Vanni Lab at UNIFR, Switzerland
@labvanni.bsky.social
Computational biophysics and other amenities...
"More thinking and less pipetting"
"More thinking and less pipetting"
Pinned
Happy to share the latest work from the lab, led by @mudgal17.bsky.social, in collaboration with the Weis lab @ethzurich.bsky.social.
How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)
How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)
Reposted by Vanni Lab at UNIFR, Switzerland
Join us for the 2026 Glycolipid & Sphingolipid Biology Gordon Research Conference (GRC).
📍 Renaissance Tuscany Il Ciocco (Italy)
🗓️ March 22 - 27, 2026
Theme: "Molecular Codes of Cell Identity and Recognition"
#LipidResearch #Sphingolipids #GRC2026 #ScienceConference #Lipidtime
📍 Renaissance Tuscany Il Ciocco (Italy)
🗓️ March 22 - 27, 2026
Theme: "Molecular Codes of Cell Identity and Recognition"
#LipidResearch #Sphingolipids #GRC2026 #ScienceConference #Lipidtime
December 19, 2025 at 9:09 AM
Join us for the 2026 Glycolipid & Sphingolipid Biology Gordon Research Conference (GRC).
📍 Renaissance Tuscany Il Ciocco (Italy)
🗓️ March 22 - 27, 2026
Theme: "Molecular Codes of Cell Identity and Recognition"
#LipidResearch #Sphingolipids #GRC2026 #ScienceConference #Lipidtime
📍 Renaissance Tuscany Il Ciocco (Italy)
🗓️ March 22 - 27, 2026
Theme: "Molecular Codes of Cell Identity and Recognition"
#LipidResearch #Sphingolipids #GRC2026 #ScienceConference #Lipidtime
Reposted by Vanni Lab at UNIFR, Switzerland
Join us for a two-and-a-half-day meeting in the scenic Wye Valley, to discuss how membrane contact sites shape cellular homeostasis across organelles, organisms, and approaches.
📍 Chepstow, South Wales, UK | 🗓️ 28–30 September 2026
👉 :
www.eventsforce.net/biochemsoc/f...
📍 Chepstow, South Wales, UK | 🗓️ 28–30 September 2026
👉 :
www.eventsforce.net/biochemsoc/f...
December 19, 2025 at 3:12 PM
Join us for a two-and-a-half-day meeting in the scenic Wye Valley, to discuss how membrane contact sites shape cellular homeostasis across organelles, organisms, and approaches.
📍 Chepstow, South Wales, UK | 🗓️ 28–30 September 2026
👉 :
www.eventsforce.net/biochemsoc/f...
📍 Chepstow, South Wales, UK | 🗓️ 28–30 September 2026
👉 :
www.eventsforce.net/biochemsoc/f...
Reposted by Vanni Lab at UNIFR, Switzerland
TT in Experimental Biophysics
The Danish Institute for Advanced Study and the Dept of Physics, Chemistry and Pharmacy at the University of Southern Denmark is hiring a tenure track Assistant Professor in Biophysics or a related discipline
fa-eosd-saasfaprod1.fa.ocs.oraclecloud.com/hcmUI/Candid...
The Danish Institute for Advanced Study and the Dept of Physics, Chemistry and Pharmacy at the University of Southern Denmark is hiring a tenure track Assistant Professor in Biophysics or a related discipline
fa-eosd-saasfaprod1.fa.ocs.oraclecloud.com/hcmUI/Candid...
DIAS Fellow in Experimental Biophysics
The Danish Institute for Advanced Study (DIAS) and the Department of Physics, Chemistry and Pharmacy (FKF) at the University of Southern Denmark (SDU) seek an excellent candidate to fill a tenure trac...
fa-eosd-saasfaprod1.fa.ocs.oraclecloud.com
December 6, 2025 at 7:40 PM
TT in Experimental Biophysics
The Danish Institute for Advanced Study and the Dept of Physics, Chemistry and Pharmacy at the University of Southern Denmark is hiring a tenure track Assistant Professor in Biophysics or a related discipline
fa-eosd-saasfaprod1.fa.ocs.oraclecloud.com/hcmUI/Candid...
The Danish Institute for Advanced Study and the Dept of Physics, Chemistry and Pharmacy at the University of Southern Denmark is hiring a tenure track Assistant Professor in Biophysics or a related discipline
fa-eosd-saasfaprod1.fa.ocs.oraclecloud.com/hcmUI/Candid...
Reposted by Vanni Lab at UNIFR, Switzerland
The Frankfurt Institute for Advanced Studies (FIAS) and the newly funded Cluster of Excellence SCALE are seeking several Independent Research Group Leaders to drive theoretical and computational research in molecular and cellular life science.
fias.institute/de/das-fias/...
fias.institute/de/das-fias/...
Independent Research Group Leaders (f/m/d) SCALE / FIAS
fias.institute
December 5, 2025 at 5:30 PM
The Frankfurt Institute for Advanced Studies (FIAS) and the newly funded Cluster of Excellence SCALE are seeking several Independent Research Group Leaders to drive theoretical and computational research in molecular and cellular life science.
fias.institute/de/das-fias/...
fias.institute/de/das-fias/...
Reposted by Vanni Lab at UNIFR, Switzerland
Happy to share our cryoEM Ensemble Optimization method! 🎉It infers optimal structures and their weights directly from individual cryoEM images - no maps just physics! with David Sliva-Sánchez, @erikhthiede.bsky.social & Roy Lederman www.biorxiv.org/content/10.6...
Cryo-electron microscopy ensemble optimization using individual particles and physical constraints
Biomolecules are inherently dynamic, and understanding their conformational ensemble distributions is essential for understanding their dynamics and biological roles. Cryo-electron microscopy (cryo-EM...
www.biorxiv.org
December 5, 2025 at 4:13 PM
Happy to share our cryoEM Ensemble Optimization method! 🎉It infers optimal structures and their weights directly from individual cryoEM images - no maps just physics! with David Sliva-Sánchez, @erikhthiede.bsky.social & Roy Lederman www.biorxiv.org/content/10.6...
This is an exciting story! Happy to have contributed a little with @mudgal17.bsky.social. So many things we don't (yet) understand in membrane biology...
New preprint from the lab!!🎉
We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments?
www.biorxiv.org/content/10.1...
We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments?
www.biorxiv.org/content/10.1...
Molecular basis for cellular compartmentalization by an ancient membrane fission mechanism
The emergence of cell compartmentalization depends on membrane fission to create the endomembrane compartments. In eukaryotes, membrane fission is commonly executed by ESCRT-III, a protein complex con...
www.biorxiv.org
December 1, 2025 at 12:43 PM
This is an exciting story! Happy to have contributed a little with @mudgal17.bsky.social. So many things we don't (yet) understand in membrane biology...
Thrilled to share that the work from @cristianrocharoa.bsky.social, identifying TMEM170 proteins as lipid scramblases that associate with bridge lipid transporters, is now out in @natsmb.nature.com
Unexpectedly, the scrambling pathway does not "feed" directly into the BLTP cavity...
rdcu.be/eRSst
Unexpectedly, the scrambling pathway does not "feed" directly into the BLTP cavity...
rdcu.be/eRSst
November 26, 2025 at 5:01 PM
Thrilled to share that the work from @cristianrocharoa.bsky.social, identifying TMEM170 proteins as lipid scramblases that associate with bridge lipid transporters, is now out in @natsmb.nature.com
Unexpectedly, the scrambling pathway does not "feed" directly into the BLTP cavity...
rdcu.be/eRSst
Unexpectedly, the scrambling pathway does not "feed" directly into the BLTP cavity...
rdcu.be/eRSst
Reposted by Vanni Lab at UNIFR, Switzerland
Thrilled to share our latest work showing that the bridge lipid transport protein ATG2A transfers diacylglycerol (DAG), and some TAG/PA, from the ER to LDs, thereby recruiting DGAT2 to drive local TAG synthesis, promoting LD expansion while protecting ER membranes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth - Nature Structural & Molecular Biology
Elhan et al. show that ATG2A acts with DGAT2, the enzyme producing triacylglycerol (TAG), in lipid droplet growth. By delivering diacylglycerol to lipid droplets, ATG2A not only fuels TAG production b...
www.nature.com
November 17, 2025 at 10:57 PM
Thrilled to share our latest work showing that the bridge lipid transport protein ATG2A transfers diacylglycerol (DAG), and some TAG/PA, from the ER to LDs, thereby recruiting DGAT2 to drive local TAG synthesis, promoting LD expansion while protecting ER membranes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Vanni Lab at UNIFR, Switzerland
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
November 10, 2025 at 1:26 PM
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Reposted by Vanni Lab at UNIFR, Switzerland
**Job Alert** Exciting postdoc position available: theoretical and experimental cryo-EM studies of flexible biomolecules. Competitive salary, collaborative environment at NYSBC and Flatiron Institute. Please share!! and contact: pcossio@flatironinstitute.org
October 22, 2025 at 2:55 PM
**Job Alert** Exciting postdoc position available: theoretical and experimental cryo-EM studies of flexible biomolecules. Competitive salary, collaborative environment at NYSBC and Flatiron Institute. Please share!! and contact: pcossio@flatironinstitute.org
Reposted by Vanni Lab at UNIFR, Switzerland
We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
October 20, 2025 at 11:26 AM
We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
Reposted by Vanni Lab at UNIFR, Switzerland
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
October 17, 2025 at 2:56 PM
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
Reposted by Vanni Lab at UNIFR, Switzerland
🚨🚨🚨 We are launching the 2nd application round for the Erasmus Mundus Joint Master’s Program MemBioMed, offering cutting-edge training on exploring the complex behavior of cellular membranes & unlocking their therapeutic potential. Students can apply here: life.univ-cotedazur.eu/internationa...
October 17, 2025 at 3:18 PM
🚨🚨🚨 We are launching the 2nd application round for the Erasmus Mundus Joint Master’s Program MemBioMed, offering cutting-edge training on exploring the complex behavior of cellular membranes & unlocking their therapeutic potential. Students can apply here: life.univ-cotedazur.eu/internationa...
Thanks to @snsf.ch, we are hiring two PhD students to investigate frontier topics in lipid biology using a combination of MD simulations and experiments. Preferred starting date: ASAP. Fribourg - and Switzerland - are quite nice, for both work and private life! Please spread the word!
October 13, 2025 at 2:17 PM
Thanks to @snsf.ch, we are hiring two PhD students to investigate frontier topics in lipid biology using a combination of MD simulations and experiments. Preferred starting date: ASAP. Fribourg - and Switzerland - are quite nice, for both work and private life! Please spread the word!
Reposted by Vanni Lab at UNIFR, Switzerland
Please spread the word! 10 days left to apply for this #sciencejobs as Assistant Professor Tenure Track in Quantitative Cell Biology 👩🔬
@izb-unibern.bsky.social @unibe.ch! ohws.prospective.ch/public/v1/jo...
#QueerInSTEM #DisabledInSTEM #BlackInSTEM #WomenInSTEM #CarersInSTEM #AcademicSky #HigherED
@izb-unibern.bsky.social @unibe.ch! ohws.prospective.ch/public/v1/jo...
#QueerInSTEM #DisabledInSTEM #BlackInSTEM #WomenInSTEM #CarersInSTEM #AcademicSky #HigherED
Uni Bern: Assistant Professor with tenure-track for Quantitative Cell Biology
Start date of employment: anticipated for August 2027
ohws.prospective.ch
October 7, 2025 at 11:17 AM
Please spread the word! 10 days left to apply for this #sciencejobs as Assistant Professor Tenure Track in Quantitative Cell Biology 👩🔬
@izb-unibern.bsky.social @unibe.ch! ohws.prospective.ch/public/v1/jo...
#QueerInSTEM #DisabledInSTEM #BlackInSTEM #WomenInSTEM #CarersInSTEM #AcademicSky #HigherED
@izb-unibern.bsky.social @unibe.ch! ohws.prospective.ch/public/v1/jo...
#QueerInSTEM #DisabledInSTEM #BlackInSTEM #WomenInSTEM #CarersInSTEM #AcademicSky #HigherED
Reposted by Vanni Lab at UNIFR, Switzerland
This is an really amazing opportunity. If you get it, you can essentially pick you institute. The package really is rather competitive.
Springboard for an international scientific career! 🧬🧪🔭⚛️🧠🌱 Call for #MaxPlanckResearchGroups launched; applications are possible until October 14, 2025 www.mpg.de/max-planck-r... #ScienceCareer
September 10, 2025 at 4:56 AM
This is an really amazing opportunity. If you get it, you can essentially pick you institute. The package really is rather competitive.
Reposted by Vanni Lab at UNIFR, Switzerland
Job alert 📣 Our faculty looks for a Junior Professor W1 with tt to W2 in Membrane Biology! We are looking for #ECRs working on membrane biogenesis,contact sites,composition & other aspects of membranes in 🌱 and other organisms! DM me if you need more details!
jobs.ruhr-uni-bochum.de/jobposting/f...
jobs.ruhr-uni-bochum.de/jobposting/f...
W1TTW2 Professorship in Membrane Biology (m/f/d)
jobs.ruhr-uni-bochum.de
August 22, 2025 at 1:47 PM
Job alert 📣 Our faculty looks for a Junior Professor W1 with tt to W2 in Membrane Biology! We are looking for #ECRs working on membrane biogenesis,contact sites,composition & other aspects of membranes in 🌱 and other organisms! DM me if you need more details!
jobs.ruhr-uni-bochum.de/jobposting/f...
jobs.ruhr-uni-bochum.de/jobposting/f...
Reposted by Vanni Lab at UNIFR, Switzerland
Ne manquez pas le 20e GERLI International Lipid Meeting, Strasbourg, 3-5 nov 2025
Rejoignez chercheurs et experts pour explorer les dernières avancées en biologie des lipides, assistez à des conférences, posters et prix scientifiques !
Plus d'info : : www.gerli.com/congres/welc...
Rejoignez chercheurs et experts pour explorer les dernières avancées en biologie des lipides, assistez à des conférences, posters et prix scientifiques !
Plus d'info : : www.gerli.com/congres/welc...
August 21, 2025 at 10:03 AM
Ne manquez pas le 20e GERLI International Lipid Meeting, Strasbourg, 3-5 nov 2025
Rejoignez chercheurs et experts pour explorer les dernières avancées en biologie des lipides, assistez à des conférences, posters et prix scientifiques !
Plus d'info : : www.gerli.com/congres/welc...
Rejoignez chercheurs et experts pour explorer les dernières avancées en biologie des lipides, assistez à des conférences, posters et prix scientifiques !
Plus d'info : : www.gerli.com/congres/welc...
Reposted by Vanni Lab at UNIFR, Switzerland
We are hiring!
If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland!
More information on www.epfl.ch/labs/gr-schu...
If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland!
More information on www.epfl.ch/labs/gr-schu...
Open positions
GR-SCHUHMACHER
www.epfl.ch
August 12, 2025 at 9:32 AM
We are hiring!
If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland!
More information on www.epfl.ch/labs/gr-schu...
If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland!
More information on www.epfl.ch/labs/gr-schu...
Happy to share the latest from the lab, led by Daniel Alvarez, in collaboration with @lizconibear.bsky.social. In this AA-MD tour-de-force, we delve deep into the mechanism and energetics of lipid uptake by bridge-like lipid transfer proteins, and we learn a few interesting things along the way...
August 7, 2025 at 8:45 AM
Happy to share the latest from the lab, led by Daniel Alvarez, in collaboration with @lizconibear.bsky.social. In this AA-MD tour-de-force, we delve deep into the mechanism and energetics of lipid uptake by bridge-like lipid transfer proteins, and we learn a few interesting things along the way...
Happy to share the latest work from the lab, led by @mudgal17.bsky.social, in collaboration with the Weis lab @ethzurich.bsky.social.
How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)
How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)
July 23, 2025 at 11:40 AM
Happy to share the latest work from the lab, led by @mudgal17.bsky.social, in collaboration with the Weis lab @ethzurich.bsky.social.
How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)
How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)
Reposted by Vanni Lab at UNIFR, Switzerland
Hey there!✨I’m thrilled to share that our latest research, in collaboration with the Tontonoz Lab (UCLA), has just been published in Nature Metabolism. Our study explores the fascinating role of polyunsaturated fatty acids in fat storage. Check it out!
@labvanni.bsky.social
@natmetabolism.nature.com
@labvanni.bsky.social
@natmetabolism.nature.com
July 1, 2025 at 4:30 PM
Hey there!✨I’m thrilled to share that our latest research, in collaboration with the Tontonoz Lab (UCLA), has just been published in Nature Metabolism. Our study explores the fascinating role of polyunsaturated fatty acids in fat storage. Check it out!
@labvanni.bsky.social
@natmetabolism.nature.com
@labvanni.bsky.social
@natmetabolism.nature.com
Reposted by Vanni Lab at UNIFR, Switzerland
I am looking to hire a protein #biochemist, #biophysicist or structural biologist: efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
- 2-year position working on lipid transport proteins.
- Experience in protein expression, purification and biochemical and biophysical assay development.
Please share!
- 2-year position working on lipid transport proteins.
- Experience in protein expression, purification and biochemical and biophysical assay development.
Please share!
Postdoctoral fellowship in protein biochemistry and biophysics - DTU Chemistry
Do you want to contribute to an exciting chemical biology project? This postdoctoral fellowship deals with the synthesis of probes aimed at studying cholesterol transport proteins in health and diseas...
efzu.fa.em2.oraclecloud.com
June 23, 2025 at 12:40 PM
I am looking to hire a protein #biochemist, #biophysicist or structural biologist: efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
- 2-year position working on lipid transport proteins.
- Experience in protein expression, purification and biochemical and biophysical assay development.
Please share!
- 2-year position working on lipid transport proteins.
- Experience in protein expression, purification and biochemical and biophysical assay development.
Please share!
Reposted by Vanni Lab at UNIFR, Switzerland
Learn about #LipidDroplet #biology, their role in human disease and more at EMBO Workshop "Lipid Droplets: Cell-Biological Control of #Metabolism" in Sant Feliu de Guíxols, Spain, 21–26 September 2025
Deadline: 10 June 2025
meetings.embo.org/event/25-lip...
#EMBOlipidDroplets #EMBOevents 🧪
Deadline: 10 June 2025
meetings.embo.org/event/25-lip...
#EMBOlipidDroplets #EMBOevents 🧪
Lipid Droplets: Cell-Biological Control of Metabolism
Lipid droplets are master regulators of nutrient and energy homeostasis, but their functions go far beyond these classical roles: They are important in cellular differentiation and various stress res…
meetings.embo.org
June 4, 2025 at 6:14 AM
Learn about #LipidDroplet #biology, their role in human disease and more at EMBO Workshop "Lipid Droplets: Cell-Biological Control of #Metabolism" in Sant Feliu de Guíxols, Spain, 21–26 September 2025
Deadline: 10 June 2025
meetings.embo.org/event/25-lip...
#EMBOlipidDroplets #EMBOevents 🧪
Deadline: 10 June 2025
meetings.embo.org/event/25-lip...
#EMBOlipidDroplets #EMBOevents 🧪
Reposted by Vanni Lab at UNIFR, Switzerland
Cette année le @cnrs.fr ouvre une Chaire de Professeur Junior "Méthodes de modélisation et simulations moléculaires" pour rejoindre à labo à Toulouse (@laascnrs.bsky.social), Palaiseau (LIX) ou Nancy (LORIA), vous avez jusqu'au 14 juillet pour candidater !
emploi.cnrs.fr/Offres/CPJ/C...
emploi.cnrs.fr/Offres/CPJ/C...
Portail Emploi CNRS - Offre d'emploi - Méthodes de modélisation et de simulation moléculaire H/F
emploi.cnrs.fr
May 26, 2025 at 11:47 AM
Cette année le @cnrs.fr ouvre une Chaire de Professeur Junior "Méthodes de modélisation et simulations moléculaires" pour rejoindre à labo à Toulouse (@laascnrs.bsky.social), Palaiseau (LIX) ou Nancy (LORIA), vous avez jusqu'au 14 juillet pour candidater !
emploi.cnrs.fr/Offres/CPJ/C...
emploi.cnrs.fr/Offres/CPJ/C...