Nature Reviews Endocrinology
@natrevendo.nature.com
We publish Reviews and opinion articles on all aspects of endocrinology and metabolism.
https://www.nature.com/nrendo/
https://www.nature.com/nrendo/
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Featured in our February issue: Victoria J. Vieira-Potter, Gargi Mishra & Kristy L. Townsend discuss the role of oestrogen in adipose tissue metabolism and its wider implications for systemic metabolic health rdcu.be/eZLA4 #EndoSky #MedSky
New content online: Brain neurons promote skeletal dysfunction in ageing
Brain neurons promote skeletal dysfunction in ageing
Nature Reviews Endocrinology, Published online: 03 February 2026; doi:10.1038/s41574-026-01233-0Brain neurons promote skeletal dysfunction in ageing
dlvr.it
February 4, 2026 at 9:13 AM
New content online: Brain neurons promote skeletal dysfunction in ageing
New content online: Blood–brain barrier permeability of adipokines and myokines
Blood–brain barrier permeability of adipokines and myokines
Nature Reviews Endocrinology, Published online: 03 February 2026; doi:10.1038/s41574-026-01232-1The use of adipokines and myokines measured in serum or cerebrospinal fluid as biomarkers or disease modifiers in neurological disorders is limited. Their permeability to the blood–brain barrier is either unknown or overlooked. A novel classification of adipokines and myokines on the basis of their cerebrospinal fluid to serum ratio is warranted.
dlvr.it
February 4, 2026 at 9:13 AM
New content online: Blood–brain barrier permeability of adipokines and myokines
Our Key Advances in Endocrinology collection has been updated! It now includes our Year in Review articles covering advances in 2025 (from UPFs to EDCs), as well as related Reviews from the past few years -> go.nature.com/3Z6MPRT
#EndoSky #MedSky
#EndoSky #MedSky
January 29, 2026 at 3:13 PM
Our Key Advances in Endocrinology collection has been updated! It now includes our Year in Review articles covering advances in 2025 (from UPFs to EDCs), as well as related Reviews from the past few years -> go.nature.com/3Z6MPRT
#EndoSky #MedSky
#EndoSky #MedSky
This Review discusses the intricate molecular mechanisms and signalling pathways that control the development of the tuberal hypothalamus, focusing on aspects that shape metabolic outcomes (£) go.nature.com/4qAwCQS
#EndoSky #MedSky
#EndoSky #MedSky
January 23, 2026 at 2:03 PM
This Review discusses the intricate molecular mechanisms and signalling pathways that control the development of the tuberal hypothalamus, focusing on aspects that shape metabolic outcomes (£) go.nature.com/4qAwCQS
#EndoSky #MedSky
#EndoSky #MedSky
Here, Rhonda D. Kineman, Mercedes del Rio-Moreno & David J. Waxman review the roles of growth hormone and insulin-like growth factor 1 signalling in reducing the risk of metabolic dysfunction-associated steatotic liver disease (£) go.nature.com/49WwS5L
#EndoSky #MedSky
#EndoSky #MedSky
January 23, 2026 at 2:01 PM
Here, Rhonda D. Kineman, Mercedes del Rio-Moreno & David J. Waxman review the roles of growth hormone and insulin-like growth factor 1 signalling in reducing the risk of metabolic dysfunction-associated steatotic liver disease (£) go.nature.com/49WwS5L
#EndoSky #MedSky
#EndoSky #MedSky
In this Review, Dunya Tomic et al discuss the incidence, prevalence and disease burden of type 1 diabetes mellitus in older adults in diverse geographical regions (£) go.nature.com/3YV9O2g
#EndoSky #MedSky
#EndoSky #MedSky
January 23, 2026 at 1:58 PM
In this Review, Dunya Tomic et al discuss the incidence, prevalence and disease burden of type 1 diabetes mellitus in older adults in diverse geographical regions (£) go.nature.com/3YV9O2g
#EndoSky #MedSky
#EndoSky #MedSky
This Review outlines the complex actions of metformin in metabolic regulation, with a focus on gestational diabetes (£) go.nature.com/4jVQlrH
#EndoSky #MedSky
#EndoSky #MedSky
January 23, 2026 at 1:56 PM
This Review outlines the complex actions of metformin in metabolic regulation, with a focus on gestational diabetes (£) go.nature.com/4jVQlrH
#EndoSky #MedSky
#EndoSky #MedSky
From our February issue: Dianna J. Magliano and colleagues outline the available evidence and highlights research gaps in our understanding of how diabetes mellitus affects work participation (£) go.nature.com/4sODQSU
January 19, 2026 at 6:07 PM
From our February issue: Dianna J. Magliano and colleagues outline the available evidence and highlights research gaps in our understanding of how diabetes mellitus affects work participation (£) go.nature.com/4sODQSU
Our February issues includes a Reviews from Tamara Tchkonia and colleagues, which explores the translation of senotherapeutics into clinical practice for metabolic disorders (£) go.nature.com/3LUGWnM
January 19, 2026 at 6:04 PM
Our February issues includes a Reviews from Tamara Tchkonia and colleagues, which explores the translation of senotherapeutics into clinical practice for metabolic disorders (£) go.nature.com/3LUGWnM
In our February issue, Roger R. Fan, John D. Beckham & Kartik N. Rajagopalan discuss how leptin and melanocortin signalling affect the response to infection (£) go.nature.com/4jLfrJP #EndoSky #MedSky
January 19, 2026 at 6:01 PM
In our February issue, Roger R. Fan, John D. Beckham & Kartik N. Rajagopalan discuss how leptin and melanocortin signalling affect the response to infection (£) go.nature.com/4jLfrJP #EndoSky #MedSky
In our latest issue, Sun-Wei Guo highlights key papers in the field of adenomyosis from the past year go.nature.com/49YDvpn (£) #EndoSky #MedSky
Cracking the enigma of adenomyosis: prospects and challenges - Nature Reviews Endocrinology
Whole-exome sequencing and single-cell technologies are providing unprecedented insights into adenomyosis, uncovering a complex phylogenetic relationship between eutopic and ectopic endometria and ide...
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January 19, 2026 at 5:57 PM
In our latest issue, Sun-Wei Guo highlights key papers in the field of adenomyosis from the past year go.nature.com/49YDvpn (£) #EndoSky #MedSky
From our February issue: Benjamin E. Clayton & David A. Guertin outline key advances from the past year in the field of brown adipose biology go.nature.com/3YP02Pb (£) #EndoSky #MedSky
Brown adipose tissue remains hot - Nature Reviews Endocrinology
Brown adipose tissue is a heat-generating organ and promising therapeutic target for treating obesity and metabolic diseases. Its presence in adults supports metabolic health, whereas its decline with...
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January 19, 2026 at 5:56 PM
From our February issue: Benjamin E. Clayton & David A. Guertin outline key advances from the past year in the field of brown adipose biology go.nature.com/3YP02Pb (£) #EndoSky #MedSky
In our latest issue, Paloma Alonso-Magdalena discusses key papers from the past year looking at the hidden health effects of endocrine-disrupting chemicals go.nature.com/4sMTAWz (£) #EndoSky #MedSky
The hidden health effects of endocrine-disrupting chemicals - Nature Reviews Endocrinology
The quest to understand the adverse health outcomes linked to endocrine-disrupting chemicals continued in 2025. Insights have been gained regarding their effects on metabolic health, their key charact...
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January 19, 2026 at 5:54 PM
In our latest issue, Paloma Alonso-Magdalena discusses key papers from the past year looking at the hidden health effects of endocrine-disrupting chemicals go.nature.com/4sMTAWz (£) #EndoSky #MedSky
In our February issue, Timo Müller highlight advances in incretin-based drug discovery in 2025 go.nature.com/4r7rEeB (£) #EndoSKy #MedSky
Advances in incretin-based drug discovery in 2025 - Nature Reviews Endocrinology
The efficacy of anti-obesity drugs that use glucagon-like peptide 1 receptor agonism and glucose-dependent insulinotropic polypeptide agonism raises critical questions about how next-generation drugs ...
https://go.nature.com/4r7rEeB(£)
January 19, 2026 at 5:53 PM
In our February issue, Timo Müller highlight advances in incretin-based drug discovery in 2025 go.nature.com/4r7rEeB (£) #EndoSKy #MedSky
From our latest issue: Mathilde Touvier summarises advances in our understanding of the effected of ultra-processed food from the past year (£) go.nature.com/3Nl74sB
Health effects of ultra-processed food: uncovering causal mechanisms - Nature Reviews Endocrinology
Growing evidence has linked ultra-processed food consumption to chronic disease risk. In 2025, this field reached a turning point, with experimental, clinical and epidemiological studies convergi...
go.nature.com
January 19, 2026 at 5:51 PM
From our latest issue: Mathilde Touvier summarises advances in our understanding of the effected of ultra-processed food from the past year (£) go.nature.com/3Nl74sB
Featured in our February issue: Victoria J. Vieira-Potter, Gargi Mishra & Kristy L. Townsend discuss the role of oestrogen in adipose tissue metabolism and its wider implications for systemic metabolic health rdcu.be/eZLA4 #EndoSky #MedSky
January 19, 2026 at 5:49 PM
Featured in our February issue: Victoria J. Vieira-Potter, Gargi Mishra & Kristy L. Townsend discuss the role of oestrogen in adipose tissue metabolism and its wider implications for systemic metabolic health rdcu.be/eZLA4 #EndoSky #MedSky
Our February issue is now live! Featuring Year in Review articles from across endocrinology & metabolism and Reviews on adipose, leptin & melanocortin signalling in infection, cellular senescence and diabetes in the workplace -> www.nature.com/nrendo/ #EndoSky #MedSky
January 19, 2026 at 5:46 PM
Our February issue is now live! Featuring Year in Review articles from across endocrinology & metabolism and Reviews on adipose, leptin & melanocortin signalling in infection, cellular senescence and diabetes in the workplace -> www.nature.com/nrendo/ #EndoSky #MedSky
Reposted by Nature Reviews Endocrinology
This Review has been taking shape in my mind for a long time and I felt this is the perfect time to write it. It found a perfect home too: @natrevendo.nature.com. We summarize the hormonal control of the hepatic fasting response and describe how hormones cooperate rdcu.be/eYjH8
January 17, 2026 at 5:41 AM
This Review has been taking shape in my mind for a long time and I felt this is the perfect time to write it. It found a perfect home too: @natrevendo.nature.com. We summarize the hormonal control of the hepatic fasting response and describe how hormones cooperate rdcu.be/eYjH8
ICYMI: New content online: GPR110 as a regulator of MASH
GPR110 as a regulator of MASH
Nature Reviews Endocrinology, Published online: 16 January 2026; doi:10.1038/s41574-026-01231-2GPR110 as a regulator of MASH
dlvr.it
January 18, 2026 at 9:02 PM
ICYMI: New content online: GPR110 as a regulator of MASH
ICYMI: New content online: Blood-based obesity biomarkers and their relevance for disease risk
Blood-based obesity biomarkers and their relevance for disease risk
Nature Reviews Endocrinology, Published online: 15 January 2026; doi:10.1038/s41574-025-01229-2Obesity is associated with changes in levels of many blood-based factors, such as cytokines and adipokines. This Review explores the utility of such factors as biomarkers for quantifying and predicting obesity-associated disease risk, including the identification of causal relationships.
dlvr.it
January 17, 2026 at 3:15 PM
ICYMI: New content online: Blood-based obesity biomarkers and their relevance for disease risk
New content online: GPR110 as a regulator of MASH
GPR110 as a regulator of MASH
Nature Reviews Endocrinology, Published online: 16 January 2026; doi:10.1038/s41574-026-01231-2GPR110 as a regulator of MASH
dlvr.it
January 16, 2026 at 9:01 PM
New content online: GPR110 as a regulator of MASH
New content online: Blood-based obesity biomarkers and their relevance for disease risk
Blood-based obesity biomarkers and their relevance for disease risk
Nature Reviews Endocrinology, Published online: 15 January 2026; doi:10.1038/s41574-025-01229-2Obesity is associated with changes in levels of many blood-based factors, such as cytokines and adipokines. This Review explores the utility of such factors as biomarkers for quantifying and predicting obesity-associated disease risk, including the identification of causal relationships.
dlvr.it
January 15, 2026 at 3:14 PM
New content online: Blood-based obesity biomarkers and their relevance for disease risk
ICYMI: New content online: Endocrine regulation of the hepatic fasting response: cues, cooperation and consequences
Endocrine regulation of the hepatic fasting response: cues, cooperation and consequences
Nature Reviews Endocrinology, Published online: 09 January 2026; doi:10.1038/s41574-025-01228-3During fasting, the liver produces fuel under the control of several hormonal and metabolic cues. In this Review, the authors outline the effects of the cues (glucagon, glucocorticoids, growth hormone, adrenaline, free fatty acids, asprosin and GP73) that are known to directly signal to hepatocytes under fasting conditions.
dlvr.it
January 11, 2026 at 9:55 PM
ICYMI: New content online: Endocrine regulation of the hepatic fasting response: cues, cooperation and consequences
ICYMI: New content online: The public health burden of diabetes mellitus and thyroid disease: twin epidemics
The public health burden of diabetes mellitus and thyroid disease: twin epidemics
Nature Reviews Endocrinology, Published online: 08 January 2026; doi:10.1038/s41574-025-01226-5This Review explores the link between diabetes mellitus and thyroid disease from an epidemiological and mechanistic perspective, and discusses the public health implications of this link and provides recommendations for clinical management and public health policy.
dlvr.it
January 10, 2026 at 12:59 PM
ICYMI: New content online: The public health burden of diabetes mellitus and thyroid disease: twin epidemics
New content online: Endocrine regulation of the hepatic fasting response: cues, cooperation and consequences
Endocrine regulation of the hepatic fasting response: cues, cooperation and consequences
Nature Reviews Endocrinology, Published online: 09 January 2026; doi:10.1038/s41574-025-01228-3During fasting, the liver produces fuel under the control of several hormonal and metabolic cues. In this Review, the authors outline the effects of the cues (glucagon, glucocorticoids, growth hormone, adrenaline, free fatty acids, asprosin and GP73) that are known to directly signal to hepatocytes under fasting conditions.
dlvr.it
January 9, 2026 at 9:54 PM
New content online: Endocrine regulation of the hepatic fasting response: cues, cooperation and consequences