Dan Bose
@danbose.bsky.social
scientist (enhancers, eRNAs and chromatin), Sir Henry Dale Fellow; bike-fettling, bird-watching, accordion-botherer
www.bose-lab.org
@danbose@biologists.social
www.bose-lab.org
@danbose@biologists.social
Pinned
Dan Bose
@danbose.bsky.social
· Jun 6
CBP-IDRs regulate acetylation and gene expression.
Intrinsically disordered regions (IDRs) have emerged as crucial regulators of protein function, allowing proteins to sense and respond to their environment. Creb binding protein (CBP) and EP300 (p300)...
tinyurl.com
Hot off the press for your Friday morning! 🔥 Our new (and highly revised!) preprint is out. It significantly expands on our previous work, unveiling exciting new data on how CBP's intrinsically disordered regions (IDRs) regulate genes.
Link to preprint: tinyurl.com/5npjkyps
#IDRs #condensates #CBP
Link to preprint: tinyurl.com/5npjkyps
#IDRs #condensates #CBP
Reposted by Dan Bose
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
November 6, 2025 at 2:49 PM
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
Amazing work from the team at Oxford to pull apart how chromatin structure is organised at enhancers.
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 5, 2025 at 6:25 PM
Amazing work from the team at Oxford to pull apart how chromatin structure is organised at enhancers.
This is a super resource - looking forward to having a good poke around
Stoked to share our latest work entitled: “Large-scale discovery of neural enhancers for cis-regulation therapies”
shorturl.at/H3Qww
This is an enormous team effort that I had the honour of spearheading with Nick Page and Florence Chardon.
Bluetorial below.
shorturl.at/H3Qww
This is an enormous team effort that I had the honour of spearheading with Nick Page and Florence Chardon.
Bluetorial below.
November 5, 2025 at 3:38 PM
This is a super resource - looking forward to having a good poke around
Awesome work looking inside #RNA structural ensembles during folding- congrats!
Excited to share my first PhD student’s @biorxivpreprint.bsky.social!
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
November 1, 2025 at 6:39 AM
Awesome work looking inside #RNA structural ensembles during folding- congrats!
Reposted by Dan Bose
I’m a fair-weather poster on here to say the least. However, I'm pleased to present our latest paper. A great effort from all authors and an interesting insight into transcriptional regulation (we think!).
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Sequential verification of transcription by Integrator and Restrictor
Estell and Łazowski et al. show that Integrator and Restrictor form distinct pathways
for early attenuation of RNA polymerase II: Integrator acts at the promoter-proximal
pause site, whereas Restricto...
www.cell.com
October 17, 2025 at 5:19 PM
I’m a fair-weather poster on here to say the least. However, I'm pleased to present our latest paper. A great effort from all authors and an interesting insight into transcriptional regulation (we think!).
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
This is super cool!
🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for genetic code expansion - Nature
Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins with novel func...
www.nature.com
October 17, 2025 at 8:34 AM
This is super cool!
Reposted by Dan Bose
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
Enhancer-promoter compatibility is mediated by the promoter-proximal region
Gene promoters induce transcription in response to distal enhancers. How enhancers specifically activate their target promoter while bypassing other promoters remains unclear. Here, we find that the p...
www.biorxiv.org
October 16, 2025 at 3:06 PM
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
Great review of the super #NeuroBioUK2025 meeting in September. Well done to everyone who organised it @exdrososcientia.bsky.social @alexfellows1.bsky.social and @dozenoaks.bsky.social for putting together such a great meeting for the community! 👏🧠🔬 tinyurl.com/4jn7yrmt roll on next year!
NeuroBio UK 2025: Insights, Innovation, and Inspiration in Neuroscience - FocalPlane
NeuroBio UK 2025: Insights, Innovation, and Inspiration in Neuroscience -
tinyurl.com
October 6, 2025 at 7:32 PM
Great review of the super #NeuroBioUK2025 meeting in September. Well done to everyone who organised it @exdrososcientia.bsky.social @alexfellows1.bsky.social and @dozenoaks.bsky.social for putting together such a great meeting for the community! 👏🧠🔬 tinyurl.com/4jn7yrmt roll on next year!
Reposted by Dan Bose
Collective challenges need collective solutions. Happy to share the insights we've gained from the way our cells handle this: www.nature.com/articles/s41... and its summary www.crick.ac.uk/news/2025-09....
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
September 24, 2025 at 4:25 PM
Collective challenges need collective solutions. Happy to share the insights we've gained from the way our cells handle this: www.nature.com/articles/s41... and its summary www.crick.ac.uk/news/2025-09....
Reposted by Dan Bose
We have space for two postdoctoral fellows in the Taipale Lab at the @sangerinstitute.bsky.social. This is a core-funded open position! Come with your ideas and interests and we can develop a project together.
sanger.wd103.myworkdayjobs.com/en-US/Wellco...
sanger.wd103.myworkdayjobs.com/en-US/Wellco...
Postdoctoral Fellow - Gene Regulation and Functional Genomics
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
sanger.wd103.myworkdayjobs.com
September 25, 2025 at 10:58 AM
We have space for two postdoctoral fellows in the Taipale Lab at the @sangerinstitute.bsky.social. This is a core-funded open position! Come with your ideas and interests and we can develop a project together.
sanger.wd103.myworkdayjobs.com/en-US/Wellco...
sanger.wd103.myworkdayjobs.com/en-US/Wellco...
Reposted by Dan Bose
Our study on the role of LTR5HS and SVAs in regulation of human neural crest migration is now published as peer-reviewed paper on @molsystbiol.org!
Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social
www.embopress.org/doi/full/10....
Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social
www.embopress.org/doi/full/10....
September 22, 2025 at 11:24 AM
Our study on the role of LTR5HS and SVAs in regulation of human neural crest migration is now published as peer-reviewed paper on @molsystbiol.org!
Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social
www.embopress.org/doi/full/10....
Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social
www.embopress.org/doi/full/10....
Come and hear about our latest story! It's a really nice series as well- sign up for the mailing list for updates #condensates #UKcondensates
Come join us for the next monthly on-line seminar (3rd October, 1 pm BST) aimed to connect the UK Biomolecular Condensate community (All are welcome to come and listen). @danbose.bsky.social @physicsoflifeuk.bsky.social
September 23, 2025 at 2:41 PM
Come and hear about our latest story! It's a really nice series as well- sign up for the mailing list for updates #condensates #UKcondensates
This looks super useful!
🚀 Our new paper is out @natmethods.nature.com!
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
September 22, 2025 at 6:45 PM
This looks super useful!
Such a cool story- great to see it finally out in the wild #enhancers #geneRegulation
✨Exciting news: the main story of my PhD is out in Science!
Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation.
📖 Read the full story here: www.science.org/doi/10.1126/...
Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation.
📖 Read the full story here: www.science.org/doi/10.1126/...
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...
www.science.org
September 19, 2025 at 3:24 PM
Such a cool story- great to see it finally out in the wild #enhancers #geneRegulation
Reposted by Dan Bose
✨Exciting news: the main story of my PhD is out in Science!
Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation.
📖 Read the full story here: www.science.org/doi/10.1126/...
Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation.
📖 Read the full story here: www.science.org/doi/10.1126/...
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...
www.science.org
September 19, 2025 at 2:09 PM
✨Exciting news: the main story of my PhD is out in Science!
Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation.
📖 Read the full story here: www.science.org/doi/10.1126/...
Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation.
📖 Read the full story here: www.science.org/doi/10.1126/...
Reposted by Dan Bose
New review on computational design of intrinsically disordered proteins 🖥️🍝 by @giuliotesei.bsky.social @fpesce.bsky.social & 👴
doi.org/10.48550/arX...
doi.org/10.48550/arX...
September 17, 2025 at 4:17 PM
New review on computational design of intrinsically disordered proteins 🖥️🍝 by @giuliotesei.bsky.social @fpesce.bsky.social & 👴
doi.org/10.48550/arX...
doi.org/10.48550/arX...
Reposted by Dan Bose
We (and many!) have been thinking a lot about how to quantifiably measure the material properties of biomolecular condensates inside cells. Chris (my final year PhD student) wrote this great review article about microscopy-based techniques link.springer.com/article/10.1... @phar.cam.ac.uk
Microscopy-based techniques for studying the material properties of biomolecular condensates in the cellular environment - Biophysical Reviews
The material properties of biomolecular condensates, such as interfacial tension, viscoelasticity, stiffness, and molecular dynamics, are crucial for their biological functions in processes like signa...
link.springer.com
July 28, 2025 at 4:19 PM
We (and many!) have been thinking a lot about how to quantifiably measure the material properties of biomolecular condensates inside cells. Chris (my final year PhD student) wrote this great review article about microscopy-based techniques link.springer.com/article/10.1... @phar.cam.ac.uk
Looking forward to catching up with everyone at the @biochemsoc.bsky.social #transcription and #chromatin UK #TCUK meeting today in sunny Manchester! #BiochemEvent 🧬🔬☔️ www.eventsforce.net/biochemsoc/f...
www.eventsforce.net
September 17, 2025 at 6:06 AM
Looking forward to catching up with everyone at the @biochemsoc.bsky.social #transcription and #chromatin UK #TCUK meeting today in sunny Manchester! #BiochemEvent 🧬🔬☔️ www.eventsforce.net/biochemsoc/f...
Reposted by Dan Bose
New online! Is enhancer-driven gene regulation all wrapped up?
Is enhancer-driven gene regulation all wrapped up?
Nature Reviews Genetics, Published online: 16 September 2025; doi:10.1038/s41576-025-00880-9In this Comment, Wendy Bickmore discusses mechanistic models of how 3D genome organization facilitates communication between distant enhancers and their target promoters to regulate gene expression.
www.nature.com
September 16, 2025 at 3:31 PM
New online! Is enhancer-driven gene regulation all wrapped up?
The role of intrinsically disordered domains in regulating G protein coupled receptor signaling https://www.biorxiv.org/content/10.1101/2025.09.10.675278v1
September 11, 2025 at 9:07 PM
Reposted by Dan Bose
👀
Multiple human enhancer RNAs contain long translated open reading frames
genesdev.cshlp.org/content/earl...
Multiple human enhancer RNAs contain long translated open reading frames
genesdev.cshlp.org/content/earl...
Multiple human enhancer RNAs contain long translated open reading frames
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
September 11, 2025 at 9:17 AM
👀
Multiple human enhancer RNAs contain long translated open reading frames
genesdev.cshlp.org/content/earl...
Multiple human enhancer RNAs contain long translated open reading frames
genesdev.cshlp.org/content/earl...
Reposted by Dan Bose
Really excited to get our seminars back up and running. @gracebower.bsky.social is going 1st and if you haven't read her range extender story, you're in for a treat!
+
@creminslab.bsky.social has the 2nd talk and will tell us about the amazing work happening in her lab!
+
@creminslab.bsky.social has the 2nd talk and will tell us about the amazing work happening in her lab!
Let’s kickstart new series of #FragileNucleosome seminars! We are delighted to have @gracebower.bsky.social from Kvon lab and @creminslab.bsky.social to present their work!
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
September 8, 2025 at 5:34 PM
Really excited to get our seminars back up and running. @gracebower.bsky.social is going 1st and if you haven't read her range extender story, you're in for a treat!
+
@creminslab.bsky.social has the 2nd talk and will tell us about the amazing work happening in her lab!
+
@creminslab.bsky.social has the 2nd talk and will tell us about the amazing work happening in her lab!
Reposted by Dan Bose
Reposted by Dan Bose
Great news, no more grant deadlines 😀 MRC applicant-led funding – UKRI share.google/lP742F01GmuK...
Simplifying access to MRC applicant-led funding
We’re introducing a new flexible research grant and removing closing dates from our board funding opportunities.
share.google
September 8, 2025 at 6:30 PM
Great news, no more grant deadlines 😀 MRC applicant-led funding – UKRI share.google/lP742F01GmuK...
Reposted by Dan Bose
