@adamezracohen.bsky.social
History of modern art: abstracts expressionism and cerealism.
November 1, 2025 at 12:33 PM
History of modern art: abstracts expressionism and cerealism.
Reposted
Excited to share the latest from the lab on the molecular mechanisms of silencing and un-silencing a hippocampal engram ensemble. Was fun using a variant of the EPSILON technique developed by Adam Cohen's lab.
(1/2)
www.sciencedirect.com/science/arti...
(1/2)
www.sciencedirect.com/science/arti...
Molecular mechanisms mediating engram ensemble retrievability state in mice
Engrams, ensembles of neurons that store memories, exist along a continuum of retrievability. Normally, sensory cues can reactivate a latent engram to…
www.sciencedirect.com
October 30, 2025 at 3:32 PM
Excited to share the latest from the lab on the molecular mechanisms of silencing and un-silencing a hippocampal engram ensemble. Was fun using a variant of the EPSILON technique developed by Adam Cohen's lab.
(1/2)
www.sciencedirect.com/science/arti...
(1/2)
www.sciencedirect.com/science/arti...
In small enclosed structures (like vesicles), the flickering of individual ion channels can have substantial effects on membrane voltage and internal ion concentrations. Mean-field conductance-based models break down. We studied what happens:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Electrophysiology in small compartments
Voltage-gated ion channels are found in many membrane-enclosed structures, including synaptic vesicles, endosomes, mitochondria, chloroplasts, viruses and bacteria. In small compartments, assumptions ...
www.biorxiv.org
September 5, 2025 at 2:56 AM
In small enclosed structures (like vesicles), the flickering of individual ion channels can have substantial effects on membrane voltage and internal ion concentrations. Mean-field conductance-based models break down. We studied what happens:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted
Nemo needs gap junctions, too. New preprint with Marleen Klann, Vincent Laudet, et al. showing anemonefish Snowflake mutant due to E42K substitution in Connexin Gja5b. Found exact same E42K in zebrafish gja5b (= leopard) by ENU, to the nucleotide! Details, inferences: www.biorxiv.org/content/10.1...
August 26, 2025 at 12:50 PM
Nemo needs gap junctions, too. New preprint with Marleen Klann, Vincent Laudet, et al. showing anemonefish Snowflake mutant due to E42K substitution in Connexin Gja5b. Found exact same E42K in zebrafish gja5b (= leopard) by ENU, to the nucleotide! Details, inferences: www.biorxiv.org/content/10.1...
Reposted
Voltage Imaging of CA1 Pyramidal Cells and SST+ Interneurons Reveals Stability and Plasticity Mechanisms of Spatial Firing https://www.biorxiv.org/content/10.1101/2025.08.20.671230v1
August 23, 2025 at 7:16 AM
Voltage Imaging of CA1 Pyramidal Cells and SST+ Interneurons Reveals Stability and Plasticity Mechanisms of Spatial Firing https://www.biorxiv.org/content/10.1101/2025.08.20.671230v1
"The axon does not think. It only ax." George Bishop, 1965 😂
Dynamics of Excitability in Axonal Trees https://www.biorxiv.org/content/10.1101/2025.07.24.666461v1
July 29, 2025 at 8:23 PM
"The axon does not think. It only ax." George Bishop, 1965 😂
I like this 😀.
Astrocytes connect specific brain regions through plastic gap junctional networks https://www.biorxiv.org/content/10.1101/2025.07.18.665573v1
July 22, 2025 at 9:55 PM
I like this 😀.
Jurassic parking.
July 1, 2025 at 9:36 PM
Jurassic parking.
A rare appearance of my Dad on the internet!
For “Reflections on the history of modeling and theory”, @sarperotto.bsky.social and I met with Joel Cohen. We learn how he navigated math and biology, the value of embracing ignorance, and what is a population. Or really, what _isn't_ a population: www.youtube.com/watch?v=RCt9...
@smtpb.bsky.social
@smtpb.bsky.social
Reflections on Modeling and Theory in Population Biology: Joel Cohen
YouTube video by SMTPB
www.youtube.com
June 26, 2025 at 5:09 PM
A rare appearance of my Dad on the internet!
Reposted
My father worked in a tire factory in Appalachia. Friends and family in the military. Used to vote Republican. Got into college on a diversity program for the underprivileged. Ended up a Harvard professor. And now my funding is terminated because we're trying to stick it to the elites.
May 28, 2025 at 3:07 PM
My father worked in a tire factory in Appalachia. Friends and family in the military. Used to vote Republican. Got into college on a diversity program for the underprivileged. Ended up a Harvard professor. And now my funding is terminated because we're trying to stick it to the elites.
I wrote about the government's attacks on Harvard. Hope this reaches a few persuadable minds.
prosyn.org/PhWi74r?h=Ky...
prosyn.org/PhWi74r?h=Ky...
Defunding Harvard Hurts America | by Adam Ezra Cohen - Project Syndicate
Adam Ezra Cohen explains the real-world consequences of canceling federal research grants in the name of fighting antisemitism.
prosyn.org
May 28, 2025 at 12:52 PM
I wrote about the government's attacks on Harvard. Hope this reaches a few persuadable minds.
prosyn.org/PhWi74r?h=Ky...
prosyn.org/PhWi74r?h=Ky...
Reposted
My debut on BlueSky! Here’s how we harvest the firing of neurons to see them better in the living brain! 👇
www.nature.com/articles/s41...
Grateful for the amazing dyes from @rhodamine110.bsky.social and insightful suggestions from @adamezracohen.bsky.social !
www.nature.com/articles/s41...
Grateful for the amazing dyes from @rhodamine110.bsky.social and insightful suggestions from @adamezracohen.bsky.social !
May 23, 2025 at 12:49 PM
My debut on BlueSky! Here’s how we harvest the firing of neurons to see them better in the living brain! 👇
www.nature.com/articles/s41...
Grateful for the amazing dyes from @rhodamine110.bsky.social and insightful suggestions from @adamezracohen.bsky.social !
www.nature.com/articles/s41...
Grateful for the amazing dyes from @rhodamine110.bsky.social and insightful suggestions from @adamezracohen.bsky.social !
Now out in JACS. pubs.acs.org/doi/full/10....
Grateful to thoughtful reviewers who found some errors in our model and encouraged us to make a better one! A renaissance in magnetobiology is coming...
Grateful to thoughtful reviewers who found some errors in our model and encouraged us to make a better one! A renaissance in magnetobiology is coming...
May 15, 2025 at 4:04 PM
Now out in JACS. pubs.acs.org/doi/full/10....
Grateful to thoughtful reviewers who found some errors in our model and encouraged us to make a better one! A renaissance in magnetobiology is coming...
Grateful to thoughtful reviewers who found some errors in our model and encouraged us to make a better one! A renaissance in magnetobiology is coming...
This guy deserves a Nobel Prize, an IgNobel Prize, and a Darwin Award (honorable mention, for effort).
www.nprillinois.org/2025-05-02/h...
www.nprillinois.org/2025-05-02/h...
He let snakes bite him some 200 times to create a better snakebite antivenom
Scientists have created a broadly effective antivenom using the blood of a Wisconsin man who has spent years exposing himself to deadly snakebites from black mambas, taipans, cobras and many others.
www.nprillinois.org
May 4, 2025 at 2:17 AM
This guy deserves a Nobel Prize, an IgNobel Prize, and a Darwin Award (honorable mention, for effort).
www.nprillinois.org/2025-05-02/h...
www.nprillinois.org/2025-05-02/h...
Using light to sculpt vertebrate development! OptoNodal2 converts patterns of illumination into patterns of morphogen signaling.
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
May 2, 2025 at 12:37 AM
Using light to sculpt vertebrate development! OptoNodal2 converts patterns of illumination into patterns of morphogen signaling.
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
Reposted
Thrilled that our paper has been published in @elife.bsky.social
doi.org/10.7554/eLif...
We ask: how can a neuron integrate information across multiple time scales?
Twist: This neuron has extreme properties that helps it work ~300x times faster than neurons in the hippocampus
Summary 🧵to follow
doi.org/10.7554/eLif...
We ask: how can a neuron integrate information across multiple time scales?
Twist: This neuron has extreme properties that helps it work ~300x times faster than neurons in the hippocampus
Summary 🧵to follow
April 18, 2025 at 4:10 PM
Thrilled that our paper has been published in @elife.bsky.social
doi.org/10.7554/eLif...
We ask: how can a neuron integrate information across multiple time scales?
Twist: This neuron has extreme properties that helps it work ~300x times faster than neurons in the hippocampus
Summary 🧵to follow
doi.org/10.7554/eLif...
We ask: how can a neuron integrate information across multiple time scales?
Twist: This neuron has extreme properties that helps it work ~300x times faster than neurons in the hippocampus
Summary 🧵to follow
Here's a little essay on dendritic excitations -- what are they for? (hint: I don't think it's for integration, at least not in hippocampal pyramidal cells) brain.harvard.edu/hbi_news/exc...
Excitement Over Dendritic Excitations - Harvard Brain Science Initiative
brain.harvard.edu
April 17, 2025 at 6:01 PM
Here's a little essay on dendritic excitations -- what are they for? (hint: I don't think it's for integration, at least not in hippocampal pyramidal cells) brain.harvard.edu/hbi_news/exc...
Reposted
Injury-induced electrochemical coupling triggers regenerative cell proliferation https://www.biorxiv.org/content/10.1101/2025.04.03.647033v1
April 8, 2025 at 10:47 PM
Injury-induced electrochemical coupling triggers regenerative cell proliferation https://www.biorxiv.org/content/10.1101/2025.04.03.647033v1
Reposted
Honored to help enable two back-to-back papers in @natureneuro.bsky.social; first DELTA www.nature.com/articles/s41... with collaborators at @hhmijanelia.bsky.social and then EPSILON www.nature.com/articles/s41... with @adamezracohen.bsky.social; @dyerfulchymist.bsky.social is always in the mix!
DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning - Nature Neuroscience
Researchers developed DELTA, a method for brain-wide measurement of synaptic protein turnover with single-synapse resolution, providing a powerful tool to localize and study mechanisms underlying syna...
www.nature.com
April 1, 2025 at 4:06 PM
Honored to help enable two back-to-back papers in @natureneuro.bsky.social; first DELTA www.nature.com/articles/s41... with collaborators at @hhmijanelia.bsky.social and then EPSILON www.nature.com/articles/s41... with @adamezracohen.bsky.social; @dyerfulchymist.bsky.social is always in the mix!
Reposted
The claim that the destruction of essential civilizational institutions is being done in the name of the Jews is itself a form of antisemitism—cultural vandalism carried out in our name.
That, my friends, is rank bullshit.
That, my friends, is rank bullshit.
April 1, 2025 at 1:56 AM
The claim that the destruction of essential civilizational institutions is being done in the name of the Jews is itself a form of antisemitism—cultural vandalism carried out in our name.
That, my friends, is rank bullshit.
That, my friends, is rank bullshit.
Which synapses get stronger when we form a memory? We developed a technique to tag recently potentiated synapses in live mice. Pulse-chase labeling with membrane-impermeable HaloLigand dyes distinguishes fresh AMPA receptors from old ones. www.nature.com/articles/s41...
EPSILON: a method for pulse-chase labeling to probe synaptic AMPAR exocytosis during memory formation - Nature Neuroscience
Kim and coworkers describe a technique, EPSILON, to map AMPA receptor exocytosis, a proxy for synaptic plasticity, in mice. The authors demonstrated a correlation between AMPA receptor exocytosis and ...
www.nature.com
March 31, 2025 at 9:10 PM
Which synapses get stronger when we form a memory? We developed a technique to tag recently potentiated synapses in live mice. Pulse-chase labeling with membrane-impermeable HaloLigand dyes distinguishes fresh AMPA receptors from old ones. www.nature.com/articles/s41...
Reposted
Whole-brain, all-optical interrogation of neuronal dynamics underlying gut interoception in zebrafish https://www.biorxiv.org/content/10.1101/2025.03.26.645305v1
March 31, 2025 at 1:15 AM
Whole-brain, all-optical interrogation of neuronal dynamics underlying gut interoception in zebrafish https://www.biorxiv.org/content/10.1101/2025.03.26.645305v1
Reposted
We are hiring a new lab manager! Our wonderful lab manager Albert is headed off to grad school and we are looking to fill his position this summer. This is a great opportunity for a new graduate to spend a couple years immersed in research before applying to PhD or MD programs. 50% of the job is...
March 26, 2025 at 5:39 PM
We are hiring a new lab manager! Our wonderful lab manager Albert is headed off to grad school and we are looking to fill his position this summer. This is a great opportunity for a new graduate to spend a couple years immersed in research before applying to PhD or MD programs. 50% of the job is...
It's such a trip to see former lab members flourish (fluoresce?) in their independent careers. Four generations present at the Dendrites GRC!
March 24, 2025 at 9:48 PM
It's such a trip to see former lab members flourish (fluoresce?) in their independent careers. Four generations present at the Dendrites GRC!
At the Dendrites GRC. Now where, oh where, did I park?
March 24, 2025 at 12:42 AM
At the Dendrites GRC. Now where, oh where, did I park?