Leiden Early Drug Discovery & Development (LED3)
@led3hub.bsky.social
LED3 is a hub of scientists working on early drug discovery at the Leiden Institute of Chemistry, the Leiden Academic Centre for Drug Research, the Institute of Biology Leiden and the Leiden Institute of Advanced Computer Science. @LED3hub@mstdn.science
Pinned
We are excited that we could again put together a program of world-leading scientists from academia and industry for our LED3 Lectures 2025/2026. If you are interested in (some of) the topics, mark your calendars! We would be very happy to welcome you! (1/2) www.universiteitleiden.nl/en/science/l...
Are you interested in cutting-edge research in Early Drug Discovery and Development?
We have a great program for our LED3 Lectures for the remaining academic year. Check out the program and mark your calendars!
www.universiteitleiden.nl/en/science/l...
#DrugDiscovery #ChemSky #ChemBio
We have a great program for our LED3 Lectures for the remaining academic year. Check out the program and mark your calendars!
www.universiteitleiden.nl/en/science/l...
#DrugDiscovery #ChemSky #ChemBio
January 8, 2026 at 10:49 AM
Are you interested in cutting-edge research in Early Drug Discovery and Development?
We have a great program for our LED3 Lectures for the remaining academic year. Check out the program and mark your calendars!
www.universiteitleiden.nl/en/science/l...
#DrugDiscovery #ChemSky #ChemBio
We have a great program for our LED3 Lectures for the remaining academic year. Check out the program and mark your calendars!
www.universiteitleiden.nl/en/science/l...
#DrugDiscovery #ChemSky #ChemBio
We are looking forward to the LED3 Lecture of Anne Osbourn on January 29th She will talk about "Harnessing plant metabolic diversity for food and health applications".
If you are interested, make sure to come by!
www.universiteitleiden.nl/en/science/l...
#ChemBio #ChemSky #Plants #Metabolites
If you are interested, make sure to come by!
www.universiteitleiden.nl/en/science/l...
#ChemBio #ChemSky #Plants #Metabolites
January 7, 2026 at 2:45 PM
We are looking forward to the LED3 Lecture of Anne Osbourn on January 29th She will talk about "Harnessing plant metabolic diversity for food and health applications".
If you are interested, make sure to come by!
www.universiteitleiden.nl/en/science/l...
#ChemBio #ChemSky #Plants #Metabolites
If you are interested, make sure to come by!
www.universiteitleiden.nl/en/science/l...
#ChemBio #ChemSky #Plants #Metabolites
Reposted by Leiden Early Drug Discovery & Development (LED3)
Our dean Jasper Knoester addresses our faculty @leidenscience.bsky.social in his New Year's speech. Interesting insights into the future strategic goals of our faculty and great to hear him highlight the priority themes including the @led3hub.bsky.social with new theme leader @mvdstelt.bsky.social.
January 6, 2026 at 2:48 PM
Our dean Jasper Knoester addresses our faculty @leidenscience.bsky.social in his New Year's speech. Interesting insights into the future strategic goals of our faculty and great to hear him highlight the priority themes including the @led3hub.bsky.social with new theme leader @mvdstelt.bsky.social.
Reposted by Leiden Early Drug Discovery & Development (LED3)
The group of @mvdstelt.bsky.social of our @led3hub.bsky.social published CellEKT for profiling of the cellular targets of kinase inhibitors, which is further developed in the company Omivera (omivera.com). (3/12)
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
CellEKT: A Robust Chemical Proteomics Workflow to Profile Cellular Target Engagement of Kinase Inhibitors
The human genome encodes 518 protein kinases that are pivotal for drug discovery in various therapeutic areas, such as cancer and autoimmune disorders…
www.sciencedirect.com
January 4, 2026 at 6:44 AM
The group of @mvdstelt.bsky.social of our @led3hub.bsky.social published CellEKT for profiling of the cellular targets of kinase inhibitors, which is further developed in the company Omivera (omivera.com). (3/12)
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Leiden Early Drug Discovery & Development (LED3)
The group of @sebastianpomplun.bsky.social of our @led3hub.bsky.social developed self-encoded libraries (SELs) that allow affinity-selection MS-based screening of protein binders from large libraries in a single experiment without the need for a barcode. (6/12)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Barcode-free hit discovery from massive libraries enabled by automated small molecule structure annotation - Nature Communications
Affinity-selection platforms are powerful tools in early drug discovery, but current technologies such as DNA-encoded libraries (DELs) are limited by synthesis complexity and incompatibility with nucl...
www.nature.com
January 4, 2026 at 6:44 AM
The group of @sebastianpomplun.bsky.social of our @led3hub.bsky.social developed self-encoded libraries (SELs) that allow affinity-selection MS-based screening of protein binders from large libraries in a single experiment without the need for a barcode. (6/12)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Leiden Early Drug Discovery & Development (LED3)
The groups of Nathaniel Martin of our @led3hub.bsky.social and the @smitslab.bsky.social published the powerful semisynthetic guanidino lipoglycopeptide EVG7 to treat Clostridioides difficile infections. (11/12)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Experimental glycopeptide antibiotic EVG7 prevents recurrent Clostridioides difficile infection by sparing members of the Lachnospiraceae family - Nature Communications
Treatment of Clostridioides difficile infections (CDI) with vancomycin is associated with high relapse rates. In this study, the experimental glycopeptide antibiotic EVG7 was found to effectively trea...
www.nature.com
January 4, 2026 at 6:44 AM
The groups of Nathaniel Martin of our @led3hub.bsky.social and the @smitslab.bsky.social published the powerful semisynthetic guanidino lipoglycopeptide EVG7 to treat Clostridioides difficile infections. (11/12)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Leiden Early Drug Discovery & Development (LED3)
Exciting news that @fda.gov has approved the first oral GLP-1 agonist for clinical use for @novonordisk.bsky.social.
www.novonordisk.com/content/nnco...
It was amazing to hear about the science behind these medications directly from Lotte Bjerre Knudsen in her @led3hub.bsky.social Lecture.
www.novonordisk.com/content/nnco...
It was amazing to hear about the science behind these medications directly from Lotte Bjerre Knudsen in her @led3hub.bsky.social Lecture.
News Details
www.novonordisk.com
December 23, 2025 at 7:11 AM
Exciting news that @fda.gov has approved the first oral GLP-1 agonist for clinical use for @novonordisk.bsky.social.
www.novonordisk.com/content/nnco...
It was amazing to hear about the science behind these medications directly from Lotte Bjerre Knudsen in her @led3hub.bsky.social Lecture.
www.novonordisk.com/content/nnco...
It was amazing to hear about the science behind these medications directly from Lotte Bjerre Knudsen in her @led3hub.bsky.social Lecture.
Reposted by Leiden Early Drug Discovery & Development (LED3)
Excited to be part of the @led3hub.bsky.social of @leidenscience.bsky.social and of the organizing committee of the #LED3Lectures and #LED3Symposium. I am convinced that these are amazing initiatives that strengthen our collaborative spirit. New exciting activities are coming in 2026 and 2027.
Another exciting year for our LED3 hub comes to a close. We were able to celebrate many successes including grants, publications, awards and started companies. In 2025, the activities of LED3 were also formalized in the theme "Drug Discovery and Development" of @leidenscience.bsky.social. (1/3)
December 23, 2025 at 6:32 AM
Excited to be part of the @led3hub.bsky.social of @leidenscience.bsky.social and of the organizing committee of the #LED3Lectures and #LED3Symposium. I am convinced that these are amazing initiatives that strengthen our collaborative spirit. New exciting activities are coming in 2026 and 2027.
Another exciting year for our LED3 hub comes to a close. We were able to celebrate many successes including grants, publications, awards and started companies. In 2025, the activities of LED3 were also formalized in the theme "Drug Discovery and Development" of @leidenscience.bsky.social. (1/3)
December 23, 2025 at 6:29 AM
Another exciting year for our LED3 hub comes to a close. We were able to celebrate many successes including grants, publications, awards and started companies. In 2025, the activities of LED3 were also formalized in the theme "Drug Discovery and Development" of @leidenscience.bsky.social. (1/3)
Reposted by Leiden Early Drug Discovery & Development (LED3)
Interesting article by the American Peptide Society about the recent publication by the group of @sebastianpomplun.bsky.social of our @led3hub.bsky.social on using BindCraft to predict #peptide binders to high value protein targets.
americanpeptidesociety.org/aps-news/bin...
americanpeptidesociety.org/aps-news/bin...
December 21, 2025 at 5:29 AM
Interesting article by the American Peptide Society about the recent publication by the group of @sebastianpomplun.bsky.social of our @led3hub.bsky.social on using BindCraft to predict #peptide binders to high value protein targets.
americanpeptidesociety.org/aps-news/bin...
americanpeptidesociety.org/aps-news/bin...
Congratulations to the LED3 members that received NWO XS grants:
@mads-chem.bsky.social - Inhibiting the growth of brain tumours
Margo Dona - Rapid personalised treatment for anaplastic thyroid cancer
Sandra Irmisch - Producing rare substances for medicines
www.universiteitleiden.nl/en/news/2025...
@mads-chem.bsky.social - Inhibiting the growth of brain tumours
Margo Dona - Rapid personalised treatment for anaplastic thyroid cancer
Sandra Irmisch - Producing rare substances for medicines
www.universiteitleiden.nl/en/news/2025...
Eleven Open Competition Domain Science XS grants for Leiden researchers
Eleven researchers from Leiden University have been awarded an Open Competition Domain Science ENW XS grant by the Dutch Research Council for their research projects. They are researching how to make ...
www.universiteitleiden.nl
December 19, 2025 at 9:51 AM
Congratulations to the LED3 members that received NWO XS grants:
@mads-chem.bsky.social - Inhibiting the growth of brain tumours
Margo Dona - Rapid personalised treatment for anaplastic thyroid cancer
Sandra Irmisch - Producing rare substances for medicines
www.universiteitleiden.nl/en/news/2025...
@mads-chem.bsky.social - Inhibiting the growth of brain tumours
Margo Dona - Rapid personalised treatment for anaplastic thyroid cancer
Sandra Irmisch - Producing rare substances for medicines
www.universiteitleiden.nl/en/news/2025...
New Publication from our LED3 hub!
The group of @sebastianpomplun.bsky.social published "ReCHEMbinant stapling enhances intracellular delivery and bioactivity of engineered protein inhibitors" in the journal Chem.
www.sciencedirect.com/science/arti...
#ChemSky #ChemBio #DrugDiscovery #MYC #Cancer
The group of @sebastianpomplun.bsky.social published "ReCHEMbinant stapling enhances intracellular delivery and bioactivity of engineered protein inhibitors" in the journal Chem.
www.sciencedirect.com/science/arti...
#ChemSky #ChemBio #DrugDiscovery #MYC #Cancer
ReCHEMbinant stapling enhances intracellular delivery and bioactivity of engineered protein inhibitors
Protein therapeutics have transformed drug discovery by enabling modulation of challenging targets inaccessible to small molecules. However, most prot…
www.sciencedirect.com
December 18, 2025 at 11:29 AM
New Publication from our LED3 hub!
The group of @sebastianpomplun.bsky.social published "ReCHEMbinant stapling enhances intracellular delivery and bioactivity of engineered protein inhibitors" in the journal Chem.
www.sciencedirect.com/science/arti...
#ChemSky #ChemBio #DrugDiscovery #MYC #Cancer
The group of @sebastianpomplun.bsky.social published "ReCHEMbinant stapling enhances intracellular delivery and bioactivity of engineered protein inhibitors" in the journal Chem.
www.sciencedirect.com/science/arti...
#ChemSky #ChemBio #DrugDiscovery #MYC #Cancer
Reposted by Leiden Early Drug Discovery & Development (LED3)
Interesting paper by the group of @sebastianpomplun.bsky.social of our @led3hub.bsky.social. Chemical stapling of recombinant proteins on the example of the Myc inhibitor Omomyc leads to enhanced serum stability, cellular uptake and intracellular activity.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
ReCHEMbinant stapling enhances intracellular delivery and bioactivity of engineered protein inhibitors
Protein therapeutics have transformed drug discovery by enabling modulation of challenging targets inaccessible to small molecules. However, most prot…
www.sciencedirect.com
December 18, 2025 at 11:26 AM
Interesting paper by the group of @sebastianpomplun.bsky.social of our @led3hub.bsky.social. Chemical stapling of recombinant proteins on the example of the Myc inhibitor Omomyc leads to enhanced serum stability, cellular uptake and intracellular activity.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
It is great to see, how highly represented LED3 researchers are at the #iCNS meeting of the Institute for Chemical Neuroscience. Exciting that our researchers are making so many important contributions to this innovative research direction. (1/4)
#ChemSky #ChemBio #Neuroscience #DrugDiscovery
#ChemSky #ChemBio #Neuroscience #DrugDiscovery
December 16, 2025 at 3:27 PM
It is great to see, how highly represented LED3 researchers are at the #iCNS meeting of the Institute for Chemical Neuroscience. Exciting that our researchers are making so many important contributions to this innovative research direction. (1/4)
#ChemSky #ChemBio #Neuroscience #DrugDiscovery
#ChemSky #ChemBio #Neuroscience #DrugDiscovery
Reposted by Leiden Early Drug Discovery & Development (LED3)
Interested in computationally predicting peptide binders to a protein-of interest?
Check out this @science.org blog post by @dereklowe.bsky.social on the work by @sebastianpomplun.bsky.social of our @led3hub.bsky.social on predicting peptide binders using BindCraft.
www.science.org/content/blog...
Check out this @science.org blog post by @dereklowe.bsky.social on the work by @sebastianpomplun.bsky.social of our @led3hub.bsky.social on predicting peptide binders using BindCraft.
www.science.org/content/blog...
Cheap Computation of Small Peptide Binders
www.science.org
December 16, 2025 at 5:27 AM
Interested in computationally predicting peptide binders to a protein-of interest?
Check out this @science.org blog post by @dereklowe.bsky.social on the work by @sebastianpomplun.bsky.social of our @led3hub.bsky.social on predicting peptide binders using BindCraft.
www.science.org/content/blog...
Check out this @science.org blog post by @dereklowe.bsky.social on the work by @sebastianpomplun.bsky.social of our @led3hub.bsky.social on predicting peptide binders using BindCraft.
www.science.org/content/blog...
Exciting to see the study on the prediction of high-affinity #peptide binders to proteins-of-interests by the group of @sebastianpomplun.bsky.social of our LED3hub highlighted by @dereklowe.bsky.social in his @science.org blog.
www.science.org/content/blog...
#ChemSky #ChemBio #DrugDiscovery
www.science.org/content/blog...
#ChemSky #ChemBio #DrugDiscovery
Cheap Computation of Small Peptide Binders
www.science.org
December 16, 2025 at 5:32 AM
Exciting to see the study on the prediction of high-affinity #peptide binders to proteins-of-interests by the group of @sebastianpomplun.bsky.social of our LED3hub highlighted by @dereklowe.bsky.social in his @science.org blog.
www.science.org/content/blog...
#ChemSky #ChemBio #DrugDiscovery
www.science.org/content/blog...
#ChemSky #ChemBio #DrugDiscovery
Reposted by Leiden Early Drug Discovery & Development (LED3)
Exciting paper by the group of @sebastianpomplun.bsky.social of our @led3hub.bsky.social in @natcomms.nature.com. They developed self-encoded libraries (SELs) that allow affinity-selection MS-based screening of protein binders from >500,000 member libraries. doi.org/10.1038/s414...
#ChemSky #ChemBio
#ChemSky #ChemBio
Barcode-free hit discovery from massive libraries enabled by automated small molecule structure annotation
Nature Communications - Affinity-selection platforms are powerful tools in early drug discovery, but current technologies such as DNA-encoded libraries (DELs) are limited by synthesis complexity...
doi.org
December 15, 2025 at 2:00 PM
Exciting paper by the group of @sebastianpomplun.bsky.social of our @led3hub.bsky.social in @natcomms.nature.com. They developed self-encoded libraries (SELs) that allow affinity-selection MS-based screening of protein binders from >500,000 member libraries. doi.org/10.1038/s414...
#ChemSky #ChemBio
#ChemSky #ChemBio
Reposted by Leiden Early Drug Discovery & Development (LED3)
Interesting paper by the group of @sebastianpomplun.bsky.social of our @led3hub.bsky.social in ChemMedChem. Based on the AlphaFold-Multimer structure of MYC/Miz-1, they designed a stapled peptide that disrupts the MYC/MAX interaction.
chemistry-europe.onl...
chemistry-europe.onl...
December 12, 2025 at 10:00 AM
Interesting paper by the group of @sebastianpomplun.bsky.social of our @led3hub.bsky.social in ChemMedChem. Based on the AlphaFold-Multimer structure of MYC/Miz-1, they designed a stapled peptide that disrupts the MYC/MAX interaction.
chemistry-europe.onl...
chemistry-europe.onl...
Reposted by Leiden Early Drug Discovery & Development (LED3)
Great talk by Cristina Lopez Gallego from the group of Marcellus Ubbink of our @led3hub.bsky.social of @leidenscience.bsky.social at #NWOCHAINS. She talked about the study of second sphere residues and their effect on the structure, dynamics and function of beta-lactamases.
#Biochemistry #Evolution
#Biochemistry #Evolution
December 3, 2025 at 1:33 PM
Great talk by Cristina Lopez Gallego from the group of Marcellus Ubbink of our @led3hub.bsky.social of @leidenscience.bsky.social at #NWOCHAINS. She talked about the study of second sphere residues and their effect on the structure, dynamics and function of beta-lactamases.
#Biochemistry #Evolution
#Biochemistry #Evolution
Reposted by Leiden Early Drug Discovery & Development (LED3)
Insightful talk by Bob van Puffelen from the groups of Jeroen Codee and Dima Filippov @leidenadpr.bsky.social of the @led3hub.bsky.social at #NWOCHAINS. He talked about a glycan modification of the bacterial flagellum and how they use synthetic tools to study its biosynthesis.
#ChemSky #ChemBio
#ChemSky #ChemBio
December 3, 2025 at 1:47 PM
Insightful talk by Bob van Puffelen from the groups of Jeroen Codee and Dima Filippov @leidenadpr.bsky.social of the @led3hub.bsky.social at #NWOCHAINS. He talked about a glycan modification of the bacterial flagellum and how they use synthetic tools to study its biosynthesis.
#ChemSky #ChemBio
#ChemSky #ChemBio
Reposted by Leiden Early Drug Discovery & Development (LED3)
Excited that Yorick van Aalst represented our group of the @led3hub.bsky.social with a talk at #NWOCHAINS. He talked about mining #AlphaFold structures of the entire proteome for pockets and using this information to prioritize hits from #Chemoproteomic screens.
#ChemSky #ChemBio #ProudPI
#ChemSky #ChemBio #ProudPI
December 3, 2025 at 1:55 PM
Excited that Yorick van Aalst represented our group of the @led3hub.bsky.social with a talk at #NWOCHAINS. He talked about mining #AlphaFold structures of the entire proteome for pockets and using this information to prioritize hits from #Chemoproteomic screens.
#ChemSky #ChemBio #ProudPI
#ChemSky #ChemBio #ProudPI
Reposted by Leiden Early Drug Discovery & Development (LED3)
@seanmckenna.bsky.social represented the group of @sebastianpomplun.bsky.social and the @led3hub.bsky.social with an exciting talk at #NWOCHAINS. He talked about using a combination of in silico screening and semi-automated synthesis to accelerate #DrugDiscovery.
#ChemSky #ChemBio
#ChemSky #ChemBio
December 3, 2025 at 1:59 PM
@seanmckenna.bsky.social represented the group of @sebastianpomplun.bsky.social and the @led3hub.bsky.social with an exciting talk at #NWOCHAINS. He talked about using a combination of in silico screening and semi-automated synthesis to accelerate #DrugDiscovery.
#ChemSky #ChemBio
#ChemSky #ChemBio
Reposted by Leiden Early Drug Discovery & Development (LED3)
Interesting talk by Foteini Skoulikopoulou of the group of @armstrongchembio.bsky.social of the @led3hub.bsky.social at #NWOCHAINS. She talked about her research into the synthesis of stable 9-O-acetylated sialic acid mimics with potential applications as #antivirals.
#glycotime #ChemSky #ChemBio
#glycotime #ChemSky #ChemBio
December 3, 2025 at 2:13 PM
Interesting talk by Foteini Skoulikopoulou of the group of @armstrongchembio.bsky.social of the @led3hub.bsky.social at #NWOCHAINS. She talked about her research into the synthesis of stable 9-O-acetylated sialic acid mimics with potential applications as #antivirals.
#glycotime #ChemSky #ChemBio
#glycotime #ChemSky #ChemBio
Reposted by Leiden Early Drug Discovery & Development (LED3)
Very happy that @marnixroseboom.bsky.social represented our group of the @led3hub.bsky.social with a very well-attended talk at #NWOCHAINS. He reported on his #PhD work on developing #ChemoProteomics technologies to study #CovalentInhibitor target engagement at arginines.
#ChemSky #ChemBio #ProudPI
#ChemSky #ChemBio #ProudPI
December 3, 2025 at 2:28 PM
Very happy that @marnixroseboom.bsky.social represented our group of the @led3hub.bsky.social with a very well-attended talk at #NWOCHAINS. He reported on his #PhD work on developing #ChemoProteomics technologies to study #CovalentInhibitor target engagement at arginines.
#ChemSky #ChemBio #ProudPI
#ChemSky #ChemBio #ProudPI
Reposted by Leiden Early Drug Discovery & Development (LED3)
"Rapid Antibiotic Discovery using a Direct-to-Biology Approach"
Storm van der Voort from the group of Hermen Overkleeft and our group at the @led3hub.bsky.social presented his research into efficiently finding new antibacterially active #CovalentInhibitors and their targets.
#ChemSky #ChemBio
Storm van der Voort from the group of Hermen Overkleeft and our group at the @led3hub.bsky.social presented his research into efficiently finding new antibacterially active #CovalentInhibitors and their targets.
#ChemSky #ChemBio
December 3, 2025 at 9:46 AM
"Rapid Antibiotic Discovery using a Direct-to-Biology Approach"
Storm van der Voort from the group of Hermen Overkleeft and our group at the @led3hub.bsky.social presented his research into efficiently finding new antibacterially active #CovalentInhibitors and their targets.
#ChemSky #ChemBio
Storm van der Voort from the group of Hermen Overkleeft and our group at the @led3hub.bsky.social presented his research into efficiently finding new antibacterially active #CovalentInhibitors and their targets.
#ChemSky #ChemBio