Surfin' NuRD
@surfinnurd.bsky.social
Ahh well-a everybody's heard
about the NuRD.
#NuRDistheWord
Cycling/Chromatin Remodelling/Transcription/Enhancers/StemCells
We've got it all.
Living Systems Institute, University of Exeter
https://lsi.exeter.ac.uk/groups/hendrich-group/
about the NuRD.
#NuRDistheWord
Cycling/Chromatin Remodelling/Transcription/Enhancers/StemCells
We've got it all.
Living Systems Institute, University of Exeter
https://lsi.exeter.ac.uk/groups/hendrich-group/
Doing happy mini preps today.
Wait until they find out what solutions im about to put in them.
Wait until they find out what solutions im about to put in them.
January 21, 2026 at 9:46 AM
Doing happy mini preps today.
Wait until they find out what solutions im about to put in them.
Wait until they find out what solutions im about to put in them.
Reposted by Surfin' NuRD
Once again I'm more than happy to accept invitations to talk in Edinburgh and the North of England in July 2027. In fact, let's get a group together to tour all of these towns. Who's in? #TourdeTourdeFrance
www.theguardian.com/sport/2026/j...
www.theguardian.com/sport/2026/j...
Tour de France reveals plans for six UK stages with historic 2027 Grands Départs
Men’s race will visit Edinburgh, Carlisle, Keswick, Liverpool, Welshpool and Cardiff, while women will head from Leeds to Manchester, then to Sheffield and also includes a central London stage
www.theguardian.com
January 16, 2026 at 7:30 AM
Once again I'm more than happy to accept invitations to talk in Edinburgh and the North of England in July 2027. In fact, let's get a group together to tour all of these towns. Who's in? #TourdeTourdeFrance
www.theguardian.com/sport/2026/j...
www.theguardian.com/sport/2026/j...
Is it LTNs? No wait! Bike Lanes, right?
Of course it can't be due to TOO MANY FEKKIN CARS!
Source: Devon Live
search.app/XxSnu
Of course it can't be due to TOO MANY FEKKIN CARS!
Source: Devon Live
search.app/XxSnu
Exeter named one of the worst UK cities for traffic
It confirms what many motorists stuck on Exe Bridges or Bridge Road have long thought
search.app
January 13, 2026 at 7:33 PM
Is it LTNs? No wait! Bike Lanes, right?
Of course it can't be due to TOO MANY FEKKIN CARS!
Source: Devon Live
search.app/XxSnu
Of course it can't be due to TOO MANY FEKKIN CARS!
Source: Devon Live
search.app/XxSnu
What an absurd article. I'm all for preservation of and education about local cultures, but if you go to a world class Uni like York, don't be surprised if the student population is made up of a large number of people from outside Yorkshire.
www.theguardian.com/education/20...
www.theguardian.com/education/20...
‘Oh my gosh, they’re all from London and Cambridge’: York University’s northerners fight back
Lucy Morville, from Burnley, thought most students would be from the north and felt ‘culture shock’ surrounded by southerners
www.theguardian.com
January 4, 2026 at 5:43 PM
What an absurd article. I'm all for preservation of and education about local cultures, but if you go to a world class Uni like York, don't be surprised if the student population is made up of a large number of people from outside Yorkshire.
www.theguardian.com/education/20...
www.theguardian.com/education/20...
Reposted by Surfin' NuRD
Here's an idea for 2026...
January 2, 2026 at 4:14 AM
Here's an idea for 2026...
And time for a Japanese Negroni. Thanks, Maya!
December 29, 2025 at 4:23 PM
And time for a Japanese Negroni. Thanks, Maya!
Reposted by Surfin' NuRD
Oh my giddy aunt this is amazing. I'm in awe of the avocado.
This story is absolutely wild. Did you know that avocados change sex over the course of a day? And that it's controlled by a single ancient balanced polymorphism? This is flat our crazy
Balanced polymorphism in a floral transcription factor underlies an ancient rhythm of daily sex alternation in avocado https://www.biorxiv.org/content/10.64898/2025.12.22.695989v1
December 25, 2025 at 11:27 AM
Oh my giddy aunt this is amazing. I'm in awe of the avocado.
Check it, kids.
@anzymiller.bsky.social has taken dTAG-mediated protein expression control to the next level.
@anzymiller.bsky.social has taken dTAG-mediated protein expression control to the next level.
Engineering protein expression dynamics with Tet-ON and dTAG degron systems: from precise control to oscillations https://www.biorxiv.org/content/10.64898/2025.12.16.694651v1
December 19, 2025 at 12:02 PM
Check it, kids.
@anzymiller.bsky.social has taken dTAG-mediated protein expression control to the next level.
@anzymiller.bsky.social has taken dTAG-mediated protein expression control to the next level.
Wow. Cells ratcheted up the Transposon Arms Race a notch further than we'd realised.
December 12, 2025 at 1:43 PM
Wow. Cells ratcheted up the Transposon Arms Race a notch further than we'd realised.
Reposted by Surfin' NuRD
An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
SET1/MLL complexes control transcription independently of H3K4me3
Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...
www.biorxiv.org
December 11, 2025 at 6:09 AM
An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Did a journal club on this yesterday.
Very insightful and clever treatment of gene expression: for a protein involved in noise suppression, p≤0.05 isn't the whole story. Stratification of p-values shows what you can get by thinking outside the "standard" methods.
Nicely done!
Very insightful and clever treatment of gene expression: for a protein involved in noise suppression, p≤0.05 isn't the whole story. Stratification of p-values shows what you can get by thinking outside the "standard" methods.
Nicely done!
5/8 Second, we explored the action of SALL4 on the (epi-)genome of stem cells 🧬 This transcription factor has a preference for short AT-rich motifs which are very frequent and dispersed across the genome, so how does this protein control gene expression?
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Pervasive binding of the stem cell transcription factor SALL4 shapes the chromatin landscape
Mechanistic understanding of how gene activity is regulated has focussed on the roles of transcription factors at promoters and enhancers, whereas mechanisms capable of globally fine-tuning gene expre...
doi.org
December 3, 2025 at 10:35 AM
Did a journal club on this yesterday.
Very insightful and clever treatment of gene expression: for a protein involved in noise suppression, p≤0.05 isn't the whole story. Stratification of p-values shows what you can get by thinking outside the "standard" methods.
Nicely done!
Very insightful and clever treatment of gene expression: for a protein involved in noise suppression, p≤0.05 isn't the whole story. Stratification of p-values shows what you can get by thinking outside the "standard" methods.
Nicely done!
Reposted by Surfin' NuRD
Looking for a PhD? 3 days left to apply for a fully funded China Scholarship Council & University of Exeter studentship! Join the Living Systems Institute—where Maths, Physics, Bio and Biomed meet—and carry out cutting-edge interdisciplinary research. tinyurl.com/y3ufdnxf @exeter.ac.uk
November 28, 2025 at 2:00 PM
Looking for a PhD? 3 days left to apply for a fully funded China Scholarship Council & University of Exeter studentship! Join the Living Systems Institute—where Maths, Physics, Bio and Biomed meet—and carry out cutting-edge interdisciplinary research. tinyurl.com/y3ufdnxf @exeter.ac.uk
Reposted by Surfin' NuRD
Last chance to apply for one of the LSI PhD projects intake Sept 2026! Deadline tomorrow, 26.11.2025, noon. www.exeter.ac.uk/research/ins... @exeter.ac.uk @lsiexeter.bsky.social
November 25, 2025 at 5:07 PM
Last chance to apply for one of the LSI PhD projects intake Sept 2026! Deadline tomorrow, 26.11.2025, noon. www.exeter.ac.uk/research/ins... @exeter.ac.uk @lsiexeter.bsky.social
The Zaphrod Beeblebrox of anemones.
Very cool new paper from the Rentzsch group!!
Our paper on the role of neurons in Nematostella head regeneration is now out at @currentbiology.bsky.social Big thank you to all collaborators, it was a pleasure!
Ectopic head regeneration after nervous system ablation in a sea anemone: Current Biology www.cell.com/current-biol...
Ectopic head regeneration after nervous system ablation in a sea anemone: Current Biology www.cell.com/current-biol...
November 22, 2025 at 11:56 AM
The Zaphrod Beeblebrox of anemones.
Reposted by Surfin' NuRD
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
November 5, 2025 at 9:18 AM
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
@teamlabouruk.bsky.social please take note.
This is yet another example of how you beat the far right. By beating them, not trying to be them. By having your own agenda, not aping theirs. With courage and conviction - and humour - not fear and timidity.
November 5, 2025 at 7:39 AM
@teamlabouruk.bsky.social please take note.
Reposted by Surfin' NuRD
This is yet another example of how you beat the far right. By beating them, not trying to be them. By having your own agenda, not aping theirs. With courage and conviction - and humour - not fear and timidity.
November 5, 2025 at 6:35 AM
This is yet another example of how you beat the far right. By beating them, not trying to be them. By having your own agenda, not aping theirs. With courage and conviction - and humour - not fear and timidity.
Reposted by Surfin' NuRD
Language models cannot reliably distinguish belief from knowledge and fact #AI
Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation.
www.nature.com/articles/s42...
Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation.
www.nature.com/articles/s42...
Language models cannot reliably distinguish belief from knowledge and fact - Nature Machine Intelligence
Suzgun et al. find that current large language models cannot reliably distinguish between belief, knowledge and fact, raising concerns for their use in healthcare, law and journalism, where such disti...
www.nature.com
November 4, 2025 at 10:13 AM
Language models cannot reliably distinguish belief from knowledge and fact #AI
Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation.
www.nature.com/articles/s42...
Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation.
www.nature.com/articles/s42...
Reposted by Surfin' NuRD
Reposted by Surfin' NuRD
Are you looking for a PhD starting in September 2026/27? Then do not miss the fantastic opportunity to be part of the LSI PhD Community. New positions for the LSI PhD Programme are out now. www.exeter.ac.uk/research/ins... Deadline: 26.11.2025
October 28, 2025 at 9:34 AM
Are you looking for a PhD starting in September 2026/27? Then do not miss the fantastic opportunity to be part of the LSI PhD Community. New positions for the LSI PhD Programme are out now. www.exeter.ac.uk/research/ins... Deadline: 26.11.2025
Reposted by Surfin' NuRD
about PAE #alphafold
PAE viewer pae-viewer.uni-goettingen.de
PAE Figure editor thecodingbiologist.com/tools/pae.html
PAE viewer pae-viewer.uni-goettingen.de
PAE Figure editor thecodingbiologist.com/tools/pae.html
October 27, 2025 at 7:27 AM
about PAE #alphafold
PAE viewer pae-viewer.uni-goettingen.de
PAE Figure editor thecodingbiologist.com/tools/pae.html
PAE viewer pae-viewer.uni-goettingen.de
PAE Figure editor thecodingbiologist.com/tools/pae.html
Reposted by Surfin' NuRD
🚀 Excited to share my latest paper on using SHAP, to predict direct target genes of chromatin-associated factors! Check it out for insights into gene regulation and the power of explainable AI in genomics! #XAI #SHAP #Genomics
doi.org/10.1371/jour...
Let's break down what we found! 👇
doi.org/10.1371/jour...
Let's break down what we found! 👇
Modelling transcription with explainable AI uncovers context-specific epigenetic gene regulation at promoters and gene bodies
Author summary Genes are turned on or off through complex processes involving many proteins that interact with DNA wrapped histones and modify their structure. These changes, known as epigenetic modif...
doi.org
October 24, 2025 at 11:37 AM
🚀 Excited to share my latest paper on using SHAP, to predict direct target genes of chromatin-associated factors! Check it out for insights into gene regulation and the power of explainable AI in genomics! #XAI #SHAP #Genomics
doi.org/10.1371/jour...
Let's break down what we found! 👇
doi.org/10.1371/jour...
Let's break down what we found! 👇