AMPA receptors (AMPARs) are multimodal transducers of glutamatergic signals throughout the brain. Their diversity is exemplified in the cerebellum; at afferent synapses, AMPARs mediate high-frequency ...

Nature Communications - The communication hinge, found in type IV ABC transporters, forms a bidirectional communication between ATP- and substrate-binding sites. This is an unexplored allosteric...

Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09677-6 Structures of GDP-bound MOR–Gi conformational states combined with pharmacological assays show an inverse correlation between ligand efficacy and GDP affinity, where agonists decrease GDP affinity, promoting GTP exchange, and antagonists increase GDP affinity, dampening activation, thus providing structural and mechanistic insights into G protein activation.

We discover and study reverse transcriptases

The effects of mutations in a neuronal Gα protein associated with neurological disorders are characterized.

Telomerase counteracts telomere shortening by repeatedly adding DNA repeats to chromosome ends. We identified the replication protein A (RPA) heterotrimer as a telomerase processivity factor critical ...

Studies of the G-protein-coupled receptor NTSR1 show that the G protein selectivity of this receptor can be modified by small molecules, enabling the design of drugs that work by switching receptor su...

Nature Communications - Otopetrins form proton channels in animals ranging from nematodes to humans. Here, authors identify small molecule inhibitors and characterize their binding in the...

The Franklin College of Arts and Sciences at the University of Georgia (UGA) invites applications for multiple open faculty positions, beginning August 1, 2026. We are broadly interested in scientists...

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