IMP
@impvienna.bsky.social
The IMP is a leading life science centre in Europe with 220 researchers from 40 countries. Part of the ViennaBioCenter.
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IMP
@impvienna.bsky.social
· Feb 10
At the IMP we’re dedicated to the fun of finding out. Few places in the world let you dive into curiosity-driven science like we do.
📽️Watch what the IMP is all about: youtu.be/mtl5Vod652Q
@viennabiocenter.bsky.social
📽️Watch what the IMP is all about: youtu.be/mtl5Vod652Q
@viennabiocenter.bsky.social
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
November 10, 2025 at 1:26 PM
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Congrats to our Paul Welzl and Robert Kalis! 🎉
🏆 Paul (Plaschka & Balzarotti labs) received the 2025 Lauwers Award for his Monday Seminar talk on super-resolved mRNA imaging.
🏆 Robert (Zuber lab) won a Vienna BioCenter PhD Award for his work on cancer cell metabolism.
🏆 Paul (Plaschka & Balzarotti labs) received the 2025 Lauwers Award for his Monday Seminar talk on super-resolved mRNA imaging.
🏆 Robert (Zuber lab) won a Vienna BioCenter PhD Award for his work on cancer cell metabolism.
November 7, 2025 at 5:19 PM
Congrats to our Paul Welzl and Robert Kalis! 🎉
🏆 Paul (Plaschka & Balzarotti labs) received the 2025 Lauwers Award for his Monday Seminar talk on super-resolved mRNA imaging.
🏆 Robert (Zuber lab) won a Vienna BioCenter PhD Award for his work on cancer cell metabolism.
🏆 Paul (Plaschka & Balzarotti labs) received the 2025 Lauwers Award for his Monday Seminar talk on super-resolved mRNA imaging.
🏆 Robert (Zuber lab) won a Vienna BioCenter PhD Award for his work on cancer cell metabolism.
New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
November 6, 2025 at 4:04 PM
New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
What’s it like doing a PhD between two labs? In our latest Behind the Science, Júlia Portell i de Montserrat, shared PhD student in the Plaschka lab at the IMP and the Brennecke lab at @imbavienna.bsky.social, tells us more about her unusual but rewarding PhD journey: bit.ly/3IHXtdp
October 13, 2025 at 3:07 PM
What’s it like doing a PhD between two labs? In our latest Behind the Science, Júlia Portell i de Montserrat, shared PhD student in the Plaschka lab at the IMP and the Brennecke lab at @imbavienna.bsky.social, tells us more about her unusual but rewarding PhD journey: bit.ly/3IHXtdp
Reposted by IMP
Scientists from DKFZ and @impvienna.bsky.social have discovered that the acidic pH value in tumor tissue is a decisive factor in how pancreatic cancer cells adapt their energy metabolism in order to survive under adverse conditions. @wilhelmpalm.bsky.social @science.org
t1p.de/wm8je
t1p.de/wm8je
Acidic tumor environment promotes survival and growth of cancer cells
Tumors are not a comfortable place to live: oxygen deficiency, nutrient scarcity, and the accumulation of sometimes harmful metabolic products constantly stress cancer cells. A research team from the ...
t1p.de
October 10, 2025 at 9:57 AM
Scientists from DKFZ and @impvienna.bsky.social have discovered that the acidic pH value in tumor tissue is a decisive factor in how pancreatic cancer cells adapt their energy metabolism in order to survive under adverse conditions. @wilhelmpalm.bsky.social @science.org
t1p.de/wm8je
t1p.de/wm8je
Reposted by IMP
Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
October 9, 2025 at 7:37 PM
Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
🧪 How does cancer turn sour into power?
Cancer cells thrive in hostile, acidic environments.
A team led by Johannes Zuber (IMP) & Wilhelm Palm (DKFZ) shows that acidosis acts as a master switch, rewiring tumour metabolism and boosting resilience.
➡️ www.science.org/doi/10.1126/...
Cancer cells thrive in hostile, acidic environments.
A team led by Johannes Zuber (IMP) & Wilhelm Palm (DKFZ) shows that acidosis acts as a master switch, rewiring tumour metabolism and boosting resilience.
➡️ www.science.org/doi/10.1126/...
October 9, 2025 at 6:14 PM
🧪 How does cancer turn sour into power?
Cancer cells thrive in hostile, acidic environments.
A team led by Johannes Zuber (IMP) & Wilhelm Palm (DKFZ) shows that acidosis acts as a master switch, rewiring tumour metabolism and boosting resilience.
➡️ www.science.org/doi/10.1126/...
Cancer cells thrive in hostile, acidic environments.
A team led by Johannes Zuber (IMP) & Wilhelm Palm (DKFZ) shows that acidosis acts as a master switch, rewiring tumour metabolism and boosting resilience.
➡️ www.science.org/doi/10.1126/...
Reposted by IMP
Before Jürgen Knoblich became known for his groundbreaking brain organoid research, he studied asymmetric cell division in Drosophila at the @impvienna.bsky.social.
📖 Read the full milestone essay: https://www.imp.ac.at/achievements/research-milestones/knoblich-asymmetric-cell-division
📖 Read the full milestone essay: https://www.imp.ac.at/achievements/research-milestones/knoblich-asymmetric-cell-division
October 8, 2025 at 12:20 PM
Before Jürgen Knoblich became known for his groundbreaking brain organoid research, he studied asymmetric cell division in Drosophila at the @impvienna.bsky.social.
📖 Read the full milestone essay: https://www.imp.ac.at/achievements/research-milestones/knoblich-asymmetric-cell-division
📖 Read the full milestone essay: https://www.imp.ac.at/achievements/research-milestones/knoblich-asymmetric-cell-division
Reposted by IMP
Our PhD program offers many training activities and courses for your future career. Check out the range of fully-funded PhD positions in our Autumn call before 10 October 2025: www.vbcphd.at
October 5, 2025 at 11:00 AM
Our PhD program offers many training activities and courses for your future career. Check out the range of fully-funded PhD positions in our Autumn call before 10 October 2025: www.vbcphd.at
Congratulations to Sakurako Nagumo Wong, former PhD student in the @knoblich-lab.bsky.social at @imbavienna.bsky.social, who was awarded the 2025 Rabitsch Award for her remarkable contributions to the study of human cortical development and neurodevelopmental disorders. Read more: bit.ly/4ntgI9r
October 2, 2025 at 9:50 AM
Congratulations to Sakurako Nagumo Wong, former PhD student in the @knoblich-lab.bsky.social at @imbavienna.bsky.social, who was awarded the 2025 Rabitsch Award for her remarkable contributions to the study of human cortical development and neurodevelopmental disorders. Read more: bit.ly/4ntgI9r
Reposted by IMP
Manuel Matzinger, Senior Core Scientist & Deputy Head of the Proteomics Tech Hub of IMP, IMBA and GMI, received the Society Medal of the Austrian Proteomics and Metabolomics Association (APMA) for his pioneering contributions to single-cell proteomics. More:
www.viennabiocenter.org/about/news/m...
www.viennabiocenter.org/about/news/m...
September 30, 2025 at 11:08 AM
Manuel Matzinger, Senior Core Scientist & Deputy Head of the Proteomics Tech Hub of IMP, IMBA and GMI, received the Society Medal of the Austrian Proteomics and Metabolomics Association (APMA) for his pioneering contributions to single-cell proteomics. More:
www.viennabiocenter.org/about/news/m...
www.viennabiocenter.org/about/news/m...
🎉Congrats to our @vdeneke.bsky.social, postdoc in the @pauligroup.bsky.social, who has received the 2025 Life Sciences Research Award Austria from the ÖGMBT!
She's recognised for her groundbreaking work on the molecular mechanisms of fertilisation: www.imp.ac.at/news/article...
She's recognised for her groundbreaking work on the molecular mechanisms of fertilisation: www.imp.ac.at/news/article...
September 26, 2025 at 8:41 AM
🎉Congrats to our @vdeneke.bsky.social, postdoc in the @pauligroup.bsky.social, who has received the 2025 Life Sciences Research Award Austria from the ÖGMBT!
She's recognised for her groundbreaking work on the molecular mechanisms of fertilisation: www.imp.ac.at/news/article...
She's recognised for her groundbreaking work on the molecular mechanisms of fertilisation: www.imp.ac.at/news/article...
Reposted by IMP
Explore projects in Stem Cells, development + more in our Autumn PhD call which is OPEN!
20+ fully funded positions across diverse life science disciplines. 👉 www.vbcphd.at
Apply by 10 Oct 2025
20+ fully funded positions across diverse life science disciplines. 👉 www.vbcphd.at
Apply by 10 Oct 2025
September 14, 2025 at 2:02 PM
Explore projects in Stem Cells, development + more in our Autumn PhD call which is OPEN!
20+ fully funded positions across diverse life science disciplines. 👉 www.vbcphd.at
Apply by 10 Oct 2025
20+ fully funded positions across diverse life science disciplines. 👉 www.vbcphd.at
Apply by 10 Oct 2025
Congratulations to our @obenaufa.bsky.social on receiving the highly prestigious Dr. Josef Steiner Cancer Research Award 2025! 🎉
Read more in this interview with Anna: www.imp.ac.at/news/article...
Read more in this interview with Anna: www.imp.ac.at/news/article...
September 12, 2025 at 4:01 PM
Congratulations to our @obenaufa.bsky.social on receiving the highly prestigious Dr. Josef Steiner Cancer Research Award 2025! 🎉
Read more in this interview with Anna: www.imp.ac.at/news/article...
Read more in this interview with Anna: www.imp.ac.at/news/article...
Exciting news! We're thrilled to announce the six outstanding laureates of the International Birnstiel Award for Doctoral Studies in Molecular Life Sciences 2025!
🏆Congratulations to all awardees and honourable mentions! 🎉 1/ ➡️ www.imp.ac.at/news/article...
🏆Congratulations to all awardees and honourable mentions! 🎉 1/ ➡️ www.imp.ac.at/news/article...
September 10, 2025 at 10:19 AM
Exciting news! We're thrilled to announce the six outstanding laureates of the International Birnstiel Award for Doctoral Studies in Molecular Life Sciences 2025!
🏆Congratulations to all awardees and honourable mentions! 🎉 1/ ➡️ www.imp.ac.at/news/article...
🏆Congratulations to all awardees and honourable mentions! 🎉 1/ ➡️ www.imp.ac.at/news/article...
David Baltimore, Nobel laureate, pioneering biologist, and friend of the IMP since its foundation, passed away at the age of 87. Obituary: www.imp.ac.at/news/article...
September 9, 2025 at 8:58 AM
David Baltimore, Nobel laureate, pioneering biologist, and friend of the IMP since its foundation, passed away at the age of 87. Obituary: www.imp.ac.at/news/article...
New paper by our Plaschka lab with Brennecke’s lab at IMBA!
Researchers at the Vienna BioCenter have solved a 20-year-old mystery in genome biology, revealing how PIWI proteins engage partner molecules to silence “jumping genes” that threaten genetic stability.
Researchers at the Vienna BioCenter have solved a 20-year-old mystery in genome biology, revealing how PIWI proteins engage partner molecules to silence “jumping genes” that threaten genetic stability.
How cells lock down “jumping genes”:
Researchers from IMBA and IMP identify the first protein interactions that trigger PIWI–piRNA–mediated transposon silencing, using AlphaFold predictions, genetics, biochemistry and cell biology.
Read more: www.viennabiocenter.org/about/news/t...
Researchers from IMBA and IMP identify the first protein interactions that trigger PIWI–piRNA–mediated transposon silencing, using AlphaFold predictions, genetics, biochemistry and cell biology.
Read more: www.viennabiocenter.org/about/news/t...
September 8, 2025 at 9:10 AM
New paper by our Plaschka lab with Brennecke’s lab at IMBA!
Researchers at the Vienna BioCenter have solved a 20-year-old mystery in genome biology, revealing how PIWI proteins engage partner molecules to silence “jumping genes” that threaten genetic stability.
Researchers at the Vienna BioCenter have solved a 20-year-old mystery in genome biology, revealing how PIWI proteins engage partner molecules to silence “jumping genes” that threaten genetic stability.
Reposted by IMP
The Vienna BioCenter PhD program in Molecular BioSciences will offer 20+ fully-funded positions in the Autumn Call which is now open. Have a look at what our campus has to offer: www.vbcphd.at
September 7, 2025 at 12:48 PM
The Vienna BioCenter PhD program in Molecular BioSciences will offer 20+ fully-funded positions in the Autumn Call which is now open. Have a look at what our campus has to offer: www.vbcphd.at
Reposted by IMP
The Vienna BioCenter PhD program in Molecular BioSciences will offer 20+ fully-funded positions in the Autumn Call which is now open. Please share. Further details: www.vbcphd.at
September 5, 2025 at 12:18 PM
The Vienna BioCenter PhD program in Molecular BioSciences will offer 20+ fully-funded positions in the Autumn Call which is now open. Please share. Further details: www.vbcphd.at
Researchers around @clausenlab.bsky.social & @dangrabarczyk.bsky.social have unveiled the three-dimensional structure of UBR4, a giant protein complex that safeguards cells by targeting defective proteins for destruction—offering fresh insights into health & disease. www.science.org/doi/10.1126/...
Inside the cell’s recycling hub: unveiling the architecture of UBR4
Researchers from the lab of Tim Clausen and collaborators have unveiled the three-dimensional structure of UBR4, a giant protein complex that safeguards cells by targeting defective proteins for destr...
www.imp.ac.at
August 28, 2025 at 6:28 PM
Researchers around @clausenlab.bsky.social & @dangrabarczyk.bsky.social have unveiled the three-dimensional structure of UBR4, a giant protein complex that safeguards cells by targeting defective proteins for destruction—offering fresh insights into health & disease. www.science.org/doi/10.1126/...
Reposted by IMP
Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles
Grabarczyk et al. show the structure and mechanism of a non-canonical ubiquitin ligase,
which is activated through nucleic-acid-induced oligomerization and is critical for
cell survival during immune ...
www.cell.com
August 27, 2025 at 7:04 PM
Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Scientists uncovered how the immune protein ZNFX1 enables cells to walk the fine line between fighting infection & avoiding autoimmune damage. ZNFX1 can ubiquitinate & compact host & viral RNA into molecular condensates, extending ubiquitin biology to RNA itself. More: www.imp.ac.at/news/article...
ZNFX1 compacts and tags RNA to keep immunity in check
Tim Clausen’s lab at the IMP and collaborators have uncovered how the ancient immune protein ZNFX1 enables cells to walk the fine line between fighting infection and avoiding autoimmune damage. The te...
www.imp.ac.at
August 28, 2025 at 7:33 AM
Scientists uncovered how the immune protein ZNFX1 enables cells to walk the fine line between fighting infection & avoiding autoimmune damage. ZNFX1 can ubiquitinate & compact host & viral RNA into molecular condensates, extending ubiquitin biology to RNA itself. More: www.imp.ac.at/news/article...
Reposted by IMP
Only 5 days to go!
The Vienna BioCenter PostDoc Program (VIP³) is closing soon. Don’t miss your chance to apply for one of 16 fully-funded postdoctoral positions in a leading interdisciplinary research hub.
Apply here: training.vbc.ac.at/post-docs/vi...
#VBCPostDoc
The Vienna BioCenter PostDoc Program (VIP³) is closing soon. Don’t miss your chance to apply for one of 16 fully-funded postdoctoral positions in a leading interdisciplinary research hub.
Apply here: training.vbc.ac.at/post-docs/vi...
#VBCPostDoc
August 11, 2025 at 7:28 AM
Only 5 days to go!
The Vienna BioCenter PostDoc Program (VIP³) is closing soon. Don’t miss your chance to apply for one of 16 fully-funded postdoctoral positions in a leading interdisciplinary research hub.
Apply here: training.vbc.ac.at/post-docs/vi...
#VBCPostDoc
The Vienna BioCenter PostDoc Program (VIP³) is closing soon. Don’t miss your chance to apply for one of 16 fully-funded postdoctoral positions in a leading interdisciplinary research hub.
Apply here: training.vbc.ac.at/post-docs/vi...
#VBCPostDoc
Reposted by IMP
Erika Valeri & Moriz Gaidt @impvienna.bsky.social put together a very nice "Spotlights" piece in the latest issue of Molecular Cell @cp-molcell.bsky.social about the antiviral defense system VICAR and some of the avenues of research it opens.
🙏 to the authors
www.cell.com/molecular-ce...
🙏 to the authors
www.cell.com/molecular-ce...
DIY innate immune sensing: Crafting fresh DNA to detect viruses
The innate immune receptor cGAS is geared toward detecting DNA from pathogens. In
a recent Cell publication, Lahaye et al. discovered that viral infection triggers
de novo synthesis of self-DNA-activa...
www.cell.com
August 7, 2025 at 7:13 PM
Erika Valeri & Moriz Gaidt @impvienna.bsky.social put together a very nice "Spotlights" piece in the latest issue of Molecular Cell @cp-molcell.bsky.social about the antiviral defense system VICAR and some of the avenues of research it opens.
🙏 to the authors
www.cell.com/molecular-ce...
🙏 to the authors
www.cell.com/molecular-ce...
Reposted by IMP
Moritz Gaidt, a group leader at the IMP, plans to further understand how to help others achieve their goals during the 2025 edition of our #leadership program. @impvienna.bsky.social
August 5, 2025 at 11:00 AM
Moritz Gaidt, a group leader at the IMP, plans to further understand how to help others achieve their goals during the 2025 edition of our #leadership program. @impvienna.bsky.social