jp flores (he/him)
@jpflores.rbind.io
🐏 phd’ing in bioinformatics & computational biology @ unc chapel hill | phanstiel lab | interests: genome org & function 🧬 | hhmi gilliam '24 | nsf grfp ‘22 | 🐅 occidental college ‘21 |🎙host, from where does it stem? | 🏘️ co-founder @sciforgood.bsky.social
Pinned
jp flores (he/him)
@jpflores.rbind.io
· Nov 17
jp flores
phd candidate in bioinformatics & computational biology at unc chapel hill
jpflores.rbind.io
#Introductions
Hi! 🤠 I’m JP (he/him), and I’m a PhD candidate at UNC Chapel Hill studying the role of 3D chromatin structure in response to environmental stress 🧬
I host the From where does it STEM? podcast, write/edit for GeneBites, & more!
website: jpflores.rbind.io
instagram: @jpflores_31
Hi! 🤠 I’m JP (he/him), and I’m a PhD candidate at UNC Chapel Hill studying the role of 3D chromatin structure in response to environmental stress 🧬
I host the From where does it STEM? podcast, write/edit for GeneBites, & more!
website: jpflores.rbind.io
instagram: @jpflores_31
Reposted by jp flores (he/him)
When people celebrate the individual genius of folks in science, they should also
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
November 7, 2025 at 11:43 PM
When people celebrate the individual genius of folks in science, they should also
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
Reposted by jp flores (he/him)
Last time I saw him, he told me that eugenics had gotten a bad rap. That it was, in fact, a great thing. To be celebrated. As well as the usual racist & misogynistic rants.
But honestly the worst part was seeing the light die in fellow lab members eyes when they met their hero and got...that.
But honestly the worst part was seeing the light die in fellow lab members eyes when they met their hero and got...that.
Hey folks, as news of Watson's demise spreads, please don't set aside his weighty legacy of misogyny and racism. He was truly among the worst of us. www.vox.com/2019/1/15/18...
DNA scientist James Watson has a remarkably long history of sexist, racist public comments
“People say it would be terrible if we made all girls pretty,” he said in 2003. “I think it would be great.”
www.vox.com
November 8, 2025 at 12:17 AM
Last time I saw him, he told me that eugenics had gotten a bad rap. That it was, in fact, a great thing. To be celebrated. As well as the usual racist & misogynistic rants.
But honestly the worst part was seeing the light die in fellow lab members eyes when they met their hero and got...that.
But honestly the worst part was seeing the light die in fellow lab members eyes when they met their hero and got...that.
Reposted by jp flores (he/him)
I should add that above (one of the things that has been said to me) is an actual Watson quote
November 9, 2025 at 1:39 AM
I should add that above (one of the things that has been said to me) is an actual Watson quote
Reposted by jp flores (he/him)
People might not realize - this wasn’t just one problematic person. He was (and is) influential. And this has real consequences.
“Female scientists who have kids can’t be taken seriously” and many other jabs at women have been directly said to me, within the last decade, by other scientists.
“Female scientists who have kids can’t be taken seriously” and many other jabs at women have been directly said to me, within the last decade, by other scientists.
I read this book when I was 15 and fell in love with DNA. I re-read it at 32 with lived experience in Science and it filled me with rage. I cannot pick up that book now. It reveals what women were/are up against.
Based on his self-described behavior in The Double Helix and these actions it is easy and appropriate to write him off as an ignorant jerk.
38/41
38/41
November 8, 2025 at 6:02 PM
People might not realize - this wasn’t just one problematic person. He was (and is) influential. And this has real consequences.
“Female scientists who have kids can’t be taken seriously” and many other jabs at women have been directly said to me, within the last decade, by other scientists.
“Female scientists who have kids can’t be taken seriously” and many other jabs at women have been directly said to me, within the last decade, by other scientists.
November 8, 2025 at 11:12 PM
Reposted by jp flores (he/him)
Y’all these genzplyr PRs are off the hook: github.com/hadley/genzp...
Pull requests · hadley/genzplyr
dplyr but make it bussin fr fr no cap. Contribute to hadley/genzplyr development by creating an account on GitHub.
github.com
November 8, 2025 at 12:29 AM
Y’all these genzplyr PRs are off the hook: github.com/hadley/genzp...
Reposted by jp flores (he/him)
BREAKING: The Philippines declares a state of emergency after Typhoon Kalmaegi leaves at least 114 dead and hundreds missing in central provinces.
Philippines declares a state of emergency after Typhoon Kalmaegi left at least 114 people dead
Philippine President Ferdinand Marcos Jr. has declared a state of emergency after Typhoon Kalmaegi left at least 114 people dead and hundreds missing in central provinces.
bit.ly
November 6, 2025 at 3:44 AM
BREAKING: The Philippines declares a state of emergency after Typhoon Kalmaegi leaves at least 114 dead and hundreds missing in central provinces.
Reposted by jp flores (he/him)
A couple months ago, the Carolina Latinx Center reached out and asked if I’d be willing to help start a brand new STEM speaker series! I helped put together an all-star team, and we made it happen. I was PUMPED to have @cterminiphd.bsky.social come give a talk!
So inspiring!
So inspiring!
November 3, 2025 at 11:34 PM
A couple months ago, the Carolina Latinx Center reached out and asked if I’d be willing to help start a brand new STEM speaker series! I helped put together an all-star team, and we made it happen. I was PUMPED to have @cterminiphd.bsky.social come give a talk!
So inspiring!
So inspiring!
Went to my first @sacnas.bsky.social to give a talk about our work on the Atlas projects! Super thankful to be working with such passionate, kind people 🤠🫶🏽
November 3, 2025 at 11:31 PM
Went to my first @sacnas.bsky.social to give a talk about our work on the Atlas projects! Super thankful to be working with such passionate, kind people 🤠🫶🏽
I didn’t know what to expect out of Cleveland, but boy did it pop off!
Shoutout to @hhmi.org for bringing @raniaziar.bsky.social on! Such an amazing person & super grateful to know her hehe
Shoutout to @hhmi.org for bringing @raniaziar.bsky.social on! Such an amazing person & super grateful to know her hehe
November 3, 2025 at 11:29 PM
I didn’t know what to expect out of Cleveland, but boy did it pop off!
Shoutout to @hhmi.org for bringing @raniaziar.bsky.social on! Such an amazing person & super grateful to know her hehe
Shoutout to @hhmi.org for bringing @raniaziar.bsky.social on! Such an amazing person & super grateful to know her hehe
Reposted by jp flores (he/him)
Why fundamental research is fundamental to progress, seeding major breakthroughs
Editorial @nature.com this week
And 7 basic science discoveries that changed the world
nature.com/articles/d41...
nature.com/articles/d41...
Editorial @nature.com this week
And 7 basic science discoveries that changed the world
nature.com/articles/d41...
nature.com/articles/d41...
October 29, 2025 at 12:58 PM
Why fundamental research is fundamental to progress, seeding major breakthroughs
Editorial @nature.com this week
And 7 basic science discoveries that changed the world
nature.com/articles/d41...
nature.com/articles/d41...
Editorial @nature.com this week
And 7 basic science discoveries that changed the world
nature.com/articles/d41...
nature.com/articles/d41...
Reposted by jp flores (he/him)
Happy to share our latest publication, in which we show that the arrangement of nucleosomes around CTCF sites contributes to higher-order organisation of chromatin into TADs: www.embopress.org/doi/full/10....
October 27, 2025 at 11:49 AM
Happy to share our latest publication, in which we show that the arrangement of nucleosomes around CTCF sites contributes to higher-order organisation of chromatin into TADs: www.embopress.org/doi/full/10....
Being a Dodgers fan on the east coast right now is brutal. Just pitch to Ohtani😭
October 28, 2025 at 5:57 AM
Being a Dodgers fan on the east coast right now is brutal. Just pitch to Ohtani😭
Reposted by jp flores (he/him)
Please repost and share this flyer with any STEM undergrads in mentorship programs that you know! This work important to better understanding the role of mentorship in professional development.
Undergrads sign up here: go.ufl.edu/mentorshipma...
@kassstem.bsky.social #STEMeducation #mentorship
Undergrads sign up here: go.ufl.edu/mentorshipma...
@kassstem.bsky.social #STEMeducation #mentorship
October 12, 2025 at 3:41 PM
Please repost and share this flyer with any STEM undergrads in mentorship programs that you know! This work important to better understanding the role of mentorship in professional development.
Undergrads sign up here: go.ufl.edu/mentorshipma...
@kassstem.bsky.social #STEMeducation #mentorship
Undergrads sign up here: go.ufl.edu/mentorshipma...
@kassstem.bsky.social #STEMeducation #mentorship
Reposted by jp flores (he/him)
Guest piece for #Inform&Influence detailing how SNAP has succeeded as a #grassroots org coordinating multiple nationwide initiatives.
#SciPol #SciAdvocacy #SciComm #McClintockLetters
www.linkedin.com/posts/debora...
#SciPol #SciAdvocacy #SciComm #McClintockLetters
www.linkedin.com/posts/debora...
Inform & Influence 51 Guest Writer: Oh, SNAP! Getting Early-Career Scientists to Engage with Policy and Community. | Deborah D. Stine
Hello Newsletter Readers,
Exciting news! While I am off on my trip to Southern Africa, I asked several organizations to talk about their activities in science and technology policy through my newslet...
www.linkedin.com
October 27, 2025 at 5:50 PM
Guest piece for #Inform&Influence detailing how SNAP has succeeded as a #grassroots org coordinating multiple nationwide initiatives.
#SciPol #SciAdvocacy #SciComm #McClintockLetters
www.linkedin.com/posts/debora...
#SciPol #SciAdvocacy #SciComm #McClintockLetters
www.linkedin.com/posts/debora...
Reposted by jp flores (he/him)
Read about what the Scientist Network for Advancing Policy has been up to and how we support early-career scientists in policy advocacy and community engagement efforts!
Guest piece for #Inform&Influence detailing how SNAP has succeeded as a #grassroots org coordinating multiple nationwide initiatives.
#SciPol #SciAdvocacy #SciComm #McClintockLetters
www.linkedin.com/posts/debora...
#SciPol #SciAdvocacy #SciComm #McClintockLetters
www.linkedin.com/posts/debora...
Inform & Influence 51 Guest Writer: Oh, SNAP! Getting Early-Career Scientists to Engage with Policy and Community. | Deborah D. Stine
Hello Newsletter Readers,
Exciting news! While I am off on my trip to Southern Africa, I asked several organizations to talk about their activities in science and technology policy through my newslet...
www.linkedin.com
October 28, 2025 at 1:13 AM
Read about what the Scientist Network for Advancing Policy has been up to and how we support early-career scientists in policy advocacy and community engagement efforts!
Reposted by jp flores (he/him)
How New Trump Multiyear Policy Makes NIH Grants Even Harder To Get
www.forbes.com/sites/brucel...
www.forbes.com/sites/brucel...
How New Trump Multiyear Policy Makes NIH Grants Even Harder To Get
The new Trump administration multiyear funding policy for NIH grants has dropped National Cancer Institute grant funding rates from one in 10 applicants to one in 25.
www.forbes.com
October 26, 2025 at 8:10 PM
How New Trump Multiyear Policy Makes NIH Grants Even Harder To Get
www.forbes.com/sites/brucel...
www.forbes.com/sites/brucel...
Reposted by jp flores (he/him)
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
Enhancer-promoter compatibility is mediated by the promoter-proximal region
Gene promoters induce transcription in response to distal enhancers. How enhancers specifically activate their target promoter while bypassing other promoters remains unclear. Here, we find that the p...
www.biorxiv.org
October 16, 2025 at 3:06 PM
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
Reposted by jp flores (he/him)
Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Promoter-proximal gatekeepers restrict pleiotropic enhancer inputs to achieve tissue specificity
Developmental enhancers are central regulatory elements that can activate multiple genes, yet how they selectively regulate one gene over its neighbours remains unclear. Using the Drosophila twist E3 ...
www.biorxiv.org
October 16, 2025 at 12:34 PM
Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Reposted by jp flores (he/him)
@joann-trejo.bsky.social, @marymunson4.bsky.social and I have a commentary in @natcellbio.nature.com on recent attacks on DEI in biomedical research: "If scientific research, especially biomedical research, is meant to serve everyone, then it requires that everyone has an opportunity to participate"
Scaling back DEI programmes and the loss of scientific talent
Nature Cell Biology - Programmes that support diversity, equity and inclusion (DEI) in science are under attack in the USA. Data indicate that diversity in the scientific workforce increases...
www.nature.com
October 23, 2025 at 4:36 PM
@joann-trejo.bsky.social, @marymunson4.bsky.social and I have a commentary in @natcellbio.nature.com on recent attacks on DEI in biomedical research: "If scientific research, especially biomedical research, is meant to serve everyone, then it requires that everyone has an opportunity to participate"
Reposted by jp flores (he/him)
Reposted by jp flores (he/him)
I have been waiting to do a study like this for YEARS. YEARS I tell you. Glad I have something to site now when I try to convince people to let me do it.
A recent study of schoolchildren finds that the youngest students harbor the most germs.
During cold and flu season, the youngest kids really are the germiest
A recent study of schoolchildren finds that the youngest students harbor the most germs. Researchers looked at nasal swabs and symptom reports of more than 800 students and staff in Kansas City, Missouri.
bit.ly
October 23, 2025 at 11:54 AM
I have been waiting to do a study like this for YEARS. YEARS I tell you. Glad I have something to site now when I try to convince people to let me do it.
Reposted by jp flores (he/him)
3D genome folding in epigenetic regulation and cellular memory
3D genome folding in epigenetic regulation and cellular memory
The 3D folding of the genome is tightly linked to its epigenetic state which maintains gene expression programmes. Although the relationship between gene expression and genome organisation is highly context dependent, 3D genome organisation is emerging as a novel epigenetic layer to reinforce and stabilise transcriptional states. Whether regulatory information carried in genome folding could be transmitted through mitosis is an area of active investigation. In this review, we discuss the relationship between epigenetic state and nuclear organisation, as well as the interplay between transcriptional regulation and epigenetic genome folding. We also consider the architectural remodelling of nuclei as cells enter and exit mitosis, and evaluate the potential of the 3D genome to contribute to cellular memory.
dlvr.it
April 11, 2025 at 12:03 PM
3D genome folding in epigenetic regulation and cellular memory