Ivaska Lab
@ivaskalab.bsky.social
Research group interested in everything around cancer and integrins (more details on our website!). Posts by Ivaska Lab members.
Website: https://ivaskalab.utu.fi/
Website: https://ivaskalab.utu.fi/
Pinned
Ivaska Lab
@ivaskalab.bsky.social
· Nov 19
Ivaska cell adhesion and cancer Lab
Integrins, matrix, motility and mechanotransduction in cancer
ivaskalab.utu.fi
Introductory post on 🦋! We're a research group headed by Prof. Johanna Ivaska interested in understanding how integrins contribute to every step of cancer progression. We're located at the Turku Bioscience Center in Turku, Finland! Find out more about us and our interests here: ivaskalab.utu.fi
Reposted by Ivaska Lab
Final call: Applications close September 2! KI is recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. All positions: ki.se/en/about-ki/...
August 18, 2025 at 7:45 AM
Final call: Applications close September 2! KI is recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. All positions: ki.se/en/about-ki/...
Reposted by Ivaska Lab
Happy to see this dynamic micropatterning project taking its beautiful shape as a preprint!
Immune synapse enthusiasts, please take a look 👀 Maybe something to try in your projects too? 🤩
Adapting an amazing tool from @ivaskalab.bsky.social 💥
Immune synapse enthusiasts, please take a look 👀 Maybe something to try in your projects too? 🤩
Adapting an amazing tool from @ivaskalab.bsky.social 💥
I'm very happy to finally be able to show what I have been working on for the last years (with help of @sarahdezperez.bsky.social and Elmeri)!
@mattilalab.bsky.social @inflames-flagship.bsky.social @utu.fi
www.biorxiv.org/content/10.1...
@mattilalab.bsky.social @inflames-flagship.bsky.social @utu.fi
www.biorxiv.org/content/10.1...
Dynamic Micropatterning Reveals Spatial Dynamics of B Cell Receptor Signaling and Immune Synapse Formation
B cell activation by foreign antigens, recognized by the B cell receptor (BCR), is the key prerequisite for cell differentiation for antibody production. B cells typically encounter antigens bound to ...
www.biorxiv.org
August 12, 2025 at 10:36 AM
Happy to see this dynamic micropatterning project taking its beautiful shape as a preprint!
Immune synapse enthusiasts, please take a look 👀 Maybe something to try in your projects too? 🤩
Adapting an amazing tool from @ivaskalab.bsky.social 💥
Immune synapse enthusiasts, please take a look 👀 Maybe something to try in your projects too? 🤩
Adapting an amazing tool from @ivaskalab.bsky.social 💥
Latest from Ivaska Lab ▶️ Niklas Jäntti et al delve deep into the roles of EPLINα/β on integrin trafficking and breast cancer outcomes!
Congratulations to all the authors!
Check the paper out here: www.sciencedirect.com/science/arti...
Congratulations to all the authors!
Check the paper out here: www.sciencedirect.com/science/arti...
EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration
Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different c…
www.sciencedirect.com
July 16, 2025 at 7:55 AM
Latest from Ivaska Lab ▶️ Niklas Jäntti et al delve deep into the roles of EPLINα/β on integrin trafficking and breast cancer outcomes!
Congratulations to all the authors!
Check the paper out here: www.sciencedirect.com/science/arti...
Congratulations to all the authors!
Check the paper out here: www.sciencedirect.com/science/arti...
Reposted by Ivaska Lab
Excited to share our most recent study on #integrintraffic #cancer #migration #focaladhesion by @ivaskalab.bsky.social @drpaulinamoreno.bsky.social Niklas Jäntti et al www.sciencedirect.com/science/arti...
EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration
Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different c…
www.sciencedirect.com
July 16, 2025 at 7:26 AM
Excited to share our most recent study on #integrintraffic #cancer #migration #focaladhesion by @ivaskalab.bsky.social @drpaulinamoreno.bsky.social Niklas Jäntti et al www.sciencedirect.com/science/arti...
Reposted by Ivaska Lab
If you are at the FEBS Congress in Istanbul and would like to have a chat about adhesion-derived protein condensates come to see my poster today between 12:30-13:45. Looking forward to inspiring discussions! 🔬
@ivaskalab.bsky.social
@ivaskalab.bsky.social
July 7, 2025 at 8:16 AM
If you are at the FEBS Congress in Istanbul and would like to have a chat about adhesion-derived protein condensates come to see my poster today between 12:30-13:45. Looking forward to inspiring discussions! 🔬
@ivaskalab.bsky.social
@ivaskalab.bsky.social
Reposted by Ivaska Lab
Are you looking for a postdoc?
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
June 23, 2025 at 2:29 PM
Are you looking for a postdoc?
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
Reposted by Ivaska Lab
We are looking for a postdoctoral fellow to come work with us: www.cruk.manchester.ac.uk/career/mi-25... Please reach out
MI/25/33 - Postdoctoral Scientist Systems Oncology Group | Cancer Research UK Manchester Institute
Add brief description here
www.cruk.manchester.ac.uk
June 7, 2025 at 9:57 AM
We are looking for a postdoctoral fellow to come work with us: www.cruk.manchester.ac.uk/career/mi-25... Please reach out
Reposted by Ivaska Lab
1/ Beyond thrilled to see my #PhD work now published in @jcb.org
A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados
A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados
@gounismichalis.bsky.social et al. show that cells that seed early lung #metastasis in #BreastCancer have altered #metabolism. These metabolic alterations lead them to release extracellular vesicles which engender a microenvironment conducive to invasive growth. rupress.org/jcb/article/...
June 9, 2025 at 8:25 PM
1/ Beyond thrilled to see my #PhD work now published in @jcb.org
A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados
A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados
Reposted by Ivaska Lab
Miten syöpäsolut leviävät ja voidaanko sitä estää? Toistaiseksi ei, mutta tämä saattaa muuttua. Turun biotiedekeskuksen tutkijat löysivät keinon avata syöpäsolujen viestintää, ja tämän tiedon kautta saattaa löytyä lääke syöpäsolujen pysäyttämiseen.
@ivaskalab.bsky.social @johannaivaska.bsky.social
@ivaskalab.bsky.social @johannaivaska.bsky.social
Uusi koetin tekee näkyväksi syöpäsolun viestinnän, tutkijat voivat käyttää tietoa rintasyövän leviämisen estossa
Turun yliopistossa ja Turun biotiedekeskuksessa toimiva tutkimusryhmä on kehittänyt tavan kuvata leviävien rintasyöpäsolujen soluviestintää.
www.utu.fi
June 2, 2025 at 12:55 PM
Miten syöpäsolut leviävät ja voidaanko sitä estää? Toistaiseksi ei, mutta tämä saattaa muuttua. Turun biotiedekeskuksen tutkijat löysivät keinon avata syöpäsolujen viestintää, ja tämän tiedon kautta saattaa löytyä lääke syöpäsolujen pysäyttämiseen.
@ivaskalab.bsky.social @johannaivaska.bsky.social
@ivaskalab.bsky.social @johannaivaska.bsky.social
Reposted by Ivaska Lab
Signaling networks inside #cancer cells control everything from growth to movement, but visualising this in living cells requires new and refined methods. Researcher James Conway set out to see these invisible signals and came up with a new tool to do just that.
#Illusia
@ivaskalab.bsky.social
#Illusia
@ivaskalab.bsky.social
New visualisation tool helps researchers to target breast cancer dissemination
Cancer cell movement during metastasis is a dynamic process regulated by several different signals.
www.utu.fi
June 2, 2025 at 1:02 PM
Signaling networks inside #cancer cells control everything from growth to movement, but visualising this in living cells requires new and refined methods. Researcher James Conway set out to see these invisible signals and came up with a new tool to do just that.
#Illusia
@ivaskalab.bsky.social
#Illusia
@ivaskalab.bsky.social
Reposted by Ivaska Lab
Syövän nykyisillä lääkkeillä ei voida estää syövän leviämistä. Tilanne saattaa muuttua, sillä tutkijamme ovat kehittäneet tavan kuvata syöpäsolun sisäistä signalointia, joka on edellytys solun liikkumiselle.
#Illusia
@johannaivaska.bsky.social @ivaskalab.bsky.social @turkubioscience.bsky.social
#Illusia
@johannaivaska.bsky.social @ivaskalab.bsky.social @turkubioscience.bsky.social
Uusi koetin tekee näkyväksi syöpäsolun viestinnän, tutkijat voivat käyttää tietoa rintasyövän leviämisen estossa - InFLAMES-lippulaiva
Turun yliopistossa ja Turun biotiedekeskuksessa toimiva tutkimusryhmä on kehittänyt tavan kuvata leviävien rintasyöpäsolujen soluviestintää. Menetelmä on paljastunut, että muihin syöpätyyppeihin parha...
inflames.utu.fi
June 3, 2025 at 11:12 AM
Syövän nykyisillä lääkkeillä ei voida estää syövän leviämistä. Tilanne saattaa muuttua, sillä tutkijamme ovat kehittäneet tavan kuvata syöpäsolun sisäistä signalointia, joka on edellytys solun liikkumiselle.
#Illusia
@johannaivaska.bsky.social @ivaskalab.bsky.social @turkubioscience.bsky.social
#Illusia
@johannaivaska.bsky.social @ivaskalab.bsky.social @turkubioscience.bsky.social
Reposted by Ivaska Lab
In a new study led by InFLAMES PI Professor Johanna Ivaska and Dr James Conway have developed a new fluorescent probe to visualise signaling dynamics in moving cancer cells which they used to uncover a new therapeutic possibility for limiting breast cancer spread.
#Illusia
@ivaskalab.bsky.social
#Illusia
@ivaskalab.bsky.social
New visualisation tool helps researchers to target breast cancer dissemination - InFLAMES Research Flagship
Cancer cell movement during metastasis is a dynamic process regulated by several different signals. However, the way cells receive, process and respond to these signals has been extremely hard to dete...
inflames.utu.fi
June 3, 2025 at 11:18 AM
In a new study led by InFLAMES PI Professor Johanna Ivaska and Dr James Conway have developed a new fluorescent probe to visualise signaling dynamics in moving cancer cells which they used to uncover a new therapeutic possibility for limiting breast cancer spread.
#Illusia
@ivaskalab.bsky.social
#Illusia
@ivaskalab.bsky.social
Reposted by Ivaska Lab
New paper from @ivaskalab.bsky.social out now! 🍾 Watch how cancer cell adhesion dynamics are disrupted by inhibiting the phosphatase Shp2 - key to integrin β1 phosphorylation. Blocking Shp2 impairs adhesion and reduces invasion potential. 🎥👇 Read more at: www.nature.com/articles/s41...
May 26, 2025 at 10:29 AM
New paper from @ivaskalab.bsky.social out now! 🍾 Watch how cancer cell adhesion dynamics are disrupted by inhibiting the phosphatase Shp2 - key to integrin β1 phosphorylation. Blocking Shp2 impairs adhesion and reduces invasion potential. 🎥👇 Read more at: www.nature.com/articles/s41...
Reposted by Ivaska Lab
Latest from @ivaskalab.bsky.social @jrwconway.bsky.social in NCB. We find that SHP-2 inhibition stops TNBC invasion and limits metastasis by blocking integrin dephosphorylation!
Read more at:
www.nature.com/articles/s41...
Read more at:
www.nature.com/articles/s41...
Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells - Nature Cell Biology
Conway et al. show that integrin β1 phosphorylation is regulated through balanced activities of tyrosine kinases, such as Src and Arg, and phosphatases, such as PTP-PEST and Shp2, facilitating invadop...
www.nature.com
May 26, 2025 at 12:16 PM
Latest from @ivaskalab.bsky.social @jrwconway.bsky.social in NCB. We find that SHP-2 inhibition stops TNBC invasion and limits metastasis by blocking integrin dephosphorylation!
Read more at:
www.nature.com/articles/s41...
Read more at:
www.nature.com/articles/s41...
Our newest paper is out in NCB. @jrwconway.bsky.social designed a new FRET reporter, Illusia, to show the importance of integrin β1 phosphorylation dynamics in 3D invasion! Video: TNBC cells expressing Illusia with a Src (Saracatinib) or SHP2 (SHP099) inhibitor. www.nature.com/articles/s41...
May 26, 2025 at 10:13 AM
Our newest paper is out in NCB. @jrwconway.bsky.social designed a new FRET reporter, Illusia, to show the importance of integrin β1 phosphorylation dynamics in 3D invasion! Video: TNBC cells expressing Illusia with a Src (Saracatinib) or SHP2 (SHP099) inhibitor. www.nature.com/articles/s41...
Reposted by Ivaska Lab
www.is.fi/kotimaa/art-...
Great recognition to @ivaskalab.bsky.social research at @turkubioscience.bsky.social the Finnish Science Prize
thanks to all my international friends and colleagues over the years
Great recognition to @ivaskalab.bsky.social research at @turkubioscience.bsky.social the Finnish Science Prize
thanks to all my international friends and colleagues over the years
Syöpätutkija Johanna Ivaskalle 100 000 euron tiedepalkinto
Ivaskan työryhmä tutkii syöpäsolujen liikkumista ja leviämistä.
www.is.fi
May 20, 2025 at 3:46 PM
www.is.fi/kotimaa/art-...
Great recognition to @ivaskalab.bsky.social research at @turkubioscience.bsky.social the Finnish Science Prize
thanks to all my international friends and colleagues over the years
Great recognition to @ivaskalab.bsky.social research at @turkubioscience.bsky.social the Finnish Science Prize
thanks to all my international friends and colleagues over the years
We are very proud to announce @johannaivaska.bsky.social as the recipient of the Biennial Finnish Science Award, given by the Finnish Ministry of Education & Culture. Johanna was described as a distinguished researcher with pioneering work in cell biology. Warmest congrats from all of us, boss!
May 20, 2025 at 10:32 AM
We are very proud to announce @johannaivaska.bsky.social as the recipient of the Biennial Finnish Science Award, given by the Finnish Ministry of Education & Culture. Johanna was described as a distinguished researcher with pioneering work in cell biology. Warmest congrats from all of us, boss!
Reposted by Ivaska Lab
Honored to have been elected with Patrick Caswell @mcrcellmatrix.bsky.social co-chair of the 2029 Gordon Research Conference on Fibronectin, Integrins, and Related Molecules!
We have big shoes to fill: www.grc.org/fibronectin-..., but are up for the challenge!
We have big shoes to fill: www.grc.org/fibronectin-..., but are up for the challenge!
May 12, 2025 at 1:18 PM
Honored to have been elected with Patrick Caswell @mcrcellmatrix.bsky.social co-chair of the 2029 Gordon Research Conference on Fibronectin, Integrins, and Related Molecules!
We have big shoes to fill: www.grc.org/fibronectin-..., but are up for the challenge!
We have big shoes to fill: www.grc.org/fibronectin-..., but are up for the challenge!
New preprint alert!📣 @midibu.bsky.social and team take a deep dive into Tensin1 liquid-liquid phase separation (LLPS) and the mechanisms of how it regulates adhesion dynamics!
Check out the preprint here: www.biorxiv.org/content/10.1...
@johannaivaska.bsky.social
Check out the preprint here: www.biorxiv.org/content/10.1...
@johannaivaska.bsky.social
Adhesion-derived condensates control component availability to regulate adhesion dynamics
Integrin adhesion complexes mediate cell-extracellular matrix (ECM) interactions and undergo dynamic remodelling to regulate cell adhesion and migration. Here, we demonstrate that tensin 1 (TNS1), a m...
www.biorxiv.org
May 10, 2025 at 7:37 AM
New preprint alert!📣 @midibu.bsky.social and team take a deep dive into Tensin1 liquid-liquid phase separation (LLPS) and the mechanisms of how it regulates adhesion dynamics!
Check out the preprint here: www.biorxiv.org/content/10.1...
@johannaivaska.bsky.social
Check out the preprint here: www.biorxiv.org/content/10.1...
@johannaivaska.bsky.social
Reposted by Ivaska Lab
Happy to share our Tensin 1 phase separation project is now on bioRxiv.
www.biorxiv.org/content/10.1...
This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social
www.biorxiv.org/content/10.1...
This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social
Adhesion-derived condensates control component availability to regulate adhesion dynamics
Integrin adhesion complexes mediate cell-extracellular matrix (ECM) interactions and undergo dynamic remodelling to regulate cell adhesion and migration. Here, we demonstrate that tensin 1 (TNS1), a m...
www.biorxiv.org
May 9, 2025 at 2:23 PM
Happy to share our Tensin 1 phase separation project is now on bioRxiv.
www.biorxiv.org/content/10.1...
This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social
www.biorxiv.org/content/10.1...
This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social
Reposted by Ivaska Lab
Choose Science. Choose Europe.
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
May 8, 2025 at 10:12 AM
Choose Science. Choose Europe.
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
Reposted by Ivaska Lab
Very important milestone for Finnish academic drug development. The recently established Finnish Drug Development Center has started its first drug development project in collaboration with a start-up Kohde Pharma. ddcenter.fi/kohde-pharma...
Kohde Pharma Oy Secures Investment from Finnish Drug Discovery Center Ltd - Finnish Drug Discovery Center
Vantaa, Finland – May 8th 2025 – Kohde Pharma Oy, a newly incorporated pharmaceutical company in Finland, is pleased to announce that it has secured its first investment from Finnish Drug Discovery Ce...
ddcenter.fi
May 8, 2025 at 10:27 AM
Very important milestone for Finnish academic drug development. The recently established Finnish Drug Development Center has started its first drug development project in collaboration with a start-up Kohde Pharma. ddcenter.fi/kohde-pharma...
Reposted by Ivaska Lab
On my way home after 3 days full of great talks and lively discussions at Fort-Mahon-Plage. Thank you @clubexo-endo.bsky.social community, I had a blast!
May 7, 2025 at 9:24 PM
On my way home after 3 days full of great talks and lively discussions at Fort-Mahon-Plage. Thank you @clubexo-endo.bsky.social community, I had a blast!
Reposted by Ivaska Lab
I'm at the Fibronectin GRC till the end of the week! Come say hi and I'll tell you a bit about mitochondrial near focal adhesions😉
May 7, 2025 at 6:50 AM
I'm at the Fibronectin GRC till the end of the week! Come say hi and I'll tell you a bit about mitochondrial near focal adhesions😉
Reposted by Ivaska Lab
Currently at Fibronectin and Integrins GRC in Italy, meeting amazing people and discussing great science. If you are interested in Tensin phase separation, come and talk to me!
@ivaskalab.bsky.social
@ivaskalab.bsky.social
May 7, 2025 at 6:50 AM
Currently at Fibronectin and Integrins GRC in Italy, meeting amazing people and discussing great science. If you are interested in Tensin phase separation, come and talk to me!
@ivaskalab.bsky.social
@ivaskalab.bsky.social