Journal of Cell Biology
@jcb.org
Journal of Cell Biology publishes peer-reviewed research on all aspects of cellular structure and function. Published by Rockefeller University Press @rupress.org
🌐 https://rupress.org/jcb
🌐 https://rupress.org/jcb
RTF1 enhances CLK occupancy and #histone methylation at key #circadian clock pacemaker gene loci, say Xu Liu, Ya Huang, Yong Zhang and colleagues (Soochow University): rupress.org/jcb/article/...
#CellSignaling #Chromatin #epigenetics #Neuroscience #Genetics
#CellSignaling #Chromatin #epigenetics #Neuroscience #Genetics
November 11, 2025 at 7:45 PM
RTF1 enhances CLK occupancy and #histone methylation at key #circadian clock pacemaker gene loci, say Xu Liu, Ya Huang, Yong Zhang and colleagues (Soochow University): rupress.org/jcb/article/...
#CellSignaling #Chromatin #epigenetics #Neuroscience #Genetics
#CellSignaling #Chromatin #epigenetics #Neuroscience #Genetics
Viewpoint: @fredmast.bsky.social, Rachubinski, and Aitchison @seattlechildrens.org challenge the PPAR paradigm and show human #peroxisomes expand via hominid-specific pathways that link specialization to immunometabolic functions. rupress.org/jcb/article/...
#Organelles #Development #Metabolism
#Organelles #Development #Metabolism
November 11, 2025 at 5:01 PM
Viewpoint: @fredmast.bsky.social, Rachubinski, and Aitchison @seattlechildrens.org challenge the PPAR paradigm and show human #peroxisomes expand via hominid-specific pathways that link specialization to immunometabolic functions. rupress.org/jcb/article/...
#Organelles #Development #Metabolism
#Organelles #Development #Metabolism
Autoinhibitory calcium ATPases regulate the calcium gradient required for rapid polarized growth, say Samantha Ryken, Magdalena Bezanilla and colleagues (Dartmouth College): rupress.org/jcb/article/...
#PlantBiology #Trafficking #Cytoskeleton
#PlantBiology #Trafficking #Cytoskeleton
November 11, 2025 at 4:15 PM
Autoinhibitory calcium ATPases regulate the calcium gradient required for rapid polarized growth, say Samantha Ryken, Magdalena Bezanilla and colleagues (Dartmouth College): rupress.org/jcb/article/...
#PlantBiology #Trafficking #Cytoskeleton
#PlantBiology #Trafficking #Cytoskeleton
Systematic membrane thickness variation across cellular #organelles revealed by cryo-ET. New computational workflow developed by Desislava Glushkova (@deglushk.bsky.social), Stefanie Böhm, & Martin Beck (@becklab.bsky.social) @mpibp.bsky.social: rupress.org/jcb/article/...
#StructuralBiology #Golgi
#StructuralBiology #Golgi
November 11, 2025 at 2:45 PM
Systematic membrane thickness variation across cellular #organelles revealed by cryo-ET. New computational workflow developed by Desislava Glushkova (@deglushk.bsky.social), Stefanie Böhm, & Martin Beck (@becklab.bsky.social) @mpibp.bsky.social: rupress.org/jcb/article/...
#StructuralBiology #Golgi
#StructuralBiology #Golgi
B4GALT1 and Wntless collaborate to block LRP5/6 translocation from #Golgi to cell surface, say Xinyang Li, Yue Hua, Xiaoqing Gan and colleagues (Fudan University): rupress.org/jcb/article/...
#Biochemistry #Trafficking #CellSignaling #Wnt
#Biochemistry #Trafficking #CellSignaling #Wnt
November 10, 2025 at 7:45 PM
B4GALT1 and Wntless collaborate to block LRP5/6 translocation from #Golgi to cell surface, say Xinyang Li, Yue Hua, Xiaoqing Gan and colleagues (Fudan University): rupress.org/jcb/article/...
#Biochemistry #Trafficking #CellSignaling #Wnt
#Biochemistry #Trafficking #CellSignaling #Wnt
Yanyan Li, Hongchang Li al. reveal that Aurora A–mediated phosphorylation of Numb triggers its dissociation from the plasma membrane, thereby promoting #myosin I–dependent membrane-to-cortex adhesion required for mitotic cell rounding rupress.org/jcb/article/...
#Mitosis #CellDivision #Genetics
#Mitosis #CellDivision #Genetics
November 10, 2025 at 5:02 PM
Yanyan Li, Hongchang Li al. reveal that Aurora A–mediated phosphorylation of Numb triggers its dissociation from the plasma membrane, thereby promoting #myosin I–dependent membrane-to-cortex adhesion required for mitotic cell rounding rupress.org/jcb/article/...
#Mitosis #CellDivision #Genetics
#Mitosis #CellDivision #Genetics
Multifaceted “composite” #actin nucleator orchestrates polymerization via dynamic assembly. Jianuo Han and Yansong Miao (Nanyang Technological University) highlight recent findings from Magliozzi et al. (rupress.org/jcb/article/...), in Spotlight: rupress.org/jcb/article/...
#Cytoskeleton
#Cytoskeleton
November 10, 2025 at 3:45 PM
Multifaceted “composite” #actin nucleator orchestrates polymerization via dynamic assembly. Jianuo Han and Yansong Miao (Nanyang Technological University) highlight recent findings from Magliozzi et al. (rupress.org/jcb/article/...), in Spotlight: rupress.org/jcb/article/...
#Cytoskeleton
#Cytoskeleton
🔬 In JCB's November issue: image shows a #macrophage nibbling a #cancer cell. The bone marrow–derived mouse macrophage is expressing a Chimeric Antigen Receptor (green) that activates the Fc Receptor signaling pathway in response to Her2. From Rollins et al. rupress.org/jcb/issue/22...
November 10, 2025 at 3:03 PM
🔬 In JCB's November issue: image shows a #macrophage nibbling a #cancer cell. The bone marrow–derived mouse macrophage is expressing a Chimeric Antigen Receptor (green) that activates the Fc Receptor signaling pathway in response to Her2. From Rollins et al. rupress.org/jcb/issue/22...
#Lipid packing and local geometry influence #septin curvature sensing, say Brandy Curtis, Amy Gladfelter @gladfelterlab.bsky.social and colleagues @duke-university.bsky.social: rupress.org/jcb/article/...
#Biochemistry #Cytoskeleton
#Biochemistry #Cytoskeleton
November 10, 2025 at 2:45 PM
#Lipid packing and local geometry influence #septin curvature sensing, say Brandy Curtis, Amy Gladfelter @gladfelterlab.bsky.social and colleagues @duke-university.bsky.social: rupress.org/jcb/article/...
#Biochemistry #Cytoskeleton
#Biochemistry #Cytoskeleton
Close-up of vesicular ER exit sites by volume electron imaging using FIB-SEM. New report from Athul Nair, Tom Kirchhausen @kirchhausenlab.bsky.social and colleagues @bostonchildrens.bsky.social: rupress.org/jcb/article/...
#Trafficking #Technology #ER_literature
#Trafficking #Technology #ER_literature
November 7, 2025 at 8:30 PM
Close-up of vesicular ER exit sites by volume electron imaging using FIB-SEM. New report from Athul Nair, Tom Kirchhausen @kirchhausenlab.bsky.social and colleagues @bostonchildrens.bsky.social: rupress.org/jcb/article/...
#Trafficking #Technology #ER_literature
#Trafficking #Technology #ER_literature
#Tubulin regulates stability and localization of STMN2 by binding preferentially to its soluble form, say Xiang Deng, Timothy Mitchison and colleagues @harvardmed.bsky.social: rupress.org/jcb/article/...
#ProteinHomeostasis #Neuroscience #Biochemistry #Cytoskeleton #Neurodegeneration #ALS
#ProteinHomeostasis #Neuroscience #Biochemistry #Cytoskeleton #Neurodegeneration #ALS
November 7, 2025 at 7:30 PM
#Tubulin regulates stability and localization of STMN2 by binding preferentially to its soluble form, say Xiang Deng, Timothy Mitchison and colleagues @harvardmed.bsky.social: rupress.org/jcb/article/...
#ProteinHomeostasis #Neuroscience #Biochemistry #Cytoskeleton #Neurodegeneration #ALS
#ProteinHomeostasis #Neuroscience #Biochemistry #Cytoskeleton #Neurodegeneration #ALS
Calvo, Patel, Alonso @uva-es.bsky.social et al. describe a new bioluminescent sensor for measuring luminal Ca²⁺ in a mildly acidic subcompartment of the endo-lysosomal system. rupress.org/jcb/article/...
#CellSignaling #Organelles #Physiology #Technology #Lysosomes #Endosomes
#CellSignaling #Organelles #Physiology #Technology #Lysosomes #Endosomes
November 7, 2025 at 5:02 PM
Calvo, Patel, Alonso @uva-es.bsky.social et al. describe a new bioluminescent sensor for measuring luminal Ca²⁺ in a mildly acidic subcompartment of the endo-lysosomal system. rupress.org/jcb/article/...
#CellSignaling #Organelles #Physiology #Technology #Lysosomes #Endosomes
#CellSignaling #Organelles #Physiology #Technology #Lysosomes #Endosomes
PCMD-1 stabilizes the PCM scaffold and facilitates #centriole separation, say Alina Schreiner, Tamara Mikeladze-Dvali @tdvalilab.bsky.social and colleagues: rupress.org/jcb/article/...
@zaninlab.bsky.social
#Centrosome #PCMstability #Celegans #Development #CellDivision
@zaninlab.bsky.social
#Centrosome #PCMstability #Celegans #Development #CellDivision
November 7, 2025 at 3:30 PM
PCMD-1 stabilizes the PCM scaffold and facilitates #centriole separation, say Alina Schreiner, Tamara Mikeladze-Dvali @tdvalilab.bsky.social and colleagues: rupress.org/jcb/article/...
@zaninlab.bsky.social
#Centrosome #PCMstability #Celegans #Development #CellDivision
@zaninlab.bsky.social
#Centrosome #PCMstability #Celegans #Development #CellDivision
Roles of Srs2/PARI-family DNA helicases in NoCut checkpoint signaling and abscission regulation. New study from Monica Dam, David F. Moreno, Nicola Brownlow, Manuel Mendoza (@longchrom.bsky.social) and colleagues @igbmc.bsky.social: rupress.org/jcb/article/...
#Genetics #CellDivision #Cytokinesis
#Genetics #CellDivision #Cytokinesis
November 7, 2025 at 2:45 PM
Roles of Srs2/PARI-family DNA helicases in NoCut checkpoint signaling and abscission regulation. New study from Monica Dam, David F. Moreno, Nicola Brownlow, Manuel Mendoza (@longchrom.bsky.social) and colleagues @igbmc.bsky.social: rupress.org/jcb/article/...
#Genetics #CellDivision #Cytokinesis
#Genetics #CellDivision #Cytokinesis
Okada, Bi et al. @upenn.edu show that Bni5 interacts with #septin filaments, septin-associated kinase, and #myosin-II to regulate septin hourglass architecture and remodeling, retrograde #actin flow, and #cytokinesis rupress.org/jcb/article/...
#Biochemistry #CellDivision #Cytoskeleton #Genetics
#Biochemistry #CellDivision #Cytoskeleton #Genetics
November 6, 2025 at 5:45 PM
Okada, Bi et al. @upenn.edu show that Bni5 interacts with #septin filaments, septin-associated kinase, and #myosin-II to regulate septin hourglass architecture and remodeling, retrograde #actin flow, and #cytokinesis rupress.org/jcb/article/...
#Biochemistry #CellDivision #Cytoskeleton #Genetics
#Biochemistry #CellDivision #Cytoskeleton #Genetics
Peiyao Fan, Yang Chen et al. @pku1898.bsky.social show that tubular ER extends into retraction fibers and #migrasomes through #microtubule-dependent ER extension and ER-plasma membrane contact sites in migrating cells. rupress.org/jcb/article/...
#ER_literature #Migration #Organelles
#ER_literature #Migration #Organelles
November 6, 2025 at 5:00 PM
Peiyao Fan, Yang Chen et al. @pku1898.bsky.social show that tubular ER extends into retraction fibers and #migrasomes through #microtubule-dependent ER extension and ER-plasma membrane contact sites in migrating cells. rupress.org/jcb/article/...
#ER_literature #Migration #Organelles
#ER_literature #Migration #Organelles
Irg1l regulates neuromast size via metabolic reprogramming to promote supporting cell proliferation. New study from Xin Wang, Ruijun Shi, Yuqing Xiang, Yajing Gao, Guoqiang Wan, Shan Sun, and Dong Liu (Nantong University): rupress.org/jcb/article/...
#CellMetabolism #Development #Zebrafish
#CellMetabolism #Development #Zebrafish
November 4, 2025 at 8:02 PM
Irg1l regulates neuromast size via metabolic reprogramming to promote supporting cell proliferation. New study from Xin Wang, Ruijun Shi, Yuqing Xiang, Yajing Gao, Guoqiang Wan, Shan Sun, and Dong Liu (Nantong University): rupress.org/jcb/article/...
#CellMetabolism #Development #Zebrafish
#CellMetabolism #Development #Zebrafish
In new study from Ryken, Bezanilla et al., analysis of PIIB-type calcium pump localization and function elucidates one of the molecular mechanisms that maintains the strength of the calcium gradient during polarized growth. rupress.org/jcb/article/...
#PlantBiology #Cytoskeleton #Trafficking
#PlantBiology #Cytoskeleton #Trafficking
November 4, 2025 at 6:45 PM
In new study from Ryken, Bezanilla et al., analysis of PIIB-type calcium pump localization and function elucidates one of the molecular mechanisms that maintains the strength of the calcium gradient during polarized growth. rupress.org/jcb/article/...
#PlantBiology #Cytoskeleton #Trafficking
#PlantBiology #Cytoskeleton #Trafficking
Xu Liu, Ya Huang et al. show that the transcriptional regulator RTF1 promotes #circadian rhythm by enhancing CLOCK occupancy and H3K4me3 deposition at pacemaker gene loci. rupress.org/jcb/article/...
#Chromatin #Epigenetics
#Chromatin #Epigenetics
November 4, 2025 at 5:45 PM
Xu Liu, Ya Huang et al. show that the transcriptional regulator RTF1 promotes #circadian rhythm by enhancing CLOCK occupancy and H3K4me3 deposition at pacemaker gene loci. rupress.org/jcb/article/...
#Chromatin #Epigenetics
#Chromatin #Epigenetics
Glushkova, Böhm, & Beck @maxplanck.de develop a publicly available computational method to measure the thickness of biological membranes in cryo-electron tomograms. Analysis of algae & human cells reveals systematic membrane thickness variations within & across organelles rupress.org/jcb/article/...
November 4, 2025 at 5:30 PM
Glushkova, Böhm, & Beck @maxplanck.de develop a publicly available computational method to measure the thickness of biological membranes in cryo-electron tomograms. Analysis of algae & human cells reveals systematic membrane thickness variations within & across organelles rupress.org/jcb/article/...
Moesin strikes an "Actin"g G-balance to regulate #osteoclast fusion and activity. Marwa Zeyad and Yousef Abu-Amer @washumedicine.bsky.social highlight new work from the @chrisverollet.bsky.social group (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/...
#CellSignaling
#CellSignaling
November 3, 2025 at 7:45 PM
Moesin strikes an "Actin"g G-balance to regulate #osteoclast fusion and activity. Marwa Zeyad and Yousef Abu-Amer @washumedicine.bsky.social highlight new work from the @chrisverollet.bsky.social group (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/...
#CellSignaling
#CellSignaling
Spotlight: Jianuo Han and Yansong Miao highlight recent findings from Magliozzi et al. (rupress.org/jcb/article/...), identifying a novel “composite” #actin nucleator for the assembly of thick actin cables. rupress.org/jcb/article/...
#Biochemistry #Cytoskeleton
#Biochemistry #Cytoskeleton
November 3, 2025 at 6:30 PM
Spotlight: Jianuo Han and Yansong Miao highlight recent findings from Magliozzi et al. (rupress.org/jcb/article/...), identifying a novel “composite” #actin nucleator for the assembly of thick actin cables. rupress.org/jcb/article/...
#Biochemistry #Cytoskeleton
#Biochemistry #Cytoskeleton
Xinyang Li, Yue Hua et al. demonstrate that B4GALT1 and WLS cooperate to retain the canonical #Wnt receptor LRP5/6 on the #Golgi apparatus, leading to specific inhibition of the Wnt/β-catenin signaling in such Wnt-receiving cells that have no expression of Wnt proteins. rupress.org/jcb/article/...
November 3, 2025 at 5:45 PM
Xinyang Li, Yue Hua et al. demonstrate that B4GALT1 and WLS cooperate to retain the canonical #Wnt receptor LRP5/6 on the #Golgi apparatus, leading to specific inhibition of the Wnt/β-catenin signaling in such Wnt-receiving cells that have no expression of Wnt proteins. rupress.org/jcb/article/...
Localization of the #septin #cytoskeleton is controlled by regulatory factors, membrane curvature, & charge. In this study, @gladfelterlab.bsky.social finds changes to #lipid composition that modulate lipid packing defects to impact septin assemblies in vitro & in cells. rupress.org/jcb/article/...
November 3, 2025 at 5:01 PM
Localization of the #septin #cytoskeleton is controlled by regulatory factors, membrane curvature, & charge. In this study, @gladfelterlab.bsky.social finds changes to #lipid composition that modulate lipid packing defects to impact septin assemblies in vitro & in cells. rupress.org/jcb/article/...
JCB’s November issue is here! rupress.org/jcb/issue/22...
Cover shows a scanning electron #microscopy image of a human osteoclast derived from blood monocytes on bone slices. Image © Dufrançais and Poincloux. See doi.org/10.1083/jcb....
@chrisverollet.bsky.social
Cover shows a scanning electron #microscopy image of a human osteoclast derived from blood monocytes on bone slices. Image © Dufrançais and Poincloux. See doi.org/10.1083/jcb....
@chrisverollet.bsky.social
November 3, 2025 at 3:04 PM
JCB’s November issue is here! rupress.org/jcb/issue/22...
Cover shows a scanning electron #microscopy image of a human osteoclast derived from blood monocytes on bone slices. Image © Dufrançais and Poincloux. See doi.org/10.1083/jcb....
@chrisverollet.bsky.social
Cover shows a scanning electron #microscopy image of a human osteoclast derived from blood monocytes on bone slices. Image © Dufrançais and Poincloux. See doi.org/10.1083/jcb....
@chrisverollet.bsky.social