John Streicher
@johnstreicher.bsky.social
Biomedical scientist at the University of Arizona. Pain, opioids, and cannabinoids. He/him.
Pinned
journals.lww.com
New paper! This is the marquee effort of my talented student Jessy Bowden, who identified a unique role for Src kinase signaling in microglia for promoting opioid signal transduction and pain relief in the spinal cord. Congrats Jessy! journals.lww.com/pain/fulltex...
New paper! This is the marquee effort of my talented student Jessy Bowden, who identified a unique role for Src kinase signaling in microglia for promoting opioid signal transduction and pain relief in the spinal cord. Congrats Jessy! journals.lww.com/pain/fulltex...
journals.lww.com
October 16, 2025 at 8:46 PM
New paper! This is the marquee effort of my talented student Jessy Bowden, who identified a unique role for Src kinase signaling in microglia for promoting opioid signal transduction and pain relief in the spinal cord. Congrats Jessy! journals.lww.com/pain/fulltex...
Harassment and discrimination reporting system at the NIH: public.era.nih.gov/shape/public...
eRA Main Page
public.era.nih.gov
October 16, 2025 at 5:49 PM
Harassment and discrimination reporting system at the NIH: public.era.nih.gov/shape/public...
Reposted by John Streicher
Please please please help me get the word out about this. I’m afraid everyone is ignoring our emails. We’ve sent literally thousands and have <10 people enrolled. For reference, we need several hundred. So if you’re not a PI in one of these programs but know someone who is, pls send them this 🙏🙏🙏
Despite our grant being terminated, we are doing what we can with modest bridge funding. If you are a PI of a K24, TL1, R25, R38, or T32, you’re eligible! To learn more or enroll, check out our site!
Here’s some feedback from our last cohort:
“I thought that this training was exceptional…
Here’s some feedback from our last cohort:
“I thought that this training was exceptional…
July 30, 2025 at 12:54 AM
Please please please help me get the word out about this. I’m afraid everyone is ignoring our emails. We’ve sent literally thousands and have <10 people enrolled. For reference, we need several hundred. So if you’re not a PI in one of these programs but know someone who is, pls send them this 🙏🙏🙏
Abolish ICE
The man told Noticias Telemundo that authorities took his ID from his wallet and told him it was fake before handcuffing him.
U.S. citizen with REAL ID handcuffed and held in immigration raid before being released
The man told Noticias Telemundo that authorities took his ID from his wallet and told him it was fake before handcuffing him.
nbcnews.to
May 24, 2025 at 2:30 AM
Abolish ICE
Reposted by John Streicher
New post: On the failure of rescoring in virtual screening.
Or why automated virtual screening and docking remains hard and why expertise remains essential. medchemash.substack.com/p/on-the-fai...
Or why automated virtual screening and docking remains hard and why expertise remains essential. medchemash.substack.com/p/on-the-fai...
On the failure of rescoring in virtual screening
Why automated virtual screening and docking remains hard and why expertise remains essential
medchemash.substack.com
May 22, 2025 at 7:39 PM
New post: On the failure of rescoring in virtual screening.
Or why automated virtual screening and docking remains hard and why expertise remains essential. medchemash.substack.com/p/on-the-fai...
Or why automated virtual screening and docking remains hard and why expertise remains essential. medchemash.substack.com/p/on-the-fai...
These guys *desperately* need cognitive scientists as a part of these projects.
Demis Hassabis, the chief executive of Google DeepMind, says that “we’re quite close” to human-level artificial intelligence. After that, all bets are off. nyti.ms/45lteBF
May 23, 2025 at 5:50 PM
These guys *desperately* need cognitive scientists as a part of these projects.
Just saw a graduate fellowship that specifies an "*unmarried* female graduate student."
What????
What????
May 23, 2025 at 5:49 PM
Just saw a graduate fellowship that specifies an "*unmarried* female graduate student."
What????
What????
I've been thinking a lot about the question of replication rates. Many people claim that ~50% replication rates represent a "crisis" but I've never seen that judgment justified (or even explained). What should the rate be? Why should be expect that rate? Why SHOULDN'T it be 50%?
May 19, 2025 at 6:16 PM
I've been thinking a lot about the question of replication rates. Many people claim that ~50% replication rates represent a "crisis" but I've never seen that judgment justified (or even explained). What should the rate be? Why should be expect that rate? Why SHOULDN'T it be 50%?
Reposted by John Streicher
"Look for private foundation funding..."
Having a hard time processing this. HHMI is pausing all competitions. Very demoralizing for early career scientists like me @hhmi.org
May 16, 2025 at 6:28 PM
"Look for private foundation funding..."
Reposted by John Streicher
She was 9 weeks pregnant. She died. The state of Georgia is making the doctors keep her alive to incubate the baby. She’s been dead for three months. This is REAL. this isn’t about what should or should not be done. This is about having a VOICE. This is about having a CHOICE.
May 16, 2025 at 11:08 AM
She was 9 weeks pregnant. She died. The state of Georgia is making the doctors keep her alive to incubate the baby. She’s been dead for three months. This is REAL. this isn’t about what should or should not be done. This is about having a VOICE. This is about having a CHOICE.
And our IMSD T32 goes down. Guess we don’t want students from poor and disadvantaged backgrounds getting into science. Fuck these people. There is no hell hot enough for them.
May 5, 2025 at 3:02 PM
And our IMSD T32 goes down. Guess we don’t want students from poor and disadvantaged backgrounds getting into science. Fuck these people. There is no hell hot enough for them.
Reposted by John Streicher
The president's budget proposal cuts billions in funding from the DOE Office of Science, NIST, NASA, and the NSF — but there’s still time to change it. Tell your lawmakers why they should stand up for science using our letter-writing toolkit, targeted to your state: go.aps.org/3RP9EWF
May 2, 2025 at 9:32 PM
The president's budget proposal cuts billions in funding from the DOE Office of Science, NIST, NASA, and the NSF — but there’s still time to change it. Tell your lawmakers why they should stand up for science using our letter-writing toolkit, targeted to your state: go.aps.org/3RP9EWF
I have a very important announcement. We have a family itty bitty baby quail living in our backyard. 🥺
May 3, 2025 at 3:08 PM
I have a very important announcement. We have a family itty bitty baby quail living in our backyard. 🥺
Reposted by John Streicher
Budget released today:
40% cut to NIH
50% cut to NSF
If enacted, this will destroy academic research in the United States. It will also have a major trickle down effect on the entire academic ecosystem
40% cut to NIH
50% cut to NSF
If enacted, this will destroy academic research in the United States. It will also have a major trickle down effect on the entire academic ecosystem
May 2, 2025 at 4:39 PM
Budget released today:
40% cut to NIH
50% cut to NSF
If enacted, this will destroy academic research in the United States. It will also have a major trickle down effect on the entire academic ecosystem
40% cut to NIH
50% cut to NSF
If enacted, this will destroy academic research in the United States. It will also have a major trickle down effect on the entire academic ecosystem
Reposted by John Streicher
They aren't going to stop. Yes, there will be lawsuits and the institutions will likely get a TRO - but the administration knows this and they did it anyway. Because the goal is to destabilize and destroy, and the chaos helps them do that.
NEW: Starting May 5, NSF will implement an across-the-board 15% indirect cost rate (mirroring policies at DOE, NIH)
Also, NSF staff expect 341 additional terminations today, bringing the total number of terminations to ~1,380.
Also, NSF staff expect 341 additional terminations today, bringing the total number of terminations to ~1,380.
May 2, 2025 at 5:24 PM
They aren't going to stop. Yes, there will be lawsuits and the institutions will likely get a TRO - but the administration knows this and they did it anyway. Because the goal is to destabilize and destroy, and the chaos helps them do that.
Reposted by John Streicher
Fascist dictatorships do not stop; they have to be stopped.
"My research has found that extrajudicial detention is stopped by defeat in war, by the death of a demagogue, by independent judges, or by popular uprising — but rarely by the leader who started it."
I wrote for New York magazine about deportations to CECOT in El Salvador, which are bound up with a tradition of US extrajudicial actions in the Americas and further the long arc of concentration camps.
April 30, 2025 at 3:29 PM
Fascist dictatorships do not stop; they have to be stopped.
Abolish ICE
Please highlight this story.
ICE stormed into the wrong house, trashed the place, and made women/girls stand outside in the rain in their underwear. ICE also stole phones, laptops, and cash savings from the family, who moved to OKC two weeks ago.
kfor.com/news/local/w...
ICE stormed into the wrong house, trashed the place, and made women/girls stand outside in the rain in their underwear. ICE also stole phones, laptops, and cash savings from the family, who moved to OKC two weeks ago.
kfor.com/news/local/w...
'We're citizens!': Oklahoma City family traumatized after ICE raids home, but they weren't suspects
A woman says her family’s fresh start in Oklahoma turned into a nightmare after federal immigration agents raided their home, taking their phones, laptops, and life savings – even though they were …
kfor.com
April 29, 2025 at 4:21 PM
Abolish ICE
In the past few months, ICE has shown itself to be completely lawless. Acting with no uniforms or ID, “deputizing” vigilante groups, acting against explicit judicial authority, knowingly detaining innocent people, and lying about all of it. Abolish ICE.
April 24, 2025 at 4:31 PM
In the past few months, ICE has shown itself to be completely lawless. Acting with no uniforms or ID, “deputizing” vigilante groups, acting against explicit judicial authority, knowingly detaining innocent people, and lying about all of it. Abolish ICE.
Reposted by John Streicher
To be fair, “Trump” stands for one whole party and parts of the other as well as substantial sections of the media, without whom none of this assault on higher education and research would have been practicable.
But let’s run another profile of Chris Rufo or a piece on woke Oberlin kids taking over
But let’s run another profile of Chris Rufo or a piece on woke Oberlin kids taking over
where we are in 2025: major universities seeking a mutual-protection treaty against the U.S. president
April 24, 2025 at 1:52 PM
To be fair, “Trump” stands for one whole party and parts of the other as well as substantial sections of the media, without whom none of this assault on higher education and research would have been practicable.
But let’s run another profile of Chris Rufo or a piece on woke Oberlin kids taking over
But let’s run another profile of Chris Rufo or a piece on woke Oberlin kids taking over