Surojit Sural
@surojitsural.bsky.social
C. elegans researcher | Studies how the worm brain responds to stress in http://hobertlab.org http://hhmi.org @Columbia | @UMich & @IISERPune alum | (he/him)
Pinned
Surojit Sural
@surojitsural.bsky.social
· Sep 24
Gut epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes
Gut epithelium modulates output from distinct enteric circuits by altering secretion of insulin and noninsulin peptides.
www.science.org
Very excited to share this finding from my postdoctoral work that is now published in #ScienceAdvances. We show how the gut’s epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes.
www.science.org/doi/10.1126/...
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The mind-bending power of placebo
Studies with open-label placebos — sugar pills given without deception — suggest that the placebo effect is more psychologically complex than previously thought.
www.nature.com/articles/s41...
Studies with open-label placebos — sugar pills given without deception — suggest that the placebo effect is more psychologically complex than previously thought.
www.nature.com/articles/s41...
The mind-bending power of placebo - Nature Medicine
Studies with open-label placebos — sugar pills given without deception — suggest that the placebo effect is more psychologically complex than previously thought.
www.nature.com
November 14, 2025 at 5:43 PM
The mind-bending power of placebo
Studies with open-label placebos — sugar pills given without deception — suggest that the placebo effect is more psychologically complex than previously thought.
www.nature.com/articles/s41...
Studies with open-label placebos — sugar pills given without deception — suggest that the placebo effect is more psychologically complex than previously thought.
www.nature.com/articles/s41...
Mutation in IR or IGF1R produces features of long-lived mice while maintaining metabolic health
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
JCI Insight -
Mutation in IR or IGF1R produces features of long-lived mice while maintaining metabolic health
insight.jci.org
November 14, 2025 at 5:01 PM
Mutation in IR or IGF1R produces features of long-lived mice while maintaining metabolic health
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
Chemical modulation of gut bacterial metabolism induces colanic acid and extends the lifespan of nematode and mammalian hosts
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Chemical modulation of gut bacterial metabolism induces colanic acid and extends the lifespan of nematode and mammalian hosts
Gut microbes can influence aging, but how can this effect be chemically induced? This study shows that a low dose of cephaloridine triggers colanic acid production in commensal E. coli, extending the ...
journals.plos.org
November 14, 2025 at 5:00 PM
Chemical modulation of gut bacterial metabolism induces colanic acid and extends the lifespan of nematode and mammalian hosts
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Reposted by Surojit Sural
Our lab’s paper spearheaded by Keni and pushed to completion (and satisfaction by the reviewers) by Satish is finally out www.nature.com/articles/s41.... Was so fortunate to contribute to this project and learned a lot in both neuronal cell biology and cryoET. Also, Satish is on the job market!
November 12, 2025 at 5:35 PM
Our lab’s paper spearheaded by Keni and pushed to completion (and satisfaction by the reviewers) by Satish is finally out www.nature.com/articles/s41.... Was so fortunate to contribute to this project and learned a lot in both neuronal cell biology and cryoET. Also, Satish is on the job market!
Ectopic transcription due to inherited histone methylation may interfere with the ongoing function of differentiated neurons
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Ectopic transcription due to inherited histone methylation may interfere with the ongoing function of differentiated neurons | PNAS
How mutations in histone modifying enzymes lead to neurodevelopmental defects is unknown.
To address this question, we took advantage of the invari...
www.pnas.org
November 10, 2025 at 6:04 PM
Ectopic transcription due to inherited histone methylation may interfere with the ongoing function of differentiated neurons
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Surojit Sural
Make males live more than 400% longer and prevent sexual disfunction late in life?! We're down with it. Our latest preprint: Disruption of the insulin signaling pathway in C. elegans dramatically increases male longevity and enhances reproductive health late in life. www.biorxiv.org/content/10.1...
November 6, 2025 at 11:14 PM
Make males live more than 400% longer and prevent sexual disfunction late in life?! We're down with it. Our latest preprint: Disruption of the insulin signaling pathway in C. elegans dramatically increases male longevity and enhances reproductive health late in life. www.biorxiv.org/content/10.1...
Reposted by Surojit Sural
We’re excited to expand our partnership with @reviewcommons.org in a new collaborative model reshaping scientific publishing to streamline peer review, reduce redundancy, and improve the author and reviewer experience. Read more: buff.ly/h6SfMXF
And meet our Editorial Board! 👋
And meet our Editorial Board! 👋
November 5, 2025 at 2:01 PM
We’re excited to expand our partnership with @reviewcommons.org in a new collaborative model reshaping scientific publishing to streamline peer review, reduce redundancy, and improve the author and reviewer experience. Read more: buff.ly/h6SfMXF
And meet our Editorial Board! 👋
And meet our Editorial Board! 👋
Reposted by Surojit Sural
HLH-30/TFEB is necessary for chromatin reorganization and maintenance of cell quiescence during starvation in C. elegans https://www.biorxiv.org/content/10.1101/2025.10.31.685810v1
November 3, 2025 at 6:30 PM
HLH-30/TFEB is necessary for chromatin reorganization and maintenance of cell quiescence during starvation in C. elegans https://www.biorxiv.org/content/10.1101/2025.10.31.685810v1
Tardigrade Dsup extends C. elegans life span by impeding mitochondrial respiration and promoting oxidative stress resistance
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Tardigrade Dsup extends C. elegans life span by impeding mitochondrial respiration and promoting oxidative stress resistance
Tardigrade Dsup extends C. elegans life span by reducing mitochondrial activity and enhancing stress resistance.
www.science.org
November 4, 2025 at 4:10 PM
Tardigrade Dsup extends C. elegans life span by impeding mitochondrial respiration and promoting oxidative stress resistance
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Insulin and epidermal signals independently shape sexually dimorphic neurite branching in C. elegans
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Insulin and epidermal signals independently shape sexually dimorphic neurite branching in C. elegans | EMBO reports
imageimageSexual state-regulated insulin signaling and vulval epithelial cues engage distinct
pathways to remodel the F-actin cytoskeleton, thereby sculpting sexually dimorphic
PVP branches that are i...
www.embopress.org
November 4, 2025 at 4:01 PM
Insulin and epidermal signals independently shape sexually dimorphic neurite branching in C. elegans
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Surojit Sural
The study “Leucine inhibits degradation of outer mitochondrial membrane proteins to adapt mitochondrial respiration” in Nature Cell Biology 👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Leucine inhibits degradation of outer mitochondrial membrane proteins to adapt mitochondrial respiration - Nature Cell Biology
Li et al. uncover a connection between metabolic cues and mitochondrial protein degradation, showing that specifically leucine stabilizes outer mitochondrial membrane proteins by inhibiting ubiquityla...
www.nature.com
October 31, 2025 at 1:33 PM
The study “Leucine inhibits degradation of outer mitochondrial membrane proteins to adapt mitochondrial respiration” in Nature Cell Biology 👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation
www.science.org/doi/full/10....
www.science.org/doi/full/10....
www.science.org
November 2, 2025 at 8:58 PM
Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Reposted by Surojit Sural
Aversive Learning Induces Context-Gated Global Reorganization of Neural Dynamics in Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2025.10.31.685731v1
November 1, 2025 at 1:15 PM
Aversive Learning Induces Context-Gated Global Reorganization of Neural Dynamics in Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2025.10.31.685731v1
A positive feedback loop promotes the active internal state of the C. elegans egg-laying circuit
www.cell.com/current-biol...
www.cell.com/current-biol...
A positive feedback loop promotes the active internal state of the C. elegans egg-laying circuit
How do neural circuits switch between distinct patterns of activity, known as “internal
states”? Prashad et al. describe how PVW neurons, which lack any identified neurotransmitter,
generate one of th...
www.cell.com
November 2, 2025 at 8:10 PM
A positive feedback loop promotes the active internal state of the C. elegans egg-laying circuit
www.cell.com/current-biol...
www.cell.com/current-biol...
Reposted by Surojit Sural
A default silencing mechanism restrains stress-induced genes in C. elegans https://www.biorxiv.org/content/10.1101/2025.10.22.683740v1
October 23, 2025 at 9:32 PM
A default silencing mechanism restrains stress-induced genes in C. elegans https://www.biorxiv.org/content/10.1101/2025.10.22.683740v1
Phenotypic plasticity as the foundation of lifelong development
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
Phenotypic plasticity as the foundation of lifelong development
Summary: This Hypothesis argues that phenotypic plasticity underlies lifelong development, linking regeneration, asexual reproduction, morphological change and reverse development to environmental res...
journals.biologists.com
October 31, 2025 at 3:46 PM
Phenotypic plasticity as the foundation of lifelong development
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
The seminal fluid protein SFP-1 regulates mated hermaphrodite aging and fat metabolism in C. elegans
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
The seminal fluid protein SFP-1 regulates mated hermaphrodite aging and fat metabolism in C. elegans | The EMBO Journal
imageimageMating influences physiological responses across species, but little is known about
seminal fluid proteins driving such changes. This study characterizes the C. elegans seminal protein SFP-1...
www.embopress.org
October 31, 2025 at 3:41 PM
The seminal fluid protein SFP-1 regulates mated hermaphrodite aging and fat metabolism in C. elegans
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Surojit Sural
The importance of basic research
“no one wants to see taxpayers’ monies being misspent. But world-changing discoveries often occur unexpectedly and are built on years…decades — of fundamental research that expanded our knowledge of the world”
🧪 #Research #Scicomm
www.nature.com/articles/d41...
“no one wants to see taxpayers’ monies being misspent. But world-changing discoveries often occur unexpectedly and are built on years…decades — of fundamental research that expanded our knowledge of the world”
🧪 #Research #Scicomm
www.nature.com/articles/d41...
From MRI to Ozempic: breakthroughs that show why fundamental research must be protected
In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.
www.nature.com
October 31, 2025 at 2:33 AM
The importance of basic research
“no one wants to see taxpayers’ monies being misspent. But world-changing discoveries often occur unexpectedly and are built on years…decades — of fundamental research that expanded our knowledge of the world”
🧪 #Research #Scicomm
www.nature.com/articles/d41...
“no one wants to see taxpayers’ monies being misspent. But world-changing discoveries often occur unexpectedly and are built on years…decades — of fundamental research that expanded our knowledge of the world”
🧪 #Research #Scicomm
www.nature.com/articles/d41...
Reposted by Surojit Sural
Programmed DNA elimination was present in the last common ancestor of Caenorhabditis nematodes https://www.biorxiv.org/content/10.1101/2025.10.23.681605v1
October 24, 2025 at 9:32 PM
Programmed DNA elimination was present in the last common ancestor of Caenorhabditis nematodes https://www.biorxiv.org/content/10.1101/2025.10.23.681605v1
Reposted by Surojit Sural
DAF-16/FOXO maintains genome integrity following genotoxic stress https://www.biorxiv.org/content/10.1101/2025.10.27.684284v1
October 28, 2025 at 11:30 PM
DAF-16/FOXO maintains genome integrity following genotoxic stress https://www.biorxiv.org/content/10.1101/2025.10.27.684284v1
Reposted by Surojit Sural
First neurons didn’t appear overnight. We trace their roots to ancient secretory cells - showing how lifestyle & behavior shaped the evolution of first synapses.🧠🌊 #Evolution #Neuroscience
Our latest in @natrevneuro.nature.com
Link: rdcu.be/eMX3E
@jeffcolgren.bsky.social @msarscentre.bsky.social
Our latest in @natrevneuro.nature.com
Link: rdcu.be/eMX3E
@jeffcolgren.bsky.social @msarscentre.bsky.social
The evolutionary origins of synaptic proteins and their changing roles in different organisms across evolution
Nature Reviews Neuroscience - Recent studies have shed further light on the evolutionary origins of chemical synapses, In this Review, Colgren and Burkhardt explore how ancient proteins were...
rdcu.be
October 27, 2025 at 6:48 PM
First neurons didn’t appear overnight. We trace their roots to ancient secretory cells - showing how lifestyle & behavior shaped the evolution of first synapses.🧠🌊 #Evolution #Neuroscience
Our latest in @natrevneuro.nature.com
Link: rdcu.be/eMX3E
@jeffcolgren.bsky.social @msarscentre.bsky.social
Our latest in @natrevneuro.nature.com
Link: rdcu.be/eMX3E
@jeffcolgren.bsky.social @msarscentre.bsky.social
Reposted by Surojit Sural
'Here we find that the sense of touch interacts with nutritional state to modulate lifespan in Caenorhabditis elegans. Worms subjected to dietary restriction are shorter-lived when they perceive tactile stimuli that mimic bacterial food and/or protective soil.'
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Rewarding touch limits lifespan through neural to intestinal signaling | PNAS
In multicellular organisms, sensory perception affects many aspects of behavior and
physiology. Perception of environmental stressors like food sca...
www.pnas.org
October 24, 2025 at 9:44 AM
'Here we find that the sense of touch interacts with nutritional state to modulate lifespan in Caenorhabditis elegans. Worms subjected to dietary restriction are shorter-lived when they perceive tactile stimuli that mimic bacterial food and/or protective soil.'
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
The DEG/ENaC channel DEGT-1 is a proprioceptor of C. elegans foregut movement
www.cell.com/current-biol...
www.cell.com/current-biol...
The DEG/ENaC channel DEGT-1 is a proprioceptor of C. elegans foregut movement
Bayer et al. show that the DEGT-1 DEG/ENaC channel is specifically expressed in C.
elegans pharyngeal neurons and localizes to the pharyngeal basement membrane. They
found that DEGT-1 is required in I...
www.cell.com
October 27, 2025 at 1:52 AM
The DEG/ENaC channel DEGT-1 is a proprioceptor of C. elegans foregut movement
www.cell.com/current-biol...
www.cell.com/current-biol...