Jana Kroll
@janakroll.bsky.social
Postdoc at MDC Berlin
cryo-electron tomography, neurons, optogenetics
cryo-electron tomography, neurons, optogenetics
Pinned
Jana Kroll
@janakroll.bsky.social
· Dec 13
Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons - Nature Communications
Synaptic vesicle fusion is essential for neuronal communication, yet its nanoscale sequence has not been directly confirmed. Here, the authors use timed in situ cryo-electron tomography to visualize t...
www.nature.com
❄️🔬⏱️
I am excited to share that our study „Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons” has been published in Nature Communications www.nature.com/articles/s41...
👇 Short summary of our key findings (1/8)
I am excited to share that our study „Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons” has been published in Nature Communications www.nature.com/articles/s41...
👇 Short summary of our key findings (1/8)
❄️ With all the snow outside, I felt like sharing a cryo tomogram:
A neuronal synapse, captured by cryo-ET at the moment a neurotransmitter-filled vesicle fuses at the active zone.
Fusion was triggered optogenetically and arrested by plunge freezing.
More details: www.nature.com/articles/s41...
A neuronal synapse, captured by cryo-ET at the moment a neurotransmitter-filled vesicle fuses at the active zone.
Fusion was triggered optogenetically and arrested by plunge freezing.
More details: www.nature.com/articles/s41...
January 4, 2026 at 8:18 AM
❄️ With all the snow outside, I felt like sharing a cryo tomogram:
A neuronal synapse, captured by cryo-ET at the moment a neurotransmitter-filled vesicle fuses at the active zone.
Fusion was triggered optogenetically and arrested by plunge freezing.
More details: www.nature.com/articles/s41...
A neuronal synapse, captured by cryo-ET at the moment a neurotransmitter-filled vesicle fuses at the active zone.
Fusion was triggered optogenetically and arrested by plunge freezing.
More details: www.nature.com/articles/s41...
Reposted by Jana Kroll
Der Moment, in dem eine Nervenzelle ihre Neurotransmitter in den synaptischen Spalt ausschüttet, ist extrem kurz. Berliner Forschenden @bihatcharite.bsky.social @mdc-berlin.bsky.social konnten ihn mikroskopisch einfangen.
doi.org/10.1038/s414...
Bild: © Charité/Max Delbrück Center, Jana Kroll
doi.org/10.1038/s414...
Bild: © Charité/Max Delbrück Center, Jana Kroll
December 18, 2025 at 10:04 AM
Der Moment, in dem eine Nervenzelle ihre Neurotransmitter in den synaptischen Spalt ausschüttet, ist extrem kurz. Berliner Forschenden @bihatcharite.bsky.social @mdc-berlin.bsky.social konnten ihn mikroskopisch einfangen.
doi.org/10.1038/s414...
Bild: © Charité/Max Delbrück Center, Jana Kroll
doi.org/10.1038/s414...
Bild: © Charité/Max Delbrück Center, Jana Kroll
Reposted by Jana Kroll
A breathtaking glimpse into the #brain at work: NeuroCure researchers & colleagues @janakroll.bsky.social captured #synapses in action - revealing how #neurotransmitters are released in milliseconds 🧠 Published in NatureCommunications @Charite @mdc-berlin.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons - Nature Communications
Synaptic vesicle fusion is essential for neuronal communication, yet its nanoscale sequence has not been directly confirmed. Here, the authors use timed in situ cryo-electron tomography to visualize t...
www.nature.com
December 17, 2025 at 10:10 PM
A breathtaking glimpse into the #brain at work: NeuroCure researchers & colleagues @janakroll.bsky.social captured #synapses in action - revealing how #neurotransmitters are released in milliseconds 🧠 Published in NatureCommunications @Charite @mdc-berlin.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
❄️🔬⏱️
I am excited to share that our study „Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons” has been published in Nature Communications www.nature.com/articles/s41...
👇 Short summary of our key findings (1/8)
I am excited to share that our study „Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons” has been published in Nature Communications www.nature.com/articles/s41...
👇 Short summary of our key findings (1/8)
Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons - Nature Communications
Synaptic vesicle fusion is essential for neuronal communication, yet its nanoscale sequence has not been directly confirmed. Here, the authors use timed in situ cryo-electron tomography to visualize t...
www.nature.com
December 13, 2025 at 8:10 PM
❄️🔬⏱️
I am excited to share that our study „Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons” has been published in Nature Communications www.nature.com/articles/s41...
👇 Short summary of our key findings (1/8)
I am excited to share that our study „Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons” has been published in Nature Communications www.nature.com/articles/s41...
👇 Short summary of our key findings (1/8)
Reposted by Jana Kroll
💥I am excited to present our first research paper from the lab about caveolae lipid trafficking 🎉 Led by my fantastic PhD candidate @estherocket.bsky.social
Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
Lipid-induced Caveolin1-Lipid droplet trafficking is associated with lipid droplet growth https://www.biorxiv.org/content/10.64898/2025.12.10.693432v1
December 11, 2025 at 7:08 AM
💥I am excited to present our first research paper from the lab about caveolae lipid trafficking 🎉 Led by my fantastic PhD candidate @estherocket.bsky.social
Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
Reposted by Jana Kroll
We got a large Helmholtz Bioengineering grant with Oliver Daumke, Artur Yakimovich, Alina Bazarova, and Dietrich Ruess to use protein design to target cancer.
Five open postdoctoral positions in Generative AI & Protein Engineering. Share & apply!
jobrxiv.org/job/max-delb...
Five open postdoctoral positions in Generative AI & Protein Engineering. Share & apply!
jobrxiv.org/job/max-delb...
Postdoctoral Positions in Protein Engineering
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobrxiv.org
November 21, 2025 at 7:08 AM
We got a large Helmholtz Bioengineering grant with Oliver Daumke, Artur Yakimovich, Alina Bazarova, and Dietrich Ruess to use protein design to target cancer.
Five open postdoctoral positions in Generative AI & Protein Engineering. Share & apply!
jobrxiv.org/job/max-delb...
Five open postdoctoral positions in Generative AI & Protein Engineering. Share & apply!
jobrxiv.org/job/max-delb...
Reposted by Jana Kroll
Group Leader in Biomedical Engineering at the @mdc-berlin.bsky.social in Berlin.
It's a broad call for whoever is doing exciting Bioengineering, please apply or share. We have a great institute with amazing colleagues and core facilities,highly recommend
application.mdc-berlin.de/site/index.p...
It's a broad call for whoever is doing exciting Bioengineering, please apply or share. We have a great institute with amazing colleagues and core facilities,highly recommend
application.mdc-berlin.de/site/index.p...
MDC Berlin - Online Application System
application.mdc-berlin.de
October 1, 2025 at 3:39 PM
Group Leader in Biomedical Engineering at the @mdc-berlin.bsky.social in Berlin.
It's a broad call for whoever is doing exciting Bioengineering, please apply or share. We have a great institute with amazing colleagues and core facilities,highly recommend
application.mdc-berlin.de/site/index.p...
It's a broad call for whoever is doing exciting Bioengineering, please apply or share. We have a great institute with amazing colleagues and core facilities,highly recommend
application.mdc-berlin.de/site/index.p...
Reposted by Jana Kroll
Postdoc program at the MDC in Berlin, @mdc-berlin.bsky.social : take a look 👇👇
For this call, collaborative projects between two groups will be funded. Take a look at the call and the groups and drop me an email if interested. Share with colleagues too!
www.mdc-berlin.de/postdocs#t-g...
For this call, collaborative projects between two groups will be funded. Take a look at the call and the groups and drop me an email if interested. Share with colleagues too!
www.mdc-berlin.de/postdocs#t-g...
www.mdc-berlin.de
August 4, 2025 at 10:23 AM
Postdoc program at the MDC in Berlin, @mdc-berlin.bsky.social : take a look 👇👇
For this call, collaborative projects between two groups will be funded. Take a look at the call and the groups and drop me an email if interested. Share with colleagues too!
www.mdc-berlin.de/postdocs#t-g...
For this call, collaborative projects between two groups will be funded. Take a look at the call and the groups and drop me an email if interested. Share with colleagues too!
www.mdc-berlin.de/postdocs#t-g...
Reposted by Jana Kroll
🏆 Images from #mdcBerlin received top honors in the @helmholtzimaging.bsky.social “Best Scientific Image Contest”!
Jury Award for @janakroll.bsky.social, Daumke Lab
Public Choice Award for Dr. Rafael Deliz Aguirre, @coscialab.bsky.social
Full details: www.mdc-berlin.de/news/news/tw...
Jury Award for @janakroll.bsky.social, Daumke Lab
Public Choice Award for Dr. Rafael Deliz Aguirre, @coscialab.bsky.social
Full details: www.mdc-berlin.de/news/news/tw...
July 17, 2025 at 1:38 PM
🏆 Images from #mdcBerlin received top honors in the @helmholtzimaging.bsky.social “Best Scientific Image Contest”!
Jury Award for @janakroll.bsky.social, Daumke Lab
Public Choice Award for Dr. Rafael Deliz Aguirre, @coscialab.bsky.social
Full details: www.mdc-berlin.de/news/news/tw...
Jury Award for @janakroll.bsky.social, Daumke Lab
Public Choice Award for Dr. Rafael Deliz Aguirre, @coscialab.bsky.social
Full details: www.mdc-berlin.de/news/news/tw...
Reposted by Jana Kroll
We have a preprint for you
EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer
By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...
EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer
By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...
June 8, 2025 at 11:22 AM
We have a preprint for you
EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer
By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...
EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer
By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...
What an inspiring morning at the CatCat Symposium! Thank you so much for inviting me @gallegolab.bsky.social and @felixmendu.bsky.social, it's been a pleasure visiting you in Barcelona 😊
May 27, 2025 at 6:03 PM
What an inspiring morning at the CatCat Symposium! Thank you so much for inviting me @gallegolab.bsky.social and @felixmendu.bsky.social, it's been a pleasure visiting you in Barcelona 😊
So many amazing images! 🤩 🤩🤩
Please make sure to vote, mine is also in the list 😎
Please make sure to vote, mine is also in the list 😎
🎉 Public Voting Now OPEN – #HelmholtzImaging Best Scientific Image Contest 2025
Choose your favorite(s) & cast your vote by May 30 👉 bit.ly/BSIC2025-Public-Voting
The award recipients will be announced at our conference on June 26.
#HIBestImage25 #HIConference25
@www.helmholtz.de
Choose your favorite(s) & cast your vote by May 30 👉 bit.ly/BSIC2025-Public-Voting
The award recipients will be announced at our conference on June 26.
#HIBestImage25 #HIConference25
@www.helmholtz.de
May 12, 2025 at 6:11 PM
So many amazing images! 🤩 🤩🤩
Please make sure to vote, mine is also in the list 😎
Please make sure to vote, mine is also in the list 😎
Reposted by Jana Kroll
A broad call for a PhD researcher/ postdoc in our group at the MDC in Berlin. An ideal PhD student - a computational scientist, a postdoc - a structural biologist, but feel free to re-convince me!
We extended the deadline for after Easter, Apr 24th. Apply here www.mdc-berlin.de/career/jobs/...
We extended the deadline for after Easter, Apr 24th. Apply here www.mdc-berlin.de/career/jobs/...
Scientific Researcher – Method Developments for In situ Structural Biology (F/M/D)
The Max Delbrück Center for Molecular Medicine in the Helmholtz Association aims to transform tomorrow’s medicine through our discoveries of today. At locations in Berlin-Buch, Berlin-Mitte, Heidelber...
www.mdc-berlin.de
April 8, 2025 at 11:19 AM
A broad call for a PhD researcher/ postdoc in our group at the MDC in Berlin. An ideal PhD student - a computational scientist, a postdoc - a structural biologist, but feel free to re-convince me!
We extended the deadline for after Easter, Apr 24th. Apply here www.mdc-berlin.de/career/jobs/...
We extended the deadline for after Easter, Apr 24th. Apply here www.mdc-berlin.de/career/jobs/...
Reposted by Jana Kroll
We are looking for a PhD student/Postdoc to develop methods of cryo-ET and/or study the structure and function of membrane proteins. Great team at the MDC in Berlin.
It's a broad call, please apply and share!
jobrxiv.org/job/max-delb...
It's a broad call, please apply and share!
jobrxiv.org/job/max-delb...
PhD /Postdoc in In Situ Structural Biology by Cryo-ET
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobrxiv.org
March 28, 2025 at 8:42 AM
We are looking for a PhD student/Postdoc to develop methods of cryo-ET and/or study the structure and function of membrane proteins. Great team at the MDC in Berlin.
It's a broad call, please apply and share!
jobrxiv.org/job/max-delb...
It's a broad call, please apply and share!
jobrxiv.org/job/max-delb...
Reposted by Jana Kroll
Together with @gallegolab.bsky.social we are organizing the next CATCAT morning on "Dynamics in biology, from molecules to tissues", with an amazing lineup of local and international speakers. If in Barcelona on May 26th, don't miss it, it's free! www.catcat-celltissuebiology.cat/event/9th-ca...
March 14, 2025 at 9:57 AM
Together with @gallegolab.bsky.social we are organizing the next CATCAT morning on "Dynamics in biology, from molecules to tissues", with an amazing lineup of local and international speakers. If in Barcelona on May 26th, don't miss it, it's free! www.catcat-celltissuebiology.cat/event/9th-ca...
Cryo-confocal microscopy of a neuron expressing the glutamate sensor iGluSnFR 🥶 The neuron was optogenetically stimulated and subsequently plunge-frozen to preserve the high fluorescence intensity indicating neurotransmitter release. #FluorescenceFriday
February 21, 2025 at 8:05 AM
Cryo-confocal microscopy of a neuron expressing the glutamate sensor iGluSnFR 🥶 The neuron was optogenetically stimulated and subsequently plunge-frozen to preserve the high fluorescence intensity indicating neurotransmitter release. #FluorescenceFriday
Excited to share our new preprint "Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons" www.biorxiv.org/content/10.1...
We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️
We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️
February 12, 2025 at 10:05 PM
Excited to share our new preprint "Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons" www.biorxiv.org/content/10.1...
We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️
We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️
It's been a pleasure presenting my project at this fantastic workshop! ☺️ #EMBOinsitu
#EMBOinsitu Session 4: Single cell systems
➡️ 'Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons'
🎙️ Jana Kroll – Max Delbrück Center for Molecular Medicine, Germany
@mdc-berlin.bsky.social
➡️ 'Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons'
🎙️ Jana Kroll – Max Delbrück Center for Molecular Medicine, Germany
@mdc-berlin.bsky.social
February 6, 2025 at 5:46 PM
It's been a pleasure presenting my project at this fantastic workshop! ☺️ #EMBOinsitu
Reposted by Jana Kroll
For me, the best part of research is discovering unexpected things. That’s exactly what happened while working on this project. I’m glad to see our story come to completion and excited about how many new questions it opens up!
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
December 2, 2024 at 1:15 PM
For me, the best part of research is discovering unexpected things. That’s exactly what happened while working on this project. I’m glad to see our story come to completion and excited about how many new questions it opens up!
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Jana Kroll
Oh my. This is just gorgeous from Misha Kudryashev's lab (I don't think he's here yet?). Love to see it. V ATPase resolved directly in synaptic vesicles 🤤 Lots of other neat observations in there also. Congrats to all involved! www.pnas.org/doi/10.1073/...
December 2, 2024 at 4:30 AM
Oh my. This is just gorgeous from Misha Kudryashev's lab (I don't think he's here yet?). Love to see it. V ATPase resolved directly in synaptic vesicles 🤤 Lots of other neat observations in there also. Congrats to all involved! www.pnas.org/doi/10.1073/...
Reposted by Jana Kroll
Researchers in Misha Kudryashev's lab at the #mdcBerlin have used cryo-electron tomography to uncover new details of the molecular structure of synaptic vesicles, which help transport neurotransmitters in the brain. The study was published in @pnas.org. More 👇
www.mdc-berlin.de/news/press/i...
www.mdc-berlin.de/news/press/i...
Imaging synaptic vesicles in 3D
Researchers at the Max Delbrück Center have used cryo-electron tomography to uncover new details of the molecular structure of synaptic vesicles, which help transport neurotransmitters in the brain. T...
www.mdc-berlin.de
November 29, 2024 at 8:00 AM
Researchers in Misha Kudryashev's lab at the #mdcBerlin have used cryo-electron tomography to uncover new details of the molecular structure of synaptic vesicles, which help transport neurotransmitters in the brain. The study was published in @pnas.org. More 👇
www.mdc-berlin.de/news/press/i...
www.mdc-berlin.de/news/press/i...