Kresten Lindorff-Larsen
@lindorfflarsen.bsky.social
Protein and coffee lover, father of two, professor of biophysics and sudo scientist at the Linderstrøm-Lang Centre for Protein Science, University of Copenhagen 🇩🇰
Pinned
We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
Happy to share our newest preprint on Parkin missense variants in work led by Erna Sol &
@vvouts.bsky.social in @rhp-lab.bsky.social
Using a multiplexed assay we determined the effects of 9,212 out of 9,300 single amino acid substitutions and nonsense Parkin variants. 1/n
doi.org/10.64898/202...
@vvouts.bsky.social in @rhp-lab.bsky.social
Using a multiplexed assay we determined the effects of 9,212 out of 9,300 single amino acid substitutions and nonsense Parkin variants. 1/n
doi.org/10.64898/202...
February 16, 2026 at 4:53 PM
Happy to share our newest preprint on Parkin missense variants in work led by Erna Sol &
@vvouts.bsky.social in @rhp-lab.bsky.social
Using a multiplexed assay we determined the effects of 9,212 out of 9,300 single amino acid substitutions and nonsense Parkin variants. 1/n
doi.org/10.64898/202...
@vvouts.bsky.social in @rhp-lab.bsky.social
Using a multiplexed assay we determined the effects of 9,212 out of 9,300 single amino acid substitutions and nonsense Parkin variants. 1/n
doi.org/10.64898/202...
Reposted by Kresten Lindorff-Larsen
Roses are red
Violets are blue
If you fall in love with your hypothesis
You’ll be biased to prove it true
🧪
Violets are blue
If you fall in love with your hypothesis
You’ll be biased to prove it true
🧪
February 14, 2024 at 12:45 PM
Roses are red
Violets are blue
If you fall in love with your hypothesis
You’ll be biased to prove it true
🧪
Violets are blue
If you fall in love with your hypothesis
You’ll be biased to prove it true
🧪
tomato
What's a word that changes your opinion of someone when you hear them mis-pronounce it?
For me: 'et cetera'/'ecksetra'.
For me: 'et cetera'/'ecksetra'.
February 13, 2026 at 6:48 PM
tomato
Reposted by Kresten Lindorff-Larsen
Yeast ubiquilin Dsk2 scaffolds proteasome-containing condensates under stress via multivalent interactions – @castanedalab.bsky.social et al show how dynamic interactions among its STI1 domain & transient helices in its disordered region promote its phase-separation
link.springer.com/article/10.1...
link.springer.com/article/10.1...
STI1 domain engages transient helices to mediate Dsk2 phase separation and proteasome condensation - The EMBO Journal
Ubiquitin-binding shuttle proteins are important components of stress-induced biomolecular condensates in cells. Yeast Dsk2 scaffolds proteasome-containing condensates via multivalent interactions wit...
link.springer.com
February 11, 2026 at 2:53 PM
Yeast ubiquilin Dsk2 scaffolds proteasome-containing condensates under stress via multivalent interactions – @castanedalab.bsky.social et al show how dynamic interactions among its STI1 domain & transient helices in its disordered region promote its phase-separation
link.springer.com/article/10.1...
link.springer.com/article/10.1...
On this International Day of Women and Girls in Science I (as in previous years) take an Implicit Association Test to remind myself of my potential biases and with the goal of remembering to take them into account
You too can do this at:
implicit.harvard.edu/implicit/
You too can do this at:
implicit.harvard.edu/implicit/
February 11, 2026 at 7:11 PM
On this International Day of Women and Girls in Science I (as in previous years) take an Implicit Association Test to remind myself of my potential biases and with the goal of remembering to take them into account
You too can do this at:
implicit.harvard.edu/implicit/
You too can do this at:
implicit.harvard.edu/implicit/
Reposted by Kresten Lindorff-Larsen
And a new paper from the lab. A follow up to a previous study in which we elucidate the mechanism of the nuclear transport. Read the full story: www.nature.com/articles/s41...
February 11, 2026 at 5:12 PM
And a new paper from the lab. A follow up to a previous study in which we elucidate the mechanism of the nuclear transport. Read the full story: www.nature.com/articles/s41...
Isomorphic Labs Drug Design Engine (IsoDDE), a unified computational drug-design system
Announcement:
www.isomorphiclabs.com/articles/the...
Report:
storage.googleapis.com/isomorphicla...
Announcement:
www.isomorphiclabs.com/articles/the...
Report:
storage.googleapis.com/isomorphicla...
February 10, 2026 at 3:16 PM
Isomorphic Labs Drug Design Engine (IsoDDE), a unified computational drug-design system
Announcement:
www.isomorphiclabs.com/articles/the...
Report:
storage.googleapis.com/isomorphicla...
Announcement:
www.isomorphiclabs.com/articles/the...
Report:
storage.googleapis.com/isomorphicla...
Reposted by Kresten Lindorff-Larsen
Really excited to share the latest work from my PhD with @giuliotesei.bsky.social and @lindorfflarsen.bsky.social!
New preprint with work led by @asrauh.bsky.social in which we explore how double mutant cycles could be used to study molecular interactions in condensates, and highlight difficulties in extracting information about interactions from mutational experiments
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
February 9, 2026 at 12:55 PM
Really excited to share the latest work from my PhD with @giuliotesei.bsky.social and @lindorfflarsen.bsky.social!
Reposted by Kresten Lindorff-Larsen
It was a pleasure to write the review on the role of phase separation in transcription together with you, @bsabari.bsky.social, Mikayla and Ambuja. I learnt a lot!
I am excited to share a new review @cp-molcell.bsky.social written in collaboration with @tanjamittag.bsky.social , Mikayla Eppert, and Ambuja Navalkar where we review the current evidence for and against the role of density transitions in regulating transcription www.cell.com/molecular-ce...
February 7, 2026 at 4:00 AM
It was a pleasure to write the review on the role of phase separation in transcription together with you, @bsabari.bsky.social, Mikayla and Ambuja. I learnt a lot!
A near-complete map of human cytosolic degrons and their relevance for disease
We measured degron potency of >200,000 30-residue tiles from >5,000 human proteins, and trained a model to predict degrons from sequence
Led by @vvouts.bsky.social in @rhp-lab.bsky.social
doi.org/10.1126/scia...
We measured degron potency of >200,000 30-residue tiles from >5,000 human proteins, and trained a model to predict degrons from sequence
Led by @vvouts.bsky.social in @rhp-lab.bsky.social
doi.org/10.1126/scia...
February 7, 2026 at 7:42 AM
A near-complete map of human cytosolic degrons and their relevance for disease
We measured degron potency of >200,000 30-residue tiles from >5,000 human proteins, and trained a model to predict degrons from sequence
Led by @vvouts.bsky.social in @rhp-lab.bsky.social
doi.org/10.1126/scia...
We measured degron potency of >200,000 30-residue tiles from >5,000 human proteins, and trained a model to predict degrons from sequence
Led by @vvouts.bsky.social in @rhp-lab.bsky.social
doi.org/10.1126/scia...
Reposted by Kresten Lindorff-Larsen
I am excited to share a new review @cp-molcell.bsky.social written in collaboration with @tanjamittag.bsky.social , Mikayla Eppert, and Ambuja Navalkar where we review the current evidence for and against the role of density transitions in regulating transcription www.cell.com/molecular-ce...
February 6, 2026 at 9:20 PM
I am excited to share a new review @cp-molcell.bsky.social written in collaboration with @tanjamittag.bsky.social , Mikayla Eppert, and Ambuja Navalkar where we review the current evidence for and against the role of density transitions in regulating transcription www.cell.com/molecular-ce...
Reposted by Kresten Lindorff-Larsen
New preprint with work led by @asrauh.bsky.social in which we explore how double mutant cycles could be used to study molecular interactions in condensates, and highlight difficulties in extracting information about interactions from mutational experiments
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
February 5, 2026 at 9:54 PM
New preprint with work led by @asrauh.bsky.social in which we explore how double mutant cycles could be used to study molecular interactions in condensates, and highlight difficulties in extracting information about interactions from mutational experiments
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
New preprint with work led by @asrauh.bsky.social in which we explore how double mutant cycles could be used to study molecular interactions in condensates, and highlight difficulties in extracting information about interactions from mutational experiments
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
February 5, 2026 at 9:54 PM
New preprint with work led by @asrauh.bsky.social in which we explore how double mutant cycles could be used to study molecular interactions in condensates, and highlight difficulties in extracting information about interactions from mutational experiments
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Kresten Lindorff-Larsen
Now on bioRxiv: genome‑wide CRISPR KO reveals BAG6 (chaperone) and RNF126 (E3) as core PQC for non‑native missense proteins. VAMP seq. shows >1000 Parkin variants are BAG6 targets, including known pathogenic variants. Work led by Line Pedersen. Collab with @lindorfflarsen.bsky.social
BAG6 and RNF126 are broadly involved in protein quality control of non-native missense protein variants https://www.biorxiv.org/content/10.64898/2026.02.04.703735v1
February 5, 2026 at 7:23 AM
Now on bioRxiv: genome‑wide CRISPR KO reveals BAG6 (chaperone) and RNF126 (E3) as core PQC for non‑native missense proteins. VAMP seq. shows >1000 Parkin variants are BAG6 targets, including known pathogenic variants. Work led by Line Pedersen. Collab with @lindorfflarsen.bsky.social
Check out our newest preprint on how the chaperone BAG6 and E3 ligase RNF126 cooperate to target unstable and misfolded missense variants for degradation. Work led by Line Pedersen in @rhp-lab.bsky.social
doi.org/10.64898/202...
doi.org/10.64898/202...
Now on bioRxiv: genome‑wide CRISPR KO reveals BAG6 (chaperone) and RNF126 (E3) as core PQC for non‑native missense proteins. VAMP seq. shows >1000 Parkin variants are BAG6 targets, including known pathogenic variants. Work led by Line Pedersen. Collab with @lindorfflarsen.bsky.social
BAG6 and RNF126 are broadly involved in protein quality control of non-native missense protein variants https://www.biorxiv.org/content/10.64898/2026.02.04.703735v1
February 5, 2026 at 8:03 AM
Check out our newest preprint on how the chaperone BAG6 and E3 ligase RNF126 cooperate to target unstable and misfolded missense variants for degradation. Work led by Line Pedersen in @rhp-lab.bsky.social
doi.org/10.64898/202...
doi.org/10.64898/202...
Looking forward to speak tomorrow at the AI & SIMULATION workshop organized by @smnlssn.bsky.social & @giovannivolpe.bsky.social at University of Gothenburg & Chalmers
What better way of introducing the importance of protein disorder than by talking about this fellow
What better way of introducing the importance of protein disorder than by talking about this fellow
February 4, 2026 at 5:57 PM
Looking forward to speak tomorrow at the AI & SIMULATION workshop organized by @smnlssn.bsky.social & @giovannivolpe.bsky.social at University of Gothenburg & Chalmers
What better way of introducing the importance of protein disorder than by talking about this fellow
What better way of introducing the importance of protein disorder than by talking about this fellow
Reposted by Kresten Lindorff-Larsen
AI hallucinations in science manuscripts are a nuisance. Paranormal citations, or paracites, will be a nightmare.
www.biorxiv.org/content/10.6... (w/ @sina.bio & @lauraluebbert.com).
www.biorxiv.org/content/10.6... (w/ @sina.bio & @lauraluebbert.com).
February 3, 2026 at 5:19 PM
AI hallucinations in science manuscripts are a nuisance. Paranormal citations, or paracites, will be a nightmare.
www.biorxiv.org/content/10.6... (w/ @sina.bio & @lauraluebbert.com).
www.biorxiv.org/content/10.6... (w/ @sina.bio & @lauraluebbert.com).
Reposted by Kresten Lindorff-Larsen
Peer review is often opaque and confusing. @elife.bsky.social worked to change that.
In a new preprint, we show how eLife’s Publish, Review, Curate model makes it possible to evaluate AI-generated reviews (with OpenEval) against human peer review. w/ @lauraluebbert.com and @lpachter.bsky.social
In a new preprint, we show how eLife’s Publish, Review, Curate model makes it possible to evaluate AI-generated reviews (with OpenEval) against human peer review. w/ @lauraluebbert.com and @lpachter.bsky.social
February 3, 2026 at 5:08 PM
Peer review is often opaque and confusing. @elife.bsky.social worked to change that.
In a new preprint, we show how eLife’s Publish, Review, Curate model makes it possible to evaluate AI-generated reviews (with OpenEval) against human peer review. w/ @lauraluebbert.com and @lpachter.bsky.social
In a new preprint, we show how eLife’s Publish, Review, Curate model makes it possible to evaluate AI-generated reviews (with OpenEval) against human peer review. w/ @lauraluebbert.com and @lpachter.bsky.social
Reposted by Kresten Lindorff-Larsen
We could have this for biology if we hadnt collectively decided to spend ~10 Mio dollars per year on BioRender instead 😢
February 4, 2026 at 5:09 PM
We could have this for biology if we hadnt collectively decided to spend ~10 Mio dollars per year on BioRender instead 😢
PaperBanana: Automating Academic Illustration for AI Scientists
doi.org/10.48550/arX...
dwzhu-pku.github.io/PaperBanana/
doi.org/10.48550/arX...
dwzhu-pku.github.io/PaperBanana/
February 4, 2026 at 10:18 AM
PaperBanana: Automating Academic Illustration for AI Scientists
doi.org/10.48550/arX...
dwzhu-pku.github.io/PaperBanana/
doi.org/10.48550/arX...
dwzhu-pku.github.io/PaperBanana/
Reposted by Kresten Lindorff-Larsen
Wandering down the rabbit hole of journals published in constructed languages, are there chemistry articles in Esperanto? Klingon? #chemSky
February 2, 2026 at 4:27 PM
Wandering down the rabbit hole of journals published in constructed languages, are there chemistry articles in Esperanto? Klingon? #chemSky
Looking forward to read this from @bonomimax.bsky.social
Learning Dynamic Protein Representations at Scale with Distograms
www.biorxiv.org/content/10.6...
Learning Dynamic Protein Representations at Scale with Distograms
www.biorxiv.org/content/10.6...
February 2, 2026 at 7:24 PM
Looking forward to read this from @bonomimax.bsky.social
Learning Dynamic Protein Representations at Scale with Distograms
www.biorxiv.org/content/10.6...
Learning Dynamic Protein Representations at Scale with Distograms
www.biorxiv.org/content/10.6...
Reposted by Kresten Lindorff-Larsen
Does targeting enzymes and substrates in a condensate lead to rate enhancement? No. Here, we investigate how the condensate environment can inhibit an enzyme reaction.
Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates.
doi.org/10.64898/202...
Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates.
doi.org/10.64898/202...
February 2, 2026 at 2:25 PM
Does targeting enzymes and substrates in a condensate lead to rate enhancement? No. Here, we investigate how the condensate environment can inhibit an enzyme reaction.
Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates.
doi.org/10.64898/202...
Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates.
doi.org/10.64898/202...
Reposted by Kresten Lindorff-Larsen
1️⃣4️⃣ Don't mention gene patenting to Steven Henikoff. If you really insist, here's what will happen.
www.nature.com/articles/358...
www.nature.com/articles/358...
January 30, 2026 at 1:35 PM
1️⃣4️⃣ Don't mention gene patenting to Steven Henikoff. If you really insist, here's what will happen.
www.nature.com/articles/358...
www.nature.com/articles/358...
Reposted by Kresten Lindorff-Larsen
New lab preprint - Common and rare variant studies for the same trait identify different genes and here Diederik Laman Trip developed a protein network AI enconding to investigate if traits studied by different approaches converge on the same molecular pathways
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
January 29, 2026 at 8:12 AM
New lab preprint - Common and rare variant studies for the same trait identify different genes and here Diederik Laman Trip developed a protein network AI enconding to investigate if traits studied by different approaches converge on the same molecular pathways
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...