Yamuna Krishnan
@krishnanyamuna.bsky.social
Organelle maniac, DNA devotee, RNA fanatic, Biology addict. 👩🏽🔬🧬🦠🧪🔬 ORCID: 0000-0001-5282-8852
https://krishnanlab.uchicago.edu/
https://krishnanlab.uchicago.edu/
Pinned
Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
Yes! Please read this article from @markhisted.org whose views deeply respect.
"We cannot return to the old way of trying to ignore power and politics — if we do that, scientists will just be run over and US science will continue to collapse."
I could quote this all day, but please read the whole thing from @markhisted.org via @donmoyn.bsky.social (3/3)
I could quote this all day, but please read the whole thing from @markhisted.org via @donmoyn.bsky.social (3/3)
American biomedical science in 2026
Where we are, how we got here, and what to do next
donmoynihan.substack.com
January 31, 2026 at 1:54 PM
Yes! Please read this article from @markhisted.org whose views deeply respect.
Reposted by Yamuna Krishnan
If I were a blue state governor, I’d be looking into adding a bunch of tenure lines at my state schools.
I know that seems like “kick ‘em when they’re down,” but it’s more like “let academics who can escape to where they can do real work.”
Builds up your own schools AND protect US academic output.
I know that seems like “kick ‘em when they’re down,” but it’s more like “let academics who can escape to where they can do real work.”
Builds up your own schools AND protect US academic output.
The governor of Texas is rapidly turning world-class universities into minor regional ones. Example:
Greg Abbott halts H-1B visas at Texas universities, agencies
The governor said public universities and state agencies may not seek new visas without permission through the end of the 2027 legislative session.
www.texastribune.org
January 30, 2026 at 11:15 PM
If I were a blue state governor, I’d be looking into adding a bunch of tenure lines at my state schools.
I know that seems like “kick ‘em when they’re down,” but it’s more like “let academics who can escape to where they can do real work.”
Builds up your own schools AND protect US academic output.
I know that seems like “kick ‘em when they’re down,” but it’s more like “let academics who can escape to where they can do real work.”
Builds up your own schools AND protect US academic output.
Reposted by Yamuna Krishnan
Republicans created a slush fund for ICE—CAP’s Bobby Kogan explains how this impacts a potential government shutdown.
January 30, 2026 at 6:42 PM
Republicans created a slush fund for ICE—CAP’s Bobby Kogan explains how this impacts a potential government shutdown.
Reposted by Yamuna Krishnan
1. The thing about science that these jokers don't understand is that science cannot be vibe-coded.
Whatever its flaws, the point with vibe coding is that you're trying to quickly make something that sorta works, where you can immediately sorta see if it sorta works and then sorta use it.
Whatever its flaws, the point with vibe coding is that you're trying to quickly make something that sorta works, where you can immediately sorta see if it sorta works and then sorta use it.
“The idea is to put ChatGPT front and center inside software that scientists use to write up their work in much the same way that chatbots are now embedded into popular programming editors.
It’s vibe coding, but for science.”
It’s vibe coding, but for science.”
OpenAI’s latest product lets you vibe code science
Prism is a ChatGPT-powered text editor that automates much of the work involved in writing scientific papers.
www.technologyreview.com
January 27, 2026 at 10:09 PM
1. The thing about science that these jokers don't understand is that science cannot be vibe-coded.
Whatever its flaws, the point with vibe coding is that you're trying to quickly make something that sorta works, where you can immediately sorta see if it sorta works and then sorta use it.
Whatever its flaws, the point with vibe coding is that you're trying to quickly make something that sorta works, where you can immediately sorta see if it sorta works and then sorta use it.
Reposted by Yamuna Krishnan
I had intended to post something about this new Google DeepMind paper that appeared yesterday in Nature, but the press coverage has added to what there is to say. So this is a long 🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Advancing regulatory variant effect prediction with AlphaGenome - Nature
AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect...
www.nature.com
January 30, 2026 at 9:47 AM
I had intended to post something about this new Google DeepMind paper that appeared yesterday in Nature, but the press coverage has added to what there is to say. So this is a long 🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Yamuna Krishnan
PhD position in my lab!
January 28, 2026 at 5:25 PM
PhD position in my lab!
He just nuked local air travel. Pro tip : buy Zoom stock. Then sell before he changes his mind.
good luck flying, americans
January 30, 2026 at 1:42 AM
He just nuked local air travel. Pro tip : buy Zoom stock. Then sell before he changes his mind.
Reposted by Yamuna Krishnan
it’s fine, we’re not nearly as fucked as we would be if air travel in the United States were organized around a hub and spoke system that relied heavily on regional jets made largely in Canada and furth wait what’s that now
January 30, 2026 at 12:27 AM
it’s fine, we’re not nearly as fucked as we would be if air travel in the United States were organized around a hub and spoke system that relied heavily on regional jets made largely in Canada and furth wait what’s that now
Reposted by Yamuna Krishnan
This is personal too. My next-door neighbor growing up watched Fox, didn’t get vaccinated, and died of COVID.
I’ve heard enough locker room talk in my life that I know the primary problem is not the tone or contents of the msg, but the billionaire-owned media machine that demonized the messengers.
I’ve heard enough locker room talk in my life that I know the primary problem is not the tone or contents of the msg, but the billionaire-owned media machine that demonized the messengers.
That the loss of trust was among Republicans could have been partly due to scientists seeming disrespectful to Republicans, eg. a Fauci & Rogan interaction led Hotez to say "If we fail to embrace our conservative brothers and sisters, and treat them with dignity and respect, we lose as a nation".
January 30, 2026 at 12:43 AM
This is personal too. My next-door neighbor growing up watched Fox, didn’t get vaccinated, and died of COVID.
I’ve heard enough locker room talk in my life that I know the primary problem is not the tone or contents of the msg, but the billionaire-owned media machine that demonized the messengers.
I’ve heard enough locker room talk in my life that I know the primary problem is not the tone or contents of the msg, but the billionaire-owned media machine that demonized the messengers.
Reposted by Yamuna Krishnan
Apple & Google removed ICE tracking apps in their app stores.
TikTok reportedly suppressed videos criticizing ICE & the shooting of Alex Pretti.
Meta blocked Facebook groups tracking ICE & links to a database of agents that the government wants to keep secret.
Big Tech is enabling Trump's regime.
TikTok reportedly suppressed videos criticizing ICE & the shooting of Alex Pretti.
Meta blocked Facebook groups tracking ICE & links to a database of agents that the government wants to keep secret.
Big Tech is enabling Trump's regime.
January 29, 2026 at 8:57 PM
Apple & Google removed ICE tracking apps in their app stores.
TikTok reportedly suppressed videos criticizing ICE & the shooting of Alex Pretti.
Meta blocked Facebook groups tracking ICE & links to a database of agents that the government wants to keep secret.
Big Tech is enabling Trump's regime.
TikTok reportedly suppressed videos criticizing ICE & the shooting of Alex Pretti.
Meta blocked Facebook groups tracking ICE & links to a database of agents that the government wants to keep secret.
Big Tech is enabling Trump's regime.
Reposted by Yamuna Krishnan
New #glycotime discovery from @raflynn5.bsky.social’s lab @bostonchildrens.bsky.social @harvard.edu, cell surface glycoRNA-RBP complexes organized by heparan sulfate PG nanoclusters that modulate VEGF signaling
www.nature.com/articles/s41...
www.nature.com/articles/s41...
GlycoRNA complexed with heparan sulfate regulates VEGF-A signalling - Nature
Heparan sulfate proteoglycans facilitate the assembly of clusters of glycoRNAs and cell surface RNA-binding proteins, which negatively modulate VEGF-A signalling and angiogenesis.
www.nature.com
January 28, 2026 at 5:37 PM
New #glycotime discovery from @raflynn5.bsky.social’s lab @bostonchildrens.bsky.social @harvard.edu, cell surface glycoRNA-RBP complexes organized by heparan sulfate PG nanoclusters that modulate VEGF signaling
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Yamuna Krishnan
Truth is brutal when you are complicit in supporting fascism in any form.
FUCKING BRILLIANT!
Tom Suozzi, 1 of 7 democratic congressman who voted to expand ice funding to 10,000,000,000, was confronted by protesters at a speaking event, and receives a vicious rebuke for betraying his country, his party, his constituents, and everything he claims to stand for.
Tom Suozzi, 1 of 7 democratic congressman who voted to expand ice funding to 10,000,000,000, was confronted by protesters at a speaking event, and receives a vicious rebuke for betraying his country, his party, his constituents, and everything he claims to stand for.
January 29, 2026 at 6:35 AM
Truth is brutal when you are complicit in supporting fascism in any form.
Reposted by Yamuna Krishnan
Reposted by Yamuna Krishnan
We need to talk about the rise of "smol bean fascism" where you have all the guns and the immunity but the really scary people are the ones with whistles and phone cameras and they're giving you generational trauma and ptsd by filming you killing people for no reason
January 28, 2026 at 9:25 PM
We need to talk about the rise of "smol bean fascism" where you have all the guns and the immunity but the really scary people are the ones with whistles and phone cameras and they're giving you generational trauma and ptsd by filming you killing people for no reason
Reposted by Yamuna Krishnan
Early reviews are in:
‘Even if they showed this on a plane, people would still walk out’
‘Even if they showed this on a plane, people would still walk out’
January 28, 2026 at 7:29 AM
Early reviews are in:
‘Even if they showed this on a plane, people would still walk out’
‘Even if they showed this on a plane, people would still walk out’
Listen to this brave veteran. This is real America.
Ian Austin, an Army veteran, was arrested for protesting ICE in Minneapolis. But he’s continued protesting. Senior reporter @julialurie.bsky.social spoke to him.
“When they say, ‘Why would you be out here?’ How the fuck could I not be out here?” he says. “My nation is under attack."
“When they say, ‘Why would you be out here?’ How the fuck could I not be out here?” he says. “My nation is under attack."
January 28, 2026 at 12:24 PM
Listen to this brave veteran. This is real America.
Reposted by Yamuna Krishnan
Ian Austin, an Army veteran, was arrested for protesting ICE in Minneapolis. But he’s continued protesting. Senior reporter @julialurie.bsky.social spoke to him.
“When they say, ‘Why would you be out here?’ How the fuck could I not be out here?” he says. “My nation is under attack."
“When they say, ‘Why would you be out here?’ How the fuck could I not be out here?” he says. “My nation is under attack."
January 27, 2026 at 5:30 PM
Ian Austin, an Army veteran, was arrested for protesting ICE in Minneapolis. But he’s continued protesting. Senior reporter @julialurie.bsky.social spoke to him.
“When they say, ‘Why would you be out here?’ How the fuck could I not be out here?” he says. “My nation is under attack."
“When they say, ‘Why would you be out here?’ How the fuck could I not be out here?” he says. “My nation is under attack."
Reposted by Yamuna Krishnan
Reposted by Yamuna Krishnan
By end of Feb @bsky.app will be the 2nd largest social media source for research sharing in our database
- Google+ managed 945,000 mentions of research during its life
- Facebook pages (not people's profiles) have shared papers 6.6m times
- Reddit = 600k
Bluesky is currently at 6m and climbing
- Google+ managed 945,000 mentions of research during its life
- Facebook pages (not people's profiles) have shared papers 6.6m times
- Reddit = 600k
Bluesky is currently at 6m and climbing
January 28, 2026 at 10:23 AM
By end of Feb @bsky.app will be the 2nd largest social media source for research sharing in our database
- Google+ managed 945,000 mentions of research during its life
- Facebook pages (not people's profiles) have shared papers 6.6m times
- Reddit = 600k
Bluesky is currently at 6m and climbing
- Google+ managed 945,000 mentions of research during its life
- Facebook pages (not people's profiles) have shared papers 6.6m times
- Reddit = 600k
Bluesky is currently at 6m and climbing
Reposted by Yamuna Krishnan
Idiocracy.
www.gravityisgone.com/what-is-a-go...
www.gravityisgone.com/what-is-a-go...
What Is a Government Without Experts?
I think often of a line I came across years ago, when researching presidential science advisors: "Richard Nixon did not want science advising and took steps to be sure he would not get it." This is th...
www.gravityisgone.com
January 28, 2026 at 11:40 AM
Idiocracy.
www.gravityisgone.com/what-is-a-go...
www.gravityisgone.com/what-is-a-go...
Reposted by Yamuna Krishnan
Alex Vindman is running for U.S. Senate in Florida!!
January 27, 2026 at 5:00 PM
Alex Vindman is running for U.S. Senate in Florida!!
Reposted by Yamuna Krishnan
Le Monde's cartoon of the day, by Marco De Angelis.
January 28, 2026 at 2:57 AM
Le Monde's cartoon of the day, by Marco De Angelis.
Reposted by Yamuna Krishnan
Many of our NIH colleagues have signed a letter refusing to let HHS/NIH funding be used as a pawn to continue funding of ICE terrorism. These are people whose paychecks and lives are on the line. Where do you stand? 🧪
www.savehhs.org/letter-we-wi...
www.savehhs.org/letter-we-wi...
Save HHS | Support Public Health – Take Action Now
Save HHS is a collaboration among the National Public Health Coalition, 27 UNIHTED, and countless current and former HHS staff. Join us in calling for public health as a vital government service. The ...
www.savehhs.org
January 26, 2026 at 3:12 PM
Many of our NIH colleagues have signed a letter refusing to let HHS/NIH funding be used as a pawn to continue funding of ICE terrorism. These are people whose paychecks and lives are on the line. Where do you stand? 🧪
www.savehhs.org/letter-we-wi...
www.savehhs.org/letter-we-wi...
Reposted by Yamuna Krishnan
Street art memorializing Alex Pretti in Seattle. Per r/Seattle, it was painted on a building facing Swedish Hospital in the First Hill neighborhood www.reddit.com/r/nursing/co...
January 27, 2026 at 4:01 AM
Street art memorializing Alex Pretti in Seattle. Per r/Seattle, it was painted on a building facing Swedish Hospital in the First Hill neighborhood www.reddit.com/r/nursing/co...
Reposted by Yamuna Krishnan
Biochemist/molecular biologist Joan Steitz was born #OTD in 1941.
She (& team) figured out how our cells read/use genetic instructions to make proteins. A key person who helped crack the code on RNA—the molecule that acts like a messenger between DNA & and the proteins our bodies need. #WomenInSTEM
She (& team) figured out how our cells read/use genetic instructions to make proteins. A key person who helped crack the code on RNA—the molecule that acts like a messenger between DNA & and the proteins our bodies need. #WomenInSTEM
January 26, 2026 at 7:08 PM
Biochemist/molecular biologist Joan Steitz was born #OTD in 1941.
She (& team) figured out how our cells read/use genetic instructions to make proteins. A key person who helped crack the code on RNA—the molecule that acts like a messenger between DNA & and the proteins our bodies need. #WomenInSTEM
She (& team) figured out how our cells read/use genetic instructions to make proteins. A key person who helped crack the code on RNA—the molecule that acts like a messenger between DNA & and the proteins our bodies need. #WomenInSTEM