Nature Reviews Endocrinology
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Nature Reviews Endocrinology
@natrevendo.nature.com
3.6K followers 320 following 430 posts
We publish Reviews and opinion articles on all aspects of endocrinology and metabolism.
https://www.nature.com/nrendo/
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Here, Slingerland and colleagues explore the current understanding of associations between changes in levels of oestrogen after menopause, changes in oestrogen levels in the context of weight gain above the normal BMI category and the risk of breast cancer. (£) go.nature.com/48UEiqQ #EndoSky #MedSky
An image showing cells called adipocytes, pre-adipocytes and macrophages and changes in the activity of these cells that can occur during obesity and increase levels of inflammation and breast cancer risk.
December 5, 2025 at 11:26 AM
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In a new Year in Review article, Sun-Wei Guo covers advances in adenomyosis research that were made in 2025, as well as the work that still needs to be done to understand this disease and develop better treatments. (£) go.nature.com/48yNyzA #EndoSky #MedSky
Screenshot of a short article abstract. On the top line is the author name, Sun-Wei Guo. The abstract reads ‘Whole-exome sequencing and single-cell technologies are providing unprecedented insights into adenomyosis, uncovering a complex phylogenetic relationship between eutopic and ectopic endometria and identifying prolactin signalling as a possible pathogenic factor. However, these advances contrast with the failure of a clinical trial for a DRD2 agonist, which underscores the formidable translational challenges.
December 5, 2025 at 10:56 AM
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In this Review, Félix-Soriano and Stanford discuss animal studies and data from human study participants that show how exercise affects the placenta, breast milk and sperm in ways that improve offspring health. (£) go.nature.com/48B4fdQ #EndoSky #MedSky
ALT: An image of a mouse running on a wheel, underneath which are a box showing a placenta, a box showing mouse pups nursing and a box showing a sperm cell. In each box is a list of factors that are affected by parental exercise and that are transmitted from parents to offspring via the route shown in the image, that is, the placenta, breast milk or sperm.
December 5, 2025 at 10:44 AM
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Here, Castinetti and colleagues discuss the current understanding of the epidemiology, pathophysiology, diagnosis and clinical management of hypophysitis. (£) go.nature.com/3Xq37o6 #EndoSky #Medsky
At the top is an image showing the location and structure of the pituitary gland. Below this image are three images that represent inflammation in different areas of the pituitary gland and/or the pituitary stalk, a condition known as hypophysitis. The names of the three types of hypophysitis are also shown.
November 28, 2025 at 10:51 AM
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In this Review, Shyh-Chang and colleagues cover how metabolism affects feto–placental development by controlling mechanisms such as epigenetic changes and post-transcriptional modification of key proteins. (£) go.nature.com/3XfzSV0 #EndoSky #MedSky
An image of different structures and cell types within the placenta
November 26, 2025 at 12:29 PM
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Type 1 diabetes mellitus prevention: present and future
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#DiabetesLife #WorldDiabetesDay
Major postulated mechanisms of pancreatic β-cell damage and destruction
November 14, 2025 at 11:45 AM
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Medical nutrition therapy for the management of type 2 diabetes mellitus
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#DiabetesLife #WorldDiabetesDay
November 14, 2025 at 11:35 AM
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Advances in the management of hyperglycaemia and diabetes mellitus during hospitalization
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#DiabetesLife #WorldDiabetesDay
November 14, 2025 at 11:30 AM
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Diabetes mellitus and work participation bit.ly/3Xg3otT #DiabetesLife #WorldDiabetesDay
November 14, 2025 at 11:21 AM
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Here, Marc Schneeberger and colleagues present their perspective on how lifestyle interventions targeting weight loss, including intermittent fasting, caloric restriction and physical activity, affect the neurovascular system and neuronal networks (£) go.nature.com/4pa8WBT #EndoSky #MedSky
Figure showing the effects of lifestyle on neurovascular health.
November 12, 2025 at 5:04 PM
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In this Review, Cosimo Durante and colleagues discuss the diagnosis and management of thyroid nodules (£) go.nature.com/49yXs6D #EndoSky #MedSky
Figure showing a guide to best practices regarding the diagnosis and management of thyroid nodules.
November 12, 2025 at 5:02 PM
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An International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents go.nature.com/3WUlBwN #EndoSky #MedSky
Figure showing an overview of treatment options for paediatric patients with metastatic phaeochromocytoma and paraganglioma considering the rate of disease progression and burden of metastatic disease.
November 12, 2025 at 4:59 PM
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In this Review, Joanne Lysaght & Melissa J. Conroy outline the multifaceted influence of obesity on cancer treatment effectiveness and associated toxicities (£) go.nature.com/47QO7nZ #EndoSky #MedSky
Figure showing how increased visceral adiposity influences tumour growth at distal sites.
November 12, 2025 at 4:57 PM
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In our December issue: Yong-ho Lee, Soo Lim & Melanie J. Davies review the multifaceted cardiovascular, metabolic and renal effects of SGLT2 inhibitors, and elucidate the diverse mechanisms underpinning these benefits (£) go.nature.com/47P52Y9 #EndoSky #MedSky
Figure showing the effects of sodium–glucose cotransporter 2 inhibitors on the liver.
November 11, 2025 at 11:40 AM
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Also in our latest issue - Giovanna Muscogiuri and colleagues assess the different nutritional strategies used in the treatment of type 2 diabetes go.nature.com/4oExu6c #EndoSky #MedSky
Figure showing a comparison of the Mediterranean diet, low-energy diets and ketogenic diets across multiple parameters.
November 11, 2025 at 11:36 AM
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From our December issue: Thaer Idrees and colleagues outline approaches to managing inpatient hyperglycaemia and diabetes mellitus go.nature.com/47RtBDN #MedSky #EndoSky
Figure showing a perioperative algorithm for managing hyperglycaemia.
November 11, 2025 at 11:32 AM
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In our latest issue: a Journal Club by Sophia Metz discusses implications of the publication of the human genome sequence (£) go.nature.com/487GDyf
Against a blue background, white text reads: The publication of the human genome sequence by the International Human Genome Sequencing Consortium in Nature in 2001 heralded a fundamental shift.
November 11, 2025 at 11:25 AM
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From our December issue: Carlota Arenillas & Rodrigo A. Toledo outline the FDA fast-track approval of belzutifan for advanced phaeochromocytoma and paraganglioma (£) go.nature.com/4oziOFn #EndoSky #MedSky
Figure showing the path to belzutifan approval for phaeochromocytoma and paraganglioma.
November 11, 2025 at 11:21 AM
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Featured in our December issue: Beata Lecka-Czernik, Clifford J. Rosen & Nicola Napoli discuss our current understanding of how the skeleton regulates whole-body energy metabolism rdcu.be/ePlQg
Figure showing bone remodelling and integration of skeletal cell differentiation and function with fuel metabolism.
November 11, 2025 at 11:18 AM
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The December issue of Nature Reviews Endocrinology is now online! This issue features Reviews on the role of bone in energy homeostasis, managing hyperglycaemia during hospitalizations, diet in type 2 diabetes, and the benefits of SGLT2 inhibitors beyond glycaemia bit.ly/4hUKUZk
An image of the front cover of a journal; a matrix of bone cells against a blue background, surrounded by images of adipocytes, bones, pancreas and liver.
November 11, 2025 at 11:14 AM
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In this Review, Matthias B. Schulze & Norbert Stefan discuss the current understanding of metabolically healthy obesity (MHO), the challenges in defining MHO and how the MHO concept can be used to improve the prevention and treatment of cardiometabolic disease (£) go.nature.com/48tLZom
Figure showing energy storage under positive energy balance and metabolic health.
October 13, 2025 at 4:44 PM
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Francesca Menconi and colleagues outline the epidemiology, pathogenesis and treatment of Graves hyperthyroidism and Graves orbitopathy (£) go.nature.com/4n6rUYT #EndoSky #MedSky
Figure showing the pathogenesis of Graves orbitopathy and mechanisms of action of the most promising recently proposed therapies.
October 13, 2025 at 4:42 PM
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In this Review, Silvia Marino & Teresita Bellido discuss the role of the parathyroid hormone 1 receptor pathway in bone homeostasis and of osteocytes as mechanosensors and drivers of bone remodelling (£) go.nature.com/43fzOI0
Figure showing osteocytes as drivers of bone remodelling.
October 13, 2025 at 4:36 PM
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Here, Fadil M. Hannan et al consider the available evidence on the endocrine effects of heat exposure, and map out a path for future research into this field (£) go.nature.com/4pZd2Oq
Figure showing possible involvement of hormones in thermoregulatory adaptation to heat.
October 13, 2025 at 4:34 PM
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This Perspective from Laszlo Hegedüs et al brings attention to the issue of medically not yet explained symptoms in hypothyroidism and considers effective management (£) bit.ly/3KGiPsh #EndoSky #MedSky
October 13, 2025 at 4:32 PM