jp flores (he/him)
@jpflores.rbind.io
🐏 phd’ing in bioinformatics & computational biology @ unc chapel hill | phanstiel lab | interests: genome org & function 🧬 | hhmi gilliam '24 | nsf grfp ‘22 | 🐅 occidental college ‘21 |🎙host, from where does it stem? | 🏘️ co-founder @sciforgood.bsky.social
Pinned
jp flores (he/him)
@jpflores.rbind.io
· Nov 17
jp flores
phd candidate in bioinformatics & computational biology at unc chapel hill
jpflores.rbind.io
#Introductions
Hi! 🤠 I’m JP (he/him), and I’m a PhD candidate at UNC Chapel Hill studying the role of 3D chromatin structure in response to environmental stress 🧬
I host the From where does it STEM? podcast, write/edit for GeneBites, & more!
website: jpflores.rbind.io
instagram: @jpflores_31
Hi! 🤠 I’m JP (he/him), and I’m a PhD candidate at UNC Chapel Hill studying the role of 3D chromatin structure in response to environmental stress 🧬
I host the From where does it STEM? podcast, write/edit for GeneBites, & more!
website: jpflores.rbind.io
instagram: @jpflores_31
Reposted by jp flores (he/him)
1/ 🎄 We got our Christmas present today: "Two distinct chromatin modules regulate proinflammatory gene expression" is now published @natcellbio.nature.com doi.org/10.1038/s415.... Our study introduces a scATAC-seq-based framework for genome-wide analysis of gene regulation features.
December 24, 2025 at 10:44 PM
1/ 🎄 We got our Christmas present today: "Two distinct chromatin modules regulate proinflammatory gene expression" is now published @natcellbio.nature.com doi.org/10.1038/s415.... Our study introduces a scATAC-seq-based framework for genome-wide analysis of gene regulation features.
Reposted by jp flores (he/him)
OSTP has issued a request for information, please share with them your ideas for how to improve government functions related to science funding and policy
www.federalregister.gov/documents/20...
www.federalregister.gov/documents/20...
Notice of Request for Information; Accelerating the American Scientific Enterprise
The Office of Science and Technology Policy (OSTP) requests input from all interested parties on Federal policy updates that aim to accelerate the American scientific enterprise, enable groundbreaking...
www.federalregister.gov
December 23, 2025 at 10:56 PM
OSTP has issued a request for information, please share with them your ideas for how to improve government functions related to science funding and policy
www.federalregister.gov/documents/20...
www.federalregister.gov/documents/20...
My committee >>>
Awesome--see you at the committee meeting after the holidays--enjoy some well deserved time off!
December 23, 2025 at 1:44 AM
My committee >>>
Reposted by jp flores (he/him)
Awesome--see you at the committee meeting after the holidays--enjoy some well deserved time off!
December 23, 2025 at 1:36 AM
Awesome--see you at the committee meeting after the holidays--enjoy some well deserved time off!
Reposted by jp flores (he/him)
Stress-induced loss of CTCF reveals an alternative, promoter-based mode of cohesin looping https://www.biorxiv.org/content/10.64898/2025.12.19.695003v1
December 22, 2025 at 10:32 PM
Stress-induced loss of CTCF reveals an alternative, promoter-based mode of cohesin looping https://www.biorxiv.org/content/10.64898/2025.12.19.695003v1
Excited to finally share what I’ve been working on during my PhD 😊 Best holiday gift EVER!
We just posted a new preprint from the @dphansti.bsky.social 👇
Preprint: www.biorxiv.org/content/10.6...
🧵
We just posted a new preprint from the @dphansti.bsky.social 👇
Preprint: www.biorxiv.org/content/10.6...
🧵
Stress-induced loss of CTCF reveals an alternative, promoter-based mode of cohesin looping
Cells continually encounter environmental stressors that challenge homeostasis. How three-dimensional (3D) chromatin structure contributes to these stress responses, particularly under hyperosmotic co...
www.biorxiv.org
December 22, 2025 at 11:19 PM
Excited to finally share what I’ve been working on during my PhD 😊 Best holiday gift EVER!
We just posted a new preprint from the @dphansti.bsky.social 👇
Preprint: www.biorxiv.org/content/10.6...
🧵
We just posted a new preprint from the @dphansti.bsky.social 👇
Preprint: www.biorxiv.org/content/10.6...
🧵
Just submitted my main PhD project today! biorxiv post coming soon! 🤠🤠🤠
December 19, 2025 at 3:41 PM
Just submitted my main PhD project today! biorxiv post coming soon! 🤠🤠🤠
Reposted by jp flores (he/him)
Unfortunately the drop in ESI funding rates is not paired with changes in funding required to get tenure. It’s not just the next three years of our labs at risk, but the rest of our careers. We are also the cohort that started in the COVID pandemic- it’s been nothing but “unprecedented times”…
December 19, 2025 at 2:16 AM
Unfortunately the drop in ESI funding rates is not paired with changes in funding required to get tenure. It’s not just the next three years of our labs at risk, but the rest of our careers. We are also the cohort that started in the COVID pandemic- it’s been nothing but “unprecedented times”…
Reposted by jp flores (he/him)
Reposted by jp flores (he/him)
Rebuilding trust in science requires people to see themselves in science: expanding representation and social connection across race, gender, class, religion, and rural identity, not just sharing more information.
Representation in science and trust in scientists in the USA - Nature Human Behaviour
Druckman et al. document gaps in trust in scientists in the USA. People from groups less represented among scientists (for example, women and those with lower economic status) are less trusting. Incre...
www.nature.com
December 15, 2025 at 4:23 PM
Rebuilding trust in science requires people to see themselves in science: expanding representation and social connection across race, gender, class, religion, and rural identity, not just sharing more information.
Reposted by jp flores (he/him)
Did we infer 3D chromatin function a TAD too early?
"We find that while TAD boundaries pair more frequently than non-boundary regions, these interactions are infrequent and are uncorrelated with transcriptional activity of genes within the TAD. (...) These results suggest that TAD boundary architecture and gene activity are largely uncoupled"
TAD boundary architecture and gene activity are uncoupled
Topologically associating domains (TADs) are prominent features of genome organization. A proposed function of TADs is to contribute to gene regulation by promoting chromatin interactions within a TAD...
www.biorxiv.org
December 18, 2025 at 8:02 PM
Did we infer 3D chromatin function a TAD too early?
Reposted by jp flores (he/him)
"We find that while TAD boundaries pair more frequently than non-boundary regions, these interactions are infrequent and are uncorrelated with transcriptional activity of genes within the TAD. (...) These results suggest that TAD boundary architecture and gene activity are largely uncoupled"
TAD boundary architecture and gene activity are uncoupled
Topologically associating domains (TADs) are prominent features of genome organization. A proposed function of TADs is to contribute to gene regulation by promoting chromatin interactions within a TAD...
www.biorxiv.org
December 18, 2025 at 11:43 AM
"We find that while TAD boundaries pair more frequently than non-boundary regions, these interactions are infrequent and are uncorrelated with transcriptional activity of genes within the TAD. (...) These results suggest that TAD boundary architecture and gene activity are largely uncoupled"
Reposted by jp flores (he/him)
All the centers they’re cutting add up to less than $7 million in spending.
UNC athletics budget is $185.4 million for the 2025-26 fiscal year.
UNC athletics budget is $185.4 million for the 2025-26 fiscal year.
December 18, 2025 at 12:45 AM
All the centers they’re cutting add up to less than $7 million in spending.
UNC athletics budget is $185.4 million for the 2025-26 fiscal year.
UNC athletics budget is $185.4 million for the 2025-26 fiscal year.
Reposted by jp flores (he/him)
CiFi: accurate long-read chromosome conformation capture with low-input requirements. #HiFi #LongRead #Sequencing @natcomms.nature.com 🧪🧬 🖥️
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 16, 2025 at 11:30 AM
CiFi: accurate long-read chromosome conformation capture with low-input requirements. #HiFi #LongRead #Sequencing @natcomms.nature.com 🧪🧬 🖥️
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by jp flores (he/him)
In a new guest article for the @pspdg.bsky.social blog, I explore the history of eugenics, its lingering impacts on society, and the potential of educational strategies to undermine false beliefs about genetics: www.pspdg.com/blog/2025/12...
Thanks to the blog team for their help with editing!
Thanks to the blog team for their help with editing!
What Remains Of Eugenics: The Legacy Of “Improving” The Human Breeding Stock — Penn Science Policy and Diplomacy Group
Guest post by Amanda N. Weiss People have long used selective breeding of crops and livestock to produce food and work animals with traits suited for our purposes. But ideas about good breeding stoc...
www.pspdg.com
December 16, 2025 at 7:01 PM
In a new guest article for the @pspdg.bsky.social blog, I explore the history of eugenics, its lingering impacts on society, and the potential of educational strategies to undermine false beliefs about genetics: www.pspdg.com/blog/2025/12...
Thanks to the blog team for their help with editing!
Thanks to the blog team for their help with editing!
Reposted by jp flores (he/him)
PROVIDENCE, R.I. (AP) — Authorities say they will release person of interest detained in Brown University shooting that killed 2 and wounded 9.
December 15, 2025 at 4:07 AM
PROVIDENCE, R.I. (AP) — Authorities say they will release person of interest detained in Brown University shooting that killed 2 and wounded 9.
Reposted by jp flores (he/him)
"At least two of the Brown University students who were on campus when a deadly shooting unfolded there on Saturday have survived school shootings before."
2 Students at Brown Witnessed School Shootings as Children
www.nytimes.com
December 14, 2025 at 3:09 PM
"At least two of the Brown University students who were on campus when a deadly shooting unfolded there on Saturday have survived school shootings before."
Reposted by jp flores (he/him)
One argument I used to make to my students about why it was important to learn history (and historical thinking) is that someone was always going to be trying to tell you things were natural or had always been this way and that you needed to be able to see that as an exercise of power.
December 7, 2025 at 10:09 PM
One argument I used to make to my students about why it was important to learn history (and historical thinking) is that someone was always going to be trying to tell you things were natural or had always been this way and that you needed to be able to see that as an exercise of power.
Reposted by jp flores (he/him)
I wrote a guide on constructive peer review. This is a polished version of an internal guide I had for my group. Of course, constructive feedback is welcome, peers!
deboer.bme.ubc.ca/2025/12/09/g...
deboer.bme.ubc.ca/2025/12/09/g...
December 9, 2025 at 6:38 PM
I wrote a guide on constructive peer review. This is a polished version of an internal guide I had for my group. Of course, constructive feedback is welcome, peers!
deboer.bme.ubc.ca/2025/12/09/g...
deboer.bme.ubc.ca/2025/12/09/g...
Reposted by jp flores (he/him)
A little reading before the Christmas break by the one and only @nucleosomepolice.bsky.social in @annualreviews.bsky.social
The expanding Histone universe: Histone-Based DNA organization in noneukaryotic organisms
www.annualreviews.org/content/jour...
The expanding Histone universe: Histone-Based DNA organization in noneukaryotic organisms
www.annualreviews.org/content/jour...
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms
Histones are small basic proteins that form the proteinaceous core of the nucleosome, the repeating building block of chromatin in all eukaryotes. Long thought to be exclusive to eukaryotes, histones ...
www.annualreviews.org
December 9, 2025 at 8:07 AM
A little reading before the Christmas break by the one and only @nucleosomepolice.bsky.social in @annualreviews.bsky.social
The expanding Histone universe: Histone-Based DNA organization in noneukaryotic organisms
www.annualreviews.org/content/jour...
The expanding Histone universe: Histone-Based DNA organization in noneukaryotic organisms
www.annualreviews.org/content/jour...
Reposted by jp flores (he/him)
Still haven’t unlocked the session recordings package from #ASHG25? Thousands joined live—now access these standout sessions before the year ends.
🎥AI-Powered Genomics
🎥AI & Machine Learning Tools
Click here to claim access: https://learning.ashg.org/am-2025-session-recordings #ASHG #HumanGenetics
🎥AI-Powered Genomics
🎥AI & Machine Learning Tools
Click here to claim access: https://learning.ashg.org/am-2025-session-recordings #ASHG #HumanGenetics
December 8, 2025 at 6:07 PM
Still haven’t unlocked the session recordings package from #ASHG25? Thousands joined live—now access these standout sessions before the year ends.
🎥AI-Powered Genomics
🎥AI & Machine Learning Tools
Click here to claim access: https://learning.ashg.org/am-2025-session-recordings #ASHG #HumanGenetics
🎥AI-Powered Genomics
🎥AI & Machine Learning Tools
Click here to claim access: https://learning.ashg.org/am-2025-session-recordings #ASHG #HumanGenetics
Reposted by jp flores (he/him)
I taught Genetics again this year. We need to include discussion of the problematic history of our field, especially as the claims of eugenics are once again centered in our political discourse. Last year I wrote this piece, explaining my reasoning and approach 🧪 1/n
www.cell.com/trends/genet...
www.cell.com/trends/genet...
December 8, 2025 at 12:37 PM
I taught Genetics again this year. We need to include discussion of the problematic history of our field, especially as the claims of eugenics are once again centered in our political discourse. Last year I wrote this piece, explaining my reasoning and approach 🧪 1/n
www.cell.com/trends/genet...
www.cell.com/trends/genet...
Reposted by jp flores (he/him)
It's official! The #tidyomics blog is up! 🚀
Here, the introductory post
tidyomics.github.io/tidyomicsBlo...
This blog aims to publish not only news about our community but also anything related to tidy interfaces, opinions, events, and more.
Plz share! 🙏
@bioconductor.bsky.social #rstats
Here, the introductory post
tidyomics.github.io/tidyomicsBlo...
This blog aims to publish not only news about our community but also anything related to tidy interfaces, opinions, events, and more.
Plz share! 🙏
@bioconductor.bsky.social #rstats
The Tidyomics Ecosystem – tidyomicsBlog
An introduction to the tidyomics ecosystem, including principles, core packages, publications, and community resources for tidy omic analysis.
tidyomics.github.io
December 7, 2025 at 11:07 PM
It's official! The #tidyomics blog is up! 🚀
Here, the introductory post
tidyomics.github.io/tidyomicsBlo...
This blog aims to publish not only news about our community but also anything related to tidy interfaces, opinions, events, and more.
Plz share! 🙏
@bioconductor.bsky.social #rstats
Here, the introductory post
tidyomics.github.io/tidyomicsBlo...
This blog aims to publish not only news about our community but also anything related to tidy interfaces, opinions, events, and more.
Plz share! 🙏
@bioconductor.bsky.social #rstats
Reposted by jp flores (he/him)
More from my OpEd project co-fellows:
Hurricane Melissa proves prediction does not equal protection
theopinionpages.com/2025/12/hurr...
Hurricane Melissa proves prediction does not equal protection
theopinionpages.com/2025/12/hurr...
Hurricane Melissa proves prediction does not equal protection | The Opinion Pages
Last month it was Typhoon Kalmaegi hitting Vietnam. Before that it was Hurricane Melissa tearing through the Caribbean. Many of us watch these natural disasters from our living rooms, scrolling throug...
theopinionpages.com
December 5, 2025 at 10:13 PM
More from my OpEd project co-fellows:
Hurricane Melissa proves prediction does not equal protection
theopinionpages.com/2025/12/hurr...
Hurricane Melissa proves prediction does not equal protection
theopinionpages.com/2025/12/hurr...
Reposted by jp flores (he/him)
The first crop of op-eds are starting to roll out from my fellow Fellows and I just have to share this beautiful and insightful piece from Maria B. Olujic:
The Words We Learn to Fear
publicseminar.org/2025/12/the-...
The Words We Learn to Fear
publicseminar.org/2025/12/the-...
The Words We Learn to Fear - Public Seminar
A reflection on growing up under Yugoslavia’s speech laws and how even today authoritarianism begins with the policing of language.
publicseminar.org
December 4, 2025 at 10:03 PM
The first crop of op-eds are starting to roll out from my fellow Fellows and I just have to share this beautiful and insightful piece from Maria B. Olujic:
The Words We Learn to Fear
publicseminar.org/2025/12/the-...
The Words We Learn to Fear
publicseminar.org/2025/12/the-...