Wyoming Wormboy
@wyomingwormboy.bsky.social
Science, students, and service. Serious academic meets incurable class clown.
Reposted by Wyoming Wormboy
🎉 LEE LAB PAPER ANNOUNCEMENT for this month's issue of #GENETICS! We're celebrating from both coasts, bc after defending her MS in 2024, Deepshi's now a biotech researcher in the Bay Area.
tl;dr: nucleosome remodeling is necessary to repair germline DNA damage 🧬
academic.oup.com/genetics/art...
tl;dr: nucleosome remodeling is necessary to repair germline DNA damage 🧬
academic.oup.com/genetics/art...
February 9, 2026 at 6:26 PM
🎉 LEE LAB PAPER ANNOUNCEMENT for this month's issue of #GENETICS! We're celebrating from both coasts, bc after defending her MS in 2024, Deepshi's now a biotech researcher in the Bay Area.
tl;dr: nucleosome remodeling is necessary to repair germline DNA damage 🧬
academic.oup.com/genetics/art...
tl;dr: nucleosome remodeling is necessary to repair germline DNA damage 🧬
academic.oup.com/genetics/art...
Sadly I’ve heard of Kid Rock and even more sadly I’ve heard Kid Rock (not in person).
February 10, 2026 at 12:15 AM
Sadly I’ve heard of Kid Rock and even more sadly I’ve heard Kid Rock (not in person).
One thing to add is that all the sledgehammers in the world won’t save you from a bad plan. So, think things through carefully!
Also, science can be surprising and is unpredictable, so you also need to NOTICE THINGS while you’re doing the experiment and not ignore red flags. These are the keys.
Also, science can be surprising and is unpredictable, so you also need to NOTICE THINGS while you’re doing the experiment and not ignore red flags. These are the keys.
February 8, 2026 at 5:46 PM
One thing to add is that all the sledgehammers in the world won’t save you from a bad plan. So, think things through carefully!
Also, science can be surprising and is unpredictable, so you also need to NOTICE THINGS while you’re doing the experiment and not ignore red flags. These are the keys.
Also, science can be surprising and is unpredictable, so you also need to NOTICE THINGS while you’re doing the experiment and not ignore red flags. These are the keys.
Reposted by Wyoming Wormboy
I would like to think @wyomingwormboy.bsky.social for describing the Sledgehammer Approach (to research) in WormBook. It is invaluable advice that I share with every trainee.
February 8, 2026 at 3:47 AM
I would like to think @wyomingwormboy.bsky.social for describing the Sledgehammer Approach (to research) in WormBook. It is invaluable advice that I share with every trainee.
Thank you Joe!
February 8, 2026 at 3:06 PM
Thank you Joe!
I was feeling somewhat guilty about saying No to many recent requests but then I re-read the “children’s book”, The Giving Tree. Felt better.
Apparently some people interpret the tree’s hyper accommodating behavior as a positive example! I’m pretty sure that was not the author’s intention!
Apparently some people interpret the tree’s hyper accommodating behavior as a positive example! I’m pretty sure that was not the author’s intention!
February 5, 2026 at 11:28 PM
I was feeling somewhat guilty about saying No to many recent requests but then I re-read the “children’s book”, The Giving Tree. Felt better.
Apparently some people interpret the tree’s hyper accommodating behavior as a positive example! I’m pretty sure that was not the author’s intention!
Apparently some people interpret the tree’s hyper accommodating behavior as a positive example! I’m pretty sure that was not the author’s intention!
Reposted by Wyoming Wormboy
Please stop saying the bill allows "no more multi-year funding" - or at least be clear the 'more' is in reference to disastrous FY25 levels.
The bill allows 39% MYF, same as in FY25, which contributed substantially to a 24% drop in new research.
The bill has some wins. MYF is not one of them.
The bill allows 39% MYF, same as in FY25, which contributed substantially to a 24% drop in new research.
The bill has some wins. MYF is not one of them.
Both chambers of Congress have now passed the FY26 minibus with NIH provisions. The President will sign.
(1) $48.7 billion for NIH
(2) Full IDC recovery
(3) No more multi-year funding
(4) No NIH reorganization, maintaining the current IC structure.
(1) $48.7 billion for NIH
(2) Full IDC recovery
(3) No more multi-year funding
(4) No NIH reorganization, maintaining the current IC structure.
February 3, 2026 at 9:38 PM
Please stop saying the bill allows "no more multi-year funding" - or at least be clear the 'more' is in reference to disastrous FY25 levels.
The bill allows 39% MYF, same as in FY25, which contributed substantially to a 24% drop in new research.
The bill has some wins. MYF is not one of them.
The bill allows 39% MYF, same as in FY25, which contributed substantially to a 24% drop in new research.
The bill has some wins. MYF is not one of them.
Reposted by Wyoming Wormboy
For the same reason that Indiana, which is virtually the same size as Massachusetts received nearly $349 million last year in farm subsidies, while Massachusetts got only about $9 million, 1/39th of Indiana’s boon.
February 3, 2026 at 10:03 PM
For the same reason that Indiana, which is virtually the same size as Massachusetts received nearly $349 million last year in farm subsidies, while Massachusetts got only about $9 million, 1/39th of Indiana’s boon.
Reposted by Wyoming Wormboy
Excited to see this out in the world. The CGC is launching a curated strains collection, the first being protein degradation systems and this is a pilot primer to pair with it authored by myself, Dave Reiner, Ann Rougvie, and Aric Daul. We review the state of the field and provide use guidance (1)
The Caenorhabditis Genetics Center Curated Special Collections: a guide to protein degradation systems
academic.oup.com/genetics/adv...
academic.oup.com/genetics/adv...
The Caenorhabditis Genetics Center Curated Special Collections: a guide to protein degradation systems
Abstract. The Caenorhabditis Genetics Center is launching a new website feature—“Curated Special Collections”—designed to help researchers navigate the eve
academic.oup.com
January 29, 2026 at 9:16 PM
Excited to see this out in the world. The CGC is launching a curated strains collection, the first being protein degradation systems and this is a pilot primer to pair with it authored by myself, Dave Reiner, Ann Rougvie, and Aric Daul. We review the state of the field and provide use guidance (1)
I have an answer. He’s just another self promoting D-bag who traded in legit credentials for cash.
January 25, 2026 at 12:58 AM
I have an answer. He’s just another self promoting D-bag who traded in legit credentials for cash.
One reason to have kids is that they sometimes do clever things. (Note the signs on the side of the trail)
January 25, 2026 at 12:51 AM
One reason to have kids is that they sometimes do clever things. (Note the signs on the side of the trail)
Reposted by Wyoming Wormboy
Absolutely essential
NIH needs statutory protections against partisan politicized decision-making - especially around grant terminations. This bill is a solid start to achieving those aims.
degette.house.gov/media-center...
degette.house.gov/media-center...
DeGette Introduces Bill to Protect NIH From Political Interference
WASHINGTON, D.C. – Today, Congresswoman Diana DeGette (CO-01), Ranking Member of the Energy and Commerce Subcommittee on Health, introduced the Follow the Science Act to shield the National Institutes...
degette.house.gov
January 24, 2026 at 1:31 AM
Absolutely essential
Reposted by Wyoming Wormboy
January 21, 2026 at 6:42 PM
Reposted by Wyoming Wormboy
Going through boxes of old tee shirts today…
January 17, 2026 at 11:16 PM
Going through boxes of old tee shirts today…
Cool paper from Ron Ellis and colleagues.
Haldane’s law works through X:Autosome incompatibility in Caenorhabditis briggsae/C. nigoni hybrids - Nature Communications
Haldane’s rule suggests that in hybrid crosses, the heterogametic sex is often rare or sterile. This study crosses Caenorhabditis nematodes, and determines that an underlying feature of Haldane’s rule...
www.nature.com
January 17, 2026 at 2:53 AM
Cool paper from Ron Ellis and colleagues.
I'll take it! What's a virus?
January 16, 2026 at 3:14 PM
I'll take it! What's a virus?
Reposted by Wyoming Wormboy
Job alert! Assistant professor position in the Department of Molecular Genetics (University of Toronto). Amazing department and city. jobs.utoronto.ca/job/Toronto-... Please share.
Assistant Professor - Virology
Assistant Professor - Virology
jobs.utoronto.ca
January 15, 2026 at 8:04 PM
Job alert! Assistant professor position in the Department of Molecular Genetics (University of Toronto). Amazing department and city. jobs.utoronto.ca/job/Toronto-... Please share.
Somewhat humorously, when you google "SciENcv opinions", this is the top hit. I've also been told that it will be far less informative for reviewers because you can't easily figure out what the applicant has accomplished publication-wise.
January 16, 2026 at 3:13 PM
Somewhat humorously, when you google "SciENcv opinions", this is the top hit. I've also been told that it will be far less informative for reviewers because you can't easily figure out what the applicant has accomplished publication-wise.
But please don't make that your end goal! Our field can be very competitive and unforgiving. Job markets can wax and wane a lot! You will always be much safer, and also better prepared scientifically, if you've brought several solid projects to fruition. 1st-author pubs are the main currency. 3/3
January 9, 2026 at 1:44 AM
But please don't make that your end goal! Our field can be very competitive and unforgiving. Job markets can wax and wane a lot! You will always be much safer, and also better prepared scientifically, if you've brought several solid projects to fruition. 1st-author pubs are the main currency. 3/3
And it also offered some protection to PIs. Talking to colleagues, however, it seems that some students now view one 1st-author paper as the end goal. I think that's the wrong idea! And I also get that sometimes one really great 1st-author paper is a huge accomplishment and worthy of a PhD. 2/3
January 9, 2026 at 1:44 AM
And it also offered some protection to PIs. Talking to colleagues, however, it seems that some students now view one 1st-author paper as the end goal. I think that's the wrong idea! And I also get that sometimes one really great 1st-author paper is a huge accomplishment and worthy of a PhD. 2/3
When I was the DGS of an umbrella-type PhD program, I worked to put in a rule that PhD students needed a minimum of one 1st-author research paper to graduate. The main intent was to protect students from advisors that were slackers about publishing. No 1st-author pubs really hurts students. 1/3
January 9, 2026 at 1:44 AM
When I was the DGS of an umbrella-type PhD program, I worked to put in a rule that PhD students needed a minimum of one 1st-author research paper to graduate. The main intent was to protect students from advisors that were slackers about publishing. No 1st-author pubs really hurts students. 1/3
Reposted by Wyoming Wormboy
Qiuyuan Yin, Chonglin Yang et al. reveal a plasma membrane-to-lysosome signaling pathway mediated by the non-receptor tyrosine kinase FGR and the serine/threonine kinase AKT2, which regulates TFEB/TFE3 activation for #lysosome biogenesis in #endocytosis. rupress.org/jcb/article/...
#Organelles
#Organelles
January 7, 2026 at 4:15 PM
Qiuyuan Yin, Chonglin Yang et al. reveal a plasma membrane-to-lysosome signaling pathway mediated by the non-receptor tyrosine kinase FGR and the serine/threonine kinase AKT2, which regulates TFEB/TFE3 activation for #lysosome biogenesis in #endocytosis. rupress.org/jcb/article/...
#Organelles
#Organelles
Sadly, not really. Or maybe just a little. But we’re all in the same boat. ✊
January 7, 2026 at 6:50 PM
Sadly, not really. Or maybe just a little. But we’re all in the same boat. ✊