As usual, more info on the website (which will hopefully be updated soon :)
felixcampelo.wixsite.com/membranetraf...
cc/ @ishier.bsky.social @franbottanelli.bsky.social

Many thanks Adrien! Indeed, while there are still lots of unknowns (which makes it quite an interesting topic), I believe there is a lot of hidden secretion regulatory layers to be discovered 😃 Any feedback (mechanochemical or not 🤣) will be very much appreciated!

And many, many thanks to those who contributed to this work, from everyone at @icfo.eu and Paris labs, to Anabel-Lise and @pereroca.bsky.social at @ibecbarcelona.eu 🙏

And another recent preprint on bioRxiv from Domenico Russo and Ricardo Rizzo' labs showed that matrix stiffness stimulates secretion via a Src–FAK–AMPK–GBF1 pathway, further supporting the view of the Golgi as a central mechanoresponsive organelle: www.biorxiv.org/content/10.1... 💪🥞

So we propose that the Golgi is not a "passive" trafficking hub, but it actively adapts its membrane properties and function to extracellular mechanical cues. This Golgi-based mechanoadaptation could be key in contexts like cancer invasion or fibrosis, so much more to come!

I think this may "close" a functional feedback loop: external forces/focal adhesion establishment → tubulin acetylation + DAG/PKD + Golgi tension changes → Transport carrier biogenesis at the Golgi → increased exocytosis to focal adhesion-proximal hotspots → feedback to adhesion & spreading.