Leiden Early Drug Discovery & Development (LED3)
@led3hub.bsky.social
LED3 is a hub of scientists working on early drug discovery at the Leiden Institute of Chemistry, the Leiden Academic Centre for Drug Research, the Institute of Biology Leiden and the Leiden Institute of Advanced Computer Science. @LED3hub@mstdn.science
Pinned
We are excited that we could again put together a program of world-leading scientists from academia and industry for our LED3 Lectures 2025/2026. If you are interested in (some of) the topics, mark your calendars! We would be very happy to welcome you! (1/2) www.universiteitleiden.nl/en/science/l...
Reposted by Leiden Early Drug Discovery & Development (LED3)
Very happy that Storm van der Voort - PhD in the group of Hermen Overkleeft and in our group - was selected for a talk at the #Reedijk Symposium. He gave an excellent presentation on using direct-to-biology to efficiently make covalent libraries for antibacterial screening
#ChemSky #ChemBio #ProudPI
#ChemSky #ChemBio #ProudPI
November 7, 2025 at 1:42 PM
Reposted by Leiden Early Drug Discovery & Development (LED3)
Insightful talk by Jeroen Codee at the #Reedijk Symposium. He talked about the importance of synthetic organic chemistry to make complex glycans to better understand #glycobiology. Very impressive, systematic work on glycosylation reactions. pubs.rsc.org/en/content/a...
#ChemSky #ChemBio #Glycotime
#ChemSky #ChemBio #Glycotime
November 7, 2025 at 12:54 PM
Insightful talk by Jeroen Codee at the #Reedijk Symposium. He talked about the importance of synthetic organic chemistry to make complex glycans to better understand #glycobiology. Very impressive, systematic work on glycosylation reactions. pubs.rsc.org/en/content/a...
#ChemSky #ChemBio #Glycotime
#ChemSky #ChemBio #Glycotime
Jeroen Codee speaks at the #Reedijk Symposium: "A new twist in the tale - stereoselective glycosylation reactions for bacterial glycan assembly". Exciting insights into the importance of advanced glycosylation chemistries to make complex glycosides to better understand (bacterial) biology.
November 7, 2025 at 12:47 PM
Jeroen Codee speaks at the #Reedijk Symposium: "A new twist in the tale - stereoselective glycosylation reactions for bacterial glycan assembly". Exciting insights into the importance of advanced glycosylation chemistries to make complex glycosides to better understand (bacterial) biology.
Reposted by Leiden Early Drug Discovery & Development (LED3)
Inspiring #Havinga Medal lecture by @craigmcrews.bsky.social at the #Reedijk Symposium. Amazing to hear him talk about the full story of the development of induced proximity into a new paradigm of event-driven pharmacology for #DrugDiscovery.
www.nature.com/articles/s41...
#ChemSky #ChemBio #TPD
www.nature.com/articles/s41...
#ChemSky #ChemBio #TPD
November 7, 2025 at 10:31 AM
Inspiring #Havinga Medal lecture by @craigmcrews.bsky.social at the #Reedijk Symposium. Amazing to hear him talk about the full story of the development of induced proximity into a new paradigm of event-driven pharmacology for #DrugDiscovery.
www.nature.com/articles/s41...
#ChemSky #ChemBio #TPD
www.nature.com/articles/s41...
#ChemSky #ChemBio #TPD
Huge congratulations to @craigmcrews.bsky.social on being awarded the #Havinga medal at the #Reedijk Symposium of the Leiden Institute of Chemistry for his groundbreaking work on induced proximity, including targeted protein degradation, as a new paradigm for #DrugDiscovery.
#ChemSky #ChemBio #TPD
#ChemSky #ChemBio #TPD
November 7, 2025 at 10:20 AM
Huge congratulations to @craigmcrews.bsky.social on being awarded the #Havinga medal at the #Reedijk Symposium of the Leiden Institute of Chemistry for his groundbreaking work on induced proximity, including targeted protein degradation, as a new paradigm for #DrugDiscovery.
#ChemSky #ChemBio #TPD
#ChemSky #ChemBio #TPD
Reposted by Leiden Early Drug Discovery & Development (LED3)
Great talk by @kimmb1.bsky.social of our @led3hub.bsky.social at the #Reedijk Symposium. She talked about the power of activity-based probes to study protein function on the example of live cell imaging of myeloperoxidase activity to study NETosis. www.nature.com/articles/s42...
#ChemBio #ChemSky
#ChemBio #ChemSky
November 7, 2025 at 9:07 AM
Great talk by @kimmb1.bsky.social of our @led3hub.bsky.social at the #Reedijk Symposium. She talked about the power of activity-based probes to study protein function on the example of live cell imaging of myeloperoxidase activity to study NETosis. www.nature.com/articles/s42...
#ChemBio #ChemSky
#ChemBio #ChemSky
Kim Bonger (@kimmb1.bsky.social) represents our @led3hub.bsky.social at the #Reedijk Symposium of the Leiden Institute of Chemistry with a great talk on "Chemical tools for profiling protein activity and cell targeting in (auto)immune disease".
#ChemBio #ChemSky #DrugDiscovery #FluorescenceFriday
#ChemBio #ChemSky #DrugDiscovery #FluorescenceFriday
November 7, 2025 at 9:00 AM
Kim Bonger (@kimmb1.bsky.social) represents our @led3hub.bsky.social at the #Reedijk Symposium of the Leiden Institute of Chemistry with a great talk on "Chemical tools for profiling protein activity and cell targeting in (auto)immune disease".
#ChemBio #ChemSky #DrugDiscovery #FluorescenceFriday
#ChemBio #ChemSky #DrugDiscovery #FluorescenceFriday
Reposted by Leiden Early Drug Discovery & Development (LED3)
I was very happy to host Nicolas Winssinger today for a well-attended @led3hub.bsky.social Lecture.
He gave us exciting insights into the power of nucleic acid assemblies. Very exciting data on a highly selective thrombin inhibitor that can be switched off on demand. www.nature.com/articles/s41...
He gave us exciting insights into the power of nucleic acid assemblies. Very exciting data on a highly selective thrombin inhibitor that can be switched off on demand. www.nature.com/articles/s41...
October 30, 2025 at 3:35 PM
I was very happy to host Nicolas Winssinger today for a well-attended @led3hub.bsky.social Lecture.
He gave us exciting insights into the power of nucleic acid assemblies. Very exciting data on a highly selective thrombin inhibitor that can be switched off on demand. www.nature.com/articles/s41...
He gave us exciting insights into the power of nucleic acid assemblies. Very exciting data on a highly selective thrombin inhibitor that can be switched off on demand. www.nature.com/articles/s41...
We are very happy that Nicolas Winssinger visited us today for a LED3 Lecture. He talked about his group's research into using functional nucleic acid assemblies for various applications including highly selective protein inhibitors and targeted photodynamic therapy.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 30, 2025 at 3:28 PM
We are very happy that Nicolas Winssinger visited us today for a LED3 Lecture. He talked about his group's research into using functional nucleic acid assemblies for various applications including highly selective protein inhibitors and targeted photodynamic therapy.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
How can the selectivity of covalent inhibitors be studied at diverse amino acids?
In their Nature Chemistry paper the group of @stephanhacker2.bsky.social of our LED3hub developed an unbiased workflow to study electrophile reactivity and selectivity proteome-wide.(1/2)
www.nature.com/articles/s41...
In their Nature Chemistry paper the group of @stephanhacker2.bsky.social of our LED3hub developed an unbiased workflow to study electrophile reactivity and selectivity proteome-wide.(1/2)
www.nature.com/articles/s41...
Profiling the proteome-wide selectivity of diverse electrophiles - Nature Chemistry
Covalent inhibitors are powerful entities in drug discovery. Now the amino acid selectivity and reactivity of a diverse electrophile library have been assessed proteome-wide using an unbiased workflow...
www.nature.com
October 30, 2025 at 10:53 AM
How can the selectivity of covalent inhibitors be studied at diverse amino acids?
In their Nature Chemistry paper the group of @stephanhacker2.bsky.social of our LED3hub developed an unbiased workflow to study electrophile reactivity and selectivity proteome-wide.(1/2)
www.nature.com/articles/s41...
In their Nature Chemistry paper the group of @stephanhacker2.bsky.social of our LED3hub developed an unbiased workflow to study electrophile reactivity and selectivity proteome-wide.(1/2)
www.nature.com/articles/s41...
Reposted by Leiden Early Drug Discovery & Development (LED3)
How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid?
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Profiling the proteome-wide selectivity of diverse electrophiles - Nature Chemistry
Covalent inhibitors are powerful entities in drug discovery. Now the amino acid selectivity and reactivity of a diverse electrophile library have been assessed proteome-wide using an unbiased workflow...
www.nature.com
October 30, 2025 at 10:27 AM
How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid?
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Reposted by Leiden Early Drug Discovery & Development (LED3)
If you want to learn more, also check out the "In the Pipeline" blog post by @dereklowe.bsky.social from when the preprint was released: www.science.org/content/blog...
CC: @led3hub.bsky.social, @leidenscience.bsky.social, @unileiden.bsky.social, @tum.de
(7/7)
CC: @led3hub.bsky.social, @leidenscience.bsky.social, @unileiden.bsky.social, @tum.de
(7/7)
Comprehensive Covalent Probe Time
I really enjoyed this new paper on ChemRxiv, a Munich/Michigan/Berkeley collaboration on reactive covalent groups and their profile across different proteins. There have been a number of papers addres...
www.science.org
October 30, 2025 at 10:27 AM
If you want to learn more, also check out the "In the Pipeline" blog post by @dereklowe.bsky.social from when the preprint was released: www.science.org/content/blog...
CC: @led3hub.bsky.social, @leidenscience.bsky.social, @unileiden.bsky.social, @tum.de
(7/7)
CC: @led3hub.bsky.social, @leidenscience.bsky.social, @unileiden.bsky.social, @tum.de
(7/7)
We are looking forward to the LED3 Lecture of Nicolas Winssinger on Thursday October 30th: "Programing responsive assemblies from PNA-encoded and folded peptides"
If you are interested, make sure to come by!
www.universiteitleiden.nl/en/science/l...
#ChemBio #Chemistry #DrugDiscovery
If you are interested, make sure to come by!
www.universiteitleiden.nl/en/science/l...
#ChemBio #Chemistry #DrugDiscovery
October 29, 2025 at 11:56 AM
We are looking forward to the LED3 Lecture of Nicolas Winssinger on Thursday October 30th: "Programing responsive assemblies from PNA-encoded and folded peptides"
If you are interested, make sure to come by!
www.universiteitleiden.nl/en/science/l...
#ChemBio #Chemistry #DrugDiscovery
If you are interested, make sure to come by!
www.universiteitleiden.nl/en/science/l...
#ChemBio #Chemistry #DrugDiscovery
We are looking forward to the LED3 Lecture of Nicolas Winssinger on Thursday October 30th: "Programing responsive assemblies from PNA-encoded and folded peptides"
If you are interested, make sure to come by! www.universiteitleiden.nl/en/science/l...
#ChemBio #ChemSky #DrugDiscovery
If you are interested, make sure to come by! www.universiteitleiden.nl/en/science/l...
#ChemBio #ChemSky #DrugDiscovery
October 25, 2025 at 7:06 AM
We are looking forward to the LED3 Lecture of Nicolas Winssinger on Thursday October 30th: "Programing responsive assemblies from PNA-encoded and folded peptides"
If you are interested, make sure to come by! www.universiteitleiden.nl/en/science/l...
#ChemBio #ChemSky #DrugDiscovery
If you are interested, make sure to come by! www.universiteitleiden.nl/en/science/l...
#ChemBio #ChemSky #DrugDiscovery
What will future last resort #antibiotics look like? How can we make them safer to use?
In their project PRADA, the group of Nathaniel Martin is setting out to answer these questions.
Check out the linked video to learn more.
www.linkedin.com/posts/biotec...
#ChemSky #DrugDiscovery #Antibiotics
In their project PRADA, the group of Nathaniel Martin is setting out to answer these questions.
Check out the linked video to learn more.
www.linkedin.com/posts/biotec...
#ChemSky #DrugDiscovery #Antibiotics
Meet PRADA! 🔬🧬
Antimicrobial resistance (AMR) is making it harder to treat infections, forcing doctors to rely on powerful “last-resort” antibiotics like polymyxins. While effective, these drugs… | B...
Meet PRADA! 🔬🧬
Antimicrobial resistance (AMR) is making it harder to treat infections, forcing doctors to rely on powerful “last-resort” antibiotics like polymyxins. While effective, these drugs can ...
www.linkedin.com
October 25, 2025 at 7:00 AM
What will future last resort #antibiotics look like? How can we make them safer to use?
In their project PRADA, the group of Nathaniel Martin is setting out to answer these questions.
Check out the linked video to learn more.
www.linkedin.com/posts/biotec...
#ChemSky #DrugDiscovery #Antibiotics
In their project PRADA, the group of Nathaniel Martin is setting out to answer these questions.
Check out the linked video to learn more.
www.linkedin.com/posts/biotec...
#ChemSky #DrugDiscovery #Antibiotics
Reposted by Leiden Early Drug Discovery & Development (LED3)
It is my pleasure to invite you to the upcoming Kroese-Duijsters Symposium at Leiden University on 17th November. We have a great lineup of speakers covering time-resolved X-ray crystallography, time-resolved cryo-EM, microED, and AI approaches including a talk from DeepMind.
Are you interested in #StructuralBiology?
Register for the Kroese-Duijsters Symposium 2025 organized by our LED3 colleagues @steffenbruenle.bsky.social and Sebastian Geibel.
A great lineup of speakers including keynotes Ulrich Lorenz and Jörg Standfuss.
www.universiteitleiden.nl/en/kroese-du...
Register for the Kroese-Duijsters Symposium 2025 organized by our LED3 colleagues @steffenbruenle.bsky.social and Sebastian Geibel.
A great lineup of speakers including keynotes Ulrich Lorenz and Jörg Standfuss.
www.universiteitleiden.nl/en/kroese-du...
Kroese-Duijsters Symposium 2025
The Kroese-Duijsters Symposia aim to provide researchers from different fields and different career stages to meet in an informal setting, to stimulate discussions and to start new collaborations. The...
www.universiteitleiden.nl
October 17, 2025 at 11:21 AM
It is my pleasure to invite you to the upcoming Kroese-Duijsters Symposium at Leiden University on 17th November. We have a great lineup of speakers covering time-resolved X-ray crystallography, time-resolved cryo-EM, microED, and AI approaches including a talk from DeepMind.
Reposted by Leiden Early Drug Discovery & Development (LED3)
Why do #HeartAttacks and #Strokes remain a threat even in patients receiving treatment?
If you want to learn more about this, join us for the @leidenscience.bsky.social Tuesday Talk by @led3hub.bsky.social researcher Ilze Bot on November 11th.
www.universiteitleiden.nl/en/events/20...
If you want to learn more about this, join us for the @leidenscience.bsky.social Tuesday Talk by @led3hub.bsky.social researcher Ilze Bot on November 11th.
www.universiteitleiden.nl/en/events/20...
On November 11th, Ilze Bot will present her exciting research in our LED3hub at the @leidenscience.bsky.social Tuesday Talks to the Faculty. She will talk about "Breaking the Cycle of Heart Attacks".
If you are interested, make sure to register: www.universiteitleiden.nl/en/events/20...
If you are interested, make sure to register: www.universiteitleiden.nl/en/events/20...
October 17, 2025 at 10:11 AM
Why do #HeartAttacks and #Strokes remain a threat even in patients receiving treatment?
If you want to learn more about this, join us for the @leidenscience.bsky.social Tuesday Talk by @led3hub.bsky.social researcher Ilze Bot on November 11th.
www.universiteitleiden.nl/en/events/20...
If you want to learn more about this, join us for the @leidenscience.bsky.social Tuesday Talk by @led3hub.bsky.social researcher Ilze Bot on November 11th.
www.universiteitleiden.nl/en/events/20...
On November 11th, Ilze Bot will present her exciting research in our LED3hub at the @leidenscience.bsky.social Tuesday Talks to the Faculty. She will talk about "Breaking the Cycle of Heart Attacks".
If you are interested, make sure to register: www.universiteitleiden.nl/en/events/20...
If you are interested, make sure to register: www.universiteitleiden.nl/en/events/20...
October 17, 2025 at 10:08 AM
On November 11th, Ilze Bot will present her exciting research in our LED3hub at the @leidenscience.bsky.social Tuesday Talks to the Faculty. She will talk about "Breaking the Cycle of Heart Attacks".
If you are interested, make sure to register: www.universiteitleiden.nl/en/events/20...
If you are interested, make sure to register: www.universiteitleiden.nl/en/events/20...
Are you interested in #StructuralBiology?
Register for the Kroese-Duijsters Symposium 2025 organized by our LED3 colleagues @steffenbruenle.bsky.social and Sebastian Geibel.
A great lineup of speakers including keynotes Ulrich Lorenz and Jörg Standfuss.
www.universiteitleiden.nl/en/kroese-du...
Register for the Kroese-Duijsters Symposium 2025 organized by our LED3 colleagues @steffenbruenle.bsky.social and Sebastian Geibel.
A great lineup of speakers including keynotes Ulrich Lorenz and Jörg Standfuss.
www.universiteitleiden.nl/en/kroese-du...
Kroese-Duijsters Symposium 2025
The Kroese-Duijsters Symposia aim to provide researchers from different fields and different career stages to meet in an informal setting, to stimulate discussions and to start new collaborations. The...
www.universiteitleiden.nl
October 17, 2025 at 9:59 AM
Are you interested in #StructuralBiology?
Register for the Kroese-Duijsters Symposium 2025 organized by our LED3 colleagues @steffenbruenle.bsky.social and Sebastian Geibel.
A great lineup of speakers including keynotes Ulrich Lorenz and Jörg Standfuss.
www.universiteitleiden.nl/en/kroese-du...
Register for the Kroese-Duijsters Symposium 2025 organized by our LED3 colleagues @steffenbruenle.bsky.social and Sebastian Geibel.
A great lineup of speakers including keynotes Ulrich Lorenz and Jörg Standfuss.
www.universiteitleiden.nl/en/kroese-du...
Reposted by Leiden Early Drug Discovery & Development (LED3)
Exciting Tuesday Talk by Kim Bonger (@kimmb1.bsky.social) at @leidenscience.bsky.social. She talked about her group's exciting research into antigen-drug conjugates to target autoreactive B-cells as well as into CAR-T cell therapies for #cancer therapy. pubs.acs.org/doi/full/10....
October 14, 2025 at 2:57 PM
Exciting Tuesday Talk by Kim Bonger (@kimmb1.bsky.social) at @leidenscience.bsky.social. She talked about her group's exciting research into antigen-drug conjugates to target autoreactive B-cells as well as into CAR-T cell therapies for #cancer therapy. pubs.acs.org/doi/full/10....
Great talk by Kim Bonger (@kimmb1.bsky.social) at our Faculty's (@leidenscience.bsky.social) Tuesday Talks. She talked about her group's exciting research into precision medicine with a special focus on autoimmune diseases.
#ChemBio #ChemSky #DrugDiscovery
#ChemBio #ChemSky #DrugDiscovery
October 14, 2025 at 2:28 PM
Great talk by Kim Bonger (@kimmb1.bsky.social) at our Faculty's (@leidenscience.bsky.social) Tuesday Talks. She talked about her group's exciting research into precision medicine with a special focus on autoimmune diseases.
#ChemBio #ChemSky #DrugDiscovery
#ChemBio #ChemSky #DrugDiscovery
Reposted by Leiden Early Drug Discovery & Development (LED3)
Great interview with my @led3hub.bsky.social colleague @gillesvanwezel.bsky.social in C2W mens & molecule. He talks about new developments in #antibiotic #DrugDiscovery, the applications of #AI and opportunities to foster antibiotic development.
www.sciencelink.net/verdieping/p...
#ChemSky #ChemBio
www.sciencelink.net/verdieping/p...
#ChemSky #ChemBio
October 11, 2025 at 9:01 AM
Great interview with my @led3hub.bsky.social colleague @gillesvanwezel.bsky.social in C2W mens & molecule. He talks about new developments in #antibiotic #DrugDiscovery, the applications of #AI and opportunities to foster antibiotic development.
www.sciencelink.net/verdieping/p...
#ChemSky #ChemBio
www.sciencelink.net/verdieping/p...
#ChemSky #ChemBio
Hoe zou #antibioticaonderzoek er in de toekomst uit kunnen zien? Hoe kan de ontwikkeling van #antibiotica economisch aantrekkelijker worden gemaakt?
Als u geïnteresseerd bent in deze vragen, lees dan het interview met @gillesvanwezel.bsky.social
www.sciencelink.net/verdieping/p...
#Chemie #ChemBio
Als u geïnteresseerd bent in deze vragen, lees dan het interview met @gillesvanwezel.bsky.social
www.sciencelink.net/verdieping/p...
#Chemie #ChemBio
‘Prioriteren is het sleutelwoord’
De 'stille pandemie' van antibioticaresistentie kruipt verontrustend voort. Ondanks dat de farmaceutische industrie weinig interesse toont in het ontwikkelen van nieuwe antibiotica, zijn er genoeg ini...
www.sciencelink.net
October 11, 2025 at 8:55 AM
Hoe zou #antibioticaonderzoek er in de toekomst uit kunnen zien? Hoe kan de ontwikkeling van #antibiotica economisch aantrekkelijker worden gemaakt?
Als u geïnteresseerd bent in deze vragen, lees dan het interview met @gillesvanwezel.bsky.social
www.sciencelink.net/verdieping/p...
#Chemie #ChemBio
Als u geïnteresseerd bent in deze vragen, lees dan het interview met @gillesvanwezel.bsky.social
www.sciencelink.net/verdieping/p...
#Chemie #ChemBio
How could #antibiotic research look like in the future? How can antibiotic development be made more economically rewarding?
Check out the interview with LED3 hub researcher @gillesvanwezel.bsky.social (Dutch only).
www.sciencelink.net/verdieping/p...
#ChemSky #ChemBio #DrugDiscovery
Check out the interview with LED3 hub researcher @gillesvanwezel.bsky.social (Dutch only).
www.sciencelink.net/verdieping/p...
#ChemSky #ChemBio #DrugDiscovery
October 11, 2025 at 8:52 AM
How could #antibiotic research look like in the future? How can antibiotic development be made more economically rewarding?
Check out the interview with LED3 hub researcher @gillesvanwezel.bsky.social (Dutch only).
www.sciencelink.net/verdieping/p...
#ChemSky #ChemBio #DrugDiscovery
Check out the interview with LED3 hub researcher @gillesvanwezel.bsky.social (Dutch only).
www.sciencelink.net/verdieping/p...
#ChemSky #ChemBio #DrugDiscovery
Reposted by Leiden Early Drug Discovery & Development (LED3)
Very much looking forward to hosting Nicolas Winssinger for a @led3hub.bsky.social Lecture on October 30th.
If you are interested in nucleic acid-encoded libraries, mark your calendars and join us in Leiden @leidenscience.bsky.social.
www.universiteitleiden.nl/en/science/l...
#ChemBio #ChemSky
If you are interested in nucleic acid-encoded libraries, mark your calendars and join us in Leiden @leidenscience.bsky.social.
www.universiteitleiden.nl/en/science/l...
#ChemBio #ChemSky
October 8, 2025 at 9:11 AM
Very much looking forward to hosting Nicolas Winssinger for a @led3hub.bsky.social Lecture on October 30th.
If you are interested in nucleic acid-encoded libraries, mark your calendars and join us in Leiden @leidenscience.bsky.social.
www.universiteitleiden.nl/en/science/l...
#ChemBio #ChemSky
If you are interested in nucleic acid-encoded libraries, mark your calendars and join us in Leiden @leidenscience.bsky.social.
www.universiteitleiden.nl/en/science/l...
#ChemBio #ChemSky