Yamuna Krishnan
@krishnanyamuna.bsky.social
Organelle maniac, DNA devotee, RNA fanatic, Biology addict. 👩🏽🔬🧬🦠🧪🔬 ORCID: 0000-0001-5282-8852
https://krishnanlab.uchicago.edu/
https://krishnanlab.uchicago.edu/
Pinned
Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
Reposted by Yamuna Krishnan
Threatening comedians is fascist shit. just FYI.
The president of the United States is personally threatening a comedian for mocking him.
February 2, 2026 at 12:08 PM
Threatening comedians is fascist shit. just FYI.
Reposted by Yamuna Krishnan
Measles has one of the highest basic reproduction numbers (R₀) of any disease (12 to 18), meaning one infected person can spread it to 12 to 18 others in a fully susceptible population, making it extremely contagious. Need 95% vaccination status to achieve herd immunity. Get vaccinated!!
February 1, 2026 at 3:19 PM
Measles has one of the highest basic reproduction numbers (R₀) of any disease (12 to 18), meaning one infected person can spread it to 12 to 18 others in a fully susceptible population, making it extremely contagious. Need 95% vaccination status to achieve herd immunity. Get vaccinated!!
Reposted by Yamuna Krishnan
RIP in peace Researchfish
Elsevier to close controversial Researchfish platform - Research Professional News
Impact-tracking service used by UK Research and Innovation to be shut down by July 2027
www.researchprofessionalnews.com
February 2, 2026 at 9:28 AM
RIP in peace Researchfish
Reposted by Yamuna Krishnan
At 70,000 feet, sealed inside a full pressure suit in the cockpit of a U-2, I made this photograph of Earth. For a brief stretch of time, the only people higher were the astronauts aboard the International Space Station. #SciArt
February 1, 2026 at 3:05 PM
At 70,000 feet, sealed inside a full pressure suit in the cockpit of a U-2, I made this photograph of Earth. For a brief stretch of time, the only people higher were the astronauts aboard the International Space Station. #SciArt
Woah! The ER, mitos and endolysosomes contact make 3-way contact to pinch endolysosomes and form lysosomes!
Check out our newest findings on how #lysosomes are generated from #endolysosomes. Great work from @samit2104.bsky.social ! @biozentrum.unibas.ch , @unibas.ch #cellbio #cell #organelles
Ca2+ and DRP1 drive endocytic lysosome reformation at tripartite contact sites www.biorxiv.org/content/10.6...
Ca2+ and DRP1 drive endocytic lysosome reformation at tripartite contact sites www.biorxiv.org/content/10.6...
Ca2+ and DRP1 drive endocytic lysosome reformation at tripartite contact sites
Lysosomes are essential in maintaining cellular health. Endocytic lysosome reformation (ELR) regenerates functional lysosomes following degradation of endocytic cargo, yet the mechanisms driving this process remain largely unknown. Here, we define the molecular machinery underlying ELR. We find that unlike autophagic lysosome reformation (ALR), ELR proceeds independently of mTOR and dynamin 2, but requires the mitochondrial fission GTPase DRP1. DRP1 mediates scission of endolysosomal tubules at contact sites with the endoplasmic reticulum (ER) and mitochondria. Disruption of DRP1 function or ER endolysosome contact results in elongated tubules, indicating defective lysosome reformation. Moreover, mitochondrial activity is essential for tubule initiation, and Ca2+ transfer from endolysosomes to mitochondria is crucial for ELR onset. Our findings reveal a dual role for mitochondria in ELR: first in ELR initiation and second in DRP1-dependent tubule fission at ER-mitochondria-endolysosome tripartite contact sites, uncovering the previously unappreciated role of mitochondria in endolysosome remodeling and fission. ### Competing Interest Statement The authors have declared no competing interest. Swiss National Science Foundation, 320030-231859, 310030-197779 University of Basel, https://ror.org/02s6k3f65
www.biorxiv.org
February 2, 2026 at 11:53 AM
Woah! The ER, mitos and endolysosomes contact make 3-way contact to pinch endolysosomes and form lysosomes!
Reposted by Yamuna Krishnan
Whenever abuse starts getting exposed in a culture of abuse, the question posed is "where does it all end?" to avoid asking “*how* will we make this end?”
But I'll answer. Where does it end?
It ends when we excise the abusive ice, from hummock to bummock. www.the-reframe.com/where-it-ends/
But I'll answer. Where does it end?
It ends when we excise the abusive ice, from hummock to bummock. www.the-reframe.com/where-it-ends/
Where It Ends
Answering the enabler's constant question, and contemplating the depraved depths of the billionaire mindset.
www.the-reframe.com
February 2, 2026 at 11:06 AM
Whenever abuse starts getting exposed in a culture of abuse, the question posed is "where does it all end?" to avoid asking “*how* will we make this end?”
But I'll answer. Where does it end?
It ends when we excise the abusive ice, from hummock to bummock. www.the-reframe.com/where-it-ends/
But I'll answer. Where does it end?
It ends when we excise the abusive ice, from hummock to bummock. www.the-reframe.com/where-it-ends/
Reposted by Yamuna Krishnan
NEW: What’s happening in the US is TECHNOFASCISM.
It’s fascism + surveillance technologies. Palantir is playing a central role. And the UK is next in line.
My latest for @thenerve.news
1/
www.thenerve.news/p/technofasc...
It’s fascism + surveillance technologies. Palantir is playing a central role. And the UK is next in line.
My latest for @thenerve.news
1/
www.thenerve.news/p/technofasc...
What’s happening in America is technofascism. It could happen here
Peter Thiel's data surveillance company Palantir is powering Trump's ICE operation in the US. Carole Cadwalladr argues that the UK will be next
www.thenerve.news
February 1, 2026 at 2:44 PM
NEW: What’s happening in the US is TECHNOFASCISM.
It’s fascism + surveillance technologies. Palantir is playing a central role. And the UK is next in line.
My latest for @thenerve.news
1/
www.thenerve.news/p/technofasc...
It’s fascism + surveillance technologies. Palantir is playing a central role. And the UK is next in line.
My latest for @thenerve.news
1/
www.thenerve.news/p/technofasc...
Reposted by Yamuna Krishnan
.@neilshubin.bsky.social is a paleontologist, evolutionary biologist, and writer whose work has reshaped how we understand the deep history written into the human body. He is best known for leading the discovery of Tiktaalik, a fossil that illuminated the transition from fish to land animals.
February 1, 2026 at 11:17 PM
.@neilshubin.bsky.social is a paleontologist, evolutionary biologist, and writer whose work has reshaped how we understand the deep history written into the human body. He is best known for leading the discovery of Tiktaalik, a fossil that illuminated the transition from fish to land animals.
Reposted by Yamuna Krishnan
Thinking about remodeling? Mitochondria do that too... and our speaker knows all about it.
This thursday, usual time and place.
See you there?
This thursday, usual time and place.
See you there?
February 2, 2026 at 11:32 AM
Thinking about remodeling? Mitochondria do that too... and our speaker knows all about it.
This thursday, usual time and place.
See you there?
This thursday, usual time and place.
See you there?
Reposted by Yamuna Krishnan
This is truly incredible (and not in a good way).
February 2, 2026 at 1:39 AM
This is truly incredible (and not in a good way).
Reposted by Yamuna Krishnan
Taylor Rehmet, a Democrat (& @runforsomething.net candidate!) flipped a state senate district in Texas that Trump had won by 17 points.
Expand your imagination. When great candidates rooted in community step up to lead, anything is possible.
Expand your imagination. When great candidates rooted in community step up to lead, anything is possible.
February 1, 2026 at 12:19 PM
Taylor Rehmet, a Democrat (& @runforsomething.net candidate!) flipped a state senate district in Texas that Trump had won by 17 points.
Expand your imagination. When great candidates rooted in community step up to lead, anything is possible.
Expand your imagination. When great candidates rooted in community step up to lead, anything is possible.
Reposted by Yamuna Krishnan
Do you get it now?
January 31, 2026 at 7:30 PM
Do you get it now?
Reposted by Yamuna Krishnan
::taps mic::
beyond being an absolutely miserable illness, measles can cause immune amnesia. It wipes out your immune systems memory of how to fight every infection, every vaccine you've ever had.
beyond being an absolutely miserable illness, measles can cause immune amnesia. It wipes out your immune systems memory of how to fight every infection, every vaccine you've ever had.
A measles outbreak is growing in a rural area of West Texas where vaccination rates are well below the recommended level.
Measles outbreak expands in West Texas around county with low vaccination rate | CNN
A measles outbreak is growing in a rural area of West Texas where vaccination rates are well below the recommended level.
www.cnn.com
February 8, 2025 at 12:36 AM
::taps mic::
beyond being an absolutely miserable illness, measles can cause immune amnesia. It wipes out your immune systems memory of how to fight every infection, every vaccine you've ever had.
beyond being an absolutely miserable illness, measles can cause immune amnesia. It wipes out your immune systems memory of how to fight every infection, every vaccine you've ever had.
Reposted by Yamuna Krishnan
This is why Democrats need to compete EVERYWHERE.
We won’t win every race, but it’s stupid and irresponsible to simply forfeit certain races to incumbents. Always but especially now, we need competitive elections. And at the bare minimum, make them spend money defending seats they had won by 17 pts
We won’t win every race, but it’s stupid and irresponsible to simply forfeit certain races to incumbents. Always but especially now, we need competitive elections. And at the bare minimum, make them spend money defending seats they had won by 17 pts
JUST IN: Democrats flip a red seat in the Texas Senate.
Taylor Rehmet wins against Leigh Wambsganss, a conservative activist who helped lead right-wing efforts to take over TX school boards.
With all early vote, and 95% of precincts, in, Dem up 57/43.
Trump won this seat by 17% in Tarrant County.
Taylor Rehmet wins against Leigh Wambsganss, a conservative activist who helped lead right-wing efforts to take over TX school boards.
With all early vote, and 95% of precincts, in, Dem up 57/43.
Trump won this seat by 17% in Tarrant County.
February 1, 2026 at 12:54 PM
This is why Democrats need to compete EVERYWHERE.
We won’t win every race, but it’s stupid and irresponsible to simply forfeit certain races to incumbents. Always but especially now, we need competitive elections. And at the bare minimum, make them spend money defending seats they had won by 17 pts
We won’t win every race, but it’s stupid and irresponsible to simply forfeit certain races to incumbents. Always but especially now, we need competitive elections. And at the bare minimum, make them spend money defending seats they had won by 17 pts
Reposted by Yamuna Krishnan
THE FINGER-TAKER’S SON
Whenever the king became displeased with one of his subjects, he would send out his soldiers, and before long the offender would find themselves in the basement of the king’s finger-taker.
The finger-taker claimed to be a persuadable man.
www.the-reframe.com/the-finger-t...
Whenever the king became displeased with one of his subjects, he would send out his soldiers, and before long the offender would find themselves in the basement of the king’s finger-taker.
The finger-taker claimed to be a persuadable man.
www.the-reframe.com/the-finger-t...
The Finger-Taker's Son
Rules of engagement, and what it means to find "common ground" with supremacists.
www.the-reframe.com
February 1, 2026 at 11:42 AM
THE FINGER-TAKER’S SON
Whenever the king became displeased with one of his subjects, he would send out his soldiers, and before long the offender would find themselves in the basement of the king’s finger-taker.
The finger-taker claimed to be a persuadable man.
www.the-reframe.com/the-finger-t...
Whenever the king became displeased with one of his subjects, he would send out his soldiers, and before long the offender would find themselves in the basement of the king’s finger-taker.
The finger-taker claimed to be a persuadable man.
www.the-reframe.com/the-finger-t...
Reposted by Yamuna Krishnan
Today I saw ICE gas little white kids in the streets of Portland with chemical weapons. Imagine what they're doing to brown and black kids in the detention camps
February 1, 2026 at 2:08 AM
Today I saw ICE gas little white kids in the streets of Portland with chemical weapons. Imagine what they're doing to brown and black kids in the detention camps
Reposted by Yamuna Krishnan
"It may take time to prove you're right, but you have to stick to it."
- Fred Korematsu
Jailed for refusing to abide by FDR's Exec Order 9066, he took his case against internment all the way to the Supreme Court - and lost. Remember him on Korematsu Day, January 30th. 1/
- Fred Korematsu
Jailed for refusing to abide by FDR's Exec Order 9066, he took his case against internment all the way to the Supreme Court - and lost. Remember him on Korematsu Day, January 30th. 1/
January 30, 2026 at 10:32 PM
"It may take time to prove you're right, but you have to stick to it."
- Fred Korematsu
Jailed for refusing to abide by FDR's Exec Order 9066, he took his case against internment all the way to the Supreme Court - and lost. Remember him on Korematsu Day, January 30th. 1/
- Fred Korematsu
Jailed for refusing to abide by FDR's Exec Order 9066, he took his case against internment all the way to the Supreme Court - and lost. Remember him on Korematsu Day, January 30th. 1/
Reposted by Yamuna Krishnan
ICE protester says her Global Entry was revoked after agent scanned her face
ICE protester says her Global Entry was revoked after agent scanned her face
Global Entry and Precheck revoked three days after incident, court filing says.
arstechnica.com
January 31, 2026 at 2:37 AM
ICE protester says her Global Entry was revoked after agent scanned her face
Yes! Please read this article from @markhisted.org whose views deeply respect.
"We cannot return to the old way of trying to ignore power and politics — if we do that, scientists will just be run over and US science will continue to collapse."
I could quote this all day, but please read the whole thing from @markhisted.org via @donmoyn.bsky.social (3/3)
I could quote this all day, but please read the whole thing from @markhisted.org via @donmoyn.bsky.social (3/3)
American biomedical science in 2026
Where we are, how we got here, and what to do next
donmoynihan.substack.com
January 31, 2026 at 1:54 PM
Yes! Please read this article from @markhisted.org whose views deeply respect.
Reposted by Yamuna Krishnan
If I were a blue state governor, I’d be looking into adding a bunch of tenure lines at my state schools.
I know that seems like “kick ‘em when they’re down,” but it’s more like “let academics who can escape to where they can do real work.”
Builds up your own schools AND protect US academic output.
I know that seems like “kick ‘em when they’re down,” but it’s more like “let academics who can escape to where they can do real work.”
Builds up your own schools AND protect US academic output.
The governor of Texas is rapidly turning world-class universities into minor regional ones. Example:
Greg Abbott halts H-1B visas at Texas universities, agencies
The governor said public universities and state agencies may not seek new visas without permission through the end of the 2027 legislative session.
www.texastribune.org
January 30, 2026 at 11:15 PM
If I were a blue state governor, I’d be looking into adding a bunch of tenure lines at my state schools.
I know that seems like “kick ‘em when they’re down,” but it’s more like “let academics who can escape to where they can do real work.”
Builds up your own schools AND protect US academic output.
I know that seems like “kick ‘em when they’re down,” but it’s more like “let academics who can escape to where they can do real work.”
Builds up your own schools AND protect US academic output.
Reposted by Yamuna Krishnan
Republicans created a slush fund for ICE—CAP’s Bobby Kogan explains how this impacts a potential government shutdown.
January 30, 2026 at 6:42 PM
Republicans created a slush fund for ICE—CAP’s Bobby Kogan explains how this impacts a potential government shutdown.
Reposted by Yamuna Krishnan
1. The thing about science that these jokers don't understand is that science cannot be vibe-coded.
Whatever its flaws, the point with vibe coding is that you're trying to quickly make something that sorta works, where you can immediately sorta see if it sorta works and then sorta use it.
Whatever its flaws, the point with vibe coding is that you're trying to quickly make something that sorta works, where you can immediately sorta see if it sorta works and then sorta use it.
“The idea is to put ChatGPT front and center inside software that scientists use to write up their work in much the same way that chatbots are now embedded into popular programming editors.
It’s vibe coding, but for science.”
It’s vibe coding, but for science.”
OpenAI’s latest product lets you vibe code science
Prism is a ChatGPT-powered text editor that automates much of the work involved in writing scientific papers.
www.technologyreview.com
January 27, 2026 at 10:09 PM
1. The thing about science that these jokers don't understand is that science cannot be vibe-coded.
Whatever its flaws, the point with vibe coding is that you're trying to quickly make something that sorta works, where you can immediately sorta see if it sorta works and then sorta use it.
Whatever its flaws, the point with vibe coding is that you're trying to quickly make something that sorta works, where you can immediately sorta see if it sorta works and then sorta use it.
Reposted by Yamuna Krishnan
I had intended to post something about this new Google DeepMind paper that appeared yesterday in Nature, but the press coverage has added to what there is to say. So this is a long 🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Advancing regulatory variant effect prediction with AlphaGenome - Nature
AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect...
www.nature.com
January 30, 2026 at 9:47 AM
I had intended to post something about this new Google DeepMind paper that appeared yesterday in Nature, but the press coverage has added to what there is to say. So this is a long 🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Yamuna Krishnan
PhD position in my lab!
January 28, 2026 at 5:25 PM
PhD position in my lab!
He just nuked local air travel. Pro tip : buy Zoom stock. Then sell before he changes his mind.
good luck flying, americans
January 30, 2026 at 1:42 AM
He just nuked local air travel. Pro tip : buy Zoom stock. Then sell before he changes his mind.