Yamuna Krishnan
@krishnanyamuna.bsky.social
Organelle maniac, DNA devotee, RNA fanatic, Biology addict. 👩🏽🔬🧬🦠🧪🔬 ORCID: 0000-0001-5282-8852
https://krishnanlab.uchicago.edu/
https://krishnanlab.uchicago.edu/
Pinned
Raphael Rodriguez and I wrote this historical perspective on Next Generation Sequencing by synthesis, because we were both postdocs in Shankar’s lab during the time it was being developed at Solexa…. 1/n🧵 www.nature.com/articles/s41...
Reposted by Yamuna Krishnan
Good news.
Faculty expressing their concerns seems to be having effects.
If you are in academia, make sure your administration knows your views on the compact.
Faculty expressing their concerns seems to be having effects.
If you are in academia, make sure your administration knows your views on the compact.
UNC-Chapel Hill's chancellor says the university will not sign on to a higher education compact from the Trump administration.
www.wunc.org/education/20...
www.wunc.org/education/20...
After faculty raise concerns, UNC-Chapel Hill Chancellor says university will not sign Trump's higher ed compact
Lee Roberts called the "preferential treatment" proposal a clear infringement on academic freedom.
www.wunc.org
November 10, 2025 at 9:42 PM
Good news.
Faculty expressing their concerns seems to be having effects.
If you are in academia, make sure your administration knows your views on the compact.
Faculty expressing their concerns seems to be having effects.
If you are in academia, make sure your administration knows your views on the compact.
Reposted by Yamuna Krishnan
🚨🆕🧪🔬That “wild-type” Nav1.5 variant everyone’s been using may not be so WT after all. Melgari et al. reveal T559A causes loss-of-function ⚡️❌ decades of WT controls weren’t truly WT, time to double-check those studies🧐🧬
#IonChannel #Physiology #Reproducibility
journals.physiology.org/doi/full/10....
#IonChannel #Physiology #Reproducibility
journals.physiology.org/doi/full/10....
November 11, 2025 at 11:46 AM
🚨🆕🧪🔬That “wild-type” Nav1.5 variant everyone’s been using may not be so WT after all. Melgari et al. reveal T559A causes loss-of-function ⚡️❌ decades of WT controls weren’t truly WT, time to double-check those studies🧐🧬
#IonChannel #Physiology #Reproducibility
journals.physiology.org/doi/full/10....
#IonChannel #Physiology #Reproducibility
journals.physiology.org/doi/full/10....
Reposted by Yamuna Krishnan
The Sikhs have it right.
If you show up at a Gurdwara, and ask you get fed. You can show up in a $2,000 suit, no one asks, you just get fed.
To ask that people humble themselves by justifying their need is about the most anti-spiritual and soul crushing thing I can think of.
If you show up at a Gurdwara, and ask you get fed. You can show up in a $2,000 suit, no one asks, you just get fed.
To ask that people humble themselves by justifying their need is about the most anti-spiritual and soul crushing thing I can think of.
November 11, 2025 at 2:11 AM
The Sikhs have it right.
If you show up at a Gurdwara, and ask you get fed. You can show up in a $2,000 suit, no one asks, you just get fed.
To ask that people humble themselves by justifying their need is about the most anti-spiritual and soul crushing thing I can think of.
If you show up at a Gurdwara, and ask you get fed. You can show up in a $2,000 suit, no one asks, you just get fed.
To ask that people humble themselves by justifying their need is about the most anti-spiritual and soul crushing thing I can think of.
Reposted by Yamuna Krishnan
The average SNAP benefit per month is $177 a person.
The average ACA benefit per month is up to $550 a person.
People want us to hold the line for a reason. This is not a matter of appealing to a base. It’s about people’s lives.
And working people want leaders whose word means something to them.
The average ACA benefit per month is up to $550 a person.
People want us to hold the line for a reason. This is not a matter of appealing to a base. It’s about people’s lives.
And working people want leaders whose word means something to them.
November 10, 2025 at 1:49 AM
The average SNAP benefit per month is $177 a person.
The average ACA benefit per month is up to $550 a person.
People want us to hold the line for a reason. This is not a matter of appealing to a base. It’s about people’s lives.
And working people want leaders whose word means something to them.
The average ACA benefit per month is up to $550 a person.
People want us to hold the line for a reason. This is not a matter of appealing to a base. It’s about people’s lives.
And working people want leaders whose word means something to them.
Reposted by Yamuna Krishnan
Mamdani created vision that shamed this cowardice: by having standards, and then showing everyone what his standards are, and then proving that he truly held those standards by standing for something without shame. This tapped into something powerful.
www.the-reframe.com/the-extraord...
www.the-reframe.com/the-extraord...
The Extraordinary Power of Standing For Something
Winning by creating vision in the positive space of shared standards, and expertly negotiating the negative space of shame.
www.the-reframe.com
November 10, 2025 at 11:32 AM
Mamdani created vision that shamed this cowardice: by having standards, and then showing everyone what his standards are, and then proving that he truly held those standards by standing for something without shame. This tapped into something powerful.
www.the-reframe.com/the-extraord...
www.the-reframe.com/the-extraord...
Reposted by Yamuna Krishnan
Tonight was a very bad night.
November 10, 2025 at 3:09 AM
Tonight was a very bad night.
Reposted by Yamuna Krishnan
This is not a deal — it's an empty promise.
Trump and his Republican Congress are making healthcare more expensive for the middle class and ending it for working families.
Time for Democrats to stand tall for affordable healthcare. www.politico.com/news/2025/11...
Trump and his Republican Congress are making healthcare more expensive for the middle class and ending it for working families.
Time for Democrats to stand tall for affordable healthcare. www.politico.com/news/2025/11...
Senate reaches deal on ending the shutdown
Democrats are coalescing around a bipartisan agreement to fund the government.
www.politico.com
November 10, 2025 at 12:50 AM
This is not a deal — it's an empty promise.
Trump and his Republican Congress are making healthcare more expensive for the middle class and ending it for working families.
Time for Democrats to stand tall for affordable healthcare. www.politico.com/news/2025/11...
Trump and his Republican Congress are making healthcare more expensive for the middle class and ending it for working families.
Time for Democrats to stand tall for affordable healthcare. www.politico.com/news/2025/11...
Reposted by Yamuna Krishnan
Keep organizing, y’all. It is, and always has been, on all of us.
• Get connected to the resistance:
www.fiftyfifty.one
• Get trained on noncooperation:
nokings.org/rise
• Get bold for rapid response:
nokings.org/next
• Get engaged in politics:
pol-rev.com
• Get started:
Choosedemocracy.us
• Get connected to the resistance:
www.fiftyfifty.one
• Get trained on noncooperation:
nokings.org/rise
• Get bold for rapid response:
nokings.org/next
• Get engaged in politics:
pol-rev.com
• Get started:
Choosedemocracy.us
November 10, 2025 at 3:55 AM
Keep organizing, y’all. It is, and always has been, on all of us.
• Get connected to the resistance:
www.fiftyfifty.one
• Get trained on noncooperation:
nokings.org/rise
• Get bold for rapid response:
nokings.org/next
• Get engaged in politics:
pol-rev.com
• Get started:
Choosedemocracy.us
• Get connected to the resistance:
www.fiftyfifty.one
• Get trained on noncooperation:
nokings.org/rise
• Get bold for rapid response:
nokings.org/next
• Get engaged in politics:
pol-rev.com
• Get started:
Choosedemocracy.us
Reposted by Yamuna Krishnan
To which I will reply “sorry, all of my donation money will now be going to my healthcare premiums”
November 10, 2025 at 3:41 AM
To which I will reply “sorry, all of my donation money will now be going to my healthcare premiums”
Reposted by Yamuna Krishnan
Unacceptable. There are 189,000 people in my district who will be paying 50–300% more for the same, and in many cases worse, healthcare.
I won’t do that to the people I represent. I’m a NO on this “deal.”
I won’t do that to the people I represent. I’m a NO on this “deal.”
November 9, 2025 at 9:47 PM
Unacceptable. There are 189,000 people in my district who will be paying 50–300% more for the same, and in many cases worse, healthcare.
I won’t do that to the people I represent. I’m a NO on this “deal.”
I won’t do that to the people I represent. I’m a NO on this “deal.”
Reposted by Yamuna Krishnan
Reposted by Yamuna Krishnan
I've definitely worked my butt off, but I have benefitted from 'younger sibling' status throughout my life and career. Growing up, my older brother trailblazed and I learned from his successes and failures, and jumped on any resources he built on his journey. 1/3
November 9, 2025 at 8:34 PM
I've definitely worked my butt off, but I have benefitted from 'younger sibling' status throughout my life and career. Growing up, my older brother trailblazed and I learned from his successes and failures, and jumped on any resources he built on his journey. 1/3
Reposted by Yamuna Krishnan
Jeremy, I have followed your science advocacy on this platform with respect, but I find this thread deeply hurtful and sad and I am going to tell you why. While my wife did her postdoc at CSHL, she and our many dear friends had to endure the racist rhetoric of this man, which did constant harm
On one evening, the speakers were divided up and went to dinner parties hosted by some of the wealthy folks who lived around Cold Spring Harbor on Long Island. My dinner was delightful, with good conversation with our host (the mayor of a nearby village), his friends, and some other speakers.
34/41
34/41
November 8, 2025 at 5:15 PM
Jeremy, I have followed your science advocacy on this platform with respect, but I find this thread deeply hurtful and sad and I am going to tell you why. While my wife did her postdoc at CSHL, she and our many dear friends had to endure the racist rhetoric of this man, which did constant harm
I lost so many uncles/grand uncles to early AM heart attacks that my family used to dread early morning phone calls. Always wondered if there was a connection. Amazing finding 👇🏽
🚨🆕🧪🔬on 💓🕒 Delisle et al. 😉show the circadian clock gene BMAL1 drives sex-specific daily patterns in cardiac ion channels ⚡️❤️🔥 in 🐭, shaping when arrhythmias may strike in males vs females 🧠➡️❤️
#Circadian #Physiology #Heart #Arrhythmia #Sex #Science #Cardiosky
www.sciencedirect.com/science/arti...
#Circadian #Physiology #Heart #Arrhythmia #Sex #Science #Cardiosky
www.sciencedirect.com/science/arti...
BMAL1 mediates sex-specific circadian regulation of cardiac ion channels and temporal arrhythmia vulnerability
www.sciencedirect.com
November 9, 2025 at 1:59 PM
I lost so many uncles/grand uncles to early AM heart attacks that my family used to dread early morning phone calls. Always wondered if there was a connection. Amazing finding 👇🏽
Reposted by Yamuna Krishnan
'She certainly felt insulted when she found that the main dining room at King's, where scientists would meet for discussions over lunch or coffee, was open only to men; this un-Parisian attitude was hard to take even if not unusual in English colleges at the time.'
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
November 9, 2025 at 9:08 AM
'She certainly felt insulted when she found that the main dining room at King's, where scientists would meet for discussions over lunch or coffee, was open only to men; this un-Parisian attitude was hard to take even if not unusual in English colleges at the time.'
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Reposted by Yamuna Krishnan
Beating iPSC-derived heart muscle cells videoed through a microscope. Alpha-actinin-2 is shown. #CellBiology
November 9, 2025 at 3:12 AM
Beating iPSC-derived heart muscle cells videoed through a microscope. Alpha-actinin-2 is shown. #CellBiology
Reposted by Yamuna Krishnan
As a new Assistant Professor at the University Chicago in 2001 I was excited to hear Watson give a lecture on campus. 10 mins in, I was so mortified by his blatant mysogyny and racism I walked out, leaving from the front seats. Outrageous. Deplorable. Should never have been given a platform.
I read this book when I was 15 and fell in love with DNA. I re-read it at 32 with lived experience in Science and it filled me with rage. I cannot pick up that book now. It reveals what women were/are up against.
Based on his self-described behavior in The Double Helix and these actions it is easy and appropriate to write him off as an ignorant jerk.
38/41
38/41
November 9, 2025 at 3:15 AM
As a new Assistant Professor at the University Chicago in 2001 I was excited to hear Watson give a lecture on campus. 10 mins in, I was so mortified by his blatant mysogyny and racism I walked out, leaving from the front seats. Outrageous. Deplorable. Should never have been given a platform.
Reposted by Yamuna Krishnan
People might not realize - this wasn’t just one problematic person. He was (and is) influential. And this has real consequences.
“Female scientists who have kids can’t be taken seriously” and many other jabs at women have been directly said to me, within the last decade, by other scientists.
“Female scientists who have kids can’t be taken seriously” and many other jabs at women have been directly said to me, within the last decade, by other scientists.
I read this book when I was 15 and fell in love with DNA. I re-read it at 32 with lived experience in Science and it filled me with rage. I cannot pick up that book now. It reveals what women were/are up against.
Based on his self-described behavior in The Double Helix and these actions it is easy and appropriate to write him off as an ignorant jerk.
38/41
38/41
November 8, 2025 at 6:02 PM
People might not realize - this wasn’t just one problematic person. He was (and is) influential. And this has real consequences.
“Female scientists who have kids can’t be taken seriously” and many other jabs at women have been directly said to me, within the last decade, by other scientists.
“Female scientists who have kids can’t be taken seriously” and many other jabs at women have been directly said to me, within the last decade, by other scientists.
Reposted by Yamuna Krishnan
Just need everyone to Google the name "Rosalind Franklin" at this moment.
Hey folks, as news of Watson's demise spreads, please don't set aside his weighty legacy of misogyny and racism. He was truly among the worst of us. www.vox.com/2019/1/15/18...
DNA scientist James Watson has a remarkably long history of sexist, racist public comments
“People say it would be terrible if we made all girls pretty,” he said in 2003. “I think it would be great.”
www.vox.com
November 7, 2025 at 8:19 PM
Just need everyone to Google the name "Rosalind Franklin" at this moment.
Reposted by Yamuna Krishnan
Hey folks, as news of Watson's demise spreads, please don't set aside his weighty legacy of misogyny and racism. He was truly among the worst of us. www.vox.com/2019/1/15/18...
DNA scientist James Watson has a remarkably long history of sexist, racist public comments
“People say it would be terrible if we made all girls pretty,” he said in 2003. “I think it would be great.”
www.vox.com
November 7, 2025 at 7:45 PM
Hey folks, as news of Watson's demise spreads, please don't set aside his weighty legacy of misogyny and racism. He was truly among the worst of us. www.vox.com/2019/1/15/18...
Reposted by Yamuna Krishnan
Scientific breakthroughs are rarely unique; someone else would’ve made them soon enough. But when prominent scientists cause harm, that harm isn’t inevitable; the world might simply have been better had the harm not been inflicted.
liorpachter.wordpress.com/2018/05/18/j...
liorpachter.wordpress.com/2018/05/18/j...
James Watson in his own words
“Some anti-Semitism is justified” “Whenever you interview fat people, you feel bad, because you know you’re not going to hire them” “Japan should be bombed for d…
liorpachter.wordpress.com
November 8, 2025 at 4:29 AM
Scientific breakthroughs are rarely unique; someone else would’ve made them soon enough. But when prominent scientists cause harm, that harm isn’t inevitable; the world might simply have been better had the harm not been inflicted.
liorpachter.wordpress.com/2018/05/18/j...
liorpachter.wordpress.com/2018/05/18/j...
I read this book when I was 15 and fell in love with DNA. I re-read it at 32 with lived experience in Science and it filled me with rage. I cannot pick up that book now. It reveals what women were/are up against.
Based on his self-described behavior in The Double Helix and these actions it is easy and appropriate to write him off as an ignorant jerk.
38/41
38/41
November 8, 2025 at 2:21 PM
I read this book when I was 15 and fell in love with DNA. I re-read it at 32 with lived experience in Science and it filled me with rage. I cannot pick up that book now. It reveals what women were/are up against.
Reposted by Yamuna Krishnan
Weekend reading: Where America stands, one year after Trump’s election.
A fascistic movement controls the government; they are trying to build an authoritarian state; but they have not consolidated authoritarian rule.
A democracy no more, but not a stable autocratic regime yet.
This week’s piece:
A fascistic movement controls the government; they are trying to build an authoritarian state; but they have not consolidated authoritarian rule.
A democracy no more, but not a stable autocratic regime yet.
This week’s piece:
Escalation, Authoritarian “Normalization,” or a Democratic Turnaround?
One year after the election: What we can say with certainty about the state of the Trumpist assault, where uncertainty lies, and where America might go from here
steady.page
November 8, 2025 at 2:03 PM
Weekend reading: Where America stands, one year after Trump’s election.
A fascistic movement controls the government; they are trying to build an authoritarian state; but they have not consolidated authoritarian rule.
A democracy no more, but not a stable autocratic regime yet.
This week’s piece:
A fascistic movement controls the government; they are trying to build an authoritarian state; but they have not consolidated authoritarian rule.
A democracy no more, but not a stable autocratic regime yet.
This week’s piece:
Reposted by Yamuna Krishnan
Reposted by Yamuna Krishnan
Congratulations to our two NOMIS & Science Grand Prize Winners @rachitdubey.bsky.social and Jiacheng Miao whose essays just published in @science.org
www.science.org/content/page...
www.science.org/content/page...
November 7, 2025 at 12:00 PM
Congratulations to our two NOMIS & Science Grand Prize Winners @rachitdubey.bsky.social and Jiacheng Miao whose essays just published in @science.org
www.science.org/content/page...
www.science.org/content/page...