Dan Bose
@danbose.bsky.social
scientist (enhancers, eRNAs, IDRs and chromatin), Group Leader; bike-fettling, bird-watching, sword dancing, accordion-botherer
www.bose-lab.org
@danbose@biologists.social
www.bose-lab.org
@danbose@biologists.social
Pinned
Dan Bose
@danbose.bsky.social
· Jun 6
CBP-IDRs regulate acetylation and gene expression.
Intrinsically disordered regions (IDRs) have emerged as crucial regulators of protein function, allowing proteins to sense and respond to their environment. Creb binding protein (CBP) and EP300 (p300)...
tinyurl.com
Hot off the press for your Friday morning! 🔥 Our new (and highly revised!) preprint is out. It significantly expands on our previous work, unveiling exciting new data on how CBP's intrinsically disordered regions (IDRs) regulate genes.
Link to preprint: tinyurl.com/5npjkyps
#IDRs #condensates #CBP
Link to preprint: tinyurl.com/5npjkyps
#IDRs #condensates #CBP
Reposted by Dan Bose
PDRA position still open in my lab for anyone who wants to solve some outstanding questions in limb development. We have a variety of models and approaches (everything from stem cells to chicks and catsharks). Please share!
A BBSRC-funded PDRA position is available in my lab investigating vertebrate limb development! Please contact me for more details. www.jobs.ac.uk/job/DQH553/r....
Research Associate in Developmental Biology at University of Sheffield
An opportunity for an academic position as a Research Associate in Developmental Biology is available, as advertised on jobs.ac.uk. Apply now and explore other academic job openings.
www.jobs.ac.uk
February 16, 2026 at 9:14 AM
PDRA position still open in my lab for anyone who wants to solve some outstanding questions in limb development. We have a variety of models and approaches (everything from stem cells to chicks and catsharks). Please share!
Really important work unpicking how #IDR context imparts protein function- fantastic to see this finally out! Congratulations!
Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now?
www.nature.com/articles/s41...
More functional data, many thousands of words removed, and a few other updates from last year's preprint.
www.nature.com/articles/s41...
More functional data, many thousands of words removed, and a few other updates from last year's preprint.
February 14, 2026 at 8:07 AM
Really important work unpicking how #IDR context imparts protein function- fantastic to see this finally out! Congratulations!
Reposted by Dan Bose
Interested in antisense oligonucleotides?
Check our story about downstream-of-gene ASOs (DG-ASOs)!
Together with the Roche Innovation Center we
identified transcription termination windows of protein-coding genes as ASO target regions.
link to BioRxiv:
www.biorxiv.org/content/10.6...
Check our story about downstream-of-gene ASOs (DG-ASOs)!
Together with the Roche Innovation Center we
identified transcription termination windows of protein-coding genes as ASO target regions.
link to BioRxiv:
www.biorxiv.org/content/10.6...
February 8, 2026 at 11:03 AM
Interested in antisense oligonucleotides?
Check our story about downstream-of-gene ASOs (DG-ASOs)!
Together with the Roche Innovation Center we
identified transcription termination windows of protein-coding genes as ASO target regions.
link to BioRxiv:
www.biorxiv.org/content/10.6...
Check our story about downstream-of-gene ASOs (DG-ASOs)!
Together with the Roche Innovation Center we
identified transcription termination windows of protein-coding genes as ASO target regions.
link to BioRxiv:
www.biorxiv.org/content/10.6...
I'm a bit late with this, but awesome to see it out in the wild! A real tour de force from @dozenoaks.bsky.social @timcraggs.bsky.social An amazing example of why we need to think more about flexibility in our biological questions! www.cell.com/iscience/ful...
Kinesin-1 is highly flexible and adopts an open conformation in the absence of cargo
Kinesin-1 is an essential anterograde microtubule motor protein. The core kinesin
motor is a homodimer of two heavy chains; N-terminal motor domains hydrolyse ATP and
walk along microtubules, whilst a...
www.cell.com
February 12, 2026 at 9:28 AM
I'm a bit late with this, but awesome to see it out in the wild! A real tour de force from @dozenoaks.bsky.social @timcraggs.bsky.social An amazing example of why we need to think more about flexibility in our biological questions! www.cell.com/iscience/ful...
Great to see @tslab.bsky.social on here at last! Check them out for all things #condenstaes and #RNAs
February 9, 2026 at 9:20 AM
Great to see @tslab.bsky.social on here at last! Check them out for all things #condenstaes and #RNAs
Reposted by Dan Bose
I am excited to share a new review @cp-molcell.bsky.social written in collaboration with @tanjamittag.bsky.social , Mikayla Eppert, and Ambuja Navalkar where we review the current evidence for and against the role of density transitions in regulating transcription www.cell.com/molecular-ce...
February 6, 2026 at 9:20 PM
I am excited to share a new review @cp-molcell.bsky.social written in collaboration with @tanjamittag.bsky.social , Mikayla Eppert, and Ambuja Navalkar where we review the current evidence for and against the role of density transitions in regulating transcription www.cell.com/molecular-ce...
Reposted by Dan Bose
Finally comms from UKRI - on a Sunday evening. No mention of the hundreds of ECRs who will see their careers ended by these decisions and notably no explanation for MRC retrospectively applying cuts and wasting all the work that went into writing, reviewing and scoring applications - £millions
Today, we're sharing an open letter from our Chief Executive, Professor Sir Ian Chapman, outlining changes to UKRI investment approach, and addressing concerns about research funding and the financial position of STFC. Read his letter here: www.ukri.org/news/open-le...
Open letter from Ian Chapman to research and innovation community
UKRI Chief Executive outlines changes to UKRI investment approach, addressing concerns about research funding and the financial position of STFC.
www.ukri.org
February 1, 2026 at 7:21 PM
Finally comms from UKRI - on a Sunday evening. No mention of the hundreds of ECRs who will see their careers ended by these decisions and notably no explanation for MRC retrospectively applying cuts and wasting all the work that went into writing, reviewing and scoring applications - £millions
Reposted by Dan Bose
At a time when the UK should be capitalising on its global reputation as a great place to do science, this is an enormous own goal. I am so sorry for all those who jobs are going to be impacted.
Both MRC and BBSRC responsive modes now withdrawn until further notice. Existing applications unlikely to succeed (late 2025 round expecting 1-5% success rate).
Listen, I get that UKRI wants to pivot. But killing both at once is devastating.
Let's hope at least one opens by summer... #AcademicSky
Listen, I get that UKRI wants to pivot. But killing both at once is devastating.
Let's hope at least one opens by summer... #AcademicSky
MRC instructs grant review boards to slash funding rates - Research Professional News
Boards asked to recommend just three applications for funding, as BBSRC also suspends calls
www.researchprofessionalnews.com
February 1, 2026 at 2:07 PM
At a time when the UK should be capitalising on its global reputation as a great place to do science, this is an enormous own goal. I am so sorry for all those who jobs are going to be impacted.
Reposted by Dan Bose
Spot on.
Even if the changes are for the good (I doubt, but await the data) - implementing them like this is curtains for the careers of a bunch of postdoctoral scientists, and probably a final dissuasion for a bunch more.
And they talk and TALK about how much they want to support junior careers..
Even if the changes are for the good (I doubt, but await the data) - implementing them like this is curtains for the careers of a bunch of postdoctoral scientists, and probably a final dissuasion for a bunch more.
And they talk and TALK about how much they want to support junior careers..
February 1, 2026 at 3:47 PM
Spot on.
Even if the changes are for the good (I doubt, but await the data) - implementing them like this is curtains for the careers of a bunch of postdoctoral scientists, and probably a final dissuasion for a bunch more.
And they talk and TALK about how much they want to support junior careers..
Even if the changes are for the good (I doubt, but await the data) - implementing them like this is curtains for the careers of a bunch of postdoctoral scientists, and probably a final dissuasion for a bunch more.
And they talk and TALK about how much they want to support junior careers..
So much depressing news for UK science #funding at the moment; jobs lost, opportunities for future postdoc career development going up in smoke.
January 30, 2026 at 4:26 PM
So much depressing news for UK science #funding at the moment; jobs lost, opportunities for future postdoc career development going up in smoke.
Reposted by Dan Bose
I had intended to post something about this new Google DeepMind paper that appeared yesterday in Nature, but the press coverage has added to what there is to say. So this is a long 🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Advancing regulatory variant effect prediction with AlphaGenome - Nature
AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect...
www.nature.com
January 30, 2026 at 9:47 AM
I had intended to post something about this new Google DeepMind paper that appeared yesterday in Nature, but the press coverage has added to what there is to say. So this is a long 🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Dan Bose
CaSE: “UKRI need to explain how the cuts detailed in this letter are consistent with the commitment to protect curiosity-led research […]
“The information we have had so far is a failure in communication and transparency”
www.sciencecampaign.org.uk/press/detail...
“The information we have had so far is a failure in communication and transparency”
www.sciencecampaign.org.uk/press/detail...
Significant cuts could damage the foundations of UK research - CaSE
CaSE’s response to a letter sent by Science and Technology Facilities Council (STFC) Executive Chair Professor Michele Dougherty detailing major cuts to research funding.
www.sciencecampaign.org.uk
January 28, 2026 at 10:44 PM
CaSE: “UKRI need to explain how the cuts detailed in this letter are consistent with the commitment to protect curiosity-led research […]
“The information we have had so far is a failure in communication and transparency”
www.sciencecampaign.org.uk/press/detail...
“The information we have had so far is a failure in communication and transparency”
www.sciencecampaign.org.uk/press/detail...
Reposted by Dan Bose
Quite timely that Sir Ian Chapman, UKRI CEO, will be in front of the House of Commons Science, Innovation and Technology Committee on Tuesday next week… 👀
BREAKING: UK physics research and science facilities face ‘substantial’ cuts
Science and Technology Facilities Council seeks £162m cost savings, with existing projects facing axe
Scoop by @francesjones.bsky.social
www.researchprofessionalnews.com/rr-news-uk-r...
Science and Technology Facilities Council seeks £162m cost savings, with existing projects facing axe
Scoop by @francesjones.bsky.social
www.researchprofessionalnews.com/rr-news-uk-r...
UK physics research and science facilities face ‘substantial’ cuts - Research Professional News
Exclusive: Science and Technology Facilities Council seeks £162m cost savings, with existing projects facing axe
www.researchprofessionalnews.com
January 28, 2026 at 10:12 PM
Quite timely that Sir Ian Chapman, UKRI CEO, will be in front of the House of Commons Science, Innovation and Technology Committee on Tuesday next week… 👀
Reposted by Dan Bose
Full story by @isaacbarbosa1.bsky.social and me in today's Research Fortnight
www.researchprofessionalnews.com/rr-news-uk-r...
www.researchprofessionalnews.com/rr-news-uk-r...
‘Grave’ concerns over applicant-led funds at UK research councils - Research Professional News
Figures suggest reductions at MRC and BBSRC, with questions hanging over pending MRC grant applications
www.researchprofessionalnews.com
January 28, 2026 at 8:56 AM
Full story by @isaacbarbosa1.bsky.social and me in today's Research Fortnight
www.researchprofessionalnews.com/rr-news-uk-r...
www.researchprofessionalnews.com/rr-news-uk-r...
Reposted by Dan Bose
Launching soon! R for Biochemists 101 begins on Monday 2 February 2026. Don’t miss your chance to boost your data skills and gain confidence in R. 🧪Secure your place today: https://ow.ly/f48R50XZXh2
January 24, 2026 at 1:45 PM
Launching soon! R for Biochemists 101 begins on Monday 2 February 2026. Don’t miss your chance to boost your data skills and gain confidence in R. 🧪Secure your place today: https://ow.ly/f48R50XZXh2
I'm not a #cryoET person, but what it's capable of now is incredible!
IsoNet2 determines cellular structures at submolecular resolution without averaging https://www.biorxiv.org/content/10.64898/2025.12.09.693325v1
December 12, 2025 at 8:29 AM
I'm not a #cryoET person, but what it's capable of now is incredible!
Reposted by Dan Bose
Announcing the 2026 edition of the EMBO workshop on RNA localization and local translation! This meeting will be held June 30 - July 4 near Porto, Portugal. Come for exciting updates in the field from both established investigators and trainees. See the link below for details!
December 8, 2025 at 4:40 PM
Announcing the 2026 edition of the EMBO workshop on RNA localization and local translation! This meeting will be held June 30 - July 4 near Porto, Portugal. Come for exciting updates in the field from both established investigators and trainees. See the link below for details!
Reposted by Dan Bose
Unpause! I'm super happy to now be able to share the published version of our paper at Science Advances showing that:
1) active histone mods occur independently of transcription
2) transcription coordinates histone deacetylation at active promoters
www.science.org/doi/10.1126/...
1) active histone mods occur independently of transcription
2) transcription coordinates histone deacetylation at active promoters
www.science.org/doi/10.1126/...
RNA polymerase II coordinates histone deacetylation at active promoters
Transcription initiation limits histone acetylation and H2AZ incorporation at promoters.
www.science.org
February 12, 2025 at 9:21 PM
Unpause! I'm super happy to now be able to share the published version of our paper at Science Advances showing that:
1) active histone mods occur independently of transcription
2) transcription coordinates histone deacetylation at active promoters
www.science.org/doi/10.1126/...
1) active histone mods occur independently of transcription
2) transcription coordinates histone deacetylation at active promoters
www.science.org/doi/10.1126/...
Reposted by Dan Bose
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
November 6, 2025 at 2:49 PM
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
Amazing work from the team at Oxford to pull apart how chromatin structure is organised at enhancers.
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 5, 2025 at 6:25 PM
Amazing work from the team at Oxford to pull apart how chromatin structure is organised at enhancers.
This is a super resource - looking forward to having a good poke around
Stoked to share our latest work entitled: “Large-scale discovery of neural enhancers for cis-regulation therapies”
shorturl.at/H3Qww
This is an enormous team effort that I had the honour of spearheading with Nick Page and Florence Chardon.
Bluetorial below.
shorturl.at/H3Qww
This is an enormous team effort that I had the honour of spearheading with Nick Page and Florence Chardon.
Bluetorial below.
November 5, 2025 at 3:38 PM
This is a super resource - looking forward to having a good poke around
Awesome work looking inside #RNA structural ensembles during folding- congrats!
Excited to share my first PhD student’s @biorxivpreprint.bsky.social!
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
November 1, 2025 at 6:39 AM
Awesome work looking inside #RNA structural ensembles during folding- congrats!
Reposted by Dan Bose
I’m a fair-weather poster on here to say the least. However, I'm pleased to present our latest paper. A great effort from all authors and an interesting insight into transcriptional regulation (we think!).
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Sequential verification of transcription by Integrator and Restrictor
Estell and Łazowski et al. show that Integrator and Restrictor form distinct pathways
for early attenuation of RNA polymerase II: Integrator acts at the promoter-proximal
pause site, whereas Restricto...
www.cell.com
October 17, 2025 at 5:19 PM
I’m a fair-weather poster on here to say the least. However, I'm pleased to present our latest paper. A great effort from all authors and an interesting insight into transcriptional regulation (we think!).
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
This is super cool!
🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for genetic code expansion - Nature
Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins with novel func...
www.nature.com
October 17, 2025 at 8:34 AM
This is super cool!
Reposted by Dan Bose
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
Enhancer-promoter compatibility is mediated by the promoter-proximal region
Gene promoters induce transcription in response to distal enhancers. How enhancers specifically activate their target promoter while bypassing other promoters remains unclear. Here, we find that the p...
www.biorxiv.org
October 16, 2025 at 3:06 PM
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...