IMP
@impvienna.bsky.social
The IMP is a leading life science centre in Europe with 220 researchers from 40 countries. Part of the ViennaBioCenter.
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IMP
@impvienna.bsky.social
· Feb 10
At the IMP we’re dedicated to the fun of finding out. Few places in the world let you dive into curiosity-driven science like we do.
📽️Watch what the IMP is all about: youtu.be/mtl5Vod652Q
@viennabiocenter.bsky.social
📽️Watch what the IMP is all about: youtu.be/mtl5Vod652Q
@viennabiocenter.bsky.social
🧪Scientists from our Haselbach lab captured how proteins begin to fold as they’re being made.
Using cryo-EM, they visualised chaperones guiding nascent proteins on the ribosome: https://www.nature.com/articles/s41467-025-67685-6
Using cryo-EM, they visualised chaperones guiding nascent proteins on the ribosome: https://www.nature.com/articles/s41467-025-67685-6
January 19, 2026 at 9:40 AM
🧪Scientists from our Haselbach lab captured how proteins begin to fold as they’re being made.
Using cryo-EM, they visualised chaperones guiding nascent proteins on the ribosome: https://www.nature.com/articles/s41467-025-67685-6
Using cryo-EM, they visualised chaperones guiding nascent proteins on the ribosome: https://www.nature.com/articles/s41467-025-67685-6
Reposted by IMP
SY-Stem 2026 brings two outstanding keynote speakers to the Vienna BioCenter. SY-Stem is a symposium focusing on the next generation of stem cell researchers, organized by the @impvienna.bsky.social & @imbavienna.bsky.social
March 11-13, 2026
Program and registration: www.sy-stem.org
March 11-13, 2026
Program and registration: www.sy-stem.org
January 15, 2026 at 9:08 AM
SY-Stem 2026 brings two outstanding keynote speakers to the Vienna BioCenter. SY-Stem is a symposium focusing on the next generation of stem cell researchers, organized by the @impvienna.bsky.social & @imbavienna.bsky.social
March 11-13, 2026
Program and registration: www.sy-stem.org
March 11-13, 2026
Program and registration: www.sy-stem.org
Reposted by IMP
Not that long ago, in vivo mouse enhancer design was a dream. Today, it's a reality! Using transfer deep learning to design de novo synthetic embryonic enhancers active in the heart, limb, and CNS. Great collab with @alex-stark.bsky.social lab! @ucibiosci.bsky.social @impvienna.bsky.social
December 24, 2025 at 3:51 PM
Not that long ago, in vivo mouse enhancer design was a dream. Today, it's a reality! Using transfer deep learning to design de novo synthetic embryonic enhancers active in the heart, limb, and CNS. Great collab with @alex-stark.bsky.social lab! @ucibiosci.bsky.social @impvienna.bsky.social
Reposted by IMP
Activator-promoter compatibility in mammals - Hcfc1 is a key and intrinsically CGI-promoter-specific co-activator that cannot activate non-CGI promoters. Lead by @nemcko.bsky.social & Kevin Sabath in collab. with @plaschkalab.bsky.social @impvienna.bsky.social www.biorxiv.org/content/10.6... (1/2)
Activator-promoter compatibility in mammals: a CpG-Island-specific co-activator directly bridges transcription factors to TFIID
Transcription from CpG island (CGI) promoters controls the expression of two-thirds of mammalian genes, yet despite their prevalence, it remains unknown whether CGI-specific co-activators with intrins...
www.biorxiv.org
December 30, 2025 at 8:02 AM
Activator-promoter compatibility in mammals - Hcfc1 is a key and intrinsically CGI-promoter-specific co-activator that cannot activate non-CGI promoters. Lead by @nemcko.bsky.social & Kevin Sabath in collab. with @plaschkalab.bsky.social @impvienna.bsky.social www.biorxiv.org/content/10.6... (1/2)
Congratulations to our Anna Obenauf, Senior Group Leader at the IMP, for receiving the EJI Ita Askonas Prize 2025 for her pioneering work uncovering how cancer evolution, therapy resistance, and immune evasion are intertwined.
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December 19, 2025 at 1:40 PM
Congratulations to our Anna Obenauf, Senior Group Leader at the IMP, for receiving the EJI Ita Askonas Prize 2025 for her pioneering work uncovering how cancer evolution, therapy resistance, and immune evasion are intertwined.
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🎉 Congrats to IMP group leaders Joris van der Veeken & Moritz Gaidt on receiving FWF Stand-Alone grants! Their projects will explore how gene regulation shapes immune cell identity & function. A 3rd grant supports Manuel Matzinger:
December 17, 2025 at 3:24 PM
🎉 Congrats to IMP group leaders Joris van der Veeken & Moritz Gaidt on receiving FWF Stand-Alone grants! Their projects will explore how gene regulation shapes immune cell identity & function. A 3rd grant supports Manuel Matzinger:
In a new paper in the EMBO Journal, researchers in the Pavri lab and collaborators, show how “genetic grammar” affect the rate at which somatic hypermutation, the process by which T cells purposely mutate their DNA to generate evolved antibodies : https://bit.ly/4aHetMg
December 12, 2025 at 3:45 PM
In a new paper in the EMBO Journal, researchers in the Pavri lab and collaborators, show how “genetic grammar” affect the rate at which somatic hypermutation, the process by which T cells purposely mutate their DNA to generate evolved antibodies : https://bit.ly/4aHetMg
SY-Stem 2026 is here! The symposium focusing on the next generation of stem cell researchers returns to the Vienna BioCenter from 11–13 March 2026. Register online: sy-stem.org
December 10, 2025 at 4:10 PM
SY-Stem 2026 is here! The symposium focusing on the next generation of stem cell researchers returns to the Vienna BioCenter from 11–13 March 2026. Register online: sy-stem.org
Clemens Plaschka, Senior Group Leader at the IMP, has been awarded an ERC Consolidator grant!
His project on the fate control of messenger RNA (mRNA) will be supported with funding over the next five years.
➡️ Read more:
His project on the fate control of messenger RNA (mRNA) will be supported with funding over the next five years.
➡️ Read more:
December 9, 2025 at 2:05 PM
Clemens Plaschka, Senior Group Leader at the IMP, has been awarded an ERC Consolidator grant!
His project on the fate control of messenger RNA (mRNA) will be supported with funding over the next five years.
➡️ Read more:
His project on the fate control of messenger RNA (mRNA) will be supported with funding over the next five years.
➡️ Read more:
Nature featured work from our Pauli lab, where AlphaFold-Multimer helped reveal how Tmem81 and two sperm proteins create the pocket for the egg protein Bouncer to bind.
Andrea Pauli: “AlphaFold speeds up discovery, we use it for every project.”
🔗 www.nature.com/articles/d41...
Andrea Pauli: “AlphaFold speeds up discovery, we use it for every project.”
🔗 www.nature.com/articles/d41...
AlphaFold is five years old — these charts show how it revolutionized science
Since it was unveiled in 2020, Google DeepMind's game-changing AI tool has helped researchers all over the world to predict the 3D structures of hundreds of millions of proteins.
www.nature.com
November 27, 2025 at 1:04 PM
Nature featured work from our Pauli lab, where AlphaFold-Multimer helped reveal how Tmem81 and two sperm proteins create the pocket for the egg protein Bouncer to bind.
Andrea Pauli: “AlphaFold speeds up discovery, we use it for every project.”
🔗 www.nature.com/articles/d41...
Andrea Pauli: “AlphaFold speeds up discovery, we use it for every project.”
🔗 www.nature.com/articles/d41...
Congratulations to Paul Kirchgatterer, PhD student in Moritz Gaidt’s lab, who was awarded the Out of the Box Award for his project aiming to identify vulnerable viral genes that can be targeted to develop antiviral treatments. More: bit.ly/4pCLYDH
November 27, 2025 at 9:59 AM
Congratulations to Paul Kirchgatterer, PhD student in Moritz Gaidt’s lab, who was awarded the Out of the Box Award for his project aiming to identify vulnerable viral genes that can be targeted to develop antiviral treatments. More: bit.ly/4pCLYDH
“…[at the IMP] collaborations can develop naturally across many projects…”
We sat down with Jacob Schreiber after he wrapped up his one-year stay at the IMP, and he told us all about it: www.imp.ac.at/news/article...
@jmschreiber91.bsky.social, @viennabiocenter.bsky.social
We sat down with Jacob Schreiber after he wrapped up his one-year stay at the IMP, and he told us all about it: www.imp.ac.at/news/article...
@jmschreiber91.bsky.social, @viennabiocenter.bsky.social
November 25, 2025 at 1:42 PM
“…[at the IMP] collaborations can develop naturally across many projects…”
We sat down with Jacob Schreiber after he wrapped up his one-year stay at the IMP, and he told us all about it: www.imp.ac.at/news/article...
@jmschreiber91.bsky.social, @viennabiocenter.bsky.social
We sat down with Jacob Schreiber after he wrapped up his one-year stay at the IMP, and he told us all about it: www.imp.ac.at/news/article...
@jmschreiber91.bsky.social, @viennabiocenter.bsky.social
Reposted by IMP
How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)
November 21, 2025 at 5:37 PM
How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)
Scientists around former IMP group leader David Keays (@lmumuenchen.bsky.social show that #pigeons detect magnetic fields through their inner ear. Their discovery was now published in the journal @science.org: www.science.org/doi/10.1126/...
More: www.imp.ac.at/news/article...
More: www.imp.ac.at/news/article...
A global screen for magnetically induced neuronal activity in the pigeon brain
How animals detect the Earth’s magnetic field remains a mystery in sensory biology. Despite extensive behavioral evidence, the neural circuitry and molecular mechanisms responsible for magnetic sensin...
www.science.org
November 20, 2025 at 7:17 PM
Scientists around former IMP group leader David Keays (@lmumuenchen.bsky.social show that #pigeons detect magnetic fields through their inner ear. Their discovery was now published in the journal @science.org: www.science.org/doi/10.1126/...
More: www.imp.ac.at/news/article...
More: www.imp.ac.at/news/article...
Congratulations to Anais Elewaut, former PhD student in Anna Obenauf’s lab, who was awarded the Denise P. Barlow Award for her exceptional doctoral research on how tumours evade the immune system. More: www.imp.ac.at/news/article...
November 20, 2025 at 1:53 PM
Congratulations to Anais Elewaut, former PhD student in Anna Obenauf’s lab, who was awarded the Denise P. Barlow Award for her exceptional doctoral research on how tumours evade the immune system. More: www.imp.ac.at/news/article...
Reposted by IMP
Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/
November 19, 2025 at 11:22 PM
Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/
New paper alert! Researchers at the Proteomics Tech Hub at the @viennabiocenter.bsky.social have developed a new cross-linking mass spectrometry workflow that allows scientists to more easily detect and study protein interactions that were previously undetectable. More: bit.ly/4nV5n1w
November 12, 2025 at 9:25 AM
New paper alert! Researchers at the Proteomics Tech Hub at the @viennabiocenter.bsky.social have developed a new cross-linking mass spectrometry workflow that allows scientists to more easily detect and study protein interactions that were previously undetectable. More: bit.ly/4nV5n1w
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
November 10, 2025 at 1:26 PM
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Congrats to our Paul Welzl and Robert Kalis! 🎉
🏆 Paul (Plaschka & Balzarotti labs) received the 2025 Lauwers Award for his Monday Seminar talk on super-resolved mRNA imaging.
🏆 Robert (Zuber lab) won a Vienna BioCenter PhD Award for his work on cancer cell metabolism.
🏆 Paul (Plaschka & Balzarotti labs) received the 2025 Lauwers Award for his Monday Seminar talk on super-resolved mRNA imaging.
🏆 Robert (Zuber lab) won a Vienna BioCenter PhD Award for his work on cancer cell metabolism.
November 7, 2025 at 5:19 PM
Congrats to our Paul Welzl and Robert Kalis! 🎉
🏆 Paul (Plaschka & Balzarotti labs) received the 2025 Lauwers Award for his Monday Seminar talk on super-resolved mRNA imaging.
🏆 Robert (Zuber lab) won a Vienna BioCenter PhD Award for his work on cancer cell metabolism.
🏆 Paul (Plaschka & Balzarotti labs) received the 2025 Lauwers Award for his Monday Seminar talk on super-resolved mRNA imaging.
🏆 Robert (Zuber lab) won a Vienna BioCenter PhD Award for his work on cancer cell metabolism.
New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
November 6, 2025 at 4:04 PM
New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
What’s it like doing a PhD between two labs? In our latest Behind the Science, Júlia Portell i de Montserrat, shared PhD student in the Plaschka lab at the IMP and the Brennecke lab at @imbavienna.bsky.social, tells us more about her unusual but rewarding PhD journey: bit.ly/3IHXtdp
October 13, 2025 at 3:07 PM
What’s it like doing a PhD between two labs? In our latest Behind the Science, Júlia Portell i de Montserrat, shared PhD student in the Plaschka lab at the IMP and the Brennecke lab at @imbavienna.bsky.social, tells us more about her unusual but rewarding PhD journey: bit.ly/3IHXtdp
Reposted by IMP
Scientists from DKFZ and @impvienna.bsky.social have discovered that the acidic pH value in tumor tissue is a decisive factor in how pancreatic cancer cells adapt their energy metabolism in order to survive under adverse conditions. @wilhelmpalm.bsky.social @science.org
t1p.de/wm8je
t1p.de/wm8je
Acidic tumor environment promotes survival and growth of cancer cells
Tumors are not a comfortable place to live: oxygen deficiency, nutrient scarcity, and the accumulation of sometimes harmful metabolic products constantly stress cancer cells. A research team from the ...
t1p.de
October 10, 2025 at 9:57 AM
Scientists from DKFZ and @impvienna.bsky.social have discovered that the acidic pH value in tumor tissue is a decisive factor in how pancreatic cancer cells adapt their energy metabolism in order to survive under adverse conditions. @wilhelmpalm.bsky.social @science.org
t1p.de/wm8je
t1p.de/wm8je
Reposted by IMP
Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
October 9, 2025 at 7:37 PM
Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
🧪 How does cancer turn sour into power?
Cancer cells thrive in hostile, acidic environments.
A team led by Johannes Zuber (IMP) & Wilhelm Palm (DKFZ) shows that acidosis acts as a master switch, rewiring tumour metabolism and boosting resilience.
➡️ www.science.org/doi/10.1126/...
Cancer cells thrive in hostile, acidic environments.
A team led by Johannes Zuber (IMP) & Wilhelm Palm (DKFZ) shows that acidosis acts as a master switch, rewiring tumour metabolism and boosting resilience.
➡️ www.science.org/doi/10.1126/...
October 9, 2025 at 6:14 PM
🧪 How does cancer turn sour into power?
Cancer cells thrive in hostile, acidic environments.
A team led by Johannes Zuber (IMP) & Wilhelm Palm (DKFZ) shows that acidosis acts as a master switch, rewiring tumour metabolism and boosting resilience.
➡️ www.science.org/doi/10.1126/...
Cancer cells thrive in hostile, acidic environments.
A team led by Johannes Zuber (IMP) & Wilhelm Palm (DKFZ) shows that acidosis acts as a master switch, rewiring tumour metabolism and boosting resilience.
➡️ www.science.org/doi/10.1126/...
Reposted by IMP
Before Jürgen Knoblich became known for his groundbreaking brain organoid research, he studied asymmetric cell division in Drosophila at the @impvienna.bsky.social.
📖 Read the full milestone essay: https://www.imp.ac.at/achievements/research-milestones/knoblich-asymmetric-cell-division
📖 Read the full milestone essay: https://www.imp.ac.at/achievements/research-milestones/knoblich-asymmetric-cell-division
October 8, 2025 at 12:20 PM
Before Jürgen Knoblich became known for his groundbreaking brain organoid research, he studied asymmetric cell division in Drosophila at the @impvienna.bsky.social.
📖 Read the full milestone essay: https://www.imp.ac.at/achievements/research-milestones/knoblich-asymmetric-cell-division
📖 Read the full milestone essay: https://www.imp.ac.at/achievements/research-milestones/knoblich-asymmetric-cell-division