere-loops (t-loops) during mitotic arrest to activate the DNA damage response and signal mitotic stress.
www.nature.com/articles/s41....
“A CPC-shelterin-BTR axis regulates mitotic telomere deprotection”.
Here we identify the mechanism that unwinds telomere-loops (t-loops) during mitotic arrest to activate the DNA damage response and signal mitotic stress.
www.nature.com/articles/s41....
A CPC-shelterin-BTR axis regulates mitotic telomere deprotection - Nature Communications
Here the authors reveal how telomeres signal mitotic stress. A key protein network alters their structure exposing telomere ends to signal mitotic stress, ultimately triggering a controlled DNA damage...
www.nature.com
March 17, 2025 at 10:32 AM
1/Out today in @naturecomms.bsky.social,
“A CPC-shelterin-BTR axis regulates mitotic telomere deprotection”.
Here we identify the mechanism that unwinds telomere-loops (t-loops) during mitotic arrest to activate the DNA damage response and signal mitotic stress.
www.nature.com/articles/s41....
“A CPC-shelterin-BTR axis regulates mitotic telomere deprotection”.
Here we identify the mechanism that unwinds telomere-loops (t-loops) during mitotic arrest to activate the DNA damage response and signal mitotic stress.
www.nature.com/articles/s41....