Misha Kudryashev
@mishakudryashev.bsky.social
Scientist at the Max Delbruck Center for Molecular Medicine @mdc-berlin.bsky.social in Berlin.
Professor in Charité – Universitätsmedizin Berlin
Biophysics, data and structural biology at its coolest
Professor in Charité – Universitätsmedizin Berlin
Biophysics, data and structural biology at its coolest
We got a large Helmholtz Bioengineering grant with Oliver Daumke, Artur Yakimovich, Alina Bazarova, and Dietrich Ruess to use protein design to target cancer.
Five open postdoctoral positions in Generative AI & Protein Engineering. Share & apply!
jobrxiv.org/job/max-delb...
Five open postdoctoral positions in Generative AI & Protein Engineering. Share & apply!
jobrxiv.org/job/max-delb...
Postdoctoral Positions in Protein Engineering
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobrxiv.org
November 21, 2025 at 7:08 AM
We got a large Helmholtz Bioengineering grant with Oliver Daumke, Artur Yakimovich, Alina Bazarova, and Dietrich Ruess to use protein design to target cancer.
Five open postdoctoral positions in Generative AI & Protein Engineering. Share & apply!
jobrxiv.org/job/max-delb...
Five open postdoctoral positions in Generative AI & Protein Engineering. Share & apply!
jobrxiv.org/job/max-delb...
Reposted by Misha Kudryashev
We were very happy to help, in a very small way, in getting this beautiful structure out. The structure is remarkably conserved considering the famous 28S ribosomal RNA split. I suspect that the split has as yet unknown biological repercussions in this remarkable animal..
We have a new preprint for you. Naked mole rats are very long-lived rodents and have increased translational fidelity.
Interestingly, 28S ribosomal RNA is split. Here we investigated the structure of the ribosome by single particle cryo-EM. Take a look.
www.biorxiv.org/content/10.1...
Interestingly, 28S ribosomal RNA is split. Here we investigated the structure of the ribosome by single particle cryo-EM. Take a look.
www.biorxiv.org/content/10.1...
Cryo-EM structure of the naked mole-rat ribosome reveals a stabilized split 28S rRNA
The naked mole-rat (Heterocephalus glaber) is a long-lived mammal with remarkable resistance to cancer and hypoxia, suggesting the evolution of robust proteostasis networks. The ribosome, the central ...
www.biorxiv.org
October 29, 2025 at 2:49 PM
We were very happy to help, in a very small way, in getting this beautiful structure out. The structure is remarkably conserved considering the famous 28S ribosomal RNA split. I suspect that the split has as yet unknown biological repercussions in this remarkable animal..
We have a new preprint for you. Naked mole rats are very long-lived rodents and have increased translational fidelity.
Interestingly, 28S ribosomal RNA is split. Here we investigated the structure of the ribosome by single particle cryo-EM. Take a look.
www.biorxiv.org/content/10.1...
Interestingly, 28S ribosomal RNA is split. Here we investigated the structure of the ribosome by single particle cryo-EM. Take a look.
www.biorxiv.org/content/10.1...
Cryo-EM structure of the naked mole-rat ribosome reveals a stabilized split 28S rRNA
The naked mole-rat (Heterocephalus glaber) is a long-lived mammal with remarkable resistance to cancer and hypoxia, suggesting the evolution of robust proteostasis networks. The ribosome, the central ...
www.biorxiv.org
October 28, 2025 at 3:24 PM
We have a new preprint for you. Naked mole rats are very long-lived rodents and have increased translational fidelity.
Interestingly, 28S ribosomal RNA is split. Here we investigated the structure of the ribosome by single particle cryo-EM. Take a look.
www.biorxiv.org/content/10.1...
Interestingly, 28S ribosomal RNA is split. Here we investigated the structure of the ribosome by single particle cryo-EM. Take a look.
www.biorxiv.org/content/10.1...
Group Leader in Biomedical Engineering at the @mdc-berlin.bsky.social in Berlin.
It's a broad call for whoever is doing exciting Bioengineering, please apply or share. We have a great institute with amazing colleagues and core facilities,highly recommend
application.mdc-berlin.de/site/index.p...
It's a broad call for whoever is doing exciting Bioengineering, please apply or share. We have a great institute with amazing colleagues and core facilities,highly recommend
application.mdc-berlin.de/site/index.p...
MDC Berlin - Online Application System
application.mdc-berlin.de
October 1, 2025 at 3:39 PM
Group Leader in Biomedical Engineering at the @mdc-berlin.bsky.social in Berlin.
It's a broad call for whoever is doing exciting Bioengineering, please apply or share. We have a great institute with amazing colleagues and core facilities,highly recommend
application.mdc-berlin.de/site/index.p...
It's a broad call for whoever is doing exciting Bioengineering, please apply or share. We have a great institute with amazing colleagues and core facilities,highly recommend
application.mdc-berlin.de/site/index.p...
We have a preprint of a book chapter for you: Structural Analysis of Membrane Proteins in Cell-Derived Microvesicles.
We describe how to image membrane proteins in mid-sized vesicles using cryo-electron tomography
zenodo.org/records/1717...
We describe how to image membrane proteins in mid-sized vesicles using cryo-electron tomography
zenodo.org/records/1717...
Structural Analysis of Membrane Proteins in Cell-Derived Microvesicles
zenodo.org
September 22, 2025 at 12:36 PM
We have a preprint of a book chapter for you: Structural Analysis of Membrane Proteins in Cell-Derived Microvesicles.
We describe how to image membrane proteins in mid-sized vesicles using cryo-electron tomography
zenodo.org/records/1717...
We describe how to image membrane proteins in mid-sized vesicles using cryo-electron tomography
zenodo.org/records/1717...
I'd say it's a paper of the week if not a year
Lithium deficiency and the onset of Alzheimer’s disease
www.nature.com/articles/s41...
Lithium deficiency and the onset of Alzheimer’s disease
www.nature.com/articles/s41...
Lithium deficiency and the onset of Alzheimer’s disease - Nature
Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level...
www.nature.com
August 12, 2025 at 6:20 AM
I'd say it's a paper of the week if not a year
Lithium deficiency and the onset of Alzheimer’s disease
www.nature.com/articles/s41...
Lithium deficiency and the onset of Alzheimer’s disease
www.nature.com/articles/s41...
Postdoc program at the MDC in Berlin, @mdc-berlin.bsky.social : take a look 👇👇
For this call, collaborative projects between two groups will be funded. Take a look at the call and the groups and drop me an email if interested. Share with colleagues too!
www.mdc-berlin.de/postdocs#t-g...
For this call, collaborative projects between two groups will be funded. Take a look at the call and the groups and drop me an email if interested. Share with colleagues too!
www.mdc-berlin.de/postdocs#t-g...
www.mdc-berlin.de
August 4, 2025 at 10:23 AM
Postdoc program at the MDC in Berlin, @mdc-berlin.bsky.social : take a look 👇👇
For this call, collaborative projects between two groups will be funded. Take a look at the call and the groups and drop me an email if interested. Share with colleagues too!
www.mdc-berlin.de/postdocs#t-g...
For this call, collaborative projects between two groups will be funded. Take a look at the call and the groups and drop me an email if interested. Share with colleagues too!
www.mdc-berlin.de/postdocs#t-g...
Building atomic models to cryo-EM maps of huge molecules is intimidating: crowded, uncertain copy numbers, variable resolution ...
Fan Liu and team incl us, show how cross-linking MS can be used to build novel models of unknown complexes, like a giant Melbourne virus
biorxiv.org/content/10.1...
Fan Liu and team incl us, show how cross-linking MS can be used to build novel models of unknown complexes, like a giant Melbourne virus
biorxiv.org/content/10.1...
June 19, 2025 at 1:54 PM
Building atomic models to cryo-EM maps of huge molecules is intimidating: crowded, uncertain copy numbers, variable resolution ...
Fan Liu and team incl us, show how cross-linking MS can be used to build novel models of unknown complexes, like a giant Melbourne virus
biorxiv.org/content/10.1...
Fan Liu and team incl us, show how cross-linking MS can be used to build novel models of unknown complexes, like a giant Melbourne virus
biorxiv.org/content/10.1...
We have a preprint for you
EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer
By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...
EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer
By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...
June 8, 2025 at 11:22 AM
We have a preprint for you
EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer
By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...
EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer
By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...
It's fellowship season in the EU. If you want to talk and join our group at the amazing MDC in Berlin on a fellowship, please write me an email.
We do cryo-EM/ET, membrane proteins, data science/AI, our work: scholar.google.com/citations?so...
Fellowships: Marie Curie, EMBO, HFSP, Humboldt...
We do cryo-EM/ET, membrane proteins, data science/AI, our work: scholar.google.com/citations?so...
Fellowships: Marie Curie, EMBO, HFSP, Humboldt...
scholar.google.com
May 19, 2025 at 12:44 PM
It's fellowship season in the EU. If you want to talk and join our group at the amazing MDC in Berlin on a fellowship, please write me an email.
We do cryo-EM/ET, membrane proteins, data science/AI, our work: scholar.google.com/citations?so...
Fellowships: Marie Curie, EMBO, HFSP, Humboldt...
We do cryo-EM/ET, membrane proteins, data science/AI, our work: scholar.google.com/citations?so...
Fellowships: Marie Curie, EMBO, HFSP, Humboldt...
Our contribution to Mohit Misra, Ivan Đikić, and Co's stellar research on how a pathogenic bacterium, Legionella pneumophila, hijacks host cell signaling
It was a huge effort and took many years to combine all the data and methods, so enjoy reading👇
www.researchsquare.com/article/rs-6...
It was a huge effort and took many years to combine all the data and methods, so enjoy reading👇
www.researchsquare.com/article/rs-6...
Structural Basis for Membrane Targeting and Secretion of Legionella SidE Ubiquitin Ligases
SidE family effectors from Legionella pneumophila catalyze serine ubiquitination of host proteins via phospho-ribose (PR) linkages, disrupting host compartments, facilitating the formation of Legionel...
www.researchsquare.com
May 15, 2025 at 7:52 AM
Our contribution to Mohit Misra, Ivan Đikić, and Co's stellar research on how a pathogenic bacterium, Legionella pneumophila, hijacks host cell signaling
It was a huge effort and took many years to combine all the data and methods, so enjoy reading👇
www.researchsquare.com/article/rs-6...
It was a huge effort and took many years to combine all the data and methods, so enjoy reading👇
www.researchsquare.com/article/rs-6...
Hi Cryo-EM fellas!
What are the pros and cons of the latest cryoFIB milling tools? Any usage experience with Arctis already? Any huge advantages of plasma?
What are the pros and cons of the latest cryoFIB milling tools? Any usage experience with Arctis already? Any huge advantages of plasma?
April 28, 2025 at 4:59 AM
Hi Cryo-EM fellas!
What are the pros and cons of the latest cryoFIB milling tools? Any usage experience with Arctis already? Any huge advantages of plasma?
What are the pros and cons of the latest cryoFIB milling tools? Any usage experience with Arctis already? Any huge advantages of plasma?
A broad call for a PhD researcher/ postdoc in our group at the MDC in Berlin. An ideal PhD student - a computational scientist, a postdoc - a structural biologist, but feel free to re-convince me!
We extended the deadline for after Easter, Apr 24th. Apply here www.mdc-berlin.de/career/jobs/...
We extended the deadline for after Easter, Apr 24th. Apply here www.mdc-berlin.de/career/jobs/...
Scientific Researcher – Method Developments for In situ Structural Biology (F/M/D)
The Max Delbrück Center for Molecular Medicine in the Helmholtz Association aims to transform tomorrow’s medicine through our discoveries of today. At locations in Berlin-Buch, Berlin-Mitte, Heidelber...
www.mdc-berlin.de
April 8, 2025 at 11:19 AM
A broad call for a PhD researcher/ postdoc in our group at the MDC in Berlin. An ideal PhD student - a computational scientist, a postdoc - a structural biologist, but feel free to re-convince me!
We extended the deadline for after Easter, Apr 24th. Apply here www.mdc-berlin.de/career/jobs/...
We extended the deadline for after Easter, Apr 24th. Apply here www.mdc-berlin.de/career/jobs/...
Sooo, does anyone know the actual specs of the newly announced Thermo Fischer Krios G5?
Marketing material is wonderful, but what does it actually do ? 😁
Marketing material is wonderful, but what does it actually do ? 😁
April 3, 2025 at 7:29 PM
Sooo, does anyone know the actual specs of the newly announced Thermo Fischer Krios G5?
Marketing material is wonderful, but what does it actually do ? 😁
Marketing material is wonderful, but what does it actually do ? 😁
We are looking for a PhD student/Postdoc to develop methods of cryo-ET and/or study the structure and function of membrane proteins. Great team at the MDC in Berlin.
It's a broad call, please apply and share!
jobrxiv.org/job/max-delb...
It's a broad call, please apply and share!
jobrxiv.org/job/max-delb...
PhD /Postdoc in In Situ Structural Biology by Cryo-ET
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobrxiv.org
March 28, 2025 at 8:42 AM
We are looking for a PhD student/Postdoc to develop methods of cryo-ET and/or study the structure and function of membrane proteins. Great team at the MDC in Berlin.
It's a broad call, please apply and share!
jobrxiv.org/job/max-delb...
It's a broad call, please apply and share!
jobrxiv.org/job/max-delb...
Reposted by Misha Kudryashev
English version of the documentary about power abuse in the Max Planck Society can be found here. 144.000 views already, more than 800 comments. Share it to make colleagues aware of what happens in German academia & the MPG! #IchBinHanna #PowerAbuse
March 14, 2025 at 8:38 AM
English version of the documentary about power abuse in the Max Planck Society can be found here. 144.000 views already, more than 800 comments. Share it to make colleagues aware of what happens in German academia & the MPG! #IchBinHanna #PowerAbuse
look at this, its a really amazing preprint from Jana @janakroll.bsky.social and Co!
Excited to share our new preprint "Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons" www.biorxiv.org/content/10.1...
We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️
We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️
February 12, 2025 at 11:45 PM
look at this, its a really amazing preprint from Jana @janakroll.bsky.social and Co!
Two (!!!) postdocs got Marie Curie fellowships to work in our group. Igor Silva who is already with us scored top 3% of the applications, amazing
We need to increase funding nationally and at the EU level to attract more great scientists
marie-sklodowska-curie-actions.ec.europa.eu/news/msca-aw...
We need to increase funding nationally and at the EU level to attract more great scientists
marie-sklodowska-curie-actions.ec.europa.eu/news/msca-aw...
MSCA awards €417 million to postdoctoral researchers
1696 outstanding postdoctoral researchers were selected for funding among 10,360 applicants.
marie-sklodowska-curie-actions.ec.europa.eu
February 12, 2025 at 11:26 AM
Two (!!!) postdocs got Marie Curie fellowships to work in our group. Igor Silva who is already with us scored top 3% of the applications, amazing
We need to increase funding nationally and at the EU level to attract more great scientists
marie-sklodowska-curie-actions.ec.europa.eu/news/msca-aw...
We need to increase funding nationally and at the EU level to attract more great scientists
marie-sklodowska-curie-actions.ec.europa.eu/news/msca-aw...
Take a look at my personal perspective on the past, present, and future of in situ structural biology with cryo-ET+
While initially skeptical about the genre, I found it fun to write and hopefully, you can enjoy my experiences and some thoughts. Nice weekend y'all
www.cambridge.org/core/journal...
While initially skeptical about the genre, I found it fun to write and hopefully, you can enjoy my experiences and some thoughts. Nice weekend y'all
www.cambridge.org/core/journal...
The big chill: Growth of in situ structural biology with cryo-electron tomography | QRB Discovery | Cambridge Core
The big chill: Growth of in situ structural biology with cryo-electron tomography - Volume 5
www.cambridge.org
December 13, 2024 at 4:45 PM
Take a look at my personal perspective on the past, present, and future of in situ structural biology with cryo-ET+
While initially skeptical about the genre, I found it fun to write and hopefully, you can enjoy my experiences and some thoughts. Nice weekend y'all
www.cambridge.org/core/journal...
While initially skeptical about the genre, I found it fun to write and hopefully, you can enjoy my experiences and some thoughts. Nice weekend y'all
www.cambridge.org/core/journal...
Take a look at our recent work on the S-layer, a protective envelope on the surface of pathogenic Bacillus anthracis. Us and & Han Remaut's team used a cool combination of structural biology techniques to describe its structure in fine detail
🔬❄️🖥️🔮👇https://www.pnas.org/doi/10.1073/pnas.2415351121
🔬❄️🖥️🔮👇https://www.pnas.org/doi/10.1073/pnas.2415351121
December 10, 2024 at 8:32 AM
Take a look at our recent work on the S-layer, a protective envelope on the surface of pathogenic Bacillus anthracis. Us and & Han Remaut's team used a cool combination of structural biology techniques to describe its structure in fine detail
🔬❄️🖥️🔮👇https://www.pnas.org/doi/10.1073/pnas.2415351121
🔬❄️🖥️🔮👇https://www.pnas.org/doi/10.1073/pnas.2415351121
Take a look at our paper from last week where we probed the Molecular Architecture of Synaptic Vesicles by cryo-ET and integrative structural analysis
We found that V-ATPases interact with synaptophysin and describe some other molecules of this exciting organelle
🧠🔬❄️
www.pnas.org/doi/10.1073/...
We found that V-ATPases interact with synaptophysin and describe some other molecules of this exciting organelle
🧠🔬❄️
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
December 3, 2024 at 9:53 AM
Take a look at our paper from last week where we probed the Molecular Architecture of Synaptic Vesicles by cryo-ET and integrative structural analysis
We found that V-ATPases interact with synaptophysin and describe some other molecules of this exciting organelle
🧠🔬❄️
www.pnas.org/doi/10.1073/...
We found that V-ATPases interact with synaptophysin and describe some other molecules of this exciting organelle
🧠🔬❄️
www.pnas.org/doi/10.1073/...
Hello World!
And my first follower 👇 😍🔬🧪
And my first follower 👇 😍🔬🧪
Give warm welcome to Misha Kudryashev!
@mishakudryashev.bsky.social
@mishakudryashev.bsky.social
December 2, 2024 at 4:30 PM
Hello World!
And my first follower 👇 😍🔬🧪
And my first follower 👇 😍🔬🧪