Karolinska Institutet
@ki.se
Science news from the medical university Karolinska Institutet (KI) in Sweden. Our vision is to advance knowledge about life and strive towards better health for all. https://ki.se/
Researchers at Karolinska Institutet have identified small molecules capable of influencing a hard-to-target receptor family linked to #cancer development. The findings have been published in @natcomms.nature.com and the Journal of Biological Chemistry 🧪 #pharmacology news.ki.se/cracking-the...
Cracking the code of a hidden cancer receptor
Researchers at Karolinska Institutet have identified small molecules capable of influencing a hard-to-target receptor family linked to cancer development. The findings have been published in Nature Co...
news.ki.se
December 16, 2025 at 7:20 AM
Researchers at Karolinska Institutet have identified small molecules capable of influencing a hard-to-target receptor family linked to #cancer development. The findings have been published in @natcomms.nature.com and the Journal of Biological Chemistry 🧪 #pharmacology news.ki.se/cracking-the...
Researchers at KI and @kthuniversity.bsky.social have developed a computational method that reveals how cells change and specialise. It can provide important knowledge about why this process sometimes goes wrong and leads to disease. Published in @pnas.org 🧪 #CellBiology news.ki.se/new-algorith...
New algorithm maps how cells develop
Researchers at Karolinska Institutet and KTH have developed a computational method that can reveal how cells change and specialise in the body. The study, which has been published in the journal PNAS,...
news.ki.se
December 12, 2025 at 8:19 AM
Researchers at KI and @kthuniversity.bsky.social have developed a computational method that reveals how cells change and specialise. It can provide important knowledge about why this process sometimes goes wrong and leads to disease. Published in @pnas.org 🧪 #CellBiology news.ki.se/new-algorith...
KI researchers have captured the first detailed molecular snapshots of human polynucleotide phosphorylase in action, revealing how this essential mitochondrial enzyme degrades RNA through an elegant base-flipping mechanism. Published in @narjournal.bsky.social 🧪 #mitochondria doi.org/10.1093/nar/...
December 9, 2025 at 2:55 PM
KI researchers have captured the first detailed molecular snapshots of human polynucleotide phosphorylase in action, revealing how this essential mitochondrial enzyme degrades RNA through an elegant base-flipping mechanism. Published in @narjournal.bsky.social 🧪 #mitochondria doi.org/10.1093/nar/...
KI researchers report that human oligodendrocyte progenitor cells help eliminate synapses, highlighting a key mechanism in early #BrainDevelopment. The study was done on advanced human brain organoids, and was published today in @natcomms.nature.com 🧪 #Neuroscience news.ki.se/new-clues-to...
New clues to how human brain connections take shape
A new study from Karolinska Institutet, published in Nature Communications, reveals an unexpected role for immature glial cells known as oligodendrocyte progenitor cells (OPCs) in shaping the developi...
news.ki.se
December 5, 2025 at 4:59 PM
KI researchers report that human oligodendrocyte progenitor cells help eliminate synapses, highlighting a key mechanism in early #BrainDevelopment. The study was done on advanced human brain organoids, and was published today in @natcomms.nature.com 🧪 #Neuroscience news.ki.se/new-clues-to...
A study in @pnas.org reveals that conscious awareness is tightly linked to our sense of bodily self. Using bodily illusions and computational models, researchers show body ownership relies on conscious processing – reshaping theories of #Consciousness and self-perception 🧪 news.ki.se/new-study-re...
New study reveals how the brain prioritises bodily signals in conscious awareness
A new study shows that visual and tactile impressions that are related to our own body are prioritised for reaching conscious awareness. This helps us understand how we develop the feeling that the bo...
news.ki.se
December 4, 2025 at 6:03 PM
A study in @pnas.org reveals that conscious awareness is tightly linked to our sense of bodily self. Using bodily illusions and computational models, researchers show body ownership relies on conscious processing – reshaping theories of #Consciousness and self-perception 🧪 news.ki.se/new-study-re...
A new study published in Neurology shows impaired kidney function raises most #Alzheimers blood biomarkers, including p-tau217, but doesn’t increase dementia risk – though it may speed symptom onset. #Nephrology 🧪 news.ki.se/kidney-healt...
Kidney health affects Alzheimer’s blood biomarkers but not dementia risk
Older adults with reduced kidney function show higher levels of Alzheimer’s-related biomarkers in the blood, but are not more likely to develop dementia, according to a new study from Karolinska Insti...
news.ki.se
December 4, 2025 at 5:19 PM
A new study published in Neurology shows impaired kidney function raises most #Alzheimers blood biomarkers, including p-tau217, but doesn’t increase dementia risk – though it may speed symptom onset. #Nephrology 🧪 news.ki.se/kidney-healt...
A KI study in @alzdemjournals.bsky.social shows that common conditions like kidney disease, diabetes or vascular problems can affect #Alzheimers blood biomarkers. Adjusting for these improves test precision, with p-tau217 as the most reliable marker for brain changes 🧪 news.ki.se/study-finds-...
Study finds common health conditions can influence Alzheimer’s blood tests
How do everyday health issues affect new blood tests for Alzheimer’s disease? A study from Karolinska Institutet, in Alzheimer's & Dementia, suggests that factors like kidney function, cholesterol, an...
news.ki.se
December 3, 2025 at 9:55 AM
A KI study in @alzdemjournals.bsky.social shows that common conditions like kidney disease, diabetes or vascular problems can affect #Alzheimers blood biomarkers. Adjusting for these improves test precision, with p-tau217 as the most reliable marker for brain changes 🧪 news.ki.se/study-finds-...
A large international study published in @thelancetoncol.bsky.social shows AI can detect #PancreaticCancer on routine CT scans with higher accuracy than radiologists (AUROC 0.92 vs 0.88). This suggests AI could enable earlier diagnosis and better outcomes. #AIinMedicine 🧪 doi.org/10.1016/S147...
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doi.org
December 1, 2025 at 2:11 PM
A large international study published in @thelancetoncol.bsky.social shows AI can detect #PancreaticCancer on routine CT scans with higher accuracy than radiologists (AUROC 0.92 vs 0.88). This suggests AI could enable earlier diagnosis and better outcomes. #AIinMedicine 🧪 doi.org/10.1016/S147...
Researchers have performed a large-scale genetic screen to uncover the hidden roles of #microproteins. One of the discovered microproteins, named PIPPI, was found to protect cells from stress in the endoplasmic reticulum. Published in @narjournal.bsky.social 🧪 #proteomics news.ki.se/new-micropro...
New microprotein can help cancer cells overcome stress
In a new study published in the journal Nucleic Acid Research, a research team at Karolinska Institutet has performed a large-scale genetic screen to uncover the hidden roles of tiny proteins, so-call...
news.ki.se
November 27, 2025 at 7:55 AM
Researchers have performed a large-scale genetic screen to uncover the hidden roles of #microproteins. One of the discovered microproteins, named PIPPI, was found to protect cells from stress in the endoplasmic reticulum. Published in @narjournal.bsky.social 🧪 #proteomics news.ki.se/new-micropro...
A new study in @natneuro.nature.com by @gocastelobranco.bsky.social et al explores how oligodendrocytes respond in #MultipleSclerosis. The researchers identified distinct and early disease-related states and gene activity patterns that may help explain how #MS progresses 🧪 news.ki.se/oligodendroc...
Oligodendrocytes show early changes in multiple sclerosis
A new study from Karolinska Institutet, published in Nature Neuroscience, explores how oligodendrocytes, the cells that produce myelin in the brain and spinal cord, respond during the development of m...
news.ki.se
November 17, 2025 at 1:22 PM
A new study in @natneuro.nature.com by @gocastelobranco.bsky.social et al explores how oligodendrocytes respond in #MultipleSclerosis. The researchers identified distinct and early disease-related states and gene activity patterns that may help explain how #MS progresses 🧪 news.ki.se/oligodendroc...
Maternal #diabetes may predispose sons, but not daughters, to early #cardiovascular dysfunction, even without metabolic disease. Study in @cp-cellrepmed.bsky.social by @qiaolindeng.bsky.social and @zhaoallan.bsky.social highlights oxidative stress as a key driver🧪 news.ki.se/sons-of-moth...
November 12, 2025 at 11:34 AM
Maternal #diabetes may predispose sons, but not daughters, to early #cardiovascular dysfunction, even without metabolic disease. Study in @cp-cellrepmed.bsky.social by @qiaolindeng.bsky.social and @zhaoallan.bsky.social highlights oxidative stress as a key driver🧪 news.ki.se/sons-of-moth...
A new study by @tetsuichi.bsky.social et al published in @natgenet.nature.com shows that human blood #stemcells have stable, intrinsic lineage biases. Some replenish all blood cell types, others only a subset. These patterns persist over decades and after transplantation 🧪 #bloodcancer rdcu.be/ePlJW
Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis
Nature Genetics - This study uses somatic mutations as a natural barcoding system to retrospectively and prospectively trace the fate of hematopoietic stem cells across all major blood cell...
rdcu.be
November 12, 2025 at 8:05 AM
A new study by @tetsuichi.bsky.social et al published in @natgenet.nature.com shows that human blood #stemcells have stable, intrinsic lineage biases. Some replenish all blood cell types, others only a subset. These patterns persist over decades and after transplantation 🧪 #bloodcancer rdcu.be/ePlJW
A study by @borgkvistlab.bsky.social published in Science Advances shows that dopamine modulates basal ganglia output not via DA receptors, but through serotonin and 5-HT1B activation. Findings in mice suggest a new mechanism relevant to #Parkinsons therapy. #Neuroscience 🧪 doi.org/10.1126/scia...
Dopamine and serotonin cotransmission filters striatonigral synaptic activity via 5-HT1B receptor activation
A monoaminergic high-pass filter regulates basal ganglia output activity.
doi.org
November 6, 2025 at 5:27 PM
A study by @borgkvistlab.bsky.social published in Science Advances shows that dopamine modulates basal ganglia output not via DA receptors, but through serotonin and 5-HT1B activation. Findings in mice suggest a new mechanism relevant to #Parkinsons therapy. #Neuroscience 🧪 doi.org/10.1126/scia...
Researchers at KI and @yale.edu have created a multidimensional, molecular map of how the mouse #brain develops after birth and how it reacts to #inflammation. The study is published in @nature.com. 🧪 #neuroscience news.ki.se/scientists-m...
November 6, 2025 at 10:45 AM
Researchers at KI and @yale.edu have created a multidimensional, molecular map of how the mouse #brain develops after birth and how it reacts to #inflammation. The study is published in @nature.com. 🧪 #neuroscience news.ki.se/scientists-m...
New cryo-EM structures of HSV-1 origin-binding protein reveal how herpesvirus initiates DNA replication, offering new antiviral targets beyond DNA polymerase. Study published in
@narjournal.bsky.social 🧪
academic.oup.com/nar/article/...
@narjournal.bsky.social 🧪
academic.oup.com/nar/article/...
The herpes simplex origin-binding protein: mechanisms for sequence-specific DNA binding and dimerization revealed by Cryo-EM
Abstract. Herpes simplex viruses 1 and 2 (HSV-1,2) present growing treatment challenges due to increasing resistance to antivirals targeting viral DNA poly
academic.oup.com
October 24, 2025 at 1:55 PM
New cryo-EM structures of HSV-1 origin-binding protein reveal how herpesvirus initiates DNA replication, offering new antiviral targets beyond DNA polymerase. Study published in
@narjournal.bsky.social 🧪
academic.oup.com/nar/article/...
@narjournal.bsky.social 🧪
academic.oup.com/nar/article/...
Adrenal glia-support cells act as hidden #stemcells that regenerate tissue, but can also initiate adrenal #cancer. A new study in npj Precision Oncology by @schlisio-lab.bsky.social reveals a DLK1-NOTCH switch, deciding whether the cells build healthy tissue or fuel disease 🧪 doi.org/10.1038/s416...
Postnatal sustentacular cells as chromaffin progenitors and tumor cells of origin in VHL-related paragangliomas - npj Precision Oncology
npj Precision Oncology - Postnatal sustentacular cells as chromaffin progenitors and tumor cells of origin in VHL-related paragangliomas
doi.org
October 17, 2025 at 1:04 PM
Adrenal glia-support cells act as hidden #stemcells that regenerate tissue, but can also initiate adrenal #cancer. A new study in npj Precision Oncology by @schlisio-lab.bsky.social reveals a DLK1-NOTCH switch, deciding whether the cells build healthy tissue or fuel disease 🧪 doi.org/10.1038/s416...
The specific weight loss properties of GLP-1R agonists are key to improving neurological recovery after #stroke in diabetic mice, according to a new study from Karolinska Institutet and Södersjukhuset published in @diabetologiajnl.bsky.social 🧪 #diabetes doi.org/10.1007/s001...
Pre-stroke weight loss by glucagon-like peptide 1 receptor and neuropeptide Y receptor Y2 activation improves post-stroke functional recovery in male diabetic mouse models - Diabetologia
Aims/hypothesis Type 2 diabetes is associated with worsened stroke outcome and lasting disability. The underlying mechanisms are undetermined, and no therapy is available. We experimentally investigat...
doi.org
October 16, 2025 at 9:28 AM
The specific weight loss properties of GLP-1R agonists are key to improving neurological recovery after #stroke in diabetic mice, according to a new study from Karolinska Institutet and Södersjukhuset published in @diabetologiajnl.bsky.social 🧪 #diabetes doi.org/10.1007/s001...
A new type of #MRI technique that detects subtle changes in the brain’s microstructure can identify early signs of hereditary frontotemporal #dementia, according to an international study led by KI researchers. The study is published in Molecular Psychiatry 🧪 news.ki.se/new-brain-im...
October 16, 2025 at 7:57 AM
A new type of #MRI technique that detects subtle changes in the brain’s microstructure can identify early signs of hereditary frontotemporal #dementia, according to an international study led by KI researchers. The study is published in Molecular Psychiatry 🧪 news.ki.se/new-brain-im...
A new KI study published in Nature Immunology shows that CD56bright #NKcells temporarily reside in our organs and then leave them via the lymphatic system. The results change our understanding of how the immune system works in human organs. #Immunology 🧪 news.ki.se/the-immune-s...
October 14, 2025 at 2:38 PM
A new KI study published in Nature Immunology shows that CD56bright #NKcells temporarily reside in our organs and then leave them via the lymphatic system. The results change our understanding of how the immune system works in human organs. #Immunology 🧪 news.ki.se/the-immune-s...
AI can increase access to #CervicalCancer screening in low-resource settings, but the technology requires investments throughout the entire healthcare chain to be effective. New study from KI, Uppsala University and @helsinki.fi published in @bmj.com today 🧪 #GlobalHealth news.ki.se/ai-can-impro...
October 10, 2025 at 9:55 AM
AI can increase access to #CervicalCancer screening in low-resource settings, but the technology requires investments throughout the entire healthcare chain to be effective. New study from KI, Uppsala University and @helsinki.fi published in @bmj.com today 🧪 #GlobalHealth news.ki.se/ai-can-impro...
Eating a healthy plant-based diet may lower the risk of #dementia in older people with cardiovascular diseases, type 2 diabetes, or stroke, and the quality of the plant-based diet could be crucial. This is according to a new KI study published in JACC: Advances 🧪 news.ki.se/plant-based-...
October 9, 2025 at 7:31 AM
Eating a healthy plant-based diet may lower the risk of #dementia in older people with cardiovascular diseases, type 2 diabetes, or stroke, and the quality of the plant-based diet could be crucial. This is according to a new KI study published in JACC: Advances 🧪 news.ki.se/plant-based-...
KI researchers comment on this year’s #NobelPrize in Physiology or Medicine. The prize rewards discoveries that reveal how our immune system is kept in check, paving the way for possible new therapies for cancer and autoimmune diseases like type 1 diabetes and MS 🧪 news.ki.se/nobel-prize-...
Nobel Prize rewards key to future MS and cancer treatment
The year’s Nobel Prize in Physiology or Medicine rewards discoveries that reveal how our immune system is kept in check – in other words, how the body protects itself from attack by its own immune cel...
news.ki.se
October 8, 2025 at 12:03 PM
KI researchers comment on this year’s #NobelPrize in Physiology or Medicine. The prize rewards discoveries that reveal how our immune system is kept in check, paving the way for possible new therapies for cancer and autoimmune diseases like type 1 diabetes and MS 🧪 news.ki.se/nobel-prize-...
A study published in @pnas.org by Marie Wahren-Herlenius and colleagues at KI and @liu.se reveals that a gene associated with several rheumatic diseases affects how cells move, providing new insights into disease mechanisms and potential future therapies 🧪 #rheumatology news.ki.se/gene-linked-...
October 6, 2025 at 3:05 PM
A study published in @pnas.org by Marie Wahren-Herlenius and colleagues at KI and @liu.se reveals that a gene associated with several rheumatic diseases affects how cells move, providing new insights into disease mechanisms and potential future therapies 🧪 #rheumatology news.ki.se/gene-linked-...
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body 🧪 www.nobelprize.org/prizes/medic...
October 6, 2025 at 9:42 AM
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body 🧪 www.nobelprize.org/prizes/medic...
In a new study published in @natcomms.nature.com, researchers have investigated how the physical structure of fat tissue helps ovarian cancer cells invade the body, offering potential new treatment strategies 🧪
rdcu.be/eIJna
rdcu.be/eIJna
September 30, 2025 at 8:58 AM
In a new study published in @natcomms.nature.com, researchers have investigated how the physical structure of fat tissue helps ovarian cancer cells invade the body, offering potential new treatment strategies 🧪
rdcu.be/eIJna
rdcu.be/eIJna