Benoit Ladoux
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bladoux.bsky.social
Benoit Ladoux
@bladoux.bsky.social

Biophysics / Cell Migration / Active matter / Mechanobiology
https://mpzpm.mpg.de/research/benoit-ladoux
https://ladoux-mege-lab.cnrs.fr

Biology 50%
Engineering 28%
Pinned
Happy to share our new study @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social with C. Duclut and J. Prost. on forces generated by active fluid transport in epithelia and their role in tissue dynamics.
Congrats to Huiqiong Wu, G. Arkowitz and R. Chilupuri!
www.biorxiv.org/content/10.1...
Regulation of epithelial tissue homeostasis by active trans-epithelial transport
Epithelia are intricate tissues whose function is intimately linked to mechanics. While mechanobiology has primarily focused on factors such as cell-generated contractility and mechanical properties o...
www.biorxiv.org

Great study on human skin and amnion organoids through the interplay of signaling and mechanics. Congrats to @leanhphuong.bsky.social and the team!
www.biorxiv.org/content/10.1...
Lateral plate mesoderm directs human amnion and ventral skin organoid formation
Engineering organoids that faithfully replicate the intricate architecture and region-specific features of bodily organs and extraembryonic tissues remains a significant scientific challenge. Previous...
www.biorxiv.org

Reposted by Benoît Ladoux

📢 PhD Thesis defense

📅 November 26th
📍Institut Jacques Monod

Fanny Wodrascka ( @fanny-wodrascka.bsky.social @bladoux.bsky.social @rmmege.bsky.social ) will defend her PhD thesis "Mechanical control of epithelial cell extrusion via RhoA-dependent contractility "

➡️ buff.ly/f5VaVah

Congrats!!!👏

Reposted by Benoît Ladoux

Lecture online : youtu.be/ye-i6deGO1Q 😜👇
Pierre NASSOY : formation, morphometrics and mechanics of epiblast models
YouTube video by GDR Imabio - CNRS
youtu.be

Reposted by Benoît Ladoux

🚀 Exciting news! ERC Synergy Grant of €8.5 million to Sara Wickström @sarawickstrom.bsky.social, Daniel St Jonston @gurdoninstitute.bsky.social and Ewa Paluch @universitypress.cambridge.org! This highly interdisciplinary project will boost our understanding of tissue biology. #ERCSyG @erc.europa.eu

Reposted by Benoît Ladoux

Reposted by Benoît Ladoux

Our aftermovie shows some impressions of #NdW25 at #MPL & #MPZPM: from exciting insights into current #research projects and inspiring conversations to curious glances into our laboratories. It was truly a night, where #science came to life.

🎥 Billmann Event GmbH

#physics #medicine #light #matter

Reposted by Benoît Ladoux

📣 Paris Cytoskeleton day 2025 - Lest week to register!

📆 November 14th
📍 Institut Jacques Monod

🔗 pcd2025.sciencesconf.org

Registration closes on 7 November

@romet-jegou-lab.bsky.social
The United States was the leading destination for top scientists from all over the world.

That is ending. Politicians ended it. It will cripple our future competitiveness.

And it’s such a bitter tragedy. Almost no Americans, Conservative or Liberal, grasp what is now being stolen from them.
Top researchers consider leaving U.S. amid funding cuts: 'The science world is ending'
YouTube video by PBS NewsHour
youtu.be

Reposted by Benoît Ladoux

An intimate conversation about what drives me every day in “sharing experience” of science by getting tools of science in hands of kids everywhere.

themicroscopists.bitesizebio.com/episodes/man...

Reposted by Benoît Ladoux

Reposted by Benoît Ladoux

[Last month to register]
📣 Forces at Play: Emerging Themes in Mechanobiology – In Memoriam of Professor Michael P. Sheetz

📆 January 19-21
📍Institut Jacques Monod, Paris

Registrations at 🔗 mikeinmemoriam.sciencesconf.org?lang=en

J'imagine que la confusion vient de l'assimilation au niveau moléculaire entre le transfert de Qté de Mvt des molécules d'une couche à l'autre et le terme "friction".

Reposted by Benoît Ladoux

Kudos to @eliasbarrigalab.bsky.social for the Innovation DGZ Prize for his work on #CellMigration

A great Chilean 🇨🇱 in #STEM 💪🏽🔥

@dgz.bsky.social #DGZ50
⚠️ AU MOINS 83% DES MORTS DE GAZA SONT DES CIVILS. À partir des données chiffrées de la Direction du Renseignement militaire israélien, le quotidien britannique @theguardian.com & le magazine israélien @972mag.com ont révélé, vérifié et confirmé cette statistique stupéfiante, fin août dernier.

Reposted by Benoît Ladoux

1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social :

"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...

Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?

A thread👇
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

Reposted by Benoît Ladoux

We hire!
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...

Very nice paper on shear flows and nematic ordering in endothelial cells.
www.nature.com/articles/s41... #activematter #Mechanobiology

Although our time working together at the MPZPM was far too short, I deeply valued our scientific exchanges and the beginnings of a friendship that I am sure would have grown even stronger. I will profoundly miss you as a colleague and as a person.
With deep sadness, we share that Prof. Jochen Guck, Director at the Max Planck Institute for the Science of Light passed away on October 3. His visionary work bridged physics and medicine. We have lost a brilliant scientist and dear friend.

mpl.mpg.de/news/article...
@fau.de

📸 Stephan Spangenberg

Looks very interesting!

Reposted by Benoît Ladoux

Excited to announce the first @cshlnews.bsky.social meeting on Cell Modeling in Space and Time, June 2026 💫

meetings.cshl.edu/meetings.asp...

Bringing together experiments, computation and theory to explore dynamic, multi-scale cellular organization and function!

1/3

Reposted by Benoît Ladoux

With deep sadness, we share that Prof. Jochen Guck, Director at the Max Planck Institute for the Science of Light passed away on October 3. His visionary work bridged physics and medicine. We have lost a brilliant scientist and dear friend.

mpl.mpg.de/news/article...
@fau.de

📸 Stephan Spangenberg
Ahead of tomorrow’s #NobelPrize announcement, I went on a deep dive in search of the most obscure physics Nobel Prizes in history. That means it's time for a thread on...🧵

PHYSICS NOBEL PRIZES YOU’VE NEVER HEARD OF – PART 1

(1/n)

Reposted by Benoît Ladoux

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

Reposted by Benoît Ladoux

So: can a cell hold hands with itself…and do we care? YES and YES! Read on to learn WHY, HOW, and what this has to do with…PARIS (and tree-hugging)? Swansong of Dr. Anamika; Hannah Kim on drums; and fantastic undergrads (Margaret/Lauren) ! 1/n
advanced.onlinelibrary.wiley.com/doi/10.1002/...

Reposted by Benoît Ladoux

📣 Last chance to apply!
Applications for our URO program close tomorrow, October 1st.

Don't miss this opportunity:
mattertolife.maxplanckschools.org/uro-research...

👉 Funded 10-week research internship
👉 Learn from esteemed scientists
👉 No prior research experience required

Reposted by Benoît Ladoux

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
www.nature.com

Reposted by Benoît Ladoux

Can pressure gradients persist over long timescales in animal cells? We induced intracellular pressure gradients and examined the resulting flows in single cells. We reveal surprisingly long lasting pressure gradients.

More here: elifesciences.org/reviewed-pre...
elifesciences.org