Roberto Covino
@rocovino.bsky.social
Professor of Computational Life Science at Goethe University Frankfurt. Computer simulations of biomolecular systems, statistical modeling, and machine learning.
Crystal packing affects protein dynamics - super interesting!
📢 New preprint: Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.
We addressed a long-standing question that people debated already in the 1970s - but it still remained open:
Do proteins in crystals move as they do in solution? We used ring flips to find out.
1/n
We addressed a long-standing question that people debated already in the 1970s - but it still remained open:
Do proteins in crystals move as they do in solution? We used ring flips to find out.
1/n
August 25, 2025 at 6:04 AM
Crystal packing affects protein dynamics - super interesting!
Amazing work!!
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 21, 2025 at 5:55 AM
Amazing work!!
Reposted by Roberto Covino
On this day in 1184, this happened: Erfurt latrine disaster — en.wikipedia.org/wiki/Erfurt_...
Erfurt latrine disaster - Wikipedia
en.wikipedia.org
July 26, 2025 at 5:13 PM
On this day in 1184, this happened: Erfurt latrine disaster — en.wikipedia.org/wiki/Erfurt_...
Reposted by Roberto Covino
Are you passionate about AI for molecular engineering? Just two weeks left to apply to the 2 PhD positions currently open in our team at Chalmers! 🎓
For details: ailab.bio/join-us
For details: ailab.bio/join-us
🚨 We are currently recruiting 2 PhD students to join our team at Chalmers, which you can learn more about on our team website: ailab.bio/join-us
Details in thread below! (1/5)
Details in thread below! (1/5)
July 7, 2025 at 7:29 AM
Are you passionate about AI for molecular engineering? Just two weeks left to apply to the 2 PhD positions currently open in our team at Chalmers! 🎓
For details: ailab.bio/join-us
For details: ailab.bio/join-us
If you are interested in glycans e how they modulate the function of other biomolecules this is the CECAM meeting to be! Look at the lineup of speakers! And the location is also not too bad :P Registrations are open until 30/06/25 at www.cecam.org/workshop-det...
June 9, 2025 at 11:55 PM
If you are interested in glycans e how they modulate the function of other biomolecules this is the CECAM meeting to be! Look at the lineup of speakers! And the location is also not too bad :P Registrations are open until 30/06/25 at www.cecam.org/workshop-det...
Reposted by Roberto Covino
Reposted by Roberto Covino
🚀 Zwei neue #Exzellenzcluster für die #GoetheUni! Mit @scale-cluster-ffm.bsky.social & @cpi-exstra.bsky.social wird Frankfurt ab 2026 zum Hotspot für Zell- & Gesundheitsforschung. Nächster Schritt: Exzellenzverbund @rheinmainunis.bsky.social mit @unimainz.bsky.social & @tuda.bsky.social.
May 22, 2025 at 3:30 PM
🚀 Zwei neue #Exzellenzcluster für die #GoetheUni! Mit @scale-cluster-ffm.bsky.social & @cpi-exstra.bsky.social wird Frankfurt ab 2026 zum Hotspot für Zell- & Gesundheitsforschung. Nächster Schritt: Exzellenzverbund @rheinmainunis.bsky.social mit @unimainz.bsky.social & @tuda.bsky.social.
Reposted by Roberto Covino
🧬PSB Symposium on " #MachineLearning in Cellular #StructuralBiology ", EPN Campus Grenoble, France, 26-27 June 2025🧬
📢Reminder - Call for abstracts (posters & short talks)
Submission & registration deadline 25 May: www.psb-grenoble.eu/psbsymposium...
@esrf.fr @embl.org @illneutrons.bsky.social
📢Reminder - Call for abstracts (posters & short talks)
Submission & registration deadline 25 May: www.psb-grenoble.eu/psbsymposium...
@esrf.fr @embl.org @illneutrons.bsky.social
May 9, 2025 at 10:38 AM
🧬PSB Symposium on " #MachineLearning in Cellular #StructuralBiology ", EPN Campus Grenoble, France, 26-27 June 2025🧬
📢Reminder - Call for abstracts (posters & short talks)
Submission & registration deadline 25 May: www.psb-grenoble.eu/psbsymposium...
@esrf.fr @embl.org @illneutrons.bsky.social
📢Reminder - Call for abstracts (posters & short talks)
Submission & registration deadline 25 May: www.psb-grenoble.eu/psbsymposium...
@esrf.fr @embl.org @illneutrons.bsky.social
Reposted by Roberto Covino
Last days! 📆
🧬PSB Symposium on " #MachineLearning in Cellular #StructuralBiology ", EPN Campus Grenoble, France, 26-27 June 2025🧬
📢Reminder - Call for abstracts (posters & short talks)
Submission & registration deadline 25 May: www.psb-grenoble.eu/psbsymposium...
@esrf.fr @embl.org @illneutrons.bsky.social
📢Reminder - Call for abstracts (posters & short talks)
Submission & registration deadline 25 May: www.psb-grenoble.eu/psbsymposium...
@esrf.fr @embl.org @illneutrons.bsky.social
May 21, 2025 at 8:49 PM
Last days! 📆
Reposted by Roberto Covino
Check out the speakers!
@rommieamaro.bsky.social @jessicaandreani.bsky.social @gauravbhardwaj.bsky.social @bonomimax.bsky.social @rocovino.bsky.social @arneelof.bsky.social Sergei Grudinin @magistratolab.bsky.social Christine Orengo @joanampereira.bsky.social Maya Topf, Sameer Velankar, Basile Wicky
@rommieamaro.bsky.social @jessicaandreani.bsky.social @gauravbhardwaj.bsky.social @bonomimax.bsky.social @rocovino.bsky.social @arneelof.bsky.social Sergei Grudinin @magistratolab.bsky.social Christine Orengo @joanampereira.bsky.social Maya Topf, Sameer Velankar, Basile Wicky
May 9, 2025 at 10:38 AM
Check out the speakers!
@rommieamaro.bsky.social @jessicaandreani.bsky.social @gauravbhardwaj.bsky.social @bonomimax.bsky.social @rocovino.bsky.social @arneelof.bsky.social Sergei Grudinin @magistratolab.bsky.social Christine Orengo @joanampereira.bsky.social Maya Topf, Sameer Velankar, Basile Wicky
@rommieamaro.bsky.social @jessicaandreani.bsky.social @gauravbhardwaj.bsky.social @bonomimax.bsky.social @rocovino.bsky.social @arneelof.bsky.social Sergei Grudinin @magistratolab.bsky.social Christine Orengo @joanampereira.bsky.social Maya Topf, Sameer Velankar, Basile Wicky
Reposted by Roberto Covino
Been thinking about biomembranes? Wondering what next decade of research will be?
Wonder no more: there's an awesome conference coming up in Copenhagen in July!!
From simulations to cells and everything in between.
5 days left to submit abstract - APPLY!
www.biophysics.org/blog/beyond-...
Wonder no more: there's an awesome conference coming up in Copenhagen in July!!
From simulations to cells and everything in between.
5 days left to submit abstract - APPLY!
www.biophysics.org/blog/beyond-...
Beyond Simple Models: The Consequences of Membrane Complexity in Living Systems - Copenhagen, Denmark 2025
Dear Colleagues,
We are excited to announce the Biophysical Society Thematic Meeting on Beyond Simple Models: The Consequences of Membrane Complexity in Living Systems. This meeting will be held in ...
www.biophysics.org
May 7, 2025 at 9:36 PM
Been thinking about biomembranes? Wondering what next decade of research will be?
Wonder no more: there's an awesome conference coming up in Copenhagen in July!!
From simulations to cells and everything in between.
5 days left to submit abstract - APPLY!
www.biophysics.org/blog/beyond-...
Wonder no more: there's an awesome conference coming up in Copenhagen in July!!
From simulations to cells and everything in between.
5 days left to submit abstract - APPLY!
www.biophysics.org/blog/beyond-...
Reposted by Roberto Covino
Presenting our work on minimum energy path generation between two states for physical systems at the FPI Workshop at @ICLR tomorrow! Scaling up to solvated BPTI and observing the same conformational changes as long reference MD with six orders fewer force field evals! Drop by!
April 27, 2025 at 4:25 PM
Presenting our work on minimum energy path generation between two states for physical systems at the FPI Workshop at @ICLR tomorrow! Scaling up to solvated BPTI and observing the same conformational changes as long reference MD with six orders fewer force field evals! Drop by!
Reposted by Roberto Covino
We are recruiting a colleague to our division at Chalmers in Data-Driven Life Science (broadly defined), a competitive starting package is offered and you get to be part of a support, yet young and ambitious research environment. Apply here: www.chalmers.se/en/about-cha...
Vacancies
www.chalmers.se
April 3, 2025 at 9:55 AM
We are recruiting a colleague to our division at Chalmers in Data-Driven Life Science (broadly defined), a competitive starting package is offered and you get to be part of a support, yet young and ambitious research environment. Apply here: www.chalmers.se/en/about-cha...
Reposted by Roberto Covino
Counting particles could give wrong probabilities in Cryo-Electron Microscopy www.biorxiv.org/content/10.1101/2025.03.27.644168v1 #cryoem
March 29, 2025 at 8:56 AM
Counting particles could give wrong probabilities in Cryo-Electron Microscopy www.biorxiv.org/content/10.1101/2025.03.27.644168v1 #cryoem
Reposted by Roberto Covino
Run BioEmu in Colab - just click "Runtime → Run all"! Our notebook uses ColabFold to generate MSAs, BioEmu to predict trajectories, and Foldseek to cluster conformations.
Thanks @jjimenezluna.bsky.social for the help!
🌐 colab.research.google.com/github/sokry...
📄 www.biorxiv.org/content/10.1...
Thanks @jjimenezluna.bsky.social for the help!
🌐 colab.research.google.com/github/sokry...
📄 www.biorxiv.org/content/10.1...
Google Colab
colab.research.google.com
March 29, 2025 at 9:50 AM
Run BioEmu in Colab - just click "Runtime → Run all"! Our notebook uses ColabFold to generate MSAs, BioEmu to predict trajectories, and Foldseek to cluster conformations.
Thanks @jjimenezluna.bsky.social for the help!
🌐 colab.research.google.com/github/sokry...
📄 www.biorxiv.org/content/10.1...
Thanks @jjimenezluna.bsky.social for the help!
🌐 colab.research.google.com/github/sokry...
📄 www.biorxiv.org/content/10.1...
Reposted by Roberto Covino
⏰ Two weeks left to register for our Benzon Symposium on Protein structure prediction and design 🧶🧬🖥️
Meeting will take place in Copenhagen 🇩🇰 on Sept. 1–4, 2025, and will feature an amazing list of speakers 👨🔬👩🔬👩💻👨💻
Submit your application via:
benzon-foundation.dk/benzon-sympo...
Meeting will take place in Copenhagen 🇩🇰 on Sept. 1–4, 2025, and will feature an amazing list of speakers 👨🔬👩🔬👩💻👨💻
Submit your application via:
benzon-foundation.dk/benzon-sympo...
March 17, 2025 at 5:52 PM
⏰ Two weeks left to register for our Benzon Symposium on Protein structure prediction and design 🧶🧬🖥️
Meeting will take place in Copenhagen 🇩🇰 on Sept. 1–4, 2025, and will feature an amazing list of speakers 👨🔬👩🔬👩💻👨💻
Submit your application via:
benzon-foundation.dk/benzon-sympo...
Meeting will take place in Copenhagen 🇩🇰 on Sept. 1–4, 2025, and will feature an amazing list of speakers 👨🔬👩🔬👩💻👨💻
Submit your application via:
benzon-foundation.dk/benzon-sympo...
Reposted by Roberto Covino
CDU’s debt brake turns out to be a lot like my diet: spend many months telling everyone you meet that it’s tough but totally essential and completely inviolable, before just junking the whole thing whenever you feel like it
March 5, 2025 at 7:16 AM
CDU’s debt brake turns out to be a lot like my diet: spend many months telling everyone you meet that it’s tough but totally essential and completely inviolable, before just junking the whole thing whenever you feel like it
Reposted by Roberto Covino
Please RT: If you are interested in doing your PhD at the ILL, Grenoble in collaboration with the Hennig-Lab at University of Bayreuth, Germany, look here:
esrf.gestmax.eu/1874/1/phd-s...
esrf.gestmax.eu/1874/1/phd-s...
ESRF - PhD student at ILL: Structural biology of an RNA helicase by NMR, SANS and segmental labelling
Consultez toutes les offres d'emploi ESRF et postulez en ligne a nos annonces emploi sur le site recrutement ESRF
esrf.gestmax.eu
March 4, 2025 at 8:17 AM
Please RT: If you are interested in doing your PhD at the ILL, Grenoble in collaboration with the Hennig-Lab at University of Bayreuth, Germany, look here:
esrf.gestmax.eu/1874/1/phd-s...
esrf.gestmax.eu/1874/1/phd-s...
Reposted by Roberto Covino
Registration is now open for our Benzon Symposium on "Protein structure prediction and design"
Meeting will take place in Copenhagen 🇩🇰 on Sept. 1–4, 2025, and will feature an amazing list of speakers
Get your application in before March 31st via:
benzon-foundation.dk/benzon-sympo...
Meeting will take place in Copenhagen 🇩🇰 on Sept. 1–4, 2025, and will feature an amazing list of speakers
Get your application in before March 31st via:
benzon-foundation.dk/benzon-sympo...
March 1, 2025 at 1:29 PM
Registration is now open for our Benzon Symposium on "Protein structure prediction and design"
Meeting will take place in Copenhagen 🇩🇰 on Sept. 1–4, 2025, and will feature an amazing list of speakers
Get your application in before March 31st via:
benzon-foundation.dk/benzon-sympo...
Meeting will take place in Copenhagen 🇩🇰 on Sept. 1–4, 2025, and will feature an amazing list of speakers
Get your application in before March 31st via:
benzon-foundation.dk/benzon-sympo...
Reposted by Roberto Covino
Zelensky’s timeline right now is a thing of beauty
March 1, 2025 at 11:17 AM
Zelensky’s timeline right now is a thing of beauty
Reposted by Roberto Covino
Geht’s raus und geht’s wählen! ⚽️🗳️
February 23, 2025 at 8:39 AM
Geht’s raus und geht’s wählen! ⚽️🗳️
Reposted by Roberto Covino
The BioEmu-1 model and inference code are now public under MIT license!!!
Please go ahead, play with it and let us know if there are issues.
github.com/microsoft/bi...
Please go ahead, play with it and let us know if there are issues.
github.com/microsoft/bi...
February 19, 2025 at 8:17 PM
The BioEmu-1 model and inference code are now public under MIT license!!!
Please go ahead, play with it and let us know if there are issues.
github.com/microsoft/bi...
Please go ahead, play with it and let us know if there are issues.
github.com/microsoft/bi...
Reposted by Roberto Covino
📢 New preprint, lead by Alex Bronstein, @sankethvedula.bsky.social and colleagues:
Guiding AlphaFold with experimental data.
This approach generates conformational ensembles guided by NMR, X-ray (or whatever) data. I am thrilled to tackle lots of exciting problems with it!
arxiv.org/abs/2502.09372
Guiding AlphaFold with experimental data.
This approach generates conformational ensembles guided by NMR, X-ray (or whatever) data. I am thrilled to tackle lots of exciting problems with it!
arxiv.org/abs/2502.09372
Inverse problems with experiment-guided AlphaFold
Proteins exist as a dynamic ensemble of multiple conformations, and these motions are often crucial for their functions. However, current structure prediction methods predominantly yield a single conf...
arxiv.org
February 17, 2025 at 4:35 PM
📢 New preprint, lead by Alex Bronstein, @sankethvedula.bsky.social and colleagues:
Guiding AlphaFold with experimental data.
This approach generates conformational ensembles guided by NMR, X-ray (or whatever) data. I am thrilled to tackle lots of exciting problems with it!
arxiv.org/abs/2502.09372
Guiding AlphaFold with experimental data.
This approach generates conformational ensembles guided by NMR, X-ray (or whatever) data. I am thrilled to tackle lots of exciting problems with it!
arxiv.org/abs/2502.09372