Surojit Sural
@surojitsural.bsky.social
Using my first brain to study plasticity of both first and second brains in http://hobertlab.org http://hhmi.org @Columbia | @UMich & @IISERPune alum | (he/him)
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Surojit Sural
@surojitsural.bsky.social
· Sep 24
Gut epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes
Gut epithelium modulates output from distinct enteric circuits by altering secretion of insulin and noninsulin peptides.
www.science.org
Very excited to share this finding from my postdoctoral work that is now published in #ScienceAdvances. We show how the gut’s epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes.
www.science.org/doi/10.1126/...
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www.science.org/doi/10.1126/...
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Reposted by Surojit Sural
Caenorhabditis elegans avoids Todstoff, a novel nociceptive necrotaxis cue https://www.biorxiv.org/content/10.64898/2026.02.06.704436v1
February 10, 2026 at 5:32 PM
Caenorhabditis elegans avoids Todstoff, a novel nociceptive necrotaxis cue https://www.biorxiv.org/content/10.64898/2026.02.06.704436v1
Reposted by Surojit Sural
Exposure to deceased remains of conspecifics extends the lifespan of young and aged C. elegans via distinct pathways https://www.biorxiv.org/content/10.64898/2026.02.08.704602v1
February 10, 2026 at 10:32 PM
Exposure to deceased remains of conspecifics extends the lifespan of young and aged C. elegans via distinct pathways https://www.biorxiv.org/content/10.64898/2026.02.08.704602v1
Reposted by Surojit Sural
CUT homeobox factors modulate chromatin accessibility in neurons https://www.biorxiv.org/content/10.64898/2026.02.10.705137v1
February 11, 2026 at 11:17 AM
CUT homeobox factors modulate chromatin accessibility in neurons https://www.biorxiv.org/content/10.64898/2026.02.10.705137v1
Molecular insights into diverse heat hormesis regimens in Caenorhabditis elegans
academic.oup.com/genetics/adv...
academic.oup.com/genetics/adv...
Molecular insights into diverse heat hormesis regimens in Caenorhabditis elegans
Abstract. Heat hormesis describes a biphasic, dose-dependent response in which low levels of heat stress induce beneficial effects, such as enhanced lifesp
academic.oup.com
February 16, 2026 at 5:06 PM
Molecular insights into diverse heat hormesis regimens in Caenorhabditis elegans
academic.oup.com/genetics/adv...
academic.oup.com/genetics/adv...
Reposted by Surojit Sural
Mild Mitochondrial Impairment Activates Overlapping Longevity Pathways Converging on the Flavin-Containing Monooxygenase FMO-2 https://www.biorxiv.org/content/10.64898/2026.02.10.705198v1
February 12, 2026 at 11:32 AM
Mild Mitochondrial Impairment Activates Overlapping Longevity Pathways Converging on the Flavin-Containing Monooxygenase FMO-2 https://www.biorxiv.org/content/10.64898/2026.02.10.705198v1
Reposted by Surojit Sural
ER remodelling is a feature of ageing and depends on ER-phagy
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ER remodelling is a feature of ageing and depends on ER-phagy - Nature Cell Biology
Donahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.
www.nature.com
February 5, 2026 at 9:51 PM
ER remodelling is a feature of ageing and depends on ER-phagy
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Surojit Sural
Distinct Molecular Mechanisms Regulate Feeding State-Dependent CO2 Chemotaxis Plasticity During Different Life Stages in Caenorhabditis elegans https://www.biorxiv.org/content/10.64898/2026.02.06.704338v1
February 10, 2026 at 5:17 PM
Distinct Molecular Mechanisms Regulate Feeding State-Dependent CO2 Chemotaxis Plasticity During Different Life Stages in Caenorhabditis elegans https://www.biorxiv.org/content/10.64898/2026.02.06.704338v1
Reposted by Surojit Sural
A pilot study for whole proteome tagging in C. elegans https://www.biorxiv.org/content/10.64898/2026.02.09.704846v1
February 10, 2026 at 11:31 PM
A pilot study for whole proteome tagging in C. elegans https://www.biorxiv.org/content/10.64898/2026.02.09.704846v1
Reposted by Surojit Sural
Epitope-based labeling for improved live-imaging of endogenous proteins in C. elegans https://www.biorxiv.org/content/10.64898/2026.02.05.703904v1
February 9, 2026 at 2:31 AM
Epitope-based labeling for improved live-imaging of endogenous proteins in C. elegans https://www.biorxiv.org/content/10.64898/2026.02.05.703904v1
Reposted by Surojit Sural
Cell-specific roles for the conserved Galpha chaperone RIC-8 in cilia biology https://www.biorxiv.org/content/10.64898/2026.02.07.704597v1
February 9, 2026 at 1:32 PM
Cell-specific roles for the conserved Galpha chaperone RIC-8 in cilia biology https://www.biorxiv.org/content/10.64898/2026.02.07.704597v1
Improved Dye-Filling Protocol for Multiple Nematode Species | microPublication
www.micropublication.org
February 10, 2026 at 11:41 AM
Reposted by Surojit Sural
I've always been a fan of what the Allen Institute is doing. New in Nature: OpenScholar, an 8B RAG model for scientific literature, outperforms GPT-4o by 6% on correctness. Experts preferred its answers over human-written ones 51%-70 of the time. www.nature.com/articles/s41... 1/3 🧵
February 5, 2026 at 1:24 PM
I've always been a fan of what the Allen Institute is doing. New in Nature: OpenScholar, an 8B RAG model for scientific literature, outperforms GPT-4o by 6% on correctness. Experts preferred its answers over human-written ones 51%-70 of the time. www.nature.com/articles/s41... 1/3 🧵
Reposted by Surojit Sural
The good folks over at Nature asked me about my thoughts on open-source AI tools like OpenScholar.
You can read them in the article below:
Thanks @LizzieGibney for the opportunity to share my thoughts.
www.nature.com/articles/d4...
You can read them in the article below:
Thanks @LizzieGibney for the opportunity to share my thoughts.
www.nature.com/articles/d4...
Open-source AI tool beats giant LLMs in literature reviews — and gets citations right
Nature - Researchers can deploy the cheap and transparent model on their own computer system.
www.nature.com
February 5, 2026 at 12:42 PM
The good folks over at Nature asked me about my thoughts on open-source AI tools like OpenScholar.
You can read them in the article below:
Thanks @LizzieGibney for the opportunity to share my thoughts.
www.nature.com/articles/d4...
You can read them in the article below:
Thanks @LizzieGibney for the opportunity to share my thoughts.
www.nature.com/articles/d4...
Reposted by Surojit Sural
Our new work shows that live E. faecium reduces motor neuron degeneration and improves locomotion in a C. elegans ALS model. Protective effects depend on the induction of cytochrome P450 genes regulated by the intestinal nuclear hormone receptor NHR-86: journals.plos.org/plosbiology/...
A gut-activated NHR-86–CYP pathway mediates the neuroprotective effects of Enterococcus faecium probiotics in a nematode model of amyotrophic lateral sclerosis
Probiotics can influence neuronal health, but how microbial signals are translated into neuroprotective host responses remains poorly understood. This study shows that Enterococcus faecium activates a...
journals.plos.org
February 2, 2026 at 4:27 PM
Our new work shows that live E. faecium reduces motor neuron degeneration and improves locomotion in a C. elegans ALS model. Protective effects depend on the induction of cytochrome P450 genes regulated by the intestinal nuclear hormone receptor NHR-86: journals.plos.org/plosbiology/...
Reposted by Surojit Sural
Potential nematicides identified through targeted in vivo screening of a 5-HT-gated chloride channel, MOD-1 https://www.biorxiv.org/content/10.64898/2026.01.25.701312v1
January 27, 2026 at 6:01 PM
Potential nematicides identified through targeted in vivo screening of a 5-HT-gated chloride channel, MOD-1 https://www.biorxiv.org/content/10.64898/2026.01.25.701312v1
Reposted by Surojit Sural
A genetically encoded ionic-stress sensor reveals protons as a sleep driver https://www.biorxiv.org/content/10.64898/2026.01.27.702131v1
January 31, 2026 at 12:45 AM
A genetically encoded ionic-stress sensor reveals protons as a sleep driver https://www.biorxiv.org/content/10.64898/2026.01.27.702131v1
Reposted by Surojit Sural
ATG-18 drives longevity in an HLH-30-dependent manner https://www.biorxiv.org/content/10.64898/2026.01.27.701268v1
January 29, 2026 at 2:18 PM
ATG-18 drives longevity in an HLH-30-dependent manner https://www.biorxiv.org/content/10.64898/2026.01.27.701268v1
A new set of combinatorial dimeric codes for nuclear hormone receptor–target gene specificity
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Validate User
academic.oup.com
February 3, 2026 at 5:31 PM
A new set of combinatorial dimeric codes for nuclear hormone receptor–target gene specificity
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Reposted by Surojit Sural
The time of day for cancer immunotherapy is associated with major outcomes. Early is better. Results from a randomized trial of lung cancer, backs up the importance of our circadian rhythm and immune system
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 2, 2026 at 4:10 PM
The time of day for cancer immunotherapy is associated with major outcomes. Early is better. Results from a randomized trial of lung cancer, backs up the importance of our circadian rhythm and immune system
www.nature.com/articles/s41...
www.nature.com/articles/s41...
RiboTRAP-seq identifies spatially distinct functions for the anterior and posterior intestine in immune and metabolic regulation in C. elegans
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
RiboTRAP-seq identifies spatially distinct functions for the anterior and posterior intestine in immune and metabolic regulation in C. elegans
elifesciences.org
February 3, 2026 at 5:17 PM
RiboTRAP-seq identifies spatially distinct functions for the anterior and posterior intestine in immune and metabolic regulation in C. elegans
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
Reposted by Surojit Sural
Our first 2026 paper is out @currentbiology.bsky.social!
👏 to @nathancsharris.bsky.social (now Asst Prof, GA State) and PD Priya Dutta.
Here we show how transcriptional and trafficking pathways coordinate thermoreceptor levels to precisely modulate response plasticity
www.cell.com/current-biol...
👏 to @nathancsharris.bsky.social (now Asst Prof, GA State) and PD Priya Dutta.
Here we show how transcriptional and trafficking pathways coordinate thermoreceptor levels to precisely modulate response plasticity
www.cell.com/current-biol...
Experience-dependent reconfiguration of thermoreceptors regulates neuronal response plasticity
Harris, Dutta, et al. find that experience-dependent plasticity in the activation
threshold of the AFD thermosensory neurons is mediated by modulating warm and cold
thermoreceptor levels at the sensor...
www.cell.com
January 28, 2026 at 5:37 PM
Our first 2026 paper is out @currentbiology.bsky.social!
👏 to @nathancsharris.bsky.social (now Asst Prof, GA State) and PD Priya Dutta.
Here we show how transcriptional and trafficking pathways coordinate thermoreceptor levels to precisely modulate response plasticity
www.cell.com/current-biol...
👏 to @nathancsharris.bsky.social (now Asst Prof, GA State) and PD Priya Dutta.
Here we show how transcriptional and trafficking pathways coordinate thermoreceptor levels to precisely modulate response plasticity
www.cell.com/current-biol...
Reposted by Surojit Sural
🆕 @science.org
Revising the heritability of lifespan, from 25% to ~50%, by correcting for extrinsic factors
science.org/doi/10.1126/...
Revising the heritability of lifespan, from 25% to ~50%, by correcting for extrinsic factors
science.org/doi/10.1126/...
January 29, 2026 at 7:04 PM
🆕 @science.org
Revising the heritability of lifespan, from 25% to ~50%, by correcting for extrinsic factors
science.org/doi/10.1126/...
Revising the heritability of lifespan, from 25% to ~50%, by correcting for extrinsic factors
science.org/doi/10.1126/...
Reposted by Surojit Sural
Thanks! We were really happy with how it turned out! I got a lot of emails asking for advice about the AID system and it felt like this primer was lacking. It was great to work with Dave, Ann, and Aric and I love the idea of the curated strain collections!
January 29, 2026 at 9:14 PM
Thanks! We were really happy with how it turned out! I got a lot of emails asking for advice about the AID system and it felt like this primer was lacking. It was great to work with Dave, Ann, and Aric and I love the idea of the curated strain collections!
Reposted by Surojit Sural
The CGC has added some cool functionality to improve the searchability of the site to help find appropriate strains for your research. We are working to create a consistent nomenclature. More collections to come in the future. Folks can ask questions on Worm Slack, the Alliance forum, or here! (2)
January 29, 2026 at 9:18 PM
The CGC has added some cool functionality to improve the searchability of the site to help find appropriate strains for your research. We are working to create a consistent nomenclature. More collections to come in the future. Folks can ask questions on Worm Slack, the Alliance forum, or here! (2)
Reposted by Surojit Sural
Excited to see this out in the world. The CGC is launching a curated strains collection, the first being protein degradation systems and this is a pilot primer to pair with it authored by myself, Dave Reiner, Ann Rougvie, and Aric Daul. We review the state of the field and provide use guidance (1)
The Caenorhabditis Genetics Center Curated Special Collections: a guide to protein degradation systems
academic.oup.com/genetics/adv...
academic.oup.com/genetics/adv...
The Caenorhabditis Genetics Center Curated Special Collections: a guide to protein degradation systems
Abstract. The Caenorhabditis Genetics Center is launching a new website feature—“Curated Special Collections”—designed to help researchers navigate the eve
academic.oup.com
January 29, 2026 at 9:16 PM
Excited to see this out in the world. The CGC is launching a curated strains collection, the first being protein degradation systems and this is a pilot primer to pair with it authored by myself, Dave Reiner, Ann Rougvie, and Aric Daul. We review the state of the field and provide use guidance (1)