Calling all #Membrane enthusiasts!
Our #MembraneTrafficking online seminar series is back for the 2025-26 season: 8 fantastic speakers from Nov'25 to Feb'26.
The first talks are already next Thursday (Nov 6, 5pm CET) with @agatawitkowska.bsky.social and @abdourachidthiam.bsky.social !

And finally, what I found really cool, is that by inhibiting/blocking Golgi export (in different pharmacological or genetic ways) impaired efficient cell spreading.

Why does this matter? Previous seminal work showed that microtubule acetylation is sufficient to increase Golgi export, while DAG recruits PKD to drive carrier fission. Together, we propose these act as a mechanotransduction axis linking outside-in mechanical cues to Golgi-based secretion.

Are the mechanical properties of the Golgi also altered?Halo-Flipper FLIM revealed that extracellular forces increase membrane tension/lipid packing at the Golgi membranes. This correlated with both increased microtubule acetylation and modulation of Golgi DAG content, two key signaling steps.

So, as Golgi lovers, we asked this: Can extracellular mechanics control Golgi-based secretion? By using cell spreading assays, modulating substrate stiffness & applying equibiaxial stretch, we found that forces appear to increase the number of Golgi-derived secretory carriers.

And finally, what I found really cool, is that by inhibiting/blocking Golgi export (in different pharmacological or genetic ways) impaired efficient cell spreading.

Why does this matter? Previous seminal work showed that microtubule acetylation is sufficient to increase Golgi export, while DAG recruits PKD to drive carrier fission. Together, we propose these act as a mechanotransduction axis linking outside-in mechanical cues to Golgi-based secretion.

Are the mechanical properties of the Golgi also altered?Halo-Flipper FLIM revealed that extracellular forces increase membrane tension/lipid packing at the Golgi membranes. This correlated with both increased microtubule acetylation and modulation of Golgi DAG content, two key signaling steps.

So, as Golgi lovers, we asked this: Can extracellular mechanics control Golgi-based secretion? By using cell spreading assays, modulating substrate stiffness & applying equibiaxial stretch, we found that forces appear to increase the number of Golgi-derived secretory carriers.

Next Thursday Sept 25 (4-6pm CET) we have our first #FocalPlaneFeatures together with our #membranetrafficking community! Thanks to all who submitted such exciting abstracts. The final program is out, featuring a keynote by Gillian Griffiths. Register here: focalplane.biologists.com/2025/09/16/f...

After almost ten years at @icfo.eu, I’m excited to share that next month I’ll join the Medicine and Life Sciences department at @upf.edu as a Group Leader in Quantitative Biology, in Barcelona’s @prbb.org, the largest biomedical research hub in Southern Europe! (1/3)

#MembraneTrafficking seminars are back on June 26th at 5pm CEST! Our one and only summer gig feature an early secretory pathway lineup: @jnuechel.bsky.social TANGOing at the ER, and Maohan Su from ‪@yaleschoolofmed.bsky.social on Golgi organization by 3D super-res!

Together with @gallegolab.bsky.social we are organizing the next CATCAT morning on "Dynamics in biology, from molecules to tissues", with an amazing lineup of local and international speakers. If in Barcelona on May 26th, don't miss it, it's free! www.catcat-celltissuebiology.cat/event/9th-ca...

This is tomorrow (Thursday) at 5pm CET, looking forward to it! cc/ @ishier.bsky.social @franbottanelli.bsky.social