Michalis Gounis
@gounismichalis.bsky.social
Postdoc @Ivaskalab.bsky.social @BioscienceTurku (previously @CRUK-SI.bsky.social) with an interest in tumour microenvironment, metabolism and invasion #tumourmicroenviroment#metastasis
Pinned
@gounismichalis.bsky.social et al. show that cells that seed early lung #metastasis in #BreastCancer have altered #metabolism. These metabolic alterations lead them to release extracellular vesicles which engender a microenvironment conducive to invasive growth. rupress.org/jcb/article/...
1/ Beyond thrilled to see my #PhD work now published in @jcb.org
A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados
A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados
Reposted by Michalis Gounis
Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports
imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate
in the lung where they inhibit CD8+ T cells, promote fibr...
www.embopress.org
July 23, 2025 at 8:48 PM
Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....
Reposted by Michalis Gounis
Rijuta Lamba, Alexandra Naba @nabalabuic.bsky.social, @valerioizzi.bsky.social and team present MatriCom, a single-cell RNA-sequencing data mining tool to infer cell–ECM interactions.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess
July 16, 2025 at 8:59 AM
Rijuta Lamba, Alexandra Naba @nabalabuic.bsky.social, @valerioizzi.bsky.social and team present MatriCom, a single-cell RNA-sequencing data mining tool to infer cell–ECM interactions.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess
Reposted by Michalis Gounis
Pleased that our latest paper is now out in @jcellsci.bsky.social, in collaboration with @drmcjones.bsky.social and others from Manchester and Plymouth: Differential roles of cyclin–CDK1 complexes in cell migration and invasion url: journals.biologists.com/jcs/article/...
Differential roles of cyclin–CDK1 complexes in cell migration and invasion
Highlighted Article: Cyclin–CDK1 complexes have a previously undiscovered role in regulating normal and cancer cell migration in 3D matrices.
journals.biologists.com
July 14, 2025 at 3:54 PM
Pleased that our latest paper is now out in @jcellsci.bsky.social, in collaboration with @drmcjones.bsky.social and others from Manchester and Plymouth: Differential roles of cyclin–CDK1 complexes in cell migration and invasion url: journals.biologists.com/jcs/article/...
Reposted by Michalis Gounis
Latest from Ivaska Lab ▶️ Niklas Jäntti et al delve deep into the roles of EPLINα/β on integrin trafficking and breast cancer outcomes!
Congratulations to all the authors!
Check the paper out here: www.sciencedirect.com/science/arti...
Congratulations to all the authors!
Check the paper out here: www.sciencedirect.com/science/arti...
EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration
Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different c…
www.sciencedirect.com
July 16, 2025 at 7:55 AM
Latest from Ivaska Lab ▶️ Niklas Jäntti et al delve deep into the roles of EPLINα/β on integrin trafficking and breast cancer outcomes!
Congratulations to all the authors!
Check the paper out here: www.sciencedirect.com/science/arti...
Congratulations to all the authors!
Check the paper out here: www.sciencedirect.com/science/arti...
Reposted by Michalis Gounis
Excited to share our most recent study on #integrintraffic #cancer #migration #focaladhesion by @ivaskalab.bsky.social @drpaulinamoreno.bsky.social Niklas Jäntti et al www.sciencedirect.com/science/arti...
EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration
Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different c…
www.sciencedirect.com
July 16, 2025 at 7:26 AM
Excited to share our most recent study on #integrintraffic #cancer #migration #focaladhesion by @ivaskalab.bsky.social @drpaulinamoreno.bsky.social Niklas Jäntti et al www.sciencedirect.com/science/arti...
Reposted by Michalis Gounis
Great opportunity for a Research Support Officer to join @cellbiol-mrclmb.bsky.social, supporting @deriverylab.bsky.social in their studies of the molecular mechanisms behind receptor sorting in endosomes.
More info: www.nature.com/naturecareer...
Apply by 10 JUL
#ScienceJobs
More info: www.nature.com/naturecareer...
Apply by 10 JUL
#ScienceJobs
June 23, 2025 at 3:11 PM
Great opportunity for a Research Support Officer to join @cellbiol-mrclmb.bsky.social, supporting @deriverylab.bsky.social in their studies of the molecular mechanisms behind receptor sorting in endosomes.
More info: www.nature.com/naturecareer...
Apply by 10 JUL
#ScienceJobs
More info: www.nature.com/naturecareer...
Apply by 10 JUL
#ScienceJobs
Reposted by Michalis Gounis
Are you looking for a postdoc?
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
June 23, 2025 at 2:29 PM
Are you looking for a postdoc?
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
Reposted by Michalis Gounis
☕Conway et al. show that #integrin β1 phosphorylation is regulated through balanced activities of tyrosine kinases, such as Src and Arg, and phosphatases, such as PTP-PEST and Shp2, facilitating invadopodia formation and invasion of #BreastCancer cells.
bit.ly/4n4v3JS
bit.ly/4n4v3JS
Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells - Nature Cell Biology
Conway et al. show that integrin β1 phosphorylation is regulated through balanced activities of tyrosine kinases, such as Src and Arg, and phosphatases, such as PTP-PEST and Shp2, facilitating invadop...
bit.ly
June 12, 2025 at 3:56 PM
☕Conway et al. show that #integrin β1 phosphorylation is regulated through balanced activities of tyrosine kinases, such as Src and Arg, and phosphatases, such as PTP-PEST and Shp2, facilitating invadopodia formation and invasion of #BreastCancer cells.
bit.ly/4n4v3JS
bit.ly/4n4v3JS
Congratulations @louisefets.bsky.social and team, beautiful work!! 👏👏
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
June 12, 2025 at 3:47 AM
Congratulations @louisefets.bsky.social and team, beautiful work!! 👏👏
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
1/ Beyond thrilled to see my #PhD work now published in @jcb.org
A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados
A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados
@gounismichalis.bsky.social et al. show that cells that seed early lung #metastasis in #BreastCancer have altered #metabolism. These metabolic alterations lead them to release extracellular vesicles which engender a microenvironment conducive to invasive growth. rupress.org/jcb/article/...
June 9, 2025 at 8:25 PM
1/ Beyond thrilled to see my #PhD work now published in @jcb.org
A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados
A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados
Reposted by Michalis Gounis
Latest from @ivaskalab.bsky.social @jrwconway.bsky.social in NCB. We find that SHP-2 inhibition stops TNBC invasion and limits metastasis by blocking integrin dephosphorylation!
Read more at:
www.nature.com/articles/s41...
Read more at:
www.nature.com/articles/s41...
Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells - Nature Cell Biology
Conway et al. show that integrin β1 phosphorylation is regulated through balanced activities of tyrosine kinases, such as Src and Arg, and phosphatases, such as PTP-PEST and Shp2, facilitating invadop...
www.nature.com
May 26, 2025 at 12:16 PM
Latest from @ivaskalab.bsky.social @jrwconway.bsky.social in NCB. We find that SHP-2 inhibition stops TNBC invasion and limits metastasis by blocking integrin dephosphorylation!
Read more at:
www.nature.com/articles/s41...
Read more at:
www.nature.com/articles/s41...
Reposted by Michalis Gounis
Our newest paper is out in NCB. @jrwconway.bsky.social designed a new FRET reporter, Illusia, to show the importance of integrin β1 phosphorylation dynamics in 3D invasion! Video: TNBC cells expressing Illusia with a Src (Saracatinib) or SHP2 (SHP099) inhibitor. www.nature.com/articles/s41...
May 26, 2025 at 10:13 AM
Our newest paper is out in NCB. @jrwconway.bsky.social designed a new FRET reporter, Illusia, to show the importance of integrin β1 phosphorylation dynamics in 3D invasion! Video: TNBC cells expressing Illusia with a Src (Saracatinib) or SHP2 (SHP099) inhibitor. www.nature.com/articles/s41...
Reposted by Michalis Gounis
New paper from @ivaskalab.bsky.social out now! 🍾 Watch how cancer cell adhesion dynamics are disrupted by inhibiting the phosphatase Shp2 - key to integrin β1 phosphorylation. Blocking Shp2 impairs adhesion and reduces invasion potential. 🎥👇 Read more at: www.nature.com/articles/s41...
May 26, 2025 at 10:29 AM
New paper from @ivaskalab.bsky.social out now! 🍾 Watch how cancer cell adhesion dynamics are disrupted by inhibiting the phosphatase Shp2 - key to integrin β1 phosphorylation. Blocking Shp2 impairs adhesion and reduces invasion potential. 🎥👇 Read more at: www.nature.com/articles/s41...
Reposted by Michalis Gounis
"Academics tend to be averse to discussing mental health openly, and higher education’s mental health safety net is patchy—a forgotten footnote that all too often fails its students." #MentalHealthAwarenessMonth scim.ag/4m61iaU
May 11, 2025 at 2:07 PM
"Academics tend to be averse to discussing mental health openly, and higher education’s mental health safety net is patchy—a forgotten footnote that all too often fails its students." #MentalHealthAwarenessMonth scim.ag/4m61iaU
Reposted by Michalis Gounis
Happy to share our Tensin 1 phase separation project is now on bioRxiv.
www.biorxiv.org/content/10.1...
This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social
www.biorxiv.org/content/10.1...
This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social
Adhesion-derived condensates control component availability to regulate adhesion dynamics
Integrin adhesion complexes mediate cell-extracellular matrix (ECM) interactions and undergo dynamic remodelling to regulate cell adhesion and migration. Here, we demonstrate that tensin 1 (TNS1), a m...
www.biorxiv.org
May 9, 2025 at 2:23 PM
Happy to share our Tensin 1 phase separation project is now on bioRxiv.
www.biorxiv.org/content/10.1...
This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social
www.biorxiv.org/content/10.1...
This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social
Reposted by Michalis Gounis
In Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025. rupress.org/jcb/article/...
March 21, 2025 at 4:18 PM
In Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025. rupress.org/jcb/article/...
Reposted by Michalis Gounis
We are looking for a doctoral candidate to join the lab! If you are interested in working with human breast tissue samples straight from the clinic and do not fear large data sets, this might just be your dream project ☺️ Apply now ⬇️
ats.talentadore.com/apply/vaitos...
📸 @oonapaavolainen.bsky.social
ats.talentadore.com/apply/vaitos...
📸 @oonapaavolainen.bsky.social
March 20, 2025 at 2:04 PM
We are looking for a doctoral candidate to join the lab! If you are interested in working with human breast tissue samples straight from the clinic and do not fear large data sets, this might just be your dream project ☺️ Apply now ⬇️
ats.talentadore.com/apply/vaitos...
📸 @oonapaavolainen.bsky.social
ats.talentadore.com/apply/vaitos...
📸 @oonapaavolainen.bsky.social
Reposted by Michalis Gounis
Check this one out! This is a great read (I am bias).
But Joanna and Stefania did an amazing job putting the article together.
But Joanna and Stefania did an amazing job putting the article together.
Fresh from the press! @lankylaste.bsky.social, @guijacquemet.bsky.social and I put together a practical guide on how to develop software for life science applications.
Practical recommendations for developing software for life science applications
ABSTRACT. Developing user-friendly image analysis software is essential for advancing biological and life science research. However, the interdisciplinary gap between software developers and life scie...
doi.org
March 17, 2025 at 10:08 AM
Check this one out! This is a great read (I am bias).
But Joanna and Stefania did an amazing job putting the article together.
But Joanna and Stefania did an amazing job putting the article together.
Congratulations to the superbly talented @marthamz.bsky.social @labvousden.bsky.social 👏👏 So well-deserved, can't wait to see your exciting research 🥳
Honoured to be one of the first recipients of the EACR-Mark Foundation Postdoctoral Fellowship award to support my work on pancreatic cancer development at @labvousden.bsky.social @crick.ac.uk🥳
Thanks to everyone for the support during this journey!
Exciting research incoming 👩🔬👩🔬👩🔬
#womeninSTEM
Thanks to everyone for the support during this journey!
Exciting research incoming 👩🔬👩🔬👩🔬
#womeninSTEM
Congratulations to our first EACR-@themarkfdn Postdoctoral Fellowship winners! Julie Mazet, Christina Metoikidou and Martha Zarou 👏
This funding is awarded for a period of three years to support excellent postdoctoral researchers in laboratories throughout Europe.
magazine.eacr.org/congratulati...
This funding is awarded for a period of three years to support excellent postdoctoral researchers in laboratories throughout Europe.
magazine.eacr.org/congratulati...
March 19, 2025 at 8:08 PM
Congratulations to the superbly talented @marthamz.bsky.social @labvousden.bsky.social 👏👏 So well-deserved, can't wait to see your exciting research 🥳
Reposted by Michalis Gounis
Chikireddy, Romet-Lemonne, Jégou et al. @romet-jegou-lab.bsky.social investigate how the crosslinker fascin delays cofilin-induced #actin filament disassembly. https://buff.ly/3EBL34j
In #Mechanobiology 2025: https://buff.ly/3EK0uaq
In #Mechanobiology 2025: https://buff.ly/3EK0uaq
February 18, 2025 at 4:17 PM
Chikireddy, Romet-Lemonne, Jégou et al. @romet-jegou-lab.bsky.social investigate how the crosslinker fascin delays cofilin-induced #actin filament disassembly. https://buff.ly/3EBL34j
In #Mechanobiology 2025: https://buff.ly/3EK0uaq
In #Mechanobiology 2025: https://buff.ly/3EK0uaq
Reposted by Michalis Gounis
A truly amazing and inspiring session on Advances in Mechanobiology!!! Huge thanks to @drsarahboyle.bsky.social @carstenschulte4.bsky.social @mathildemathieu.bsky.social for sharing their research with the rest of us and @ccstorytime.bsky.social for moderating!!!! See u all in the next!!!
February 6, 2025 at 1:28 PM
A truly amazing and inspiring session on Advances in Mechanobiology!!! Huge thanks to @drsarahboyle.bsky.social @carstenschulte4.bsky.social @mathildemathieu.bsky.social for sharing their research with the rest of us and @ccstorytime.bsky.social for moderating!!!! See u all in the next!!!
Reposted by Michalis Gounis
For early career researchers interested in the Fibronectin, Integrins and Related Molecules GRS/GRC this May, don’t forget to sign up! The deadline for submitting an abstract to be considered for an oral presentation for the GRS is less than a week away! Register here: www.grc.org/fibronectin-...
2025 Fibronectin, Integrins and Related Molecules (GRS) Seminar GRC
The 2025 Gordon Research Seminar on Fibronectin, Integrins and Related Molecules (GRS) will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.
www.grc.org
January 20, 2025 at 11:17 AM
For early career researchers interested in the Fibronectin, Integrins and Related Molecules GRS/GRC this May, don’t forget to sign up! The deadline for submitting an abstract to be considered for an oral presentation for the GRS is less than a week away! Register here: www.grc.org/fibronectin-...
Reposted by Michalis Gounis
New PI positions @mrc-lms.bsky.social 👀 It's truly a great place to start a lab, definitely worth a look if you're on the job market. Please share with your networks!
We’re delighted to share our recruitment brochure for our current Programme Leader Track vacancies at the MRC Laboratory of Medical Sciences.
You can download the brochure on our vacancy web page 👇
lms.mrc.ac.uk/work/vacanci...
You can download the brochure on our vacancy web page 👇
lms.mrc.ac.uk/work/vacanci...
Programme Leader Track - MRC Laboratory of Medical Sciences
Programme Leader Track appointments are an open-ended contract, which comprises a six-year advanced career development scheme after which you will be considered for promotion to Programme Leader.
lms.mrc.ac.uk
December 19, 2024 at 8:05 PM
New PI positions @mrc-lms.bsky.social 👀 It's truly a great place to start a lab, definitely worth a look if you're on the job market. Please share with your networks!
Reposted by Michalis Gounis
🎉 The latest paper from out lab by
#Montse_Llanses with Keqian Nan, Zhe Bao, Rachele Bacchetti
Shengnan Yuan & Joe Tyler is out!!! @plosbiology.org @mcb-sheffield.bsky.social
journals.plos.org/plosbiology/...
#Montse_Llanses with Keqian Nan, Zhe Bao, Rachele Bacchetti
Shengnan Yuan & Joe Tyler is out!!! @plosbiology.org @mcb-sheffield.bsky.social
journals.plos.org/plosbiology/...
Novel kinase regulators of extracellular matrix internalisation identified by high-content screening modulate invasive carcinoma cell migration
This study identifies novel kinase regulators of extracellular matrix (ECM) internalization through a high-content screen, characterizing the α2β1 integrin/p38 signaling axis as required for the inter...
journals.plos.org
December 13, 2024 at 9:03 AM
🎉 The latest paper from out lab by
#Montse_Llanses with Keqian Nan, Zhe Bao, Rachele Bacchetti
Shengnan Yuan & Joe Tyler is out!!! @plosbiology.org @mcb-sheffield.bsky.social
journals.plos.org/plosbiology/...
#Montse_Llanses with Keqian Nan, Zhe Bao, Rachele Bacchetti
Shengnan Yuan & Joe Tyler is out!!! @plosbiology.org @mcb-sheffield.bsky.social
journals.plos.org/plosbiology/...
Reposted by Michalis Gounis
The IOP Mechanobiology meeting starts strong with @johannaivaska.bsky.social telling us that cells do not necessarily migrate towards stiff and that nuclear YAP does not necessarily correlate with cell spreading. 💪
December 4, 2024 at 11:50 AM
The IOP Mechanobiology meeting starts strong with @johannaivaska.bsky.social telling us that cells do not necessarily migrate towards stiff and that nuclear YAP does not necessarily correlate with cell spreading. 💪