Merlin Lange
@merlinlange.bsky.social
Scientist @ INSERM Institut de la Vision 🇫🇷 | Microscopy 🔬 | Transcriptomics 🧬 | Developmental Biology in 4D 🌟 - Ex Chan Zuckerberg Biohub SF 🇺🇸 / RIKEN 🇯🇵
Pinned
Merlin Lange
@merlinlange.bsky.social
· Oct 1
Update I'm back in France 🇫🇷! Joining Inserm to build a multi-omics team on retinal development, at the nexus of live imaging, omics & human embryology.
Huge thanks to CZ Biohub SF folks, esp. my mentor, friend & science soulmate @loicaroyer.bsky.social for the amazing time. More cool science soon🧪
Huge thanks to CZ Biohub SF folks, esp. my mentor, friend & science soulmate @loicaroyer.bsky.social for the amazing time. More cool science soon🧪
Kudos @ritastrack.bsky.social for the great years at NMeth!
And congrats to my former colleague Jordao Bragantini for ultrack (and the well deserved cover 🎉) and @teunhuijben.bsky.social for inTRACKtive.
Glad I could contribute to these two wonderful endeavors. GO team @loicaroyer.bsky.social! 🧪🔬
And congrats to my former colleague Jordao Bragantini for ultrack (and the well deserved cover 🎉) and @teunhuijben.bsky.social for inTRACKtive.
Glad I could contribute to these two wonderful endeavors. GO team @loicaroyer.bsky.social! 🧪🔬
I won't talk about NMeth @natmethods.nature.com forever (probably), but I do want to brag a bit about the November focus issue on cell segmentation and tracking, which is many ways is my last hurrah (and final editorial) for the journal. I am so proud of these papers!! www.nature.com/nmeth/volume...
November 13, 2025 at 11:17 PM
Kudos @ritastrack.bsky.social for the great years at NMeth!
And congrats to my former colleague Jordao Bragantini for ultrack (and the well deserved cover 🎉) and @teunhuijben.bsky.social for inTRACKtive.
Glad I could contribute to these two wonderful endeavors. GO team @loicaroyer.bsky.social! 🧪🔬
And congrats to my former colleague Jordao Bragantini for ultrack (and the well deserved cover 🎉) and @teunhuijben.bsky.social for inTRACKtive.
Glad I could contribute to these two wonderful endeavors. GO team @loicaroyer.bsky.social! 🧪🔬
Reposted by Merlin Lange
#Mifobio2025
@merlinlange.bsky.social's Lecture is online !
👉 "Building a Multimodal Atlas of Vertebrate Development"
👉 youtu.be/7pj8hMH0stA
@cnrs.fr @cnrsbiologie.bsky.social @cnrsingenierie.bsky.social @czbiohub.bsky.social
@gdr-imabio-ysn.bsky.social
#GDRimabio #InstitutdelaVision
@merlinlange.bsky.social's Lecture is online !
👉 "Building a Multimodal Atlas of Vertebrate Development"
👉 youtu.be/7pj8hMH0stA
@cnrs.fr @cnrsbiologie.bsky.social @cnrsingenierie.bsky.social @czbiohub.bsky.social
@gdr-imabio-ysn.bsky.social
#GDRimabio #InstitutdelaVision
November 6, 2025 at 12:28 PM
#Mifobio2025
@merlinlange.bsky.social's Lecture is online !
👉 "Building a Multimodal Atlas of Vertebrate Development"
👉 youtu.be/7pj8hMH0stA
@cnrs.fr @cnrsbiologie.bsky.social @cnrsingenierie.bsky.social @czbiohub.bsky.social
@gdr-imabio-ysn.bsky.social
#GDRimabio #InstitutdelaVision
@merlinlange.bsky.social's Lecture is online !
👉 "Building a Multimodal Atlas of Vertebrate Development"
👉 youtu.be/7pj8hMH0stA
@cnrs.fr @cnrsbiologie.bsky.social @cnrsingenierie.bsky.social @czbiohub.bsky.social
@gdr-imabio-ysn.bsky.social
#GDRimabio #InstitutdelaVision
On my way back from a great week at #Mifobio2025. Thanks to the organizers for the inspiring meeting.
Cool microscope, nice atmosphere, science by the beach 🔬🧪
Cool microscope, nice atmosphere, science by the beach 🔬🧪
October 17, 2025 at 9:13 AM
On my way back from a great week at #Mifobio2025. Thanks to the organizers for the inspiring meeting.
Cool microscope, nice atmosphere, science by the beach 🔬🧪
Cool microscope, nice atmosphere, science by the beach 🔬🧪
Reposted by Merlin Lange
Delighted to host Anne Beghin (@mbisg.bsky.social) ✈️ and @merlinlange.bsky.social (Institut de la Vision and @czbiohub.bsky.social ) 🐟 for the Module 4 Multiscale analysis of 3D biological samples
Good science and great people.
#MiFoBio2025 is really a grand cru 🍷
@gdrimabio.bsky.social
Good science and great people.
#MiFoBio2025 is really a grand cru 🍷
@gdrimabio.bsky.social
October 15, 2025 at 9:45 AM
Delighted to host Anne Beghin (@mbisg.bsky.social) ✈️ and @merlinlange.bsky.social (Institut de la Vision and @czbiohub.bsky.social ) 🐟 for the Module 4 Multiscale analysis of 3D biological samples
Good science and great people.
#MiFoBio2025 is really a grand cru 🍷
@gdrimabio.bsky.social
Good science and great people.
#MiFoBio2025 is really a grand cru 🍷
@gdrimabio.bsky.social
Morning coffee with a nice view of the dune, getting ready for #Mifobio2025
October 15, 2025 at 7:58 AM
Morning coffee with a nice view of the dune, getting ready for #Mifobio2025
Reposted by Merlin Lange
Job alert!
We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?
See also on the forum:
forum.image.sc/t/research-e...
We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?
See also on the forum:
forum.image.sc/t/research-e...
Research engineer in Bioimage Analysis for the researchers of the inIdEx FORMULA
Hi all We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks? The position is in the Instit...
forum.image.sc
October 7, 2025 at 12:39 PM
Job alert!
We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?
See also on the forum:
forum.image.sc/t/research-e...
We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?
See also on the forum:
forum.image.sc/t/research-e...
So happy to join my first #Mifobio2025!
It’s going to be super fun. If you’re not coming this year, consider the next edition.
Looking forward to seeing old friends and meeting new ones.
#DevelopmentAtlas 🧪🔬
It’s going to be super fun. If you’re not coming this year, consider the next edition.
Looking forward to seeing old friends and meeting new ones.
#DevelopmentAtlas 🧪🔬
#Mifobio2025
Focus on the module 4 :
👉 Multi-scale imaging of biological systems
We are delighted to welcome @merlinlange.bsky.social
Institut de la Vision Paris
Lecture : “Building a Multimodal Atlas of Vertebrate Development”
👉 imabio-cnrs.fr/mifobio-2025/
#GDRImaBio #microscopy
Focus on the module 4 :
👉 Multi-scale imaging of biological systems
We are delighted to welcome @merlinlange.bsky.social
Institut de la Vision Paris
Lecture : “Building a Multimodal Atlas of Vertebrate Development”
👉 imabio-cnrs.fr/mifobio-2025/
#GDRImaBio #microscopy
October 5, 2025 at 7:55 PM
So happy to join my first #Mifobio2025!
It’s going to be super fun. If you’re not coming this year, consider the next edition.
Looking forward to seeing old friends and meeting new ones.
#DevelopmentAtlas 🧪🔬
It’s going to be super fun. If you’re not coming this year, consider the next edition.
Looking forward to seeing old friends and meeting new ones.
#DevelopmentAtlas 🧪🔬
🧪
We have developed a new workflow to map whole human organs in 3D & at single-cell resolution
Colleague Prof. Luciane Kagohara mapped out the transcriptomic profile + aneuploidy of ovarian precancerous lesions (STIC) in healthy fallopian tube.
More here: www.biorxiv.org/content/10.1...
Colleague Prof. Luciane Kagohara mapped out the transcriptomic profile + aneuploidy of ovarian precancerous lesions (STIC) in healthy fallopian tube.
More here: www.biorxiv.org/content/10.1...
October 2, 2025 at 4:43 PM
🧪
Update I'm back in France 🇫🇷! Joining Inserm to build a multi-omics team on retinal development, at the nexus of live imaging, omics & human embryology.
Huge thanks to CZ Biohub SF folks, esp. my mentor, friend & science soulmate @loicaroyer.bsky.social for the amazing time. More cool science soon🧪
Huge thanks to CZ Biohub SF folks, esp. my mentor, friend & science soulmate @loicaroyer.bsky.social for the amazing time. More cool science soon🧪
October 1, 2025 at 12:13 PM
Update I'm back in France 🇫🇷! Joining Inserm to build a multi-omics team on retinal development, at the nexus of live imaging, omics & human embryology.
Huge thanks to CZ Biohub SF folks, esp. my mentor, friend & science soulmate @loicaroyer.bsky.social for the amazing time. More cool science soon🧪
Huge thanks to CZ Biohub SF folks, esp. my mentor, friend & science soulmate @loicaroyer.bsky.social for the amazing time. More cool science soon🧪
Students & scientists interested in multiscale integration in biological systems don’t miss this international course at
@institutcurie.bsky.social. Explore #computation #morphogenesis #biology #machinelearning & more 🧪
Deadline soon - registration here training.institut-curie.org/courses/mult...
@institutcurie.bsky.social. Explore #computation #morphogenesis #biology #machinelearning & more 🧪
Deadline soon - registration here training.institut-curie.org/courses/mult...
July 2, 2025 at 11:56 AM
Students & scientists interested in multiscale integration in biological systems don’t miss this international course at
@institutcurie.bsky.social. Explore #computation #morphogenesis #biology #machinelearning & more 🧪
Deadline soon - registration here training.institut-curie.org/courses/mult...
@institutcurie.bsky.social. Explore #computation #morphogenesis #biology #machinelearning & more 🧪
Deadline soon - registration here training.institut-curie.org/courses/mult...
🧪
Curiously... 2D projections from a Snouty light-sheet microscope (typically software generated) can also be generated OPTICALLY!
-> A pair of mirrors in front of the camera can directly 'unshear' to give ULTRAFAST 2D projections of the 3D object from different directions!
doi.org/10.1038/s415...
-> A pair of mirrors in front of the camera can directly 'unshear' to give ULTRAFAST 2D projections of the 3D object from different directions!
doi.org/10.1038/s415...
May 14, 2025 at 7:46 PM
🧪
Reposted by Merlin Lange
Happy to share that our MS on the transcriptional regulation of MDKA, a key injury response gene in #zebrafish adult telencephalon, is published @biorxivpreprint.bsky.social !Explore how multiple cis-regulatory elements collaborate to control mdka in telencephalon 🐟🧠 www.biorxiv.org/content/10.1...
April 15, 2025 at 1:07 PM
Happy to share that our MS on the transcriptional regulation of MDKA, a key injury response gene in #zebrafish adult telencephalon, is published @biorxivpreprint.bsky.social !Explore how multiple cis-regulatory elements collaborate to control mdka in telencephalon 🐟🧠 www.biorxiv.org/content/10.1...
Spring break in Paris to enjoy the @mnhn.fr and particularly the gallery of comparative anatomy, such an inspiring place for the future generations of #biologist 🧪 #science
April 17, 2025 at 7:59 PM
Spring break in Paris to enjoy the @mnhn.fr and particularly the gallery of comparative anatomy, such an inspiring place for the future generations of #biologist 🧪 #science
Reposted by Merlin Lange
It has been a while since I advertised some of the tools we have released to help researchers analyze the zebrafish genome. So a brief Bluetorial on our zebrafish genomics UCSC public data hub and the bigger effort led by @ferencmueller.bsky.social to create a zebrafish ENCODE project (Danio-CODE):
April 15, 2025 at 4:54 PM
It has been a while since I advertised some of the tools we have released to help researchers analyze the zebrafish genome. So a brief Bluetorial on our zebrafish genomics UCSC public data hub and the bigger effort led by @ferencmueller.bsky.social to create a zebrafish ENCODE project (Danio-CODE):
Zoom-in on zebrafish head development captured with a light-sheet microscope. 🧪
#zebrafish #AcademicSky #DevBio #neuroskyence
#zebrafish #AcademicSky #DevBio #neuroskyence
March 22, 2025 at 5:03 PM
Zoom-in on zebrafish head development captured with a light-sheet microscope. 🧪
#zebrafish #AcademicSky #DevBio #neuroskyence
#zebrafish #AcademicSky #DevBio #neuroskyence
Reposted by Merlin Lange
Some #zebrafish news. After consulting with the Genome Reference Consortium (GRC) we will annotate one of our Tübingen T2T assemblies as a reference genome. This is an excellent assembly that we can get into the hands of the zebrafish research community right now. We are continuing our efforts
March 20, 2025 at 8:36 PM
Some #zebrafish news. After consulting with the Genome Reference Consortium (GRC) we will annotate one of our Tübingen T2T assemblies as a reference genome. This is an excellent assembly that we can get into the hands of the zebrafish research community right now. We are continuing our efforts
If anyone needs an experienced scientist for consulting with a deep microscopy background, reach out to Emmanuel 👇
#cellbiology #academicsky #neuroscience 🧪
#cellbiology #academicsky #neuroscience 🧪
#JOBSEARCH If you are looking for a good old experienced scientist for consulting, copy-editing and all kind of science related jobs. Microscopy, cell biology, harm reduction, blaschka models. Based in France as I am supporting my wife's career and it matters. Please re post, send any offer my way
January 8, 2025 at 1:55 PM
If anyone needs an experienced scientist for consulting with a deep microscopy background, reach out to Emmanuel 👇
#cellbiology #academicsky #neuroscience 🧪
#cellbiology #academicsky #neuroscience 🧪
Fantastic work by my Biohub colleague Manu Leonetti and his amazing team published in #Cell! 🧪
Human cell #proteomics subcellular landscape and its dynamic remodeling using #organelle IP.
Paper here www.cell.com/cell/fulltex...
Explore the date organelles.czbiohub.org
Congratulations to the team
Human cell #proteomics subcellular landscape and its dynamic remodeling using #organelle IP.
Paper here www.cell.com/cell/fulltex...
Explore the date organelles.czbiohub.org
Congratulations to the team
Global organelle profiling reveals subcellular localization and remodeling at proteome scale
Organelle proteomics defines the cellular landscape of protein localization and highlights the role of subcellular remodeling in driving responses to perturbations such as viral infections.
www.cell.com
January 7, 2025 at 10:18 AM
Fantastic work by my Biohub colleague Manu Leonetti and his amazing team published in #Cell! 🧪
Human cell #proteomics subcellular landscape and its dynamic remodeling using #organelle IP.
Paper here www.cell.com/cell/fulltex...
Explore the date organelles.czbiohub.org
Congratulations to the team
Human cell #proteomics subcellular landscape and its dynamic remodeling using #organelle IP.
Paper here www.cell.com/cell/fulltex...
Explore the date organelles.czbiohub.org
Congratulations to the team
🧪🎄
1/ 🎄 What’s the best gift under the tree for a computational biologist? 🎁 A new experimental assay that refines our view of gene regulation: ACCESS-ATAC! This creative idea from Richard Sherwood was developed collaboratively between his lab and mine. #Genomics
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 26, 2024 at 10:24 AM
🧪🎄
Reposted by Merlin Lange
Back for a little while here, I tried this ‘starter pack’ for photonics & optics people: anyone else can follow up to 50 people at the click of a button: go.bsky.app/QrtPj7R. Put your name below and I will add you to the pack.
November 10, 2024 at 2:41 PM
Back for a little while here, I tried this ‘starter pack’ for photonics & optics people: anyone else can follow up to 50 people at the click of a button: go.bsky.app/QrtPj7R. Put your name below and I will add you to the pack.
🧪
And here is my condensed guide on how to science: top 5 Rules
December 15, 2024 at 6:12 PM
🧪
Reposted by Merlin Lange
Happy to be in sunny☀️San Diego for ASCB Cell Bio! Tomorrow I will present #Ultrack and #inTRACKtive (poster B513) at 11:15 am. Swing by the CZI+@czbiohub.bsky.social
booth (#119) for live demos of these tools + #napari & #zebrahub 🐠 Looking forward to connect!🤩🧪🔬
#CellBio2024 #ASCB24 #celltracking
booth (#119) for live demos of these tools + #napari & #zebrahub 🐠 Looking forward to connect!🤩🧪🔬
#CellBio2024 #ASCB24 #celltracking
December 15, 2024 at 2:33 AM
Happy to be in sunny☀️San Diego for ASCB Cell Bio! Tomorrow I will present #Ultrack and #inTRACKtive (poster B513) at 11:15 am. Swing by the CZI+@czbiohub.bsky.social
booth (#119) for live demos of these tools + #napari & #zebrahub 🐠 Looking forward to connect!🤩🧪🔬
#CellBio2024 #ASCB24 #celltracking
booth (#119) for live demos of these tools + #napari & #zebrahub 🐠 Looking forward to connect!🤩🧪🔬
#CellBio2024 #ASCB24 #celltracking
Live imaging of zebrafish 🐟 embryogenesis acquired with our light-sheet #microscope #daxi
🔬 Microscope: doi.org/10.1038/s415...
🧪 Time-lapse data from our "Zebrahub" developmental atlas: www.cell.com/cell/fulltex...
#FluorescenceFriday #zebrafish #AcademicSky #DevBio
🔬 Microscope: doi.org/10.1038/s415...
🧪 Time-lapse data from our "Zebrahub" developmental atlas: www.cell.com/cell/fulltex...
#FluorescenceFriday #zebrafish #AcademicSky #DevBio
December 13, 2024 at 6:27 PM
Live imaging of zebrafish 🐟 embryogenesis acquired with our light-sheet #microscope #daxi
🔬 Microscope: doi.org/10.1038/s415...
🧪 Time-lapse data from our "Zebrahub" developmental atlas: www.cell.com/cell/fulltex...
#FluorescenceFriday #zebrafish #AcademicSky #DevBio
🔬 Microscope: doi.org/10.1038/s415...
🧪 Time-lapse data from our "Zebrahub" developmental atlas: www.cell.com/cell/fulltex...
#FluorescenceFriday #zebrafish #AcademicSky #DevBio
December 12, 2024 at 7:19 PM
🧪
1/🚀 Excited to share RegVelo, our new cell model combining RNA velocity with gene regulatory network (GRN) dynamics to model cellular changes and predict in silico perturbations. Here's how it works and why it matters! 🧵👇
biorxiv.org/content/10.1101/2024.12.11.627935v1
biorxiv.org/content/10.1101/2024.12.11.627935v1
December 12, 2024 at 2:53 PM
🧪