Andrew G. York
@andrewgyork.bsky.social
I'm a physicist; I invent techniques to measure and control biological systems.
Homepage: andrewgyork.github.io
Homepage: andrewgyork.github.io
Pinned
Andrew G. York
@andrewgyork.bsky.social
· Nov 22
MagLOV!
MagLOV is a fluorescent protein you can "turn off" with a handheld magnet, engineered by @mariaingaramo.bsky.social.
We think/hope we can use it to turn arbitrary proteins (including drugs!) on and off in opaque creatures (including humans!).
bsky.app/profile/addg...
MagLOV is a fluorescent protein you can "turn off" with a handheld magnet, engineered by @mariaingaramo.bsky.social.
We think/hope we can use it to turn arbitrary proteins (including drugs!) on and off in opaque creatures (including humans!).
bsky.app/profile/addg...
Reposted by Andrew G. York
MagLOV quantum sensing update! Much improved imaging (>10% single cell ODMR contrast), detailed characterisation and simulation, and new experimental demonstrations taking us a step closer to applications.
www.biorxiv.org/content/10.1...
SI: www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
SI: www.biorxiv.org/content/10.1...
August 21, 2025 at 1:59 PM
MagLOV quantum sensing update! Much improved imaging (>10% single cell ODMR contrast), detailed characterisation and simulation, and new experimental demonstrations taking us a step closer to applications.
www.biorxiv.org/content/10.1...
SI: www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
SI: www.biorxiv.org/content/10.1...
Reposted by Andrew G. York
How many photons are in a GFP? — more than last year, and more than you thought. Here's a simple, cheap, and practical method to break a fundamental limit in fluorescence microscopy. But it only works in light sheet!
August 19, 2025 at 7:31 PM
How many photons are in a GFP? — more than last year, and more than you thought. Here's a simple, cheap, and practical method to break a fundamental limit in fluorescence microscopy. But it only works in light sheet!
Reposted by Andrew G. York
Very lucky to be at UCSF with such great microscopy facilities. These instruments are definitely pushing the limits of what we thought feasible in live imaging! Excited to keep exploring how these single cells organize and secrete such precise morphologies.
If you've ever wanted to know what the actin filaments on the scales in a developing moth wing look like in 3D, here you go!
Kyle DeMarr from @mullinslab.bsky.social acquired these beautiful data on the single objective light sheet at the UCSF Center for Advanced Light Microscopy.
#snouty
Kyle DeMarr from @mullinslab.bsky.social acquired these beautiful data on the single objective light sheet at the UCSF Center for Advanced Light Microscopy.
#snouty
July 26, 2025 at 7:35 PM
Very lucky to be at UCSF with such great microscopy facilities. These instruments are definitely pushing the limits of what we thought feasible in live imaging! Excited to keep exploring how these single cells organize and secrete such precise morphologies.
Reposted by Andrew G. York
Production has started for a new #Snoutscope objective, AMS-AGY v3. It has significantly larger FOV and some other tweaks from v1 and v2. Currently accepting pre-orders. The price will need to increase modestly after deliveries start late October.
July 9, 2025 at 8:00 PM
Production has started for a new #Snoutscope objective, AMS-AGY v3. It has significantly larger FOV and some other tweaks from v1 and v2. Currently accepting pre-orders. The price will need to increase modestly after deliveries start late October.
Reposted by Andrew G. York
I got a text from Yovan Bodal, who just used our #snoutscope @UCSF to image fly embryos. His quote says it all!
"This was the best results we've gotten on any instrument, possibly for the least amount of work on my end. Here's a GIF of individual mRNAs coming off the gene as they get transcribed:"
"This was the best results we've gotten on any instrument, possibly for the least amount of work on my end. Here's a GIF of individual mRNAs coming off the gene as they get transcribed:"
June 21, 2025 at 2:00 PM
I got a text from Yovan Bodal, who just used our #snoutscope @UCSF to image fly embryos. His quote says it all!
"This was the best results we've gotten on any instrument, possibly for the least amount of work on my end. Here's a GIF of individual mRNAs coming off the gene as they get transcribed:"
"This was the best results we've gotten on any instrument, possibly for the least amount of work on my end. Here's a GIF of individual mRNAs coming off the gene as they get transcribed:"
Reposted by Andrew G. York
HIGH-RESOLUTION IN VIVO BRAIN IMAGING OF DROSOPHILA 🪰
New Preprint by Tassara et al.!
www.biorxiv.org/content/10.1...
#FluorescenceMonday #SnoutClub 1/6
New Preprint by Tassara et al.!
www.biorxiv.org/content/10.1...
#FluorescenceMonday #SnoutClub 1/6
February 26, 2025 at 2:48 AM
HIGH-RESOLUTION IN VIVO BRAIN IMAGING OF DROSOPHILA 🪰
New Preprint by Tassara et al.!
www.biorxiv.org/content/10.1...
#FluorescenceMonday #SnoutClub 1/6
New Preprint by Tassara et al.!
www.biorxiv.org/content/10.1...
#FluorescenceMonday #SnoutClub 1/6
Reposted by Andrew G. York
I recommend these optomechanics for 'O2-O3' in a single-objective light-sheet (SOLS) microscope:
-> Mechanically and thermally stable.
-> Relatively straightforward to align.
-> 10 popular configurations.
Make your own:
github.com/amsikking/SO...
Or buy it from @jsdaniel02.bsky.social at ASI!
-> Mechanically and thermally stable.
-> Relatively straightforward to align.
-> 10 popular configurations.
Make your own:
github.com/amsikking/SO...
Or buy it from @jsdaniel02.bsky.social at ASI!
February 12, 2025 at 1:59 AM
I recommend these optomechanics for 'O2-O3' in a single-objective light-sheet (SOLS) microscope:
-> Mechanically and thermally stable.
-> Relatively straightforward to align.
-> 10 popular configurations.
Make your own:
github.com/amsikking/SO...
Or buy it from @jsdaniel02.bsky.social at ASI!
-> Mechanically and thermally stable.
-> Relatively straightforward to align.
-> 10 popular configurations.
Make your own:
github.com/amsikking/SO...
Or buy it from @jsdaniel02.bsky.social at ASI!
Reposted by Andrew G. York
Who else has a #Snouty objective? I currently have 25 members in #SnoutClub! But I think there's a LOT MORE out there... Anyone else care to join?
-> Just reply here with a pic of your #Snouty and I'll add you!
Why? It helps us promote and develop the technology!
amsikking.github.io/snoutclub/
-> Just reply here with a pic of your #Snouty and I'll add you!
Why? It helps us promote and develop the technology!
amsikking.github.io/snoutclub/
January 29, 2025 at 3:48 AM
Who else has a #Snouty objective? I currently have 25 members in #SnoutClub! But I think there's a LOT MORE out there... Anyone else care to join?
-> Just reply here with a pic of your #Snouty and I'll add you!
Why? It helps us promote and develop the technology!
amsikking.github.io/snoutclub/
-> Just reply here with a pic of your #Snouty and I'll add you!
Why? It helps us promote and develop the technology!
amsikking.github.io/snoutclub/
I'll be telling stories about science tonight in San Francisco. Come through!
partiful.com/e/ldwWPLR2fO...
The real draw is the crew hosting me, though. The local biotech hacker/maker/entrepreneur scene is PACKED with brilliant, inspiring folks.
No slides, just stories.
partiful.com/e/ldwWPLR2fO...
The real draw is the crew hosting me, though. The local biotech hacker/maker/entrepreneur scene is PACKED with brilliant, inspiring folks.
No slides, just stories.
RSVP to Lecture night with Andrew York | Partiful
Gather round the fire and make new friends!
Andrew is a physicist at Calico and recently co-discovered magnetic responsivity in fluorescent proteins. It’s one of my favorite discoveries because it’s ...
partiful.com
January 26, 2025 at 5:37 PM
I'll be telling stories about science tonight in San Francisco. Come through!
partiful.com/e/ldwWPLR2fO...
The real draw is the crew hosting me, though. The local biotech hacker/maker/entrepreneur scene is PACKED with brilliant, inspiring folks.
No slides, just stories.
partiful.com/e/ldwWPLR2fO...
The real draw is the crew hosting me, though. The local biotech hacker/maker/entrepreneur scene is PACKED with brilliant, inspiring folks.
No slides, just stories.
This is such a fun project! I love the kind of work that F.R.O.s attack.
🧪 E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains.
Read more: e11.bio/news/roadmap
Read more: e11.bio/news/roadmap
December 12, 2024 at 6:28 PM
This is such a fun project! I love the kind of work that F.R.O.s attack.
Reposted by Andrew G. York
MagLOV!
MagLOV is a fluorescent protein you can "turn off" with a handheld magnet, engineered by @mariaingaramo.bsky.social.
We think/hope we can use it to turn arbitrary proteins (including drugs!) on and off in opaque creatures (including humans!).
bsky.app/profile/addg...
MagLOV is a fluorescent protein you can "turn off" with a handheld magnet, engineered by @mariaingaramo.bsky.social.
We think/hope we can use it to turn arbitrary proteins (including drugs!) on and off in opaque creatures (including humans!).
bsky.app/profile/addg...
November 22, 2024 at 12:06 AM
MagLOV!
MagLOV is a fluorescent protein you can "turn off" with a handheld magnet, engineered by @mariaingaramo.bsky.social.
We think/hope we can use it to turn arbitrary proteins (including drugs!) on and off in opaque creatures (including humans!).
bsky.app/profile/addg...
MagLOV is a fluorescent protein you can "turn off" with a handheld magnet, engineered by @mariaingaramo.bsky.social.
We think/hope we can use it to turn arbitrary proteins (including drugs!) on and off in opaque creatures (including humans!).
bsky.app/profile/addg...
Reposted by Andrew G. York
"Magnetic control of the brightness of fluorescent proteins" 🧲💡
Andrew G. York is one of very few scientists, who are not just scientists - but also real inventors!
Now, fluorescent proteins that can be tuned by a magnet. 😲
andrewgyork.github.io/gfp_magnetof...
#Microscopy #FluorescentProteins
Andrew G. York is one of very few scientists, who are not just scientists - but also real inventors!
Now, fluorescent proteins that can be tuned by a magnet. 😲
andrewgyork.github.io/gfp_magnetof...
#Microscopy #FluorescentProteins
Protein Magnetofluorescence
andrewgyork.github.io
June 4, 2024 at 6:30 AM
"Magnetic control of the brightness of fluorescent proteins" 🧲💡
Andrew G. York is one of very few scientists, who are not just scientists - but also real inventors!
Now, fluorescent proteins that can be tuned by a magnet. 😲
andrewgyork.github.io/gfp_magnetof...
#Microscopy #FluorescentProteins
Andrew G. York is one of very few scientists, who are not just scientists - but also real inventors!
Now, fluorescent proteins that can be tuned by a magnet. 😲
andrewgyork.github.io/gfp_magnetof...
#Microscopy #FluorescentProteins
Reposted by Andrew G. York
If you like engineering fluorescent proteins, you'll want to check out our latest blog post! The York lab's MagLOV is a fluorescent protein that responds to magnetic fields, a promising starting point for a potential new class of tools.
blog.addgene.org/mag...
blog.addgene.org/mag...
Magnetic Control of Proteins: More than a Dream
Magnetoresponsive proteins have seemed like a dream... but Andrew York's lab has developed and deposited one, opening the possibility of magnetoresponsive tools!
blog.addgene.org
September 25, 2024 at 10:05 PM
If you like engineering fluorescent proteins, you'll want to check out our latest blog post! The York lab's MagLOV is a fluorescent protein that responds to magnetic fields, a promising starting point for a potential new class of tools.
blog.addgene.org/mag...
blog.addgene.org/mag...