Eiko Fried
@eikofried.bsky.social
Associate Prof Leiden Uni. Studying mental health problems as systems. http://eiko-fried.com. Building an early warning system for depression at http://WARN-D.com.
Pinned
Eiko Fried
@eikofried.bsky.social
· Nov 22
So many new followers!! Hi folks, nice to meet you all. 🖤
I'll introduce my core research interests by showing you some of the work we've done in recent years on the conceptualization, measurement, modeling, and theories of mental health (problems).
🧪 #PsychSciSky #psychiatry #statssky
🧵
I'll introduce my core research interests by showing you some of the work we've done in recent years on the conceptualization, measurement, modeling, and theories of mental health (problems).
🧪 #PsychSciSky #psychiatry #statssky
🧵
Anyone planning to go to APS 2026 working on clinical prediction models? We have a nice preprint on predicting depression severity in n~1700 using smartphone & smartwatch data, and would love to join a symposium or help putting one together :)
www.psychologicalscience.org/conventions/...
www.psychologicalscience.org/conventions/...
November 19, 2025 at 2:39 AM
Anyone planning to go to APS 2026 working on clinical prediction models? We have a nice preprint on predicting depression severity in n~1700 using smartphone & smartwatch data, and would love to join a symposium or help putting one together :)
www.psychologicalscience.org/conventions/...
www.psychologicalscience.org/conventions/...
Nice NYT travel section piece on Leiden :). The photo at the top right of the website shows, incidentally, one of my favourite bridges in the Netherlands!
www.nytimes.com/2025/11/12/t...
www.nytimes.com/2025/11/12/t...
All the Canals and Charm of Amsterdam. None of the Crowds.
www.nytimes.com
November 14, 2025 at 8:49 AM
Nice NYT travel section piece on Leiden :). The photo at the top right of the website shows, incidentally, one of my favourite bridges in the Netherlands!
www.nytimes.com/2025/11/12/t...
www.nytimes.com/2025/11/12/t...
After having followed papers on the gut microbiome and mental health problems for a few years, I would not be surprised if conceptual and methodological flaws undermine most claims in this literature.
The link between the gut #microbiome and autism is not backed by science, researchers say.
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
November 14, 2025 at 7:24 AM
After having followed papers on the gut microbiome and mental health problems for a few years, I would not be surprised if conceptual and methodological flaws undermine most claims in this literature.
The observed smallest worthwhile difference in this study "means that the current 15% antidepressant benefit over no treatment was sufficient for 1 in 3 people to accept antidepressants given the burdens, but 2 in 3 expected greater treatment benefits."
The average SWD for antidepressants for MDD was RD of 20%, and SMD of around 0.5. mentalhealth.bmj.com/content/27/1...
November 13, 2025 at 3:41 AM
The observed smallest worthwhile difference in this study "means that the current 15% antidepressant benefit over no treatment was sufficient for 1 in 3 people to accept antidepressants given the burdens, but 2 in 3 expected greater treatment benefits."
I'm in Sydney until December 15th.
If any tweeps (blueskyers?) are around lets get lunch or coffee!
Also ... if you allow random strangers to join your D&D* group for a few weeks ... pleeeeeeease let me know :)))
___
* or whatever pen & paper y'all are up to
If any tweeps (blueskyers?) are around lets get lunch or coffee!
Also ... if you allow random strangers to join your D&D* group for a few weeks ... pleeeeeeease let me know :)))
___
* or whatever pen & paper y'all are up to
a close up of a feather on a rock with the words `` hello '' written in white letters .
ALT: a close up of a feather on a rock with the words `` hello '' written in white letters .
media.tenor.com
November 12, 2025 at 3:42 AM
I'm in Sydney until December 15th.
If any tweeps (blueskyers?) are around lets get lunch or coffee!
Also ... if you allow random strangers to join your D&D* group for a few weeks ... pleeeeeeease let me know :)))
___
* or whatever pen & paper y'all are up to
If any tweeps (blueskyers?) are around lets get lunch or coffee!
Also ... if you allow random strangers to join your D&D* group for a few weeks ... pleeeeeeease let me know :)))
___
* or whatever pen & paper y'all are up to
Four interesting methods & stats winter courses at Leiden University also open to researchers and PhD candidates who are not affiliated with us.
www.universiteitleiden.nl/en/social-be...
www.universiteitleiden.nl/en/social-be...
November 10, 2025 at 9:20 PM
Four interesting methods & stats winter courses at Leiden University also open to researchers and PhD candidates who are not affiliated with us.
www.universiteitleiden.nl/en/social-be...
www.universiteitleiden.nl/en/social-be...
Reposted by Eiko Fried
This one surely has something on offer for every one: In this cross-sectional mediation analysis, the "effects" of soft drink consumption on depression were "mediated" by abundance of Eggerthela in the gut microbiome.
This was sent to me via dm and now you all got to suffer as well.
This was sent to me via dm and now you all got to suffer as well.
Soft Drink Consumption and Depression Mediated by Gut Microbiome Alterations
This cohort study examines the association between soft drink consumption and major depressive disorder diagnosis and severity and whether this association is mediated by changes in the gut microbiota...
jamanetwork.com
November 9, 2025 at 7:19 AM
This one surely has something on offer for every one: In this cross-sectional mediation analysis, the "effects" of soft drink consumption on depression were "mediated" by abundance of Eggerthela in the gut microbiome.
This was sent to me via dm and now you all got to suffer as well.
This was sent to me via dm and now you all got to suffer as well.
This thread has everything I loved about Twitter 2017/2018: several thoughtful expert suggestions that cover different angles, interspersed with excellent jokes, trolling of scientific journals, and philosophical debates about aging.
"Journal style does not allow 3-dimensional figures. Please rework Figure 5 into a figure with only 2 axes if possible"
a man in a suit and tie is smoking a cigarette while sitting in an airplane .
ALT: a man in a suit and tie is smoking a cigarette while sitting in an airplane .
media.tenor.com
November 6, 2025 at 12:08 AM
This thread has everything I loved about Twitter 2017/2018: several thoughtful expert suggestions that cover different angles, interspersed with excellent jokes, trolling of scientific journals, and philosophical debates about aging.
Been thinking for a few years about what I call the *replication ceiling*: the maximum replicability of an effect given constraints in data in which replication takes place (power, measurement error, sampling variability, etc). This leads to a maximum theoretical replicability which can be achieved.
November 5, 2025 at 3:09 AM
Been thinking for a few years about what I call the *replication ceiling*: the maximum replicability of an effect given constraints in data in which replication takes place (power, measurement error, sampling variability, etc). This leads to a maximum theoretical replicability which can be achieved.
Love everything about this, from the suggestive“Yes!” to back pain all the way to the “free” consultation.
November 5, 2025 at 2:16 AM
Love everything about this, from the suggestive“Yes!” to back pain all the way to the “free” consultation.
"Journal style does not allow 3-dimensional figures. Please rework Figure 5 into a figure with only 2 axes if possible"
a man in a suit and tie is smoking a cigarette while sitting in an airplane .
ALT: a man in a suit and tie is smoking a cigarette while sitting in an airplane .
media.tenor.com
November 4, 2025 at 8:44 PM
"Journal style does not allow 3-dimensional figures. Please rework Figure 5 into a figure with only 2 axes if possible"
Eye-opening work on heterogeneity among depression scales. Also, I’m a pluralist and everything, but … do we need 27 youth depression scales? Why have researchers not updated and further developed them? What does this say about the state of our field?
Great to see our content analysis of 27 Chinese youth depression scales finally out!
Following @eikofried.bsky.social excellent work on depression scales, we included 27 scales and quantified the heterogeneity by analyzing data from 12,000 youth who completed 4 of them.
Comments are welcome!
Following @eikofried.bsky.social excellent work on depression scales, we included 27 scales and quantified the heterogeneity by analyzing data from 12,000 youth who completed 4 of them.
Comments are welcome!
November 1, 2025 at 6:15 AM
Eye-opening work on heterogeneity among depression scales. Also, I’m a pluralist and everything, but … do we need 27 youth depression scales? Why have researchers not updated and further developed them? What does this say about the state of our field?
Rarely seen such severe shifts (green) of parties in just a 2 year period ... (~98% of votes counted in the national elections in the Netherlands)
October 30, 2025 at 5:55 PM
Rarely seen such severe shifts (green) of parties in just a 2 year period ... (~98% of votes counted in the national elections in the Netherlands)
Hey @cos.io, boomer here cannot figure out how to update my files on the OSF after the recent changes.
It used to be drag and drop over the files (see here dragging the supplementary.pdf) but that doesn't work, and the "edit" button is only for the wiki.
Thanks
It used to be drag and drop over the files (see here dragging the supplementary.pdf) but that doesn't work, and the "edit" button is only for the wiki.
Thanks
October 30, 2025 at 3:45 PM
Hey @cos.io, boomer here cannot figure out how to update my files on the OSF after the recent changes.
It used to be drag and drop over the files (see here dragging the supplementary.pdf) but that doesn't work, and the "edit" button is only for the wiki.
Thanks
It used to be drag and drop over the files (see here dragging the supplementary.pdf) but that doesn't work, and the "edit" button is only for the wiki.
Thanks
New commentary on problems of the emerging ketamine literature when compared to ECT.
Was surprised by first sentence stating that ECT is considered the "most effective treatment for MDD", though. Also wonder to what degree some of the issues apply to ECT literature.
thelancet.com/journals/lan...
Was surprised by first sentence stating that ECT is considered the "most effective treatment for MDD", though. Also wonder to what degree some of the issues apply to ECT literature.
thelancet.com/journals/lan...
Ketamine versus ECT for major depression: flawed evidence base
Electroconvulsive therapy (ECT) has long been considered in the scientific literature
to be the most effective treatment for major depressive episodes. Recently, this view
has been challenged by claim...
thelancet.com
October 27, 2025 at 9:52 AM
New commentary on problems of the emerging ketamine literature when compared to ECT.
Was surprised by first sentence stating that ECT is considered the "most effective treatment for MDD", though. Also wonder to what degree some of the issues apply to ECT literature.
thelancet.com/journals/lan...
Was surprised by first sentence stating that ECT is considered the "most effective treatment for MDD", though. Also wonder to what degree some of the issues apply to ECT literature.
thelancet.com/journals/lan...
New 6-month depression RCT in n=65, serial Ketamine infusions as adjunctive care vs active placebo midazolam.
Ketamine did not outperform primary nor any of the secondary efficacy, cognitive, economic, or quality-of-life outcomes.
🧪 #psychiary #PsychSciSky
jamanetwork.com/journals/jam...
Ketamine did not outperform primary nor any of the secondary efficacy, cognitive, economic, or quality-of-life outcomes.
🧪 #psychiary #PsychSciSky
jamanetwork.com/journals/jam...
Serial Ketamine Infusions for Depression
This randomized clinical trial evaluates outcomes following adjunctive ketamine infusions vs midazolam for depression.
jamanetwork.com
October 23, 2025 at 8:11 AM
New 6-month depression RCT in n=65, serial Ketamine infusions as adjunctive care vs active placebo midazolam.
Ketamine did not outperform primary nor any of the secondary efficacy, cognitive, economic, or quality-of-life outcomes.
🧪 #psychiary #PsychSciSky
jamanetwork.com/journals/jam...
Ketamine did not outperform primary nor any of the secondary efficacy, cognitive, economic, or quality-of-life outcomes.
🧪 #psychiary #PsychSciSky
jamanetwork.com/journals/jam...
So excited this project is now openly available: an ESM / EMA database that currently features 60 open datasets, with many more to come. Check out our accompanying preprins, too :)
🧪 #PsychSciSky #StatsSky #Psychiatry #PublicHealth #EpiSky
🧪 #PsychSciSky #StatsSky #Psychiatry #PublicHealth #EpiSky
We built the openESM database:
▶️60 openly available experience sampling datasets (16K+ participants, 740K+ obs.) in one place
▶️Harmonized (meta-)data, fully open-source software
▶️Filter & search all data, simply download via R/Python
Find out more:
🌐 openesmdata.org
📝 doi.org/10.31234/osf...
▶️60 openly available experience sampling datasets (16K+ participants, 740K+ obs.) in one place
▶️Harmonized (meta-)data, fully open-source software
▶️Filter & search all data, simply download via R/Python
Find out more:
🌐 openesmdata.org
📝 doi.org/10.31234/osf...
October 23, 2025 at 7:46 AM
So excited this project is now openly available: an ESM / EMA database that currently features 60 open datasets, with many more to come. Check out our accompanying preprins, too :)
🧪 #PsychSciSky #StatsSky #Psychiatry #PublicHealth #EpiSky
🧪 #PsychSciSky #StatsSky #Psychiatry #PublicHealth #EpiSky
1/n
I'm considering writing a paper with many authors & wanted to ask for feedback from people who have experience (e.g., manylabs).
Assume a core team of 25 authors, and then 500 people who participate in a delphi study who I want to give authorship specifically for the participation in delphi
I'm considering writing a paper with many authors & wanted to ask for feedback from people who have experience (e.g., manylabs).
Assume a core team of 25 authors, and then 500 people who participate in a delphi study who I want to give authorship specifically for the participation in delphi
October 22, 2025 at 9:51 AM
1/n
I'm considering writing a paper with many authors & wanted to ask for feedback from people who have experience (e.g., manylabs).
Assume a core team of 25 authors, and then 500 people who participate in a delphi study who I want to give authorship specifically for the participation in delphi
I'm considering writing a paper with many authors & wanted to ask for feedback from people who have experience (e.g., manylabs).
Assume a core team of 25 authors, and then 500 people who participate in a delphi study who I want to give authorship specifically for the participation in delphi
UK elevators are confusing
October 18, 2025 at 10:23 AM
UK elevators are confusing
Hey friends at @tilburg-university.bsky.social, something is wrong with your website
October 15, 2025 at 8:43 AM
Hey friends at @tilburg-university.bsky.social, something is wrong with your website
Reposted by Eiko Fried
Impact postdoc at the UvA: PhD preferred, good fit for someone who wants to do applied work in actual settings with actual impact
werkenbij.uva.nl/en/vacancies...
werkenbij.uva.nl/en/vacancies...
Vacancy — Amplifying the Impact of Behavioural Interventions with Complexity Science
Are you a systems thinker with affinity with the social and behavioral sciences? Are you motivated to ensure that complexity science makes its way to the real world of government communication and pol...
werkenbij.uva.nl
October 13, 2025 at 1:25 PM
Impact postdoc at the UvA: PhD preferred, good fit for someone who wants to do applied work in actual settings with actual impact
werkenbij.uva.nl/en/vacancies...
werkenbij.uva.nl/en/vacancies...
Reposted by Eiko Fried
Found this and couldn't resist ..
February 18, 2025 at 1:46 PM
Found this and couldn't resist ..