Claudia Matthaeus
@cmatthaeus.bsky.social
Assistant Professor in Cellular Physiology of Nutrition @unipotsdam.bsky.social Interested in #caveolae , metabolism and #microscopy
https://www.matthaeus-lab.de
https://www.matthaeus-lab.de
Pinned
Claudia Matthaeus
@cmatthaeus.bsky.social
· Nov 28
Hello new followers 🖖 I like looking at the plasma membrane by high res microscopy. Here, you see a platinum replica EM of a fibroblast plasma membrane with clathrin dome (in the center) and caveolae (small invaginations on the side)
Another interesting new paper showing cellular insights in caveolae mediated fatty acid uptake by Richard Lundmarks lab and @robparton.bsky.social they show caveolae -ER contact sites that might fuel fatty acids from the plasma membrane into the ER. Very exciting!
Membrane contacts between caveolae and the endoplasmic reticulum regulate uptake and metabolic trapping of long-chain fatty acids https://www.biorxiv.org/content/10.64898/2025.12.22.695939v1
December 24, 2025 at 4:33 AM
Another interesting new paper showing cellular insights in caveolae mediated fatty acid uptake by Richard Lundmarks lab and @robparton.bsky.social they show caveolae -ER contact sites that might fuel fatty acids from the plasma membrane into the ER. Very exciting!
Great opportunity for a Postdoc interested in cellular high resolution imaging: amazing lab & team, amazing campus & resources! And summer times starts early in DC ☀️I can highly recommend 👇
My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...
December 22, 2025 at 4:29 PM
Great opportunity for a Postdoc interested in cellular high resolution imaging: amazing lab & team, amazing campus & resources! And summer times starts early in DC ☀️I can highly recommend 👇
Reposted by Claudia Matthaeus
⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...
Self-renewal of neuronal mitochondria through asymmetric division
Mitochondrial ATP production is essential for life. Mitochondrial function depends on the spatio-temporal coordination of nuclear and mitochondrial genome expression, yet how this coordination occurs ...
www.biorxiv.org
December 18, 2025 at 8:36 PM
⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...
Reposted by Claudia Matthaeus
Excited to share that as my group launches across Karolinska Institutet and the University of Helsinki, we’re recruiting postdocs and research assistants to study the nanoscale architecture of lipid flux using in-cell structural biology approaches, including cryo-ET and cryo-CLEM
December 18, 2025 at 9:56 AM
Excited to share that as my group launches across Karolinska Institutet and the University of Helsinki, we’re recruiting postdocs and research assistants to study the nanoscale architecture of lipid flux using in-cell structural biology approaches, including cryo-ET and cryo-CLEM
Reposted by Claudia Matthaeus
Textbooks said neurons don’t burn fatty acids for energy🤔. Our study delivers the first in vivo demonstration that fatty acid oxidation in defined memory neurons fuels memory formation.
Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com
Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com
Neuronal fatty acid oxidation fuels memory after intensive learning in Drosophila - Nature Metabolism
Neurons are shown to use fatty acid β-oxidation as a fuel source for memory formation upon intensive learning in Drosophila, challenging the view that neurons are unable to use fatty acids for energy ...
www.nature.com
December 10, 2025 at 11:13 AM
Textbooks said neurons don’t burn fatty acids for energy🤔. Our study delivers the first in vivo demonstration that fatty acid oxidation in defined memory neurons fuels memory formation.
Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com
Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com
Reposted by Claudia Matthaeus
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1
December 17, 2025 at 12:46 AM
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
Reposted by Claudia Matthaeus
Ups we did it again! Please mark your calender. EMBO Workshop “Lipid Code to Life”, taking place September 7–11, 2026, in Dresden, organized by Maria Fedorova, @lipid.bsky.social, Valerie O'Donnell, @holthuislab.bsky.social and @molcellbiophys-lab.bsky.social 🥳 Retweets = lipidlove
December 15, 2025 at 2:36 PM
Ups we did it again! Please mark your calender. EMBO Workshop “Lipid Code to Life”, taking place September 7–11, 2026, in Dresden, organized by Maria Fedorova, @lipid.bsky.social, Valerie O'Donnell, @holthuislab.bsky.social and @molcellbiophys-lab.bsky.social 🥳 Retweets = lipidlove
💥I am excited to present our first research paper from the lab about caveolae lipid trafficking 🎉 Led by my fantastic PhD candidate @estherocket.bsky.social
Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
Lipid-induced Caveolin1-Lipid droplet trafficking is associated with lipid droplet growth https://www.biorxiv.org/content/10.64898/2025.12.10.693432v1
December 11, 2025 at 7:08 AM
💥I am excited to present our first research paper from the lab about caveolae lipid trafficking 🎉 Led by my fantastic PhD candidate @estherocket.bsky.social
Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
Reposted by Claudia Matthaeus
In our latest issue, Kerry-Anne Rye and colleagues Review HDL metabolism and function in diabetes mellitus (£) go.nature.com/495jFIA #EndoSky #MedSky
December 10, 2025 at 6:10 PM
In our latest issue, Kerry-Anne Rye and colleagues Review HDL metabolism and function in diabetes mellitus (£) go.nature.com/495jFIA #EndoSky #MedSky
Reposted by Claudia Matthaeus
Please RT‼️ #TenureTrack position @zmbh.uni-heidelberg.de one of the best #proteostasis research centres in the world. www.nature.com/naturecareer...
Tenure Track Professorship (W1 with Tenure Track to W3) in “Molecular Biology" (f/m/d) - Heidelberg job with Universität Heidelberg | 12850668
The Center for Molecular Biology of Heidelberg University (ZMBH) and the Faculty of Biosciences invite applications for a Tenure Track Professors...
www.nature.com
December 10, 2025 at 2:14 PM
Please RT‼️ #TenureTrack position @zmbh.uni-heidelberg.de one of the best #proteostasis research centres in the world. www.nature.com/naturecareer...
Reposted by Claudia Matthaeus
The fun leaving your body the moment you're done with the science and it's time to get it published
December 4, 2025 at 11:15 AM
The fun leaving your body the moment you're done with the science and it's time to get it published
Reposted by Claudia Matthaeus
And the saga continues! Our collaborative work with outstanding Justin Korfhage & Thomas Melia’s lab in PNAS shows that ATG2A transfers triglycerides and does so bidirectionally! An exciting twist in our understanding of lipid transport.
Definitely worth a deep read:
www.pnas.org/doi/10.1073/...
Definitely worth a deep read:
www.pnas.org/doi/10.1073/...
November 27, 2025 at 10:41 AM
And the saga continues! Our collaborative work with outstanding Justin Korfhage & Thomas Melia’s lab in PNAS shows that ATG2A transfers triglycerides and does so bidirectionally! An exciting twist in our understanding of lipid transport.
Definitely worth a deep read:
www.pnas.org/doi/10.1073/...
Definitely worth a deep read:
www.pnas.org/doi/10.1073/...
Reposted by Claudia Matthaeus
In this Protocol you will find comprehensive guidance for researchers, including those with limited electron microscopy experience, on the effective use of genetically encoded, multichannel EM-capsulin reporters for both fluorescence microscopy and EM workflows.
@natprot.nature.com 🧪 🔬
@natprot.nature.com 🧪 🔬
Multiplexed genetic tags for electron and fluorescence microscopy - Nature Protocols
This protocol for the use and quality control of genetically encoded reporters to label proteins and cells in correlative light and electron microscopy workflows enables the acquisition of molecular, ...
www.nature.com
November 25, 2025 at 7:12 AM
In this Protocol you will find comprehensive guidance for researchers, including those with limited electron microscopy experience, on the effective use of genetically encoded, multichannel EM-capsulin reporters for both fluorescence microscopy and EM workflows.
@natprot.nature.com 🧪 🔬
@natprot.nature.com 🧪 🔬
Very exciting Postdoc positions available 👇
We got a large Helmholtz Bioengineering grant with Oliver Daumke, Artur Yakimovich, Alina Bazarova, and Dietrich Ruess to use protein design to target cancer.
Five open postdoctoral positions in Generative AI & Protein Engineering. Share & apply!
jobrxiv.org/job/max-delb...
Five open postdoctoral positions in Generative AI & Protein Engineering. Share & apply!
jobrxiv.org/job/max-delb...
Postdoctoral Positions in Protein Engineering
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobrxiv.org
November 21, 2025 at 9:10 AM
Very exciting Postdoc positions available 👇
Reposted by Claudia Matthaeus
Junior professor position at the University of Kaiserslautern! Our Department of Biology is seeking a colleague working with microalgae. This is a wonderful place to do wonderful science with great people! Please, repost :)
Further details:
jobs.rptu.de/jobposting/1...
Further details:
jobs.rptu.de/jobposting/1...
November 20, 2025 at 3:28 PM
Junior professor position at the University of Kaiserslautern! Our Department of Biology is seeking a colleague working with microalgae. This is a wonderful place to do wonderful science with great people! Please, repost :)
Further details:
jobs.rptu.de/jobposting/1...
Further details:
jobs.rptu.de/jobposting/1...
Reposted by Claudia Matthaeus
Know the difference.
November 19, 2025 at 10:08 PM
Know the difference.
Reposted by Claudia Matthaeus
Thrilled to share our latest work showing that the bridge lipid transport protein ATG2A transfers diacylglycerol (DAG), and some TAG/PA, from the ER to LDs, thereby recruiting DGAT2 to drive local TAG synthesis, promoting LD expansion while protecting ER membranes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth - Nature Structural & Molecular Biology
Elhan et al. show that ATG2A acts with DGAT2, the enzyme producing triacylglycerol (TAG), in lipid droplet growth. By delivering diacylglycerol to lipid droplets, ATG2A not only fuels TAG production b...
www.nature.com
November 17, 2025 at 10:57 PM
Thrilled to share our latest work showing that the bridge lipid transport protein ATG2A transfers diacylglycerol (DAG), and some TAG/PA, from the ER to LDs, thereby recruiting DGAT2 to drive local TAG synthesis, promoting LD expansion while protecting ER membranes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Claudia Matthaeus
The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility
The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility
Zhao et al. identify the molecular machinery for lipid droplet motility, consisting of the type V myosin Myo2, the Myo2 adaptor protein Ldm1, and its surface receptor Ldo16. They uncover a molecular link between lipid droplet motility and retention via contact-site formation and an unexpected connection to mitochondrial motility.
dlvr.it
November 7, 2025 at 3:39 PM
The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility
Reposted by Claudia Matthaeus
Fat storage in the body relies on specialized structures called lipid droplets. In a new Science study, researchers identified the microprotein adipogenin as a regulator of adipocyte lipid droplet size, revealing a key mechanism in lipid homeostasis.
Learn more this week: https://scim.ag/4nFEGO7
Learn more this week: https://scim.ag/4nFEGO7
November 6, 2025 at 7:05 PM
Fat storage in the body relies on specialized structures called lipid droplets. In a new Science study, researchers identified the microprotein adipogenin as a regulator of adipocyte lipid droplet size, revealing a key mechanism in lipid homeostasis.
Learn more this week: https://scim.ag/4nFEGO7
Learn more this week: https://scim.ag/4nFEGO7
Reposted by Claudia Matthaeus
Reposted by Claudia Matthaeus
Required reading for cell biologists to get a sense of basic statistical principles!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Ten essential tips for robust statistics in cell biology - Nature Cell Biology
Statistical thinking is a core part of solid, trustworthy biology. However, many studies still include insufficient sample sizes, have poor experimental design or select an incorrect statistical metho...
www.nature.com
November 4, 2025 at 7:23 PM
Required reading for cell biologists to get a sense of basic statistical principles!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Claudia Matthaeus
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
October 29, 2025 at 5:11 PM
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
Reposted by Claudia Matthaeus
#ACSChemBio and #Biochemistry invite submissions to a special issue on Lipids and Lipidation guest edited by @chembiobryan.bsky.social and me! Find details in the #CallforPapers and submit your exciting findings to one of these journals by May 31, 2026. axial.acs.org/chemical-bio... #lipidtime
Call for Papers: Lipids and Lipidation | ACS Publications Chemistry Blog
This Special Issue in _ACS Chemical Biology_ will highlight the latest advancements and perspectives in the chemical biology of lipids and lipidation. Submit your manuscript by May 31, 2026.
axial.acs.org
October 28, 2025 at 3:48 PM
#ACSChemBio and #Biochemistry invite submissions to a special issue on Lipids and Lipidation guest edited by @chembiobryan.bsky.social and me! Find details in the #CallforPapers and submit your exciting findings to one of these journals by May 31, 2026. axial.acs.org/chemical-bio... #lipidtime
Apply! Great opportunity to learn about Teams, leadership, yourself .. + Bonus: meeting amazing other scientist and form a great peer (support) group
📣 Call for Applications: GSO Leadership Academy 10
Apply for one of 25 fully funded fellowships for the 10th Leadership Academy – an interactive program designed to give you the tools, network, and mindset for effective leadership.
🔗 Apply here: gsonet.org/foerderprogr...
Apply for one of 25 fully funded fellowships for the 10th Leadership Academy – an interactive program designed to give you the tools, network, and mindset for effective leadership.
🔗 Apply here: gsonet.org/foerderprogr...
October 29, 2025 at 12:20 PM
Apply! Great opportunity to learn about Teams, leadership, yourself .. + Bonus: meeting amazing other scientist and form a great peer (support) group
Reposted by Claudia Matthaeus
Calling all #Membrane enthusiasts!
Our #MembraneTrafficking online seminar series is back for the 2025-26 season: 8 fantastic speakers from Nov'25 to Feb'26.
The first talks are already next Thursday (Nov 6, 5pm CET) with @agatawitkowska.bsky.social and @abdourachidthiam.bsky.social !
Our #MembraneTrafficking online seminar series is back for the 2025-26 season: 8 fantastic speakers from Nov'25 to Feb'26.
The first talks are already next Thursday (Nov 6, 5pm CET) with @agatawitkowska.bsky.social and @abdourachidthiam.bsky.social !
October 27, 2025 at 5:02 PM
Calling all #Membrane enthusiasts!
Our #MembraneTrafficking online seminar series is back for the 2025-26 season: 8 fantastic speakers from Nov'25 to Feb'26.
The first talks are already next Thursday (Nov 6, 5pm CET) with @agatawitkowska.bsky.social and @abdourachidthiam.bsky.social !
Our #MembraneTrafficking online seminar series is back for the 2025-26 season: 8 fantastic speakers from Nov'25 to Feb'26.
The first talks are already next Thursday (Nov 6, 5pm CET) with @agatawitkowska.bsky.social and @abdourachidthiam.bsky.social !