Jess Ewald
@ewaldlab.org
Computational biologist using omics data (imaging, gene expression) to investigate the impacts of environmental contaminants on biological systems
Group Leader @EMBL-EBI (www.ewaldlab.org)
Group Leader @EMBL-EBI (www.ewaldlab.org)
It's been a great first few months at the EBI!
Meet our newest Research Group Leader: Jess Ewald @ewaldlab.org 🇨🇦
Jess’s group takes a multi-disciplinary approach to identify and characterise chemical hazards to humans and ecosystems, using cell profiling data, machine learning, and integrative data analysis.
www.ebi.ac.uk/about/news/p...
🖥️🧬
Jess’s group takes a multi-disciplinary approach to identify and characterise chemical hazards to humans and ecosystems, using cell profiling data, machine learning, and integrative data analysis.
www.ebi.ac.uk/about/news/p...
🖥️🧬
Welcome: Jess Ewald
Jess Ewald, Research Group Leader at EMBL-EBI, uses cell profiling and AI to find and characterise chemical hazards to humans and ecosysystems.
www.ebi.ac.uk
September 3, 2025 at 9:28 AM
It's been a great first few months at the EBI!
Reposted by Jess Ewald
Morph Map is now published in Nature Methods. Excited to see what the community discovers with this resource mapping ~15,000 human genes!
rdcu.be/ezGre
rdcu.be/ezGre
August 7, 2025 at 1:36 PM
Morph Map is now published in Nature Methods. Excited to see what the community discovers with this resource mapping ~15,000 human genes!
rdcu.be/ezGre
rdcu.be/ezGre
The visa is easy to obtain, for you and for any immediate family members. It allows a spouse to work in the UK.
Please reach out with any questions!
Please reach out with any questions!
August 7, 2025 at 9:14 AM
The visa is easy to obtain, for you and for any immediate family members. It allows a spouse to work in the UK.
Please reach out with any questions!
Please reach out with any questions!
Project 7: Predict cellular phenotypes induced by environmental contaminants based on compound structure and cellular images using generative AI, in collaboration with Mo Lotfollahi (www.sanger.ac.uk/group/lotfol...)
August 7, 2025 at 9:14 AM
Project 7: Predict cellular phenotypes induced by environmental contaminants based on compound structure and cellular images using generative AI, in collaboration with Mo Lotfollahi (www.sanger.ac.uk/group/lotfol...)
Project 3: Decode morphological programmes of T cell activation through multimodal imaging and machine learning, in collaboration with @gosiatrynka.bsky.social (www.sanger.ac.uk/group/trynka...)
August 7, 2025 at 9:14 AM
Project 3: Decode morphological programmes of T cell activation through multimodal imaging and machine learning, in collaboration with @gosiatrynka.bsky.social (www.sanger.ac.uk/group/trynka...)
Two of the projects are co-hosted by my lab (ewaldlab.org)
Ewald Lab
@ EMBL-EBI. We identify and characterize chemical hazards to both humans and ecosystems with cell profiling data, machine learning, and integrative data analysis.
ewaldlab.org
August 7, 2025 at 9:14 AM
Two of the projects are co-hosted by my lab (ewaldlab.org)
Check out this opportunity to join my lab as a postdoc! www.ebi.ac.uk/research/pos...
Every year, faculty from EMBL-EBI and the Wellcome Sanger Institute co-develop projects that allow fellows to be part of ✨both✨ of these amazing research institutes.
Every year, faculty from EMBL-EBI and the Wellcome Sanger Institute co-develop projects that allow fellows to be part of ✨both✨ of these amazing research institutes.
EMBL-EBI-Sanger postdoctoral fellowships (ESPOD)
The ESPOD fellowship builds on the collaborative relationship between EMBL-EBI and the Wellcome Sanger Institute, offering projects that combine experimental (wet-lab) and computational (dry-lab) appr...
www.ebi.ac.uk
August 7, 2025 at 9:14 AM
Check out this opportunity to join my lab as a postdoc! www.ebi.ac.uk/research/pos...
Every year, faculty from EMBL-EBI and the Wellcome Sanger Institute co-develop projects that allow fellows to be part of ✨both✨ of these amazing research institutes.
Every year, faculty from EMBL-EBI and the Wellcome Sanger Institute co-develop projects that allow fellows to be part of ✨both✨ of these amazing research institutes.
Two days left before the application closes!
🚨 We're hiring! 🚨 The Ewald Lab at EMBL-EBI is looking for a postdoctoral researcher in multi-omics, machine learning, and predictive toxicology to analyze a groundbreaking toxicology dataset as part of the OASIS Consortium.
More details & application here: lnkd.in/eHD7DMdX
More details & application here: lnkd.in/eHD7DMdX
March 31, 2025 at 1:49 PM
Two days left before the application closes!
Reposted by Jess Ewald
We're once again hiring a summer (+?) #bioimage #bioimageanalysis #software intern! Due to requirements of the funding program, you must be a current student, as well as work onsite in MA (+ have US work permission). Details at the link below. Spend your summer making great tools with fun people!
Software engineering intern - summer/fall 2025 - Cambridge, MA USA
If you are a current student (undergraduate/masters/PhD) with permission to work in the US and ability to work in-person in Cambridge, MA, US, consider a summer internship in the Broad Institute Imagi...
forum.image.sc
March 7, 2025 at 2:23 PM
We're once again hiring a summer (+?) #bioimage #bioimageanalysis #software intern! Due to requirements of the funding program, you must be a current student, as well as work onsite in MA (+ have US work permission). Details at the link below. Spend your summer making great tools with fun people!
Two EMBL-specific quirks:
- EMBL salaries are "after tax", so the stated salary is roughly equivalent to $70k USD
- Employees qualify for a quick & inexpensive visa exemption that allows them and their spouse/children to work in the UK (my visa was processed in 2 days and cost me $50USD)
- EMBL salaries are "after tax", so the stated salary is roughly equivalent to $70k USD
- Employees qualify for a quick & inexpensive visa exemption that allows them and their spouse/children to work in the UK (my visa was processed in 2 days and cost me $50USD)
March 6, 2025 at 9:24 PM
Two EMBL-specific quirks:
- EMBL salaries are "after tax", so the stated salary is roughly equivalent to $70k USD
- Employees qualify for a quick & inexpensive visa exemption that allows them and their spouse/children to work in the UK (my visa was processed in 2 days and cost me $50USD)
- EMBL salaries are "after tax", so the stated salary is roughly equivalent to $70k USD
- Employees qualify for a quick & inexpensive visa exemption that allows them and their spouse/children to work in the UK (my visa was processed in 2 days and cost me $50USD)
🚨 We're hiring! 🚨 The Ewald Lab at EMBL-EBI is looking for a postdoctoral researcher in multi-omics, machine learning, and predictive toxicology to analyze a groundbreaking toxicology dataset as part of the OASIS Consortium.
More details & application here: lnkd.in/eHD7DMdX
More details & application here: lnkd.in/eHD7DMdX
March 5, 2025 at 5:31 PM
🚨 We're hiring! 🚨 The Ewald Lab at EMBL-EBI is looking for a postdoctoral researcher in multi-omics, machine learning, and predictive toxicology to analyze a groundbreaking toxicology dataset as part of the OASIS Consortium.
More details & application here: lnkd.in/eHD7DMdX
More details & application here: lnkd.in/eHD7DMdX
Reposted by Jess Ewald
We link molecular and functional phenotypes of islet cells from donors with type 1 diabetes to understand impaired insulin and glucagon secretion. Immune signalling, nuclear exclusion, mTOR and lysosomes in alpha cell dysfunction.
https://www.biorxiv.org/content/10.1101/2025.02.20.639325v1
https://www.biorxiv.org/content/10.1101/2025.02.20.639325v1
February 21, 2025 at 12:40 PM
We link molecular and functional phenotypes of islet cells from donors with type 1 diabetes to understand impaired insulin and glucagon secretion. Immune signalling, nuclear exclusion, mTOR and lysosomes in alpha cell dysfunction.
https://www.biorxiv.org/content/10.1101/2025.02.20.639325v1
https://www.biorxiv.org/content/10.1101/2025.02.20.639325v1
6/ Huge thank you to my co-authors at Axiom who were wonderful to work with, as well as to the entire OASIS Consortium.
February 3, 2025 at 12:32 PM
6/ Huge thank you to my co-authors at Axiom who were wonderful to work with, as well as to the entire OASIS Consortium.
5/ These findings demonstrate the potential of image-based profiling as a sensitive, animal-free, early-stage screening tool for compound toxicity.
February 3, 2025 at 12:32 PM
5/ These findings demonstrate the potential of image-based profiling as a sensitive, animal-free, early-stage screening tool for compound toxicity.
4/ We found that the morphological profiles detect compound bioactivity at lower concentrations than standard cytotoxicity assays. In supervised analyses, they predict cytotoxicity and targeted cell-based assay readouts, but not cell-free assay readouts.
February 3, 2025 at 12:32 PM
4/ We found that the morphological profiles detect compound bioactivity at lower concentrations than standard cytotoxicity assays. In supervised analyses, they predict cytotoxicity and targeted cell-based assay readouts, but not cell-free assay readouts.
3/ We then use supervised machine learning to predict diverse in vitro assay readouts relevant to mode-of-action and cell state using image-based profiles. We also investigate optimal strategies for extracting information from images to make mode-of-action predictions.
February 3, 2025 at 12:32 PM
3/ We then use supervised machine learning to predict diverse in vitro assay readouts relevant to mode-of-action and cell state using image-based profiles. We also investigate optimal strategies for extracting information from images to make mode-of-action predictions.
2/ High-throughput, human-relevant approaches for predicting chemical toxicity are urgently needed.
In our new preprint, we use Cell Painting and cytotoxicity assays to profile >1000 compounds in primary human hepatocytes, including pharmaceuticals, pesticides, and industrial chemicals.
In our new preprint, we use Cell Painting and cytotoxicity assays to profile >1000 compounds in primary human hepatocytes, including pharmaceuticals, pesticides, and industrial chemicals.
February 3, 2025 at 12:32 PM
2/ High-throughput, human-relevant approaches for predicting chemical toxicity are urgently needed.
In our new preprint, we use Cell Painting and cytotoxicity assays to profile >1000 compounds in primary human hepatocytes, including pharmaceuticals, pesticides, and industrial chemicals.
In our new preprint, we use Cell Painting and cytotoxicity assays to profile >1000 compounds in primary human hepatocytes, including pharmaceuticals, pesticides, and industrial chemicals.
First large-scale analysis of chemical toxicity in primary human hepatocytes!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Cell Painting for cytotoxicity and mode-of-action analysis in primary human hepatocytes
High-throughput, human-relevant approaches for predicting chemical toxicity are urgently needed for better decision-making in human health. Here, we apply image-based profiling (the Cell Painting assa...
www.biorxiv.org
February 3, 2025 at 12:32 PM
First large-scale analysis of chemical toxicity in primary human hepatocytes!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jess Ewald
We've a postdoc opening for our lab at the Broad: Cambridge MA!
Must have experience in toxicology + data science
Work on the wonderful OASIS dataset we are producing... Cell Painting, transcriptomics, proteomics in various liver cell and tissue models!
broad.io/mlcbpostdoc
Must have experience in toxicology + data science
Work on the wonderful OASIS dataset we are producing... Cell Painting, transcriptomics, proteomics in various liver cell and tissue models!
broad.io/mlcbpostdoc
December 18, 2024 at 3:50 PM
We've a postdoc opening for our lab at the Broad: Cambridge MA!
Must have experience in toxicology + data science
Work on the wonderful OASIS dataset we are producing... Cell Painting, transcriptomics, proteomics in various liver cell and tissue models!
broad.io/mlcbpostdoc
Must have experience in toxicology + data science
Work on the wonderful OASIS dataset we are producing... Cell Painting, transcriptomics, proteomics in various liver cell and tissue models!
broad.io/mlcbpostdoc
Reposted by Jess Ewald
New Year, new job? Delighted to announce two early-career-level (post-BA/BS or MA) positions in my lab, and an open call for computational postdocs at the Broad!
First, an image analysis associate - work on high content screens for all kinds of cells and dimensionalities! See more at link (1/4)
First, an image analysis associate - work on high content screens for all kinds of cells and dimensionalities! See more at link (1/4)
Image analysis associate job description
Image Analysis Associate Broad Institute of MIT and Harvard, Cambridge, MA Impact the discovery of new disease therapies in the Cimini laboratory at the Imaging Platform Join our vibrant, world-clas...
docs.google.com
December 16, 2024 at 3:20 PM
New Year, new job? Delighted to announce two early-career-level (post-BA/BS or MA) positions in my lab, and an open call for computational postdocs at the Broad!
First, an image analysis associate - work on high content screens for all kinds of cells and dimensionalities! See more at link (1/4)
First, an image analysis associate - work on high content screens for all kinds of cells and dimensionalities! See more at link (1/4)
Thanks, I'll try make it out! This is right after I move.
December 15, 2024 at 2:58 PM
Thanks, I'll try make it out! This is right after I move.
I think about macromolecules a lot, but mainly as either targets of small molecules that cause target-mediated toxicity, or as something that we can measure at scale (omics data) to detect toxicity.
December 13, 2024 at 7:20 PM
I think about macromolecules a lot, but mainly as either targets of small molecules that cause target-mediated toxicity, or as something that we can measure at scale (omics data) to detect toxicity.
Thanks! Looking forward to starting!
December 13, 2024 at 5:46 PM
Thanks! Looking forward to starting!
🎉 I'm starting my own lab at EMBL-EBI (Cambridge, UK; June 2025) 🎉
We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods.
I am beginning the search for two postdocs now - stay tuned for more details!
ewaldlab.org
We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods.
I am beginning the search for two postdocs now - stay tuned for more details!
ewaldlab.org
Ewald Lab
@ EMBL-EBI. We identify and characterize chemical hazards to both humans and ecosystems with cell profiling data, machine learning, and integrative data analysis.
ewaldlab.org
December 13, 2024 at 2:12 PM
🎉 I'm starting my own lab at EMBL-EBI (Cambridge, UK; June 2025) 🎉
We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods.
I am beginning the search for two postdocs now - stay tuned for more details!
ewaldlab.org
We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods.
I am beginning the search for two postdocs now - stay tuned for more details!
ewaldlab.org
Reposted by Jess Ewald
Excited to present our spotlight paper at #NeurIPS!
MOTIVE is a new dataset + benchmark for predicting drug-target interactions, using Cell Painting data
Location: Fri 13 Dec 4:30 p.m. PST @ East Exhibit Hall A-C #4208
Poster: neurips.cc/virtual/2024...
Paper: arxiv.org/abs/2406.08649
MOTIVE is a new dataset + benchmark for predicting drug-target interactions, using Cell Painting data
Location: Fri 13 Dec 4:30 p.m. PST @ East Exhibit Hall A-C #4208
Poster: neurips.cc/virtual/2024...
Paper: arxiv.org/abs/2406.08649
December 13, 2024 at 12:39 PM
Excited to present our spotlight paper at #NeurIPS!
MOTIVE is a new dataset + benchmark for predicting drug-target interactions, using Cell Painting data
Location: Fri 13 Dec 4:30 p.m. PST @ East Exhibit Hall A-C #4208
Poster: neurips.cc/virtual/2024...
Paper: arxiv.org/abs/2406.08649
MOTIVE is a new dataset + benchmark for predicting drug-target interactions, using Cell Painting data
Location: Fri 13 Dec 4:30 p.m. PST @ East Exhibit Hall A-C #4208
Poster: neurips.cc/virtual/2024...
Paper: arxiv.org/abs/2406.08649