Pinned
Felix Campelo
@felixmendu.bsky.social
· Jul 4
Intracellular mechanics and organelle mechanobiology
Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…
meetings.embo.org
Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio
meetings.embo.org/event/26-org...
meetings.embo.org/event/26-org...
👇This is today (Jan 29th), don't miss these #MembraneTrafficking talks!
Join us this Thursday (Jan 29) at 5pm CET for the first #MembraneTrafficking seminars of 2026, featuring two outstanding scientists, Giovanni D'Angelo (EPFL) and Sean Munro (@cellbiol-mrclmb.bsky.social), and the shared topic of protein trafficking, retention & sorting at the #Golgi 🥞
January 29, 2026 at 7:59 AM
👇This is today (Jan 29th), don't miss these #MembraneTrafficking talks!
Join us this Thursday (Jan 29) at 5pm CET for the first #MembraneTrafficking seminars of 2026, featuring two outstanding scientists, Giovanni D'Angelo (EPFL) and Sean Munro (@cellbiol-mrclmb.bsky.social), and the shared topic of protein trafficking, retention & sorting at the #Golgi 🥞
January 27, 2026 at 7:51 AM
Join us this Thursday (Jan 29) at 5pm CET for the first #MembraneTrafficking seminars of 2026, featuring two outstanding scientists, Giovanni D'Angelo (EPFL) and Sean Munro (@cellbiol-mrclmb.bsky.social), and the shared topic of protein trafficking, retention & sorting at the #Golgi 🥞
Two PhD positions just opened in the Gallego lab at our department @melisupf.bsky.social @upf.edu @prbb.org! #MembraneTrafficking in cryo-tolerant systems, with wet lab and computational projects available. Come do cool (and cold 😉) science with Oriol in Barcelona!
Please share🙏:
Our lab opens 2 PhD positions to investigate fungi's evolution: #Barcelona
Wet lab in Biochemistry/Structural Biology of cryo-tolerant fungi
www.upf.edu/documents/d/...
Computational in Physical Chemistry of cellular processes under extrem environments
www.upf.edu/documents/d/...
Our lab opens 2 PhD positions to investigate fungi's evolution: #Barcelona
Wet lab in Biochemistry/Structural Biology of cryo-tolerant fungi
www.upf.edu/documents/d/...
Computational in Physical Chemistry of cellular processes under extrem environments
www.upf.edu/documents/d/...
www.upf.edu
January 26, 2026 at 4:56 PM
Two PhD positions just opened in the Gallego lab at our department @melisupf.bsky.social @upf.edu @prbb.org! #MembraneTrafficking in cryo-tolerant systems, with wet lab and computational projects available. Come do cool (and cold 😉) science with Oriol in Barcelona!
Reposted by Felix Campelo
Happy to highlight our collaborative work from our @ijmonod.bsky.social team with @destriano.bsky.social, B. Goyeau and M. Chabanon.
Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity.
Plus: a clever way to measure cell volume.
www.pnas.org/doi/10.1073/...
Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity.
Plus: a clever way to measure cell volume.
www.pnas.org/doi/10.1073/...
Cytoplasmic crowding acts as a porous medium reducing macromolecule diffusion | PNAS
Intracellular transport of macromolecules is crucial for the proper functioning of
most cellular processes. Although intracellular crowding is know...
www.pnas.org
January 26, 2026 at 9:42 AM
Happy to highlight our collaborative work from our @ijmonod.bsky.social team with @destriano.bsky.social, B. Goyeau and M. Chabanon.
Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity.
Plus: a clever way to measure cell volume.
www.pnas.org/doi/10.1073/...
Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity.
Plus: a clever way to measure cell volume.
www.pnas.org/doi/10.1073/...
Reposted by Felix Campelo
Excited to share a new story that transformed how we think about membrane domains in the ER!
rdcu.be/eR7Cn
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export
Wondering what’s so new and exciting? Skytorial below!
1/9
rdcu.be/eR7Cn
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export
Wondering what’s so new and exciting? Skytorial below!
1/9
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export
Nature Communications - Through synchronized cargo traffic experiments, the authors explore the role of raft partitioning in ER efflux. Raft-preferring cargos show specific preferences for ER exit...
rdcu.be
January 24, 2026 at 8:20 PM
Excited to share a new story that transformed how we think about membrane domains in the ER!
rdcu.be/eR7Cn
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export
Wondering what’s so new and exciting? Skytorial below!
1/9
rdcu.be/eR7Cn
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export
Wondering what’s so new and exciting? Skytorial below!
1/9
Reposted by Felix Campelo
I’ll soon share a call for a postdoc at Institut Jacques Monod (Paris) on fundamental mechanisms of membrane traffic and protein/collagen secretion in health and disease. Please get in touch if interested.
January 23, 2026 at 10:59 AM
I’ll soon share a call for a postdoc at Institut Jacques Monod (Paris) on fundamental mechanisms of membrane traffic and protein/collagen secretion in health and disease. Please get in touch if interested.
Reposted by Felix Campelo
🔬🔦 Imaging spotlight on FocalPlane
@janakroll.bsky.social and colleagues highlight their research visualising synaptic vesicle fusion using cryo-ET combined with plunge freezing and optogenetics.
focalplane.biologists.com/2026/01/21/i...
@janakroll.bsky.social and colleagues highlight their research visualising synaptic vesicle fusion using cryo-ET combined with plunge freezing and optogenetics.
focalplane.biologists.com/2026/01/21/i...
Imaging spotlight: visualising synaptic vesicle fusion by cryo-ET - FocalPlane
Imaging spotlight: visualising synaptic vesicle fusion by cryo-ET - News
focalplane.biologists.com
January 22, 2026 at 1:47 PM
🔬🔦 Imaging spotlight on FocalPlane
@janakroll.bsky.social and colleagues highlight their research visualising synaptic vesicle fusion using cryo-ET combined with plunge freezing and optogenetics.
focalplane.biologists.com/2026/01/21/i...
@janakroll.bsky.social and colleagues highlight their research visualising synaptic vesicle fusion using cryo-ET combined with plunge freezing and optogenetics.
focalplane.biologists.com/2026/01/21/i...
Reposted by Felix Campelo
0/10
🥳 our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaño-Díez labs #Quantitative_Cell_Biology
Continuum architecture dynamics of vesicle tethering in exocytosis
www.cell.com/cell/fulltex...
🥳 our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaño-Díez labs #Quantitative_Cell_Biology
Continuum architecture dynamics of vesicle tethering in exocytosis
www.cell.com/cell/fulltex...
Continuum architecture dynamics of vesicle tethering in exocytosis
Data from complementary imaging techniques were integrated into a model that resolves
the dynamic exocyst ensemble and membrane architecture during exocytosis, an essential
cellular pathway. Sec18 med...
www.cell.com
January 16, 2026 at 5:28 PM
0/10
🥳 our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaño-Díez labs #Quantitative_Cell_Biology
Continuum architecture dynamics of vesicle tethering in exocytosis
www.cell.com/cell/fulltex...
🥳 our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaño-Díez labs #Quantitative_Cell_Biology
Continuum architecture dynamics of vesicle tethering in exocytosis
www.cell.com/cell/fulltex...
Reposted by Felix Campelo
Now online! Continuum architecture dynamics of vesicle tethering in exocytosis
Continuum architecture dynamics of vesicle tethering in exocytosis
Data from complementary imaging techniques were integrated into a model that resolves the dynamic exocyst ensemble and membrane architecture during exocytosis, an essential cellular pathway. Sec18 mediates the rate of exocytosis by disassembling the exocyst higher-order structure after vesicle fusion.
dlvr.it
January 16, 2026 at 3:59 PM
Now online! Continuum architecture dynamics of vesicle tethering in exocytosis
Reposted by Felix Campelo
Happy that we could contribute to this exciting paper from the @spanglab.bsky.social!
Exciting preprint from @franbottanelli.bsky.social and @annespang.bsky.social! ARF-1 regulates FERARI-mediated endosomal kiss-and-run recycling by controlling selective cargo loading into vesicles.
ARF-1 Coordinates Cargo Sorting at FERARI Endosomal Recycling Hubs
www.biorxiv.org/content/10.6...
ARF-1 Coordinates Cargo Sorting at FERARI Endosomal Recycling Hubs
www.biorxiv.org/content/10.6...
January 13, 2026 at 8:30 PM
Happy that we could contribute to this exciting paper from the @spanglab.bsky.social!
Reposted by Felix Campelo
Exciting preprint from @franbottanelli.bsky.social and @annespang.bsky.social! ARF-1 regulates FERARI-mediated endosomal kiss-and-run recycling by controlling selective cargo loading into vesicles.
ARF-1 Coordinates Cargo Sorting at FERARI Endosomal Recycling Hubs
www.biorxiv.org/content/10.6...
ARF-1 Coordinates Cargo Sorting at FERARI Endosomal Recycling Hubs
www.biorxiv.org/content/10.6...
January 13, 2026 at 7:46 PM
Exciting preprint from @franbottanelli.bsky.social and @annespang.bsky.social! ARF-1 regulates FERARI-mediated endosomal kiss-and-run recycling by controlling selective cargo loading into vesicles.
ARF-1 Coordinates Cargo Sorting at FERARI Endosomal Recycling Hubs
www.biorxiv.org/content/10.6...
ARF-1 Coordinates Cargo Sorting at FERARI Endosomal Recycling Hubs
www.biorxiv.org/content/10.6...
Reposted by Felix Campelo
Exciting preprint from @felixmendu.bsky.social and Yuichi Wakana! A TGN carrier whose budding is driven by ER–Golgi lipid transfer, PKD activity, and a caveolin-based oligomeric coat!
A PKD-caveolin axis drives secretory carrier biogenesis at the TGN
www.biorxiv.org/content/10.6...
A PKD-caveolin axis drives secretory carrier biogenesis at the TGN
www.biorxiv.org/content/10.6...
January 14, 2026 at 4:20 PM
Exciting preprint from @felixmendu.bsky.social and Yuichi Wakana! A TGN carrier whose budding is driven by ER–Golgi lipid transfer, PKD activity, and a caveolin-based oligomeric coat!
A PKD-caveolin axis drives secretory carrier biogenesis at the TGN
www.biorxiv.org/content/10.6...
A PKD-caveolin axis drives secretory carrier biogenesis at the TGN
www.biorxiv.org/content/10.6...
Congratulations Laura, Verena, and everyone else involved!!
I'm extremely happy to say that a new preprint from Ruprecht lab is out! Check it to to know more about a novel role for the E-cadherin/catenin complex in controlling epithelial phagocytosis 🍽🐟🔬
De novo E-cadherin/catenin complex formation controls basal epithelial mechanics and force transmission for apoptotic cell clearance https://www.biorxiv.org/content/10.64898/2025.12.08.692667v1
January 14, 2026 at 1:12 PM
Congratulations Laura, Verena, and everyone else involved!!
Reposted by Felix Campelo
⏰ Última setmana per inscriure’s a #científiques 2026!
Si ets investigadora o formes part d’un centre educatiu, encara hi ets a temps.
Uneix-te a la iniciativa que ja ha portat més de 600 científiques a les aules i ha implicat més de 500 centres.
📆Termini: 22/12
🔗https://tuit.cat/TSJhl
Si ets investigadora o formes part d’un centre educatiu, encara hi ets a temps.
Uneix-te a la iniciativa que ja ha portat més de 600 científiques a les aules i ha implicat més de 500 centres.
📆Termini: 22/12
🔗https://tuit.cat/TSJhl
December 16, 2025 at 2:16 PM
⏰ Última setmana per inscriure’s a #científiques 2026!
Si ets investigadora o formes part d’un centre educatiu, encara hi ets a temps.
Uneix-te a la iniciativa que ja ha portat més de 600 científiques a les aules i ha implicat més de 500 centres.
📆Termini: 22/12
🔗https://tuit.cat/TSJhl
Si ets investigadora o formes part d’un centre educatiu, encara hi ets a temps.
Uneix-te a la iniciativa que ja ha portat més de 600 científiques a les aules i ha implicat més de 500 centres.
📆Termini: 22/12
🔗https://tuit.cat/TSJhl
Reposted by Felix Campelo
Talin didn’t evolve for integrins... integrins evolved for talin 🤯
pN force coupling via talin is ancient, conserved from amoebae to humans; signaling came later.
Read this amazing paper here 👇🏽
www.nature.com/articles/s41...
pN force coupling via talin is ancient, conserved from amoebae to humans; signaling came later.
Read this amazing paper here 👇🏽
www.nature.com/articles/s41...
Talin force coupling underlies eukaryotic cell-substrate adhesion - Nature Communications
Talin is a well-known regulator of cell adhesion and intracellular force transmission in animals. Here, the authors demonstrate that talin’s mechanical function is evolutionarily conserved and already established in unicellular eukaryotes.
www.nature.com
December 16, 2025 at 4:23 PM
Talin didn’t evolve for integrins... integrins evolved for talin 🤯
pN force coupling via talin is ancient, conserved from amoebae to humans; signaling came later.
Read this amazing paper here 👇🏽
www.nature.com/articles/s41...
pN force coupling via talin is ancient, conserved from amoebae to humans; signaling came later.
Read this amazing paper here 👇🏽
www.nature.com/articles/s41...
Reposted by Felix Campelo
❄️🔬⏱️
I am excited to share that our study „Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons” has been published in Nature Communications www.nature.com/articles/s41...
👇 Short summary of our key findings (1/8)
I am excited to share that our study „Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons” has been published in Nature Communications www.nature.com/articles/s41...
👇 Short summary of our key findings (1/8)
Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons - Nature Communications
Synaptic vesicle fusion is essential for neuronal communication, yet its nanoscale sequence has not been directly confirmed. Here, the authors use timed in situ cryo-electron tomography to visualize t...
www.nature.com
December 13, 2025 at 8:10 PM
❄️🔬⏱️
I am excited to share that our study „Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons” has been published in Nature Communications www.nature.com/articles/s41...
👇 Short summary of our key findings (1/8)
I am excited to share that our study „Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons” has been published in Nature Communications www.nature.com/articles/s41...
👇 Short summary of our key findings (1/8)
Reposted by Felix Campelo
My excellent collaborator, Giulia Zanetti, is advertising for a post-doc to work on our shared MRC grant. Please consider applying to this great lab with a supportive mentor to do some exciting structural biology.
www.ucl.ac.uk/work-at-ucl/...
www.ucl.ac.uk/work-at-ucl/...
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
www.ucl.ac.uk
December 11, 2025 at 12:53 PM
My excellent collaborator, Giulia Zanetti, is advertising for a post-doc to work on our shared MRC grant. Please consider applying to this great lab with a supportive mentor to do some exciting structural biology.
www.ucl.ac.uk/work-at-ucl/...
www.ucl.ac.uk/work-at-ucl/...
Reposted by Felix Campelo
#membrane seminars are back this THURSDAY for a super session with @dr-downes.bsky.social from the @giuliazanetti.bsky.social lab and Xin Zhou from the Ikonen lab! @felixmendu.bsky.social @ishier.bsky.social
December 3, 2025 at 11:20 AM
#membrane seminars are back this THURSDAY for a super session with @dr-downes.bsky.social from the @giuliazanetti.bsky.social lab and Xin Zhou from the Ikonen lab! @felixmendu.bsky.social @ishier.bsky.social
Reposted by Felix Campelo
New preprint from the lab!!🎉
We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments?
www.biorxiv.org/content/10.1...
We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments?
www.biorxiv.org/content/10.1...
Molecular basis for cellular compartmentalization by an ancient membrane fission mechanism
The emergence of cell compartmentalization depends on membrane fission to create the endomembrane compartments. In eukaryotes, membrane fission is commonly executed by ESCRT-III, a protein complex con...
www.biorxiv.org
December 1, 2025 at 9:09 AM
New preprint from the lab!!🎉
We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments?
www.biorxiv.org/content/10.1...
We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments?
www.biorxiv.org/content/10.1...
Last week to submit an abstract to the "Intracellular mechanics and organelle mechanobiology" EMBO workshop #EMBOmechanobio 👇
December 1, 2025 at 8:45 AM
Last week to submit an abstract to the "Intracellular mechanics and organelle mechanobiology" EMBO workshop #EMBOmechanobio 👇
Reposted by Felix Campelo
Nice paper from @leventallab.bsky.social suggess lipid-driven domains organise cargo and trafficking machinery at ERES to sort and export transmembrane proteins.
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export.
rdcu.be/eR8jj
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export.
rdcu.be/eR8jj
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export
Nature Communications - Through synchronized cargo traffic experiments, the authors explore the role of raft partitioning in ER efflux. Raft-preferring cargos show specific preferences for ER exit...
rdcu.be
November 27, 2025 at 8:35 PM
Nice paper from @leventallab.bsky.social suggess lipid-driven domains organise cargo and trafficking machinery at ERES to sort and export transmembrane proteins.
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export.
rdcu.be/eR8jj
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export.
rdcu.be/eR8jj
Reposted by Felix Campelo
It was fun, and a great honour, to receive this award in Barcelona last night. I'm speaking tonight about quantum matters for the City Biennal.
www.biennalciutaticiencia.barcelona/en/activitie...
www.biennalciutaticiencia.barcelona/en/activitie...
www.biennalciutaticiencia.barcelona
November 19, 2025 at 4:59 PM
It was fun, and a great honour, to receive this award in Barcelona last night. I'm speaking tonight about quantum matters for the City Biennal.
www.biennalciutaticiencia.barcelona/en/activitie...
www.biennalciutaticiencia.barcelona/en/activitie...
Reposted by Felix Campelo
ICYMI: New Online! Mechanistic insights into cargo sorting and export from the Golgi apparatus
Mechanistic insights into cargo sorting and export from the Golgi apparatus
Nature Reviews Molecular Cell Biology, Published online: 10 November 2025; doi:10.1038/s41580-025-00907-3Protein and lipid cargoes are modified and sorted in the Golgi apparatus and packaged for delivery to diverse cellular destinations at the trans-Golgi network (TGN). This Review discusses recent insights into Golgi transport mechanisms and carrier biogenesis at the TGN.
bit.ly
November 13, 2025 at 10:04 AM
ICYMI: New Online! Mechanistic insights into cargo sorting and export from the Golgi apparatus
Reposted by Felix Campelo
Check out our @ascbiology.bsky.social #CellBio2025 Minisymposium on ER Homeostasis. With THIS speaker lineup, this event will be as dynamic, transformative and productive as the ER itself!
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
November 9, 2025 at 6:04 PM
Check out our @ascbiology.bsky.social #CellBio2025 Minisymposium on ER Homeostasis. With THIS speaker lineup, this event will be as dynamic, transformative and productive as the ER itself!
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
Join us at @icfo.eu in Barcelona next February for the 1st @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology". I am convinced it will be very interesting! We have extended the abstract submission deadline to December 8, so no excuses :) #EMBOmechanobio
Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio
meetings.embo.org/event/26-org...
meetings.embo.org/event/26-org...
Intracellular mechanics and organelle mechanobiology
Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…
meetings.embo.org
November 12, 2025 at 4:34 PM
Join us at @icfo.eu in Barcelona next February for the 1st @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology". I am convinced it will be very interesting! We have extended the abstract submission deadline to December 8, so no excuses :) #EMBOmechanobio