Yamuna Krishnan
@krishnanyamuna.bsky.social
Organelle maniac, DNA devotee, RNA fanatic, Biology addict. 👩🏽🔬🧬🦠🧪🔬 ORCID: 0000-0001-5282-8852
https://krishnanlab.uchicago.edu/
https://krishnanlab.uchicago.edu/
Pinned
Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
Reposted by Yamuna Krishnan
These are all spectacular, but my favorite is the crab riding the jellyfish. Micromobility for the win!
February 4, 2026 at 9:59 AM
These are all spectacular, but my favorite is the crab riding the jellyfish. Micromobility for the win!
Reposted by Yamuna Krishnan
One by one, Europeans mentioned in the Epstein files who still hold political office are beginning to resign or are being forced out of office.
Meanwhile, ruled by an administration almost entirely made up of Epstein associates, the US carries on as if nothing really happened.
Meanwhile, ruled by an administration almost entirely made up of Epstein associates, the US carries on as if nothing really happened.
February 3, 2026 at 2:39 PM
One by one, Europeans mentioned in the Epstein files who still hold political office are beginning to resign or are being forced out of office.
Meanwhile, ruled by an administration almost entirely made up of Epstein associates, the US carries on as if nothing really happened.
Meanwhile, ruled by an administration almost entirely made up of Epstein associates, the US carries on as if nothing really happened.
Reposted by Yamuna Krishnan
Today is #WorldCancerDay
~1 in 5 people will develop #cancer in their lifetime
Each diagnosis affects not just one person, but families, communities, and futures
Grateful today for patients, clinicians, researchers & advocates - and to appreciate that progress depends on acting together
#WCD2026
~1 in 5 people will develop #cancer in their lifetime
Each diagnosis affects not just one person, but families, communities, and futures
Grateful today for patients, clinicians, researchers & advocates - and to appreciate that progress depends on acting together
#WCD2026
February 4, 2026 at 11:45 AM
Today is #WorldCancerDay
~1 in 5 people will develop #cancer in their lifetime
Each diagnosis affects not just one person, but families, communities, and futures
Grateful today for patients, clinicians, researchers & advocates - and to appreciate that progress depends on acting together
#WCD2026
~1 in 5 people will develop #cancer in their lifetime
Each diagnosis affects not just one person, but families, communities, and futures
Grateful today for patients, clinicians, researchers & advocates - and to appreciate that progress depends on acting together
#WCD2026
Reposted by Yamuna Krishnan
Tomorrow. See you there?
Thinking about remodeling? Mitochondria do that too... and our speaker knows all about it.
This thursday, usual time and place.
See you there?
This thursday, usual time and place.
See you there?
February 4, 2026 at 11:45 AM
Tomorrow. See you there?
Reposted by Yamuna Krishnan
HELL. YEAH.
Give it up for Chicago Mayor Brandon Johnson for putting ICE on notice by signing an order to ensure that trump's violent thugs are held accountable for their aggression.
MORE OF THIS!!!
Give it up for Chicago Mayor Brandon Johnson for putting ICE on notice by signing an order to ensure that trump's violent thugs are held accountable for their aggression.
MORE OF THIS!!!
February 4, 2026 at 4:08 AM
HELL. YEAH.
Give it up for Chicago Mayor Brandon Johnson for putting ICE on notice by signing an order to ensure that trump's violent thugs are held accountable for their aggression.
MORE OF THIS!!!
Give it up for Chicago Mayor Brandon Johnson for putting ICE on notice by signing an order to ensure that trump's violent thugs are held accountable for their aggression.
MORE OF THIS!!!
Reposted by Yamuna Krishnan
I was there too. It was challenging to sit in the room, listening to Bhattacharya alternate between sophistry and outright lies and not be able to correct the record.
But I am told my facial expressions might have done the talking for me. (Oops!) I've never had much of a poker face. :)
But I am told my facial expressions might have done the talking for me. (Oops!) I've never had much of a poker face. :)
I'm on Capitol Hill watching NIH director Jayanta Bhattacharya testify to the Senate HELP committee.
Thankfully I haven't been escorted out of this event (yet). Here's what I'm following. You can also watch live here:
www.help.senate.gov/hearings/mod...
Thankfully I haven't been escorted out of this event (yet). Here's what I'm following. You can also watch live here:
www.help.senate.gov/hearings/mod...
Modernizing the National Institutes of Health: Faster Discoveries, More Cures | The U.S. Senate Committee on Health, Education, Labor & Pensions
Full Committee Hearing on February 3, 2026 at 5:00 AM
www.help.senate.gov
February 3, 2026 at 8:56 PM
I was there too. It was challenging to sit in the room, listening to Bhattacharya alternate between sophistry and outright lies and not be able to correct the record.
But I am told my facial expressions might have done the talking for me. (Oops!) I've never had much of a poker face. :)
But I am told my facial expressions might have done the talking for me. (Oops!) I've never had much of a poker face. :)
Reposted by Yamuna Krishnan
Reposted by Yamuna Krishnan
The bureaucracy of science has grown so much, the system is collapsing upon itself:
Scientists have become administrators of grants rather than spending time on science.
Paid administrators are demanding even more administrative work from scientists.
Administrators are eating the science budget.
Scientists have become administrators of grants rather than spending time on science.
Paid administrators are demanding even more administrative work from scientists.
Administrators are eating the science budget.
February 3, 2026 at 6:52 PM
The bureaucracy of science has grown so much, the system is collapsing upon itself:
Scientists have become administrators of grants rather than spending time on science.
Paid administrators are demanding even more administrative work from scientists.
Administrators are eating the science budget.
Scientists have become administrators of grants rather than spending time on science.
Paid administrators are demanding even more administrative work from scientists.
Administrators are eating the science budget.
Reposted by Yamuna Krishnan
One observation: Several senators brought up terminated grants. Bhattacharya kept saying the agency hasn't cut any funds. That is false.
When he says no funds have been cut, he means NIH spent all its allocated money, as required by law. In fact, a watchdog found NIH illegally impounded funds.
When he says no funds have been cut, he means NIH spent all its allocated money, as required by law. In fact, a watchdog found NIH illegally impounded funds.
February 3, 2026 at 5:23 PM
One observation: Several senators brought up terminated grants. Bhattacharya kept saying the agency hasn't cut any funds. That is false.
When he says no funds have been cut, he means NIH spent all its allocated money, as required by law. In fact, a watchdog found NIH illegally impounded funds.
When he says no funds have been cut, he means NIH spent all its allocated money, as required by law. In fact, a watchdog found NIH illegally impounded funds.
Phew, thank you! My heart rate is back to normal.
There I fixed it
February 3, 2026 at 1:08 PM
Phew, thank you! My heart rate is back to normal.
Reposted by Yamuna Krishnan
MEANWHILE OVER ON TWITTER: He does the Kennedy name proud, and is handling the whole Trump destroying the Kennedy legacy thing much better than I am.
February 2, 2026 at 4:44 AM
MEANWHILE OVER ON TWITTER: He does the Kennedy name proud, and is handling the whole Trump destroying the Kennedy legacy thing much better than I am.
Reposted by Yamuna Krishnan
Important for people to realize that like 30% of all the bad stuff in society is already explicitly illegal it's just not enforced.
Three delivery apps, including UberEats, will pay NYC delivery workers $4.6 million after they violated the city's minimum pay law.
The Mamdani admin will announce the settlement today, which comes after enforcement action taken by the city.
nyc.streetsblog.org/2026/01/30/t...
The Mamdani admin will announce the settlement today, which comes after enforcement action taken by the city.
nyc.streetsblog.org/2026/01/30/t...
The Mamdani Effect: Three Delivery Apps Must Pay $5M In Minimum Pay Settlement - Streetsblog New York City
A new era: Mayor Mamdani's worker protection department announces new enforcement against UberEats, HungryPanda, and Fantuan for not complying with the minimum pay law.
nyc.streetsblog.org
January 30, 2026 at 7:52 PM
Important for people to realize that like 30% of all the bad stuff in society is already explicitly illegal it's just not enforced.
Oof 🤦🏽♀️
February 2, 2026 at 11:10 PM
Oof 🤦🏽♀️
Reposted by Yamuna Krishnan
Forbes 30 under 30 has a better arrest record than the FBI
February 2, 2026 at 8:08 PM
Forbes 30 under 30 has a better arrest record than the FBI
Reposted by Yamuna Krishnan
Congrats, Cornell, and every other university that bowed down to the bully.
The Trump administration is no longer trying to get cash from Harvard as it seeks a settlement. At this point, the White House seems happy to get a signature on anything they can call a compact.
Trump Drops Demand for Cash From Harvard After Stiff Resistance
www.nytimes.com
February 2, 2026 at 10:43 PM
Congrats, Cornell, and every other university that bowed down to the bully.
Reposted by Yamuna Krishnan
Threatening comedians is fascist shit. just FYI.
The president of the United States is personally threatening a comedian for mocking him.
February 2, 2026 at 12:08 PM
Threatening comedians is fascist shit. just FYI.
Reposted by Yamuna Krishnan
Measles has one of the highest basic reproduction numbers (R₀) of any disease (12 to 18), meaning one infected person can spread it to 12 to 18 others in a fully susceptible population, making it extremely contagious. Need 95% vaccination status to achieve herd immunity. Get vaccinated!!
February 1, 2026 at 3:19 PM
Measles has one of the highest basic reproduction numbers (R₀) of any disease (12 to 18), meaning one infected person can spread it to 12 to 18 others in a fully susceptible population, making it extremely contagious. Need 95% vaccination status to achieve herd immunity. Get vaccinated!!
Reposted by Yamuna Krishnan
RIP in peace Researchfish
Elsevier to close controversial Researchfish platform - Research Professional News
Impact-tracking service used by UK Research and Innovation to be shut down by July 2027
www.researchprofessionalnews.com
February 2, 2026 at 9:28 AM
RIP in peace Researchfish
Reposted by Yamuna Krishnan
At 70,000 feet, sealed inside a full pressure suit in the cockpit of a U-2, I made this photograph of Earth. For a brief stretch of time, the only people higher were the astronauts aboard the International Space Station. #SciArt
February 1, 2026 at 3:05 PM
At 70,000 feet, sealed inside a full pressure suit in the cockpit of a U-2, I made this photograph of Earth. For a brief stretch of time, the only people higher were the astronauts aboard the International Space Station. #SciArt
Woah! The ER, mitos and endolysosomes contact make 3-way contact to pinch endolysosomes and form lysosomes!
Check out our newest findings on how #lysosomes are generated from #endolysosomes. Great work from @samit2104.bsky.social ! @biozentrum.unibas.ch , @unibas.ch #cellbio #cell #organelles
Ca2+ and DRP1 drive endocytic lysosome reformation at tripartite contact sites www.biorxiv.org/content/10.6...
Ca2+ and DRP1 drive endocytic lysosome reformation at tripartite contact sites www.biorxiv.org/content/10.6...
Ca2+ and DRP1 drive endocytic lysosome reformation at tripartite contact sites
Lysosomes are essential in maintaining cellular health. Endocytic lysosome reformation (ELR) regenerates functional lysosomes following degradation of endocytic cargo, yet the mechanisms driving this process remain largely unknown. Here, we define the molecular machinery underlying ELR. We find that unlike autophagic lysosome reformation (ALR), ELR proceeds independently of mTOR and dynamin 2, but requires the mitochondrial fission GTPase DRP1. DRP1 mediates scission of endolysosomal tubules at contact sites with the endoplasmic reticulum (ER) and mitochondria. Disruption of DRP1 function or ER endolysosome contact results in elongated tubules, indicating defective lysosome reformation. Moreover, mitochondrial activity is essential for tubule initiation, and Ca2+ transfer from endolysosomes to mitochondria is crucial for ELR onset. Our findings reveal a dual role for mitochondria in ELR: first in ELR initiation and second in DRP1-dependent tubule fission at ER-mitochondria-endolysosome tripartite contact sites, uncovering the previously unappreciated role of mitochondria in endolysosome remodeling and fission. ### Competing Interest Statement The authors have declared no competing interest. Swiss National Science Foundation, 320030-231859, 310030-197779 University of Basel, https://ror.org/02s6k3f65
www.biorxiv.org
February 2, 2026 at 11:53 AM
Woah! The ER, mitos and endolysosomes contact make 3-way contact to pinch endolysosomes and form lysosomes!
Reposted by Yamuna Krishnan
Whenever abuse starts getting exposed in a culture of abuse, the question posed is "where does it all end?" to avoid asking “*how* will we make this end?”
But I'll answer. Where does it end?
It ends when we excise the abusive ice, from hummock to bummock. www.the-reframe.com/where-it-ends/
But I'll answer. Where does it end?
It ends when we excise the abusive ice, from hummock to bummock. www.the-reframe.com/where-it-ends/
Where It Ends
Answering the enabler's constant question, and contemplating the depraved depths of the billionaire mindset.
www.the-reframe.com
February 2, 2026 at 11:06 AM
Whenever abuse starts getting exposed in a culture of abuse, the question posed is "where does it all end?" to avoid asking “*how* will we make this end?”
But I'll answer. Where does it end?
It ends when we excise the abusive ice, from hummock to bummock. www.the-reframe.com/where-it-ends/
But I'll answer. Where does it end?
It ends when we excise the abusive ice, from hummock to bummock. www.the-reframe.com/where-it-ends/
Reposted by Yamuna Krishnan
NEW: What’s happening in the US is TECHNOFASCISM.
It’s fascism + surveillance technologies. Palantir is playing a central role. And the UK is next in line.
My latest for @thenerve.news
1/
www.thenerve.news/p/technofasc...
It’s fascism + surveillance technologies. Palantir is playing a central role. And the UK is next in line.
My latest for @thenerve.news
1/
www.thenerve.news/p/technofasc...
What’s happening in America is technofascism. It could happen here
Peter Thiel's data surveillance company Palantir is powering Trump's ICE operation in the US. Carole Cadwalladr argues that the UK will be next
www.thenerve.news
February 1, 2026 at 2:44 PM
NEW: What’s happening in the US is TECHNOFASCISM.
It’s fascism + surveillance technologies. Palantir is playing a central role. And the UK is next in line.
My latest for @thenerve.news
1/
www.thenerve.news/p/technofasc...
It’s fascism + surveillance technologies. Palantir is playing a central role. And the UK is next in line.
My latest for @thenerve.news
1/
www.thenerve.news/p/technofasc...
Reposted by Yamuna Krishnan
.@neilshubin.bsky.social is a paleontologist, evolutionary biologist, and writer whose work has reshaped how we understand the deep history written into the human body. He is best known for leading the discovery of Tiktaalik, a fossil that illuminated the transition from fish to land animals.
February 1, 2026 at 11:17 PM
.@neilshubin.bsky.social is a paleontologist, evolutionary biologist, and writer whose work has reshaped how we understand the deep history written into the human body. He is best known for leading the discovery of Tiktaalik, a fossil that illuminated the transition from fish to land animals.
Reposted by Yamuna Krishnan
Thinking about remodeling? Mitochondria do that too... and our speaker knows all about it.
This thursday, usual time and place.
See you there?
This thursday, usual time and place.
See you there?
February 2, 2026 at 11:32 AM
Thinking about remodeling? Mitochondria do that too... and our speaker knows all about it.
This thursday, usual time and place.
See you there?
This thursday, usual time and place.
See you there?
Reposted by Yamuna Krishnan
This is truly incredible (and not in a good way).
February 2, 2026 at 1:39 AM
This is truly incredible (and not in a good way).