Falk Schneider
@faldalf.bsky.social
Assistant Professor at University of Warwick
Leading FMD Lab: https://fmd-lab.org/
Postdoc in Fraser Lab (USC)
Postdoc Fritzsche Lab (Oxford)
PhD in Eggeling Lab (Oxford)
Into all things Biophysics, Fluorescence, and Membranes
https://faldalf.github.io
Leading FMD Lab: https://fmd-lab.org/
Postdoc in Fraser Lab (USC)
Postdoc Fritzsche Lab (Oxford)
PhD in Eggeling Lab (Oxford)
Into all things Biophysics, Fluorescence, and Membranes
https://faldalf.github.io
Pinned
Falk Schneider
@faldalf.bsky.social
· Apr 22
#newPI and time is running.
It has already been a month since I officially joined the University of Warwick as Assistant Professor. I am excited to announce and build the Fluorescence and Membrane Dynamics (FMD) Lab:
warwick.ac.uk/fac/sci/med/...
It has already been a month since I officially joined the University of Warwick as Assistant Professor. I am excited to announce and build the Fluorescence and Membrane Dynamics (FMD) Lab:
warwick.ac.uk/fac/sci/med/...
Reposted by Falk Schneider
📡🧵 Excited to release an updated version of our preprint: Zebrahub-Multiome: Uncovering Gene Regulatory Network Dynamics During Zebrafish Embryogenesis
🧪🧬🖥️🐠
doi.org/10.1101/2024...
A tour-de-force by @yangjoonkim with an unexpected discovery!
🧪🧬🖥️🐠
doi.org/10.1101/2024...
A tour-de-force by @yangjoonkim with an unexpected discovery!
January 23, 2026 at 6:37 AM
Reposted by Falk Schneider
Our research on magneto-sensitive fluorescent proteins and some of their applications has now been published!
Huge thank you to the many many people involved in making this happen. 🧪
www.nature.com/articles/s41...
Huge thank you to the many many people involved in making this happen. 🧪
www.nature.com/articles/s41...
Quantum spin resonance in engineered proteins for multimodal sensing - Nature
A recently developed class of magneto-sensitive fluorescent proteins are engineered to alter the properties of their response to magnetic fields and radio frequencies, enabling multimodal sensing of b...
www.nature.com
January 21, 2026 at 4:19 PM
Our research on magneto-sensitive fluorescent proteins and some of their applications has now been published!
Huge thank you to the many many people involved in making this happen. 🧪
www.nature.com/articles/s41...
Huge thank you to the many many people involved in making this happen. 🧪
www.nature.com/articles/s41...
Reposted by Falk Schneider
Great news! @mariaingaramo.bsky.social 's company (Nonfiction Labs) made a remote-controlled antibody.
Its binding turns on and off with a magnet.
This is a HUGE step towards our dream of magnetically controlled drugs. Imagine a cancer drug that ONLY attacks the tumor, not the rest of your body.
Its binding turns on and off with a magnet.
This is a HUGE step towards our dream of magnetically controlled drugs. Imagine a cancer drug that ONLY attacks the tumor, not the rest of your body.
January 13, 2026 at 4:57 AM
Great news! @mariaingaramo.bsky.social 's company (Nonfiction Labs) made a remote-controlled antibody.
Its binding turns on and off with a magnet.
This is a HUGE step towards our dream of magnetically controlled drugs. Imagine a cancer drug that ONLY attacks the tumor, not the rest of your body.
Its binding turns on and off with a magnet.
This is a HUGE step towards our dream of magnetically controlled drugs. Imagine a cancer drug that ONLY attacks the tumor, not the rest of your body.
Reposted by Falk Schneider
When is it ok to invoke a small Reynolds number approximation in finite temperature fluids?
For spatially correlated fluids, curiously the answer is…never? 🧐
arxiv.org/html/2601.05...
#fluids #fluidphysics
For spatially correlated fluids, curiously the answer is…never? 🧐
arxiv.org/html/2601.05...
#fluids #fluidphysics
Revisiting the scale dependence of the Reynolds number in correlated fluctuating fluids
arxiv.org
January 12, 2026 at 7:43 PM
When is it ok to invoke a small Reynolds number approximation in finite temperature fluids?
For spatially correlated fluids, curiously the answer is…never? 🧐
arxiv.org/html/2601.05...
#fluids #fluidphysics
For spatially correlated fluids, curiously the answer is…never? 🧐
arxiv.org/html/2601.05...
#fluids #fluidphysics
Reposted by Falk Schneider
Immune cell response to spinal cord injury in a zebrafish larva. Credit to @beckergroup.bsky.social. #ZebrafishZunday 🧪
January 11, 2026 at 10:32 AM
Immune cell response to spinal cord injury in a zebrafish larva. Credit to @beckergroup.bsky.social. #ZebrafishZunday 🧪
Reposted by Falk Schneider
Anyone have a thought about this weird mol on my hand?
January 10, 2026 at 7:58 PM
Anyone have a thought about this weird mol on my hand?
Reposted by Falk Schneider
New paper out 🔥!
Small promoter, big potential🧬 We show that the ultra-compact Calm1 promoter efficiently targets human neurons in brain organoids and is a promising alternative to hSyn for AAV gene delivery.
Huge thanks to everyone who contributed to this work!
🧠 📄: www.nature.com/articles/s41...
Small promoter, big potential🧬 We show that the ultra-compact Calm1 promoter efficiently targets human neurons in brain organoids and is a promising alternative to hSyn for AAV gene delivery.
Huge thanks to everyone who contributed to this work!
🧠 📄: www.nature.com/articles/s41...
Compact Calm1 promoter enables AAV mediated neuron-targeted expression in human iPSC-derived brain organoids - Scientific Reports
Scientific Reports - Compact Calm1 promoter enables AAV mediated neuron-targeted expression in human iPSC-derived brain organoids
www.nature.com
January 5, 2026 at 12:37 PM
New paper out 🔥!
Small promoter, big potential🧬 We show that the ultra-compact Calm1 promoter efficiently targets human neurons in brain organoids and is a promising alternative to hSyn for AAV gene delivery.
Huge thanks to everyone who contributed to this work!
🧠 📄: www.nature.com/articles/s41...
Small promoter, big potential🧬 We show that the ultra-compact Calm1 promoter efficiently targets human neurons in brain organoids and is a promising alternative to hSyn for AAV gene delivery.
Huge thanks to everyone who contributed to this work!
🧠 📄: www.nature.com/articles/s41...
Reposted by Falk Schneider
Our paper describing the development of ShapeSpaceExplorer is now out: journals.plos.org/ploscompbiol... The software and documentation is available here: github.com/cmcb-warwick... Explainer thread below.
January 6, 2026 at 3:47 PM
Our paper describing the development of ShapeSpaceExplorer is now out: journals.plos.org/ploscompbiol... The software and documentation is available here: github.com/cmcb-warwick... Explainer thread below.
Reposted by Falk Schneider
🚀 Our new Publication in Nature Biomedical Engineering!🎉
📄 Title: Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
🔗 Read the full paper here: www.nature.com/articles/s41...
📄 Title: Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
🔗 Read the full paper here: www.nature.com/articles/s41...
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors - Nature Biomedical Engineering
This study shows that T cell cross-reactivity is influenced by the co-signalling molecules CD5, CD8 and CD4, and that cytotoxic T cells with a CD8→CD4 co-receptor switch show reduced cross-reactivity ...
www.nature.com
January 5, 2026 at 10:46 AM
🚀 Our new Publication in Nature Biomedical Engineering!🎉
📄 Title: Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
🔗 Read the full paper here: www.nature.com/articles/s41...
📄 Title: Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
🔗 Read the full paper here: www.nature.com/articles/s41...
Reposted by Falk Schneider
🎄 FLIM Advent Calendar 🎄
The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up.
Day 5: Dr Falk Schneider @faldalf.bsky.social on Navigating Cross-Excitation Challenges in Multiplexed NADH FLIM.
Free Event: lnkd.in/eGUXXzNe
LinkedIn: lnkd.in/eBTRJRhq
HILIGHT: lnkd.in/ewRw4G4j
The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up.
Day 5: Dr Falk Schneider @faldalf.bsky.social on Navigating Cross-Excitation Challenges in Multiplexed NADH FLIM.
Free Event: lnkd.in/eGUXXzNe
LinkedIn: lnkd.in/eBTRJRhq
HILIGHT: lnkd.in/ewRw4G4j
December 18, 2025 at 4:12 PM
🎄 FLIM Advent Calendar 🎄
The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up.
Day 5: Dr Falk Schneider @faldalf.bsky.social on Navigating Cross-Excitation Challenges in Multiplexed NADH FLIM.
Free Event: lnkd.in/eGUXXzNe
LinkedIn: lnkd.in/eBTRJRhq
HILIGHT: lnkd.in/ewRw4G4j
The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up.
Day 5: Dr Falk Schneider @faldalf.bsky.social on Navigating Cross-Excitation Challenges in Multiplexed NADH FLIM.
Free Event: lnkd.in/eGUXXzNe
LinkedIn: lnkd.in/eBTRJRhq
HILIGHT: lnkd.in/ewRw4G4j
Reposted by Falk Schneider
I won’t buy a lens from you after seeing you put it upside down. 🙃
December 7, 2025 at 11:51 PM
I won’t buy a lens from you after seeing you put it upside down. 🙃
Reposted by Falk Schneider
Preprint drop! 🚨 Rhobin-tag your proteins and watch Saci glow at high temps! 🔥 Bright, photostable, live-cell imaging made possible with JF dyes. Huge thanks to @samjlord.bsky.social @acharlesorszag.bsky.social @mullinslab.bsky.social and Bo Huang lab at UCSF.😊
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
De novo designed bright, hyperstable rhodamine binders for fluorescence microscopy
De novo protein design has emerged as a powerful strategy with the promise to create new tools. The practical performance of designed fluorophore binders, however, has remained far from meeting fluore...
www.biorxiv.org
June 25, 2025 at 5:57 PM
Preprint drop! 🚨 Rhobin-tag your proteins and watch Saci glow at high temps! 🔥 Bright, photostable, live-cell imaging made possible with JF dyes. Huge thanks to @samjlord.bsky.social @acharlesorszag.bsky.social @mullinslab.bsky.social and Bo Huang lab at UCSF.😊
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Falk Schneider
Introducing mScarlet3-S2: a highly photostable and bright red fluorescent protein.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 4, 2025 at 8:19 PM
Introducing mScarlet3-S2: a highly photostable and bright red fluorescent protein.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Falk Schneider
When a larval zebrafish twitches its tail, the vascular endothelium lights up with a calcium signal, mediated by Piezo1. We used to think mechanosensing in endothelial cells was about sensing blood flow, but at least in this case it's about sensing body motion.
November 14, 2025 at 8:34 PM
When a larval zebrafish twitches its tail, the vascular endothelium lights up with a calcium signal, mediated by Piezo1. We used to think mechanosensing in endothelial cells was about sensing blood flow, but at least in this case it's about sensing body motion.
Reposted by Falk Schneider
Know the difference.
November 19, 2025 at 10:08 PM
Know the difference.
Reposted by Falk Schneider
Our new paper is published in the Journal of Chemical Biology! 🏮 We share StayRose, a red version of StayGold 🏮 StayRose has an unnatural amino acid-based chromophore, and has the same immense photobleach-resistance as StayGold 💡
StayRose: A photostable StayGold derivative redshifted by genetic code expansion
Photobleaching of fluorescent proteins often limits the acquisition of high-quality
images in microscopy. StayGold, a novel dimeric GFP recently monomerized through sequence
engineering, addresses thi...
www.jbc.org
November 17, 2025 at 9:03 AM
Our new paper is published in the Journal of Chemical Biology! 🏮 We share StayRose, a red version of StayGold 🏮 StayRose has an unnatural amino acid-based chromophore, and has the same immense photobleach-resistance as StayGold 💡
Reposted by Falk Schneider
#ZebrafishZunday: Cytoplasmic (or ooplasmic) streaming leads to the segregation of embryo from yolk granules. Credit to @shamipourshayan.bsky.social & @heisenbergcplab.bsky.social. 🧪
November 16, 2025 at 9:31 AM
#ZebrafishZunday: Cytoplasmic (or ooplasmic) streaming leads to the segregation of embryo from yolk granules. Credit to @shamipourshayan.bsky.social & @heisenbergcplab.bsky.social. 🧪
🌹🔬🤩
Our new paper is published in the Journal of Chemical Biology! 🏮 We share StayRose, a red version of StayGold 🏮 StayRose has an unnatural amino acid-based chromophore, and has the same immense photobleach-resistance as StayGold 💡
StayRose: A photostable StayGold derivative redshifted by genetic code expansion
Photobleaching of fluorescent proteins often limits the acquisition of high-quality
images in microscopy. StayGold, a novel dimeric GFP recently monomerized through sequence
engineering, addresses thi...
www.jbc.org
November 17, 2025 at 9:37 AM
🌹🔬🤩
Reposted by Falk Schneider
Head-mounted 2-photon miniscope voltage imaging!
Weijian Yang's group at UC Davis sped up 2p scanning by multiplexing to achieve 400-Hz voltage imaging of ~20 neurons, using ASAP4e
These are the first freely moving single-cell voltage recordings as far as I know.
URL: www.cell.com/cell-reports...
Weijian Yang's group at UC Davis sped up 2p scanning by multiplexing to achieve 400-Hz voltage imaging of ~20 neurons, using ASAP4e
These are the first freely moving single-cell voltage recordings as far as I know.
URL: www.cell.com/cell-reports...
High-speed neural imaging with multiplexed miniaturized two-photon microscopy
Zhang et al. develop two types of multiplexed miniaturized two-photon microscopes
(M-MINI2Ps) that increase imaging speed via beam multiplexing while preserving spatial
resolution and demonstrate thei...
www.cell.com
November 13, 2025 at 11:33 PM
Head-mounted 2-photon miniscope voltage imaging!
Weijian Yang's group at UC Davis sped up 2p scanning by multiplexing to achieve 400-Hz voltage imaging of ~20 neurons, using ASAP4e
These are the first freely moving single-cell voltage recordings as far as I know.
URL: www.cell.com/cell-reports...
Weijian Yang's group at UC Davis sped up 2p scanning by multiplexing to achieve 400-Hz voltage imaging of ~20 neurons, using ASAP4e
These are the first freely moving single-cell voltage recordings as far as I know.
URL: www.cell.com/cell-reports...
Reposted by Falk Schneider
New preprint 🥳! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 13, 2025 at 4:20 PM
New preprint 🥳! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Falk Schneider
Has anyone had this problem? A hydrophobic water objective? The objective is great but we struggle to keep the water on the lens...
-> Maybe a solution is to paint a circle around the nose with a 'hydrophobic barrier pap pen" (link below). Has anyone tried this?
www.fishersci.com/shop/product...
-> Maybe a solution is to paint a circle around the nose with a 'hydrophobic barrier pap pen" (link below). Has anyone tried this?
www.fishersci.com/shop/product...
November 12, 2025 at 12:56 AM
Has anyone had this problem? A hydrophobic water objective? The objective is great but we struggle to keep the water on the lens...
-> Maybe a solution is to paint a circle around the nose with a 'hydrophobic barrier pap pen" (link below). Has anyone tried this?
www.fishersci.com/shop/product...
-> Maybe a solution is to paint a circle around the nose with a 'hydrophobic barrier pap pen" (link below). Has anyone tried this?
www.fishersci.com/shop/product...
Reposted by Falk Schneider
Mind-bender: The observable universe has ~10^80 atoms. But even a simple 1000×1000 black‑and‑white image has 2^{1,000,000} ≈ 10^{301,030} possibilities — and 24‑bit color explodes to ~10^{7,224,720}. The space of (small) images dwarfs the cosmos. 🔬🧪💻
November 13, 2025 at 2:31 AM
Mind-bender: The observable universe has ~10^80 atoms. But even a simple 1000×1000 black‑and‑white image has 2^{1,000,000} ≈ 10^{301,030} possibilities — and 24‑bit color explodes to ~10^{7,224,720}. The space of (small) images dwarfs the cosmos. 🔬🧪💻
Reposted by Falk Schneider
Happy to share that I will be starting my independent research career as a Research Group Leader at the German Cancer Research Center (DKFZ). Starting from January 2026, my group will be based at DKFZ National Center for Tumor Diseases (NCT WERA), Würzburg, Germany.
November 11, 2025 at 1:33 PM
Happy to share that I will be starting my independent research career as a Research Group Leader at the German Cancer Research Center (DKFZ). Starting from January 2026, my group will be based at DKFZ National Center for Tumor Diseases (NCT WERA), Würzburg, Germany.
Reposted by Falk Schneider
Get into flow with zebrafish — soon your eyes will glow 🐟✨
Blood flow in a transparent zebrafish embryo. Credit to @damiandn.bsky.social. #ZebrafishZunday 🧪
November 9, 2025 at 12:06 PM
Get into flow with zebrafish — soon your eyes will glow 🐟✨
Reposted by Falk Schneider
Hi Fans of Feedback Microscopy,
what would you do when you have access to the pixel stream from @zeiss-microscopy.bsky.social inside @napari.org?
Btw, it works as well in Fiji&ImageJ :-)
Sidenote: Experiments started from "outside" do not update the ZEN UI. But they are executed by ZENservice.
what would you do when you have access to the pixel stream from @zeiss-microscopy.bsky.social inside @napari.org?
Btw, it works as well in Fiji&ImageJ :-)
Sidenote: Experiments started from "outside" do not update the ZEN UI. But they are executed by ZENservice.
November 7, 2025 at 7:23 PM
Hi Fans of Feedback Microscopy,
what would you do when you have access to the pixel stream from @zeiss-microscopy.bsky.social inside @napari.org?
Btw, it works as well in Fiji&ImageJ :-)
Sidenote: Experiments started from "outside" do not update the ZEN UI. But they are executed by ZENservice.
what would you do when you have access to the pixel stream from @zeiss-microscopy.bsky.social inside @napari.org?
Btw, it works as well in Fiji&ImageJ :-)
Sidenote: Experiments started from "outside" do not update the ZEN UI. But they are executed by ZENservice.