Pavel Barahtjan
@pavelbarahtjan.bsky.social
Lipids | Membranes | Tardigrades | Chemical Biology | PostDoc @EPFL | Alumnus @MPICBB
Congrats @mikelangelipid.bsky.social and @olzmannlab.bsky.social ! Amazing story and findings.
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 7:55 PM
Congrats @mikelangelipid.bsky.social and @olzmannlab.bsky.social ! Amazing story and findings.
Reposted by Pavel Barahtjan
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 6:23 AM
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Pavel Barahtjan
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 12:22 PM
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
Reposted by Pavel Barahtjan
Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...
October 9, 2025 at 9:01 AM
Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...
Reposted by Pavel Barahtjan
🌶️ Lipids bring the heat 🔥
Lipids don’t just shape membranes, they influence cellular metabolism.
We show that tuning lipidome composition strongly alters metabolic heat flow in the minimal cell JCVI-Syn3B 🦠
Fantastic collaboration with Karim Fahmy’s lab (HZDR) 🎉
www.biorxiv.org/content/10.1...
Lipids don’t just shape membranes, they influence cellular metabolism.
We show that tuning lipidome composition strongly alters metabolic heat flow in the minimal cell JCVI-Syn3B 🦠
Fantastic collaboration with Karim Fahmy’s lab (HZDR) 🎉
www.biorxiv.org/content/10.1...
Metabolic heat flow from the minimal cell JCVI-Syn3B reveals the lipidome-dependence of growth and metabolism
The cell membrane facilitates interactions with the environment and serves as an organizational platform for coordinating cellular processes, with lipids playing a central role in determining membrane...
www.biorxiv.org
September 24, 2025 at 2:40 PM
🌶️ Lipids bring the heat 🔥
Lipids don’t just shape membranes, they influence cellular metabolism.
We show that tuning lipidome composition strongly alters metabolic heat flow in the minimal cell JCVI-Syn3B 🦠
Fantastic collaboration with Karim Fahmy’s lab (HZDR) 🎉
www.biorxiv.org/content/10.1...
Lipids don’t just shape membranes, they influence cellular metabolism.
We show that tuning lipidome composition strongly alters metabolic heat flow in the minimal cell JCVI-Syn3B 🦠
Fantastic collaboration with Karim Fahmy’s lab (HZDR) 🎉
www.biorxiv.org/content/10.1...
Reposted by Pavel Barahtjan
So honored to be awarded the ERC Starting Grant! I am very grateful for this support and looking forward to more exciting #lipidtime 🥳
Also, we will have positions available next year. So stay tuned!
Also, we will have positions available next year. So stay tuned!
📣 The ERC Starting Grant call results are out!
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
September 4, 2025 at 8:18 PM
So honored to be awarded the ERC Starting Grant! I am very grateful for this support and looking forward to more exciting #lipidtime 🥳
Also, we will have positions available next year. So stay tuned!
Also, we will have positions available next year. So stay tuned!
Reposted by Pavel Barahtjan
We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)
September 4, 2025 at 8:22 AM
We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)
Reposted by Pavel Barahtjan
Happy to share our work on uMAIA, a framework for building metabolomic atlases from mass spectrometry imaging.
With uMAIA, we mapped the lipidome of zebrafish development, uncovering spatially organized metabolic programs .
www.nature.com/articles/s41...
#developmentalbiology #MSI #lipidtime
With uMAIA, we mapped the lipidome of zebrafish development, uncovering spatially organized metabolic programs .
www.nature.com/articles/s41...
#developmentalbiology #MSI #lipidtime
Unified mass imaging maps the lipidome of vertebrate development
Nature Methods - uMAIA is an analytical framework designed to enable the construction of metabolic atlases at high resolution using mass spectrometry imaging data.
www.nature.com
September 3, 2025 at 10:40 AM
Happy to share our work on uMAIA, a framework for building metabolomic atlases from mass spectrometry imaging.
With uMAIA, we mapped the lipidome of zebrafish development, uncovering spatially organized metabolic programs .
www.nature.com/articles/s41...
#developmentalbiology #MSI #lipidtime
With uMAIA, we mapped the lipidome of zebrafish development, uncovering spatially organized metabolic programs .
www.nature.com/articles/s41...
#developmentalbiology #MSI #lipidtime
Reposted by Pavel Barahtjan
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 21, 2025 at 5:19 AM
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Pavel Barahtjan
Quite a week for #lipidtime: phenomenal study using bifunctional lipid probes to quantify intracellular lipid transport from @nadlerlab.bsky.social and colleagues is now out @nature.com! www.nature.com/articles/s41...
Quantitative imaging of lipid transport in mammalian cells - Nature
Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.
www.nature.com
August 20, 2025 at 10:01 PM
Quite a week for #lipidtime: phenomenal study using bifunctional lipid probes to quantify intracellular lipid transport from @nadlerlab.bsky.social and colleagues is now out @nature.com! www.nature.com/articles/s41...
Reposted by Pavel Barahtjan
We are hiring!
If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland!
More information on www.epfl.ch/labs/gr-schu...
If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland!
More information on www.epfl.ch/labs/gr-schu...
Open positions
GR-SCHUHMACHER
www.epfl.ch
August 12, 2025 at 9:32 AM
We are hiring!
If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland!
More information on www.epfl.ch/labs/gr-schu...
If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland!
More information on www.epfl.ch/labs/gr-schu...
The world is small... Randomly found out that @mikelangelipid.bsky.social and I are both in Osaka, so we met up for some drinks and #lipidtime talk.
May 29, 2025 at 1:19 PM
The world is small... Randomly found out that @mikelangelipid.bsky.social and I are both in Osaka, so we met up for some drinks and #lipidtime talk.
Reposted by Pavel Barahtjan
Think biosensors that give absolute measurement values! So happy this is out :) congrats to everyone involved, especially @sascha-kuhn.bsky.social and @nadlerlab.bsky.social
Meet GEQO: Genetically-encoded biosensors for absolute small-molecule quantification in single cells brought to you by @sascha-kuhn.bsky.social. For simple absolute quantification of your favourite small molecule or ion, head on over to @bioarxiv and read our new preprint: doi.org/10.1101/2025...
May 13, 2025 at 2:06 PM
Think biosensors that give absolute measurement values! So happy this is out :) congrats to everyone involved, especially @sascha-kuhn.bsky.social and @nadlerlab.bsky.social
Reposted by Pavel Barahtjan
Why are biological membranes asymmetric, with different lipids in the two bilayer leaflets? Discovered in the 70s, lipid asymmetry is linked to many cellular processes, but why the cell needs it is largely unclear. @pavelbarahtjan.bsky.social addresses this question: www.biorxiv.org/content/10.1...
May 6, 2025 at 9:01 AM
Why are biological membranes asymmetric, with different lipids in the two bilayer leaflets? Discovered in the 70s, lipid asymmetry is linked to many cellular processes, but why the cell needs it is largely unclear. @pavelbarahtjan.bsky.social addresses this question: www.biorxiv.org/content/10.1...
Reposted by Pavel Barahtjan
Meet GEQO: Genetically-encoded biosensors for absolute small-molecule quantification in single cells brought to you by @sascha-kuhn.bsky.social. For simple absolute quantification of your favourite small molecule or ion, head on over to @bioarxiv and read our new preprint: doi.org/10.1101/2025...
May 13, 2025 at 8:40 AM
Meet GEQO: Genetically-encoded biosensors for absolute small-molecule quantification in single cells brought to you by @sascha-kuhn.bsky.social. For simple absolute quantification of your favourite small molecule or ion, head on over to @bioarxiv and read our new preprint: doi.org/10.1101/2025...
Reposted by Pavel Barahtjan
An amazing new enabling technology. Measurements of molecular size and shape on a chip. Couldn't be prouder of our friend Madhavi Krishnan of @ox.ac.uk this was and is one among the must fun collaborations I ever had. www.science.org/doi/10.1126/...
Measurements of molecular size and shape on a chip
Size and shape are critical discriminators between molecular species and states. We describe a microchip-based high-throughput imaging approach offering rapid and precise determination of molecular pr...
www.science.org
May 9, 2025 at 8:00 AM
An amazing new enabling technology. Measurements of molecular size and shape on a chip. Couldn't be prouder of our friend Madhavi Krishnan of @ox.ac.uk this was and is one among the must fun collaborations I ever had. www.science.org/doi/10.1126/...
Really happy that my main PhD story is out! Huge thanks to everyone involved - especially @nadlerlab.bsky.social - for giving me the opportunity to work on this amazing topic.
Why are biological membranes asymmetric, with different lipids in the two bilayer leaflets? Discovered in the 70s, lipid asymmetry is linked to many cellular processes, but why the cell needs it is largely unclear. @pavelbarahtjan.bsky.social addresses this question: www.biorxiv.org/content/10.1...
May 6, 2025 at 10:19 AM
Really happy that my main PhD story is out! Huge thanks to everyone involved - especially @nadlerlab.bsky.social - for giving me the opportunity to work on this amazing topic.
Amazing work! Of course LA is the answer to all questions :D
Are lipids actively sorted during clathrin mediated endocytosis like proteins? @mathilda95.bsky.social addresses this key open question together with our collaborators from the Honigmann and Modes labs using a new Lipid-STED workflow.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
March 10, 2025 at 1:41 PM
Amazing work! Of course LA is the answer to all questions :D
Reposted by Pavel Barahtjan
Amazing review to learn about single-cell lipid biology ! Congratulations to all authors @antonino-asaro.bsky.social @Agostina Crotta Asis @giodang.bsky.social published in @cp-trendscellbio.bsky.social !
www.cell.com/trends/cell-...
www.cell.com/trends/cell-...
Single cell lipid biology
Lipids are major cell constituents endowed with astonishing structural diversity.
The pathways responsible for the assembly and disposal of different lipid species
are energetically demanding, and gen...
www.cell.com
January 16, 2025 at 1:46 PM
Amazing review to learn about single-cell lipid biology ! Congratulations to all authors @antonino-asaro.bsky.social @Agostina Crotta Asis @giodang.bsky.social published in @cp-trendscellbio.bsky.social !
www.cell.com/trends/cell-...
www.cell.com/trends/cell-...