Jackson Hoffman
@jxhoffman.bsky.social
Scientist in North Carolina studying chromatin remodelers and transcription factors. @fnucleosome.bsky.social coorganizer
ORCID: 0000-0002-6256-144X
Views and posts are all my own
ORCID: 0000-0002-6256-144X
Views and posts are all my own
Pinned
Jackson Hoffman
@jxhoffman.bsky.social
· Feb 12
RNA polymerase II coordinates histone deacetylation at active promoters
Transcription initiation limits histone acetylation and H2AZ incorporation at promoters.
www.science.org
Unpause! I'm super happy to now be able to share the published version of our paper at Science Advances showing that:
1) active histone mods occur independently of transcription
2) transcription coordinates histone deacetylation at active promoters
www.science.org/doi/10.1126/...
1) active histone mods occur independently of transcription
2) transcription coordinates histone deacetylation at active promoters
www.science.org/doi/10.1126/...
Reposted by Jackson Hoffman
The Leading Edge Fellows gathered this week to celebrate Zara Weinberg, a beloved member of our community. Our 7th cohort of Leading Edge Fellows (2026) will be named in her honor.
The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2.
www.leadingedgesymposium.org/apply/
The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2.
www.leadingedgesymposium.org/apply/
November 5, 2025 at 5:48 PM
The Leading Edge Fellows gathered this week to celebrate Zara Weinberg, a beloved member of our community. Our 7th cohort of Leading Edge Fellows (2026) will be named in her honor.
The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2.
www.leadingedgesymposium.org/apply/
The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2.
www.leadingedgesymposium.org/apply/
Reposted by Jackson Hoffman
My lab is seeking two PhD candidates to investigate the function and regulation of endogenous retroviruses in the early stages of human development 🦠👩🔬. Apply through the International Max Planck Research School (IMPRS) program: www.molgen.mpg.de/IMPRS/applic.... www.molgen.mpg.de/5094682/Fuey...
[2026] – Endogenous retroviruses in human embryogenesis
www.molgen.mpg.de
October 23, 2025 at 8:31 PM
My lab is seeking two PhD candidates to investigate the function and regulation of endogenous retroviruses in the early stages of human development 🦠👩🔬. Apply through the International Max Planck Research School (IMPRS) program: www.molgen.mpg.de/IMPRS/applic.... www.molgen.mpg.de/5094682/Fuey...
Reposted by Jackson Hoffman
🎃We are ready & excited for the new #FragileNucleosome seminar session tomorrow with @alicelaigle.bsky.social and @seungsookim.bsky.social ! How about you ?
October 21, 2025 at 2:42 PM
🎃We are ready & excited for the new #FragileNucleosome seminar session tomorrow with @alicelaigle.bsky.social and @seungsookim.bsky.social ! How about you ?
Reposted by Jackson Hoffman
If you’re interested in exploring the relationship between chromatin organization and epigenetic memory using chromatin tracing microscopy, my group is recruiting a talented PhD student 🥳
🚨 Please share! We are seeking motivated PhD students who wish to work at the intersection of molecular life sciences and computational sciences.
#IMPRS #IMPRSBAC @freieuniversitaet.bsky.social @maxplanck.de
Check out our projects and apply by Jan 7th, 2026!
www.molgen.mpg.de/IMPRSPhDproj...
#IMPRS #IMPRSBAC @freieuniversitaet.bsky.social @maxplanck.de
Check out our projects and apply by Jan 7th, 2026!
www.molgen.mpg.de/IMPRSPhDproj...
October 8, 2025 at 5:05 PM
If you’re interested in exploring the relationship between chromatin organization and epigenetic memory using chromatin tracing microscopy, my group is recruiting a talented PhD student 🥳
Reposted by Jackson Hoffman
Still got our latest preprint bookmarked in an unread tab of your browser? We got you. @afederation.bsky.social presenting @talusbio.bsky.social's work-in-progress on Wednesday! 🧬 🖥️ 🧪 #MassSpectrometry #Proteomics
🎃 🥁This Wednesday in our 1st session of spookiest month👻 at #FragileNucleosome seminar, we are excited to host @sanimr.bsky.social & Alex Federation!
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
October 7, 2025 at 2:50 AM
Still got our latest preprint bookmarked in an unread tab of your browser? We got you. @afederation.bsky.social presenting @talusbio.bsky.social's work-in-progress on Wednesday! 🧬 🖥️ 🧪 #MassSpectrometry #Proteomics
Reposted by Jackson Hoffman
⚡⚡Excited to announce I'll be starting my lab at the Max Planck Institute of Molecular Genetics (@molgen.mpg.de) in Berlin in December! Leaving sunny California to join a fantastic environment with colleagues who do super cool work.
🔬🦠I'm hiring at all levels! 🔬🦠Check: www.molgen.mpg.de/fueyo-lab
🔬🦠I'm hiring at all levels! 🔬🦠Check: www.molgen.mpg.de/fueyo-lab
October 6, 2025 at 1:46 PM
⚡⚡Excited to announce I'll be starting my lab at the Max Planck Institute of Molecular Genetics (@molgen.mpg.de) in Berlin in December! Leaving sunny California to join a fantastic environment with colleagues who do super cool work.
🔬🦠I'm hiring at all levels! 🔬🦠Check: www.molgen.mpg.de/fueyo-lab
🔬🦠I'm hiring at all levels! 🔬🦠Check: www.molgen.mpg.de/fueyo-lab
Reposted by Jackson Hoffman
🎃 🥁This Wednesday in our 1st session of spookiest month👻 at #FragileNucleosome seminar, we are excited to host @sanimr.bsky.social & Alex Federation!
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
October 6, 2025 at 7:22 PM
🎃 🥁This Wednesday in our 1st session of spookiest month👻 at #FragileNucleosome seminar, we are excited to host @sanimr.bsky.social & Alex Federation!
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
Reposted by Jackson Hoffman
Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
A human-specific regulatory mechanism revealed in a pre-implantation model
Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.
rdcu.be
October 1, 2025 at 6:08 PM
Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
Reposted by Jackson Hoffman
FINAL REGISTRATION DEADLINE!
Last day to register for the CEEHRC Annual Meeting is FRIDAY, OCTOBER 10!
Abstracts still being accepted for the poster sessions.
Speaker lineup and other details can be found at event.fourwaves.com/...
#epigenetics #epigenomics #ceehrc
Last day to register for the CEEHRC Annual Meeting is FRIDAY, OCTOBER 10!
Abstracts still being accepted for the poster sessions.
Speaker lineup and other details can be found at event.fourwaves.com/...
#epigenetics #epigenomics #ceehrc
CEEHRC 11th Annual Canadian Conference on Epigenetics
Fourwaves - CEEHRC 11th Annual Canadian Conference on Epigenetics
event.fourwaves.com
September 29, 2025 at 8:42 PM
FINAL REGISTRATION DEADLINE!
Last day to register for the CEEHRC Annual Meeting is FRIDAY, OCTOBER 10!
Abstracts still being accepted for the poster sessions.
Speaker lineup and other details can be found at event.fourwaves.com/...
#epigenetics #epigenomics #ceehrc
Last day to register for the CEEHRC Annual Meeting is FRIDAY, OCTOBER 10!
Abstracts still being accepted for the poster sessions.
Speaker lineup and other details can be found at event.fourwaves.com/...
#epigenetics #epigenomics #ceehrc
Reposted by Jackson Hoffman
We have space for two postdoctoral fellows in the Taipale Lab at the @sangerinstitute.bsky.social. This is a core-funded open position! Come with your ideas and interests and we can develop a project together.
sanger.wd103.myworkdayjobs.com/en-US/Wellco...
sanger.wd103.myworkdayjobs.com/en-US/Wellco...
Postdoctoral Fellow - Gene Regulation and Functional Genomics
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
sanger.wd103.myworkdayjobs.com
September 25, 2025 at 10:58 AM
We have space for two postdoctoral fellows in the Taipale Lab at the @sangerinstitute.bsky.social. This is a core-funded open position! Come with your ideas and interests and we can develop a project together.
sanger.wd103.myworkdayjobs.com/en-US/Wellco...
sanger.wd103.myworkdayjobs.com/en-US/Wellco...
Starting in 3 hours!!
This Wednesday at #FragileNucleosome seminar, we are excited to host Ali Wilkening and @schvartzman.bsky.social to tell us about amazing work they are doing!
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
September 24, 2025 at 12:54 PM
Starting in 3 hours!!
Reposted by Jackson Hoffman
If you want to learn more about Ali's exciting work, register for the fragile nucleosome seminar! tomorrow 9AM PDT
This Wednesday at #FragileNucleosome seminar, we are excited to host Ali Wilkening and @schvartzman.bsky.social to tell us about amazing work they are doing!
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
September 23, 2025 at 6:26 PM
If you want to learn more about Ali's exciting work, register for the fragile nucleosome seminar! tomorrow 9AM PDT
Reposted by Jackson Hoffman
This Wednesday at #FragileNucleosome seminar, we are excited to host Ali Wilkening and @schvartzman.bsky.social to tell us about amazing work they are doing!
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
September 22, 2025 at 7:06 AM
This Wednesday at #FragileNucleosome seminar, we are excited to host Ali Wilkening and @schvartzman.bsky.social to tell us about amazing work they are doing!
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
Reposted by Jackson Hoffman
✨Exciting news: the main story of my PhD is out in Science!
Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation.
📖 Read the full story here: www.science.org/doi/10.1126/...
Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation.
📖 Read the full story here: www.science.org/doi/10.1126/...
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...
www.science.org
September 19, 2025 at 2:09 PM
✨Exciting news: the main story of my PhD is out in Science!
Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation.
📖 Read the full story here: www.science.org/doi/10.1126/...
Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation.
📖 Read the full story here: www.science.org/doi/10.1126/...
Reposted by Jackson Hoffman
It is my pleasure to share with you the latest from @jsvejstrup.bsky.social lab, where we look at how the reduction of RNAPII levels has a severe, yet organized transcriptional response in the cell.
September 19, 2025 at 9:15 AM
It is my pleasure to share with you the latest from @jsvejstrup.bsky.social lab, where we look at how the reduction of RNAPII levels has a severe, yet organized transcriptional response in the cell.
Reposted by Jackson Hoffman
Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...
HDAC3 prevents enhancer hyperactivation to enable developmental transitions
Dynamic gene regulation requires precise cooperation between transcription factors and chromatin modifiers at regulatory elements to achieve not only activation or repression, but also appropriate tra...
www.biorxiv.org
September 18, 2025 at 9:55 AM
Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...
Reposted by Jackson Hoffman
We're getting started in ~90 minutes!
In addition to watching the seminars, remember you can join us on Discord to chat about transcription and chromatin whenever you want! discord.com/invite/dXqT89r
In addition to watching the seminars, remember you can join us on Discord to chat about transcription and chromatin whenever you want! discord.com/invite/dXqT89r
September 10, 2025 at 2:28 PM
We're getting started in ~90 minutes!
In addition to watching the seminars, remember you can join us on Discord to chat about transcription and chromatin whenever you want! discord.com/invite/dXqT89r
In addition to watching the seminars, remember you can join us on Discord to chat about transcription and chromatin whenever you want! discord.com/invite/dXqT89r
Reposted by Jackson Hoffman
🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
September 8, 2025 at 3:15 PM
🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
Really excited to get our seminars back up and running. @gracebower.bsky.social is going 1st and if you haven't read her range extender story, you're in for a treat!
+
@creminslab.bsky.social has the 2nd talk and will tell us about the amazing work happening in her lab!
+
@creminslab.bsky.social has the 2nd talk and will tell us about the amazing work happening in her lab!
Let’s kickstart new series of #FragileNucleosome seminars! We are delighted to have @gracebower.bsky.social from Kvon lab and @creminslab.bsky.social to present their work!
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
September 8, 2025 at 5:34 PM
Really excited to get our seminars back up and running. @gracebower.bsky.social is going 1st and if you haven't read her range extender story, you're in for a treat!
+
@creminslab.bsky.social has the 2nd talk and will tell us about the amazing work happening in her lab!
+
@creminslab.bsky.social has the 2nd talk and will tell us about the amazing work happening in her lab!
Reposted by Jackson Hoffman
Let’s kickstart new series of #FragileNucleosome seminars! We are delighted to have @gracebower.bsky.social from Kvon lab and @creminslab.bsky.social to present their work!
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
September 5, 2025 at 9:27 PM
Let’s kickstart new series of #FragileNucleosome seminars! We are delighted to have @gracebower.bsky.social from Kvon lab and @creminslab.bsky.social to present their work!
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
Reposted by Jackson Hoffman
As part of this grant, I have a vacancy out for a PhD student to join our super nice team. It closes on September 9 (Tuesday).
If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat...
If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat...
PhD position in Gene Regulation
Are you excited about studying the crucial process of transcription? Join our supportive, young and growing team!
www.uu.nl
September 4, 2025 at 11:48 AM
As part of this grant, I have a vacancy out for a PhD student to join our super nice team. It closes on September 9 (Tuesday).
If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat...
If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat...
Reposted by Jackson Hoffman
Excited to share the first paper from the lab! 🥳 The ATG9 and lipid droplets saga continues! Open source!
Liver-specific loss of Atg9a perturbs lipid metabolism and hepatocyte integrity
The autophagy-related protein ATG9A is integral to cellular autophagy and lipid mobilization, yet its importance in mammalian physiology remains underexplored. Using a liver-specific conditional At...
doi.org
September 3, 2025 at 4:56 PM
Excited to share the first paper from the lab! 🥳 The ATG9 and lipid droplets saga continues! Open source!
Reposted by Jackson Hoffman
Honoured to be part of this awesome lineup 😍! @fnucleosome.bsky.social thanks for the opportunity! A very exciting Fall Season is about to start, I wouldn't miss it 😌🧬
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!
register here for the entire series: us06web.zoom.us/webinar/regi...
register here for the entire series: us06web.zoom.us/webinar/regi...
September 2, 2025 at 8:56 AM
Honoured to be part of this awesome lineup 😍! @fnucleosome.bsky.social thanks for the opportunity! A very exciting Fall Season is about to start, I wouldn't miss it 😌🧬
Reposted by Jackson Hoffman
Join the Fragile Nucleosome Seminar featuring @gracebower.bsky.social, who will discuss our recent discovery of the Range Extender Element. (www.nature.com/articles/s41...)
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!
register here for the entire series: us06web.zoom.us/webinar/regi...
register here for the entire series: us06web.zoom.us/webinar/regi...
September 1, 2025 at 3:18 PM
Join the Fragile Nucleosome Seminar featuring @gracebower.bsky.social, who will discuss our recent discovery of the Range Extender Element. (www.nature.com/articles/s41...)
Reposted by Jackson Hoffman
What a job done by the @fnucleosome.bsky.social organisers. Awesome autumn lineup of speakers!
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!
register here for the entire series: us06web.zoom.us/webinar/regi...
register here for the entire series: us06web.zoom.us/webinar/regi...
September 1, 2025 at 4:05 PM
What a job done by the @fnucleosome.bsky.social organisers. Awesome autumn lineup of speakers!