Nature Methods
@natmethods.nature.com
A scientific journal publishing cutting-edge methods, tools, analyses, resources, reviews, news and commentary, supporting life sciences research. Posts by the editors.
Not all scientific conferences offer childcare, but when they do, parents are happy. @vivienm.bsky.social asked conference attendees who are also mothers - and their children - about conference daycare.
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February 4, 2026 at 6:37 PM
Not all scientific conferences offer childcare, but when they do, parents are happy. @vivienm.bsky.social asked conference attendees who are also mothers - and their children - about conference daycare.
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Researchers are exploring new ways to harness the versatility of nanobodies, which are smaller camelid antibodies. @vivienm.bsky.social asked scientists about some of their current and future nanobody work.
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What nanobodies can do for you - Nature Methods
Since the chance discovery of nanobodies in the late 1980s, their uses and applications have kept growing. Researchers are now exploring new ways to harness nanobody versatility.
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February 4, 2026 at 5:39 PM
Researchers are exploring new ways to harness the versatility of nanobodies, which are smaller camelid antibodies. @vivienm.bsky.social asked scientists about some of their current and future nanobody work.
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A Comment discusses how commands, data, and metadata currently discarded by scientific instruments could be used to train AI systems to learn to conduct experiments. @henrypinkard.bsky.social @nilsnorlin.bsky.social
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The missing data for intelligent scientific instruments - Nature Methods
Most scientific instruments currently discard rich streams of commands, data and metadata from which AI systems could learn to conduct experiments with expert-level decision-making and troubleshooting...
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January 26, 2026 at 6:01 PM
A Comment discusses how commands, data, and metadata currently discarded by scientific instruments could be used to train AI systems to learn to conduct experiments. @henrypinkard.bsky.social @nilsnorlin.bsky.social
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Our latest Creature Column features the jellyfish Clytia hemisphaerica, a model for studying embryogenesis and gametogenesis.
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The jellyfish Clytia hemisphaerica - Nature Methods
The jellyfish Clytia hemisphaerica has long been established as a model for studying embryogenesis and gametogenesis because of its transparency, simple tissue architecture and evolutionary position. ...
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January 26, 2026 at 5:49 PM
Our latest Creature Column features the jellyfish Clytia hemisphaerica, a model for studying embryogenesis and gametogenesis.
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For a quick summary, read the Research Briefing here:
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January 22, 2026 at 2:43 PM
For a quick summary, read the Research Briefing here:
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MaAsLin 3: a comprehensive, flexible framework for microbiome association studies. @hutlab.bsky.social
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MaAsLin 3: refining and extending generalized multivariable linear models for meta-omic association discovery - Nature Methods
MaAsLin 3 is a comprehensive and flexible framework for microbiome association studies with expanded toolsets of statistical models, tests and types of inference.
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January 22, 2026 at 2:05 PM
MaAsLin 3: a comprehensive, flexible framework for microbiome association studies. @hutlab.bsky.social
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DBiTplus: a workflow unifying sequencing-based and imaging-based spatial omics on the same tissue section.
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Integration of imaging-based and sequencing-based spatial omics mapping on the same tissue section via DBiTplus - Nature Methods
DBiTplus represents an integrated experimental and computational workflow that unifies sequencing-based and imaging-based spatial omics, demonstrated by combining transcriptomic profiling and multiple...
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January 22, 2026 at 1:59 PM
DBiTplus: a workflow unifying sequencing-based and imaging-based spatial omics on the same tissue section.
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In this month's Editorial, we highlight some of the Nature Methods editorial team members' favorite papers we published in 2025!
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Client Challenge
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January 14, 2026 at 5:38 PM
In this month's Editorial, we highlight some of the Nature Methods editorial team members' favorite papers we published in 2025!
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SpatialZ generates virtual single-cell transcriptomics slices between experimentally measured sections, enabling accurate and efficient building of 3D cell atlases of different tissues.
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January 14, 2026 at 4:26 PM
SpatialZ generates virtual single-cell transcriptomics slices between experimentally measured sections, enabling accurate and efficient building of 3D cell atlases of different tissues.
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Pertpy: a one-stop and performant framework for single-cell perturbation analysis. @lukasheumos.bsky.social @fabiantheis.bsky.social
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January 14, 2026 at 4:20 PM
Pertpy: a one-stop and performant framework for single-cell perturbation analysis. @lukasheumos.bsky.social @fabiantheis.bsky.social
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Our January issue is now live! 🥳
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On the cover, a network of illuminated grids forms a cell-like shape representing Squidiff’s ability to predict continuous cell-state transitions under differentiation and perturbations. Paper: doi.org/10.1038/s415...
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On the cover, a network of illuminated grids forms a cell-like shape representing Squidiff’s ability to predict continuous cell-state transitions under differentiation and perturbations. Paper: doi.org/10.1038/s415...
January 14, 2026 at 3:02 PM
Our January issue is now live! 🥳
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On the cover, a network of illuminated grids forms a cell-like shape representing Squidiff’s ability to predict continuous cell-state transitions under differentiation and perturbations. Paper: doi.org/10.1038/s415...
nature.com/nmeth/volume...
On the cover, a network of illuminated grids forms a cell-like shape representing Squidiff’s ability to predict continuous cell-state transitions under differentiation and perturbations. Paper: doi.org/10.1038/s415...
For a quick summary, read the Research Briefing on this work:
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SmartEM: a smart machine learning-based pipeline for electron microscopy-based data acquisition for connectomics.
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January 9, 2026 at 5:03 PM
For a quick summary, read the Research Briefing on this work:
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For a quick summary, read the Research Briefing on this work: www.nature.com/articles/s41...
TransBrain translates brain phenotypes between mouse and human via homology mapping.
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January 9, 2026 at 5:01 PM
For a quick summary, read the Research Briefing on this work: www.nature.com/articles/s41...
cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.
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January 9, 2026 at 4:57 PM
cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.
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SmartEM: a smart machine learning-based pipeline for electron microscopy-based data acquisition for connectomics.
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January 9, 2026 at 4:53 PM
SmartEM: a smart machine learning-based pipeline for electron microscopy-based data acquisition for connectomics.
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TransBrain translates brain phenotypes between mouse and human via homology mapping.
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January 9, 2026 at 4:50 PM
TransBrain translates brain phenotypes between mouse and human via homology mapping.
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January 8, 2026 at 8:44 PM
iGluSnFR4f and iGluSnFR4s are the latest generation of genetically encoded glutamate sensors, for tracking rapid dynamics and for recording from large populations of synapses.
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January 8, 2026 at 8:40 PM
iGluSnFR4f and iGluSnFR4s are the latest generation of genetically encoded glutamate sensors, for tracking rapid dynamics and for recording from large populations of synapses.
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A scalable, open source-framework can be used as a benchmarking suite for comparing macromolecular complex structure, interfaces and ligand interactions against experimental data.
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January 8, 2026 at 8:37 PM
A scalable, open source-framework can be used as a benchmarking suite for comparing macromolecular complex structure, interfaces and ligand interactions against experimental data.
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CELTIC: a context-dependent deep learning model for in silico organelle localization in label-free microscopy images.
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January 8, 2026 at 8:33 PM
CELTIC: a context-dependent deep learning model for in silico organelle localization in label-free microscopy images.
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A new Review covers how machine learning and computer vision methods have empowered super-resolution microscopy.
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AI-empowered super-resolution microscopy: a revolution in nanoscale cellular imaging - Nature Methods
This Review provides a comprehensive discussion of how methods in machine learning and computer vision have been used to improve super-resolution microscopy to gain insights into subcellular biology.
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January 6, 2026 at 6:24 PM
A new Review covers how machine learning and computer vision methods have empowered super-resolution microscopy.
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A Perspective on 3D traction force microscopy provides practical experimental and computational guidance for users. @barrasa-fano.bsky.social
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Guidance for 3D traction force microscopy today and in the next decade - Nature Methods
This Perspective envisions the future of 3DTFM and provides practical guidelines for experimental and computation strategies for its application.
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January 6, 2026 at 5:30 PM
A Perspective on 3D traction force microscopy provides practical experimental and computational guidance for users. @barrasa-fano.bsky.social
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Two recent Reviews describe how to select optimal cell migration assays and how to analyze this data.
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Selecting the optimal cell migration assay: fundamentals and practical guidelines - Nature Methods
This Review introduces ten cell migration assays, offers practical guidance toward selecting the best assay for a specific biological question and describes how future advances can reveal important in...
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January 6, 2026 at 5:15 PM
Two recent Reviews describe how to select optimal cell migration assays and how to analyze this data.
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SpaceBar: a cellular barcoding approach for simultaneous analysis of cell clonal and spatial identities.
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SpaceBar enables single-cell-resolution clone tracing with imaging-based spatial transcriptomics - Nature Methods
SpaceBar is a cellular barcoding strategy for simultaneous analysis of cell clonal and spatial identities.
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December 19, 2025 at 7:37 PM
SpaceBar: a cellular barcoding approach for simultaneous analysis of cell clonal and spatial identities.
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