UPenn Institute of Structural Biology
@isbupenn.bsky.social
Reposted by UPenn Institute of Structural Biology
Wishing you & yours a restful & restorative holiday break! We'll see you back online in 2️⃣0️⃣2️⃣6️⃣! 💓✨
December 23, 2025 at 3:53 PM
Wishing you & yours a restful & restorative holiday break! We'll see you back online in 2️⃣0️⃣2️⃣6️⃣! 💓✨
Reposted by UPenn Institute of Structural Biology
Visualization of lysosomal membrane proteins by cryo electron tomography ft. @bridget_mcveigh, José De Jesús-Pérez, @moiseenkovabell (@PennSysPharmATT), Prerana Gogoi, @MageswaranKumar & Elaine Mihelc (@isbupenn.bsky.social) @natcomms.nature.com www.nature.com/articles/s41...
November 17, 2025 at 2:23 PM
Visualization of lysosomal membrane proteins by cryo electron tomography ft. @bridget_mcveigh, José De Jesús-Pérez, @moiseenkovabell (@PennSysPharmATT), Prerana Gogoi, @MageswaranKumar & Elaine Mihelc (@isbupenn.bsky.social) @natcomms.nature.com www.nature.com/articles/s41...
Reposted by UPenn Institute of Structural Biology
Excited to share our latest @nature.com: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation.💊🧪 🧵👇 www.nature.com/articles/s41...
November 5, 2025 at 4:23 PM
Excited to share our latest @nature.com: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation.💊🧪 🧵👇 www.nature.com/articles/s41...
We’re proud to celebrate our institute associate director, Dr. Yi-Wei Chang, for being named the 2025 recipient of the Michael S. Brown New Investigator Research Award.
@yiweichang.bsky.social
@yiweichang.bsky.social
October 24, 2025 at 1:34 PM
We’re proud to celebrate our institute associate director, Dr. Yi-Wei Chang, for being named the 2025 recipient of the Michael S. Brown New Investigator Research Award.
@yiweichang.bsky.social
@yiweichang.bsky.social
Congrats Bridget McVeigh, José De Jesús-Pérez, Elaine Mihelc & Vera Moiseenkova-Bell on your first cryoET publication "Visualization of lysosomal membrane proteins by cryo electron tomography" #cryoET #lysosomes #TRPML1
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Visualization of lysosomal membrane proteins by cryo electron tomography - Nature Communications
Lysosomes are vital for cellular health and linked to many diseases. Here, authors use cryo-ET to image intact lysosomes and resolve lysosomal protein structures, providing a platform to advance the s...
www.nature.com
October 17, 2025 at 6:43 PM
Congrats Bridget McVeigh, José De Jesús-Pérez, Elaine Mihelc & Vera Moiseenkova-Bell on your first cryoET publication "Visualization of lysosomal membrane proteins by cryo electron tomography" #cryoET #lysosomes #TRPML1
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by UPenn Institute of Structural Biology
Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit
www.nexperion.net/semcm2026
www.nexperion.net/semcm2026
September 23, 2025 at 10:42 AM
Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit
www.nexperion.net/semcm2026
www.nexperion.net/semcm2026
Reposted by UPenn Institute of Structural Biology
...and big thanks to @jiwasa.bsky.social for making this amazing video to illustrate the strand-sliding mechanism!
May 15, 2025 at 7:51 PM
...and big thanks to @jiwasa.bsky.social for making this amazing video to illustrate the strand-sliding mechanism!
Reposted by UPenn Institute of Structural Biology
Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis
Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...
www.science.org
May 15, 2025 at 7:51 PM
Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Congratulations to Drs. Lynch, Burslem, Marmorstein, Yi-Wei, and the entire research team on the publication of your latest research article in the newest issue of Science magazine! | Science www.science.org/doi/10.1126/...
Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis
Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...
www.science.org
May 15, 2025 at 6:46 PM
Congratulations to Drs. Lynch, Burslem, Marmorstein, Yi-Wei, and the entire research team on the publication of your latest research article in the newest issue of Science magazine! | Science www.science.org/doi/10.1126/...
Reposted by UPenn Institute of Structural Biology
Join the Institute of Structural Biology on 5/21 for the 4th Structural Biology Symposium! Learn more & register➡️ isb.med.upenn.edu/4th-structur... @BB_UPenn
May 8, 2025 at 2:21 PM
Join the Institute of Structural Biology on 5/21 for the 4th Structural Biology Symposium! Learn more & register➡️ isb.med.upenn.edu/4th-structur... @BB_UPenn
🔬 The 4th Structural Biology Symposium is almost here!
Don’t miss out—there’s still time to register.
bit.ly/4iM5QAm
Don’t miss out—there’s still time to register.
bit.ly/4iM5QAm
May 2, 2025 at 6:47 PM
🔬 The 4th Structural Biology Symposium is almost here!
Don’t miss out—there’s still time to register.
bit.ly/4iM5QAm
Don’t miss out—there’s still time to register.
bit.ly/4iM5QAm
Reposted by UPenn Institute of Structural Biology
Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...
May 1, 2025 at 6:17 PM
Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...
Congratulations to Roberto Dominguez and his lab on their latest Nature publication: "Mechanism of actin filament severing and capping by gelsolin"! 🧬 An exciting contribution to our understanding of cytoskeletal dynamics.📖 Read the full article here: www.nature.com/articles/s41...
Mechanism of actin filament severing and capping by gelsolin - Nature Structural & Molecular Biology
The authors use cryo-electron microscopy to reveal two structural states of Ca2+-activated gelsolin bound to the actin filament, illuminating the mechanisms of filament severing and barbed end capping...
www.nature.com
April 24, 2025 at 4:24 PM
Congratulations to Roberto Dominguez and his lab on their latest Nature publication: "Mechanism of actin filament severing and capping by gelsolin"! 🧬 An exciting contribution to our understanding of cytoskeletal dynamics.📖 Read the full article here: www.nature.com/articles/s41...
Registration is now open for the 4th Structural Biology Symposium.
Poster abstract submission is due on 4/15/2025. isb.med.upenn.edu/4th-structur...
🧬@Structuralbiology
Poster abstract submission is due on 4/15/2025. isb.med.upenn.edu/4th-structur...
🧬@Structuralbiology
March 17, 2025 at 6:21 PM
Registration is now open for the 4th Structural Biology Symposium.
Poster abstract submission is due on 4/15/2025. isb.med.upenn.edu/4th-structur...
🧬@Structuralbiology
Poster abstract submission is due on 4/15/2025. isb.med.upenn.edu/4th-structur...
🧬@Structuralbiology
Reposted by UPenn Institute of Structural Biology
Emily Whitehead and her father on CNN with Jake Tapper speaking to the value of science. She is alive thanks to CAR T therapy developed at Penn and CHOP.
March 7, 2025 at 11:46 PM
Emily Whitehead and her father on CNN with Jake Tapper speaking to the value of science. She is alive thanks to CAR T therapy developed at Penn and CHOP.
Reposted by UPenn Institute of Structural Biology
Pharmacology 💊 women in STEM 👩🏻🔬 showed up & out for scientific funding! 🧬
#standupforscience2025
#standupforsciencephilly
#standupforscience2025
#standupforsciencephilly
March 7, 2025 at 7:18 PM
Pharmacology 💊 women in STEM 👩🏻🔬 showed up & out for scientific funding! 🧬
#standupforscience2025
#standupforsciencephilly
#standupforscience2025
#standupforsciencephilly
Reposted by UPenn Institute of Structural Biology
Philadelphia Stand Up For Science! #standupforscience2025
Friday, March 7 · 11am - 1pm
Philadelphia City Hall
standupforscience2025.org
Friday, March 7 · 11am - 1pm
Philadelphia City Hall
standupforscience2025.org
February 26, 2025 at 1:35 AM
Philadelphia Stand Up For Science! #standupforscience2025
Friday, March 7 · 11am - 1pm
Philadelphia City Hall
standupforscience2025.org
Friday, March 7 · 11am - 1pm
Philadelphia City Hall
standupforscience2025.org
Congrats Kollin Schultz & Ronen Marmorstein Lab on your Nature publication: "Snapshots of acyl carrier protein shuttling in human fatty acid synthase"
www.nature.com/articles/s41...
#cryoEM #StructuralBiology
www.nature.com/articles/s41...
#cryoEM #StructuralBiology
Snapshots of acyl carrier protein shuttling in human fatty acid synthase - Nature
Using cryo-electron microscopy, the structures of mammalian fatty acid synthase reveal how the acyl carrier protein dynamically shuttles intermediates between selected active sites.
www.nature.com
February 21, 2025 at 6:10 PM
Congrats Kollin Schultz & Ronen Marmorstein Lab on your Nature publication: "Snapshots of acyl carrier protein shuttling in human fatty acid synthase"
www.nature.com/articles/s41...
#cryoEM #StructuralBiology
www.nature.com/articles/s41...
#cryoEM #StructuralBiology
Congrats Julia Rocereta & Moiseenkova-Bell Lab on your Nature Structural & Molecular Biology publication: "Structural insights into TRPV2 modulation by probenecid"
#cryoEM #TRPV2 #TRPchannels
www.nature.com/articles/s41...
#cryoEM #TRPV2 #TRPchannels
www.nature.com/articles/s41...
Structural insights into TRPV2 modulation by probenecid
Nature Structural & Molecular Biology - The authors reveal that probenecid, an FDA-approved drug, uniquely modulates TRPV2 through an intracellular pocket. Probenecid drives the channel into an...
www.nature.com
February 19, 2025 at 11:02 PM
Congrats Julia Rocereta & Moiseenkova-Bell Lab on your Nature Structural & Molecular Biology publication: "Structural insights into TRPV2 modulation by probenecid"
#cryoEM #TRPV2 #TRPchannels
www.nature.com/articles/s41...
#cryoEM #TRPV2 #TRPchannels
www.nature.com/articles/s41...
Thrilled to share our work with the Ben Black Lab, led by co-mentored star MD/PhD student Katie Kixmoeller @pennmedicine.bsky.social, now in @cellcellpress.bsky.social ! We used cryo-ET to study kinetochore features in human mitotic chromosomes. 🧬🔬❄️
authors.elsevier.com/c/1kUW9L7PXq...
authors.elsevier.com/c/1kUW9L7PXq...
authors.elsevier.com
January 23, 2025 at 7:59 PM
Thrilled to share our work with the Ben Black Lab, led by co-mentored star MD/PhD student Katie Kixmoeller @pennmedicine.bsky.social, now in @cellcellpress.bsky.social ! We used cryo-ET to study kinetochore features in human mitotic chromosomes. 🧬🔬❄️
authors.elsevier.com/c/1kUW9L7PXq...
authors.elsevier.com/c/1kUW9L7PXq...