Jon Daniels
@jsdaniel02.bsky.social
Scientific instrument developer, focused on #lightsheet and other #microscopy 🔬 at ASI
Great to see the ASI single-objective light sheet used for long-term imaging of tumor cells to study the transition between single-cell and multi-cellular spheroids: www.biorxiv.org/content/10.1...
Cells dynamically adapt their nuclear volumes and proliferation rates during single to multicellular transitions
Tumour development and progression are associated with biophysical alterations that manifest across multiple spatial scales, from the subcellular to multicellular tissue scale. While cells can dynamic...
www.biorxiv.org
October 28, 2025 at 5:11 PM
Great to see the ASI single-objective light sheet used for long-term imaging of tumor cells to study the transition between single-cell and multi-cellular spheroids: www.biorxiv.org/content/10.1...
Production has started for a new #Snoutscope objective, AMS-AGY v3. It has significantly larger FOV and some other tweaks from v1 and v2. Currently accepting pre-orders. The price will need to increase modestly after deliveries start late October.
July 9, 2025 at 8:00 PM
Production has started for a new #Snoutscope objective, AMS-AGY v3. It has significantly larger FOV and some other tweaks from v1 and v2. Currently accepting pre-orders. The price will need to increase modestly after deliveries start late October.
I'm excited to be able to be in Zurich for the mesoSPIM symposium. This is a really fantastic project.
May 15, 2025 at 6:24 PM
I'm excited to be able to be in Zurich for the mesoSPIM symposium. This is a really fantastic project.
Most high-NA air objective lenses are coverslip-corrected but sometimes you want to image in air, e.g. high-NA SOLS. We have glued coverslips onto objectives for this. To make sure it gets glued properly we take image stack of diffraction-limited beads supported on a coverslip. 🧵
March 14, 2025 at 8:39 PM
Most high-NA air objective lenses are coverslip-corrected but sometimes you want to image in air, e.g. high-NA SOLS. We have glued coverslips onto objectives for this. To make sure it gets glued properly we take image stack of diffraction-limited beads supported on a coverslip. 🧵
Interested in getting imaging data like this? ASI is commercializing single-objective light sheet microscopes and might make one like DaXi if there are people who would buy it. DaXi originally developed by @loicaroyer.bsky.social and Bin Yang. vimeo.com/801341925
Zebrafish embryo development acquired on the DaXi light-sheet microscope
Volumetric imaging of zebrafish embryo development acquired on the DaXi light-sheet microscope. Imaging volume is 1200 μm * 800 μm * 300 μm acquired every…
vimeo.com
December 6, 2024 at 4:47 PM
Interested in getting imaging data like this? ASI is commercializing single-objective light sheet microscopes and might make one like DaXi if there are people who would buy it. DaXi originally developed by @loicaroyer.bsky.social and Bin Yang. vimeo.com/801341925