Surfin' NuRD
@surfinnurd.bsky.social
Ahh well-a everybody's heard
about the NuRD.
#NuRDistheWord
Cycling/Chromatin Remodelling/Transcription/Enhancers/StemCells
We've got it all.
Living Systems Institute, University of Exeter
https://lsi.exeter.ac.uk/groups/hendrich-group/
about the NuRD.
#NuRDistheWord
Cycling/Chromatin Remodelling/Transcription/Enhancers/StemCells
We've got it all.
Living Systems Institute, University of Exeter
https://lsi.exeter.ac.uk/groups/hendrich-group/
Reposted by Surfin' NuRD
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
November 5, 2025 at 9:18 AM
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
@teamlabouruk.bsky.social please take note.
This is yet another example of how you beat the far right. By beating them, not trying to be them. By having your own agenda, not aping theirs. With courage and conviction - and humour - not fear and timidity.
November 5, 2025 at 7:39 AM
@teamlabouruk.bsky.social please take note.
Reposted by Surfin' NuRD
This is yet another example of how you beat the far right. By beating them, not trying to be them. By having your own agenda, not aping theirs. With courage and conviction - and humour - not fear and timidity.
November 5, 2025 at 6:35 AM
This is yet another example of how you beat the far right. By beating them, not trying to be them. By having your own agenda, not aping theirs. With courage and conviction - and humour - not fear and timidity.
Reposted by Surfin' NuRD
Language models cannot reliably distinguish belief from knowledge and fact #AI
Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation.
www.nature.com/articles/s42...
Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation.
www.nature.com/articles/s42...
Language models cannot reliably distinguish belief from knowledge and fact - Nature Machine Intelligence
Suzgun et al. find that current large language models cannot reliably distinguish between belief, knowledge and fact, raising concerns for their use in healthcare, law and journalism, where such disti...
www.nature.com
November 4, 2025 at 10:13 AM
Language models cannot reliably distinguish belief from knowledge and fact #AI
Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation.
www.nature.com/articles/s42...
Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation.
www.nature.com/articles/s42...
Reposted by Surfin' NuRD
Reposted by Surfin' NuRD
Are you looking for a PhD starting in September 2026/27? Then do not miss the fantastic opportunity to be part of the LSI PhD Community. New positions for the LSI PhD Programme are out now. www.exeter.ac.uk/research/ins... Deadline: 26.11.2025
October 28, 2025 at 9:34 AM
Are you looking for a PhD starting in September 2026/27? Then do not miss the fantastic opportunity to be part of the LSI PhD Community. New positions for the LSI PhD Programme are out now. www.exeter.ac.uk/research/ins... Deadline: 26.11.2025
Reposted by Surfin' NuRD
about PAE #alphafold
PAE viewer pae-viewer.uni-goettingen.de
PAE Figure editor thecodingbiologist.com/tools/pae.html
PAE viewer pae-viewer.uni-goettingen.de
PAE Figure editor thecodingbiologist.com/tools/pae.html
October 27, 2025 at 7:27 AM
about PAE #alphafold
PAE viewer pae-viewer.uni-goettingen.de
PAE Figure editor thecodingbiologist.com/tools/pae.html
PAE viewer pae-viewer.uni-goettingen.de
PAE Figure editor thecodingbiologist.com/tools/pae.html
Reposted by Surfin' NuRD
🚀 Excited to share my latest paper on using SHAP, to predict direct target genes of chromatin-associated factors! Check it out for insights into gene regulation and the power of explainable AI in genomics! #XAI #SHAP #Genomics
doi.org/10.1371/jour...
Let's break down what we found! 👇
doi.org/10.1371/jour...
Let's break down what we found! 👇
Modelling transcription with explainable AI uncovers context-specific epigenetic gene regulation at promoters and gene bodies
Author summary Genes are turned on or off through complex processes involving many proteins that interact with DNA wrapped histones and modify their structure. These changes, known as epigenetic modif...
doi.org
October 24, 2025 at 11:37 AM
🚀 Excited to share my latest paper on using SHAP, to predict direct target genes of chromatin-associated factors! Check it out for insights into gene regulation and the power of explainable AI in genomics! #XAI #SHAP #Genomics
doi.org/10.1371/jour...
Let's break down what we found! 👇
doi.org/10.1371/jour...
Let's break down what we found! 👇
Reposted by Surfin' NuRD
We did journal club today on this preprint - interesting parallels that CHD4 and its partners block aberrant TF binding in mESCs (this preprint), human cells (PMID:38281186), and fly testis (PMID:28522526).
Fascinated by how CHD4 controls cryptic regulatory elements without a strong presence there.
Fascinated by how CHD4 controls cryptic regulatory elements without a strong presence there.
Check it out, Chromatin Kids!
Chromatin remodeller does stuff to Transcription Factors!
Functions where it is seldom seen!
Both decreases and increases chromatin accessibility!
How cool is that?
Chromatin remodeller does stuff to Transcription Factors!
Functions where it is seldom seen!
Both decreases and increases chromatin accessibility!
How cool is that?
The chromatin remodeller CHD4 controls both nucleosome integrity and transcription factor binding to promote activity of active regulatory elements and to prevent activation of silent enhancers https://www.biorxiv.org/content/10.1101/2025.08.29.672645v1
October 23, 2025 at 1:59 AM
We did journal club today on this preprint - interesting parallels that CHD4 and its partners block aberrant TF binding in mESCs (this preprint), human cells (PMID:38281186), and fly testis (PMID:28522526).
Fascinated by how CHD4 controls cryptic regulatory elements without a strong presence there.
Fascinated by how CHD4 controls cryptic regulatory elements without a strong presence there.
Reposted by Surfin' NuRD
🔬 Limb regeneration depends on regenerative signaling center cells — but how do these cells influence others to proliferate, migrate, or differentiate?
We’re recruiting PhD or Postdoc candidates to explore this with our collaborator @osvaldo-chara.bsky.social !
We’re recruiting PhD or Postdoc candidates to explore this with our collaborator @osvaldo-chara.bsky.social !
October 21, 2025 at 6:56 AM
🔬 Limb regeneration depends on regenerative signaling center cells — but how do these cells influence others to proliferate, migrate, or differentiate?
We’re recruiting PhD or Postdoc candidates to explore this with our collaborator @osvaldo-chara.bsky.social !
We’re recruiting PhD or Postdoc candidates to explore this with our collaborator @osvaldo-chara.bsky.social !
Reposted by Surfin' NuRD
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
October 17, 2025 at 2:56 PM
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
Planarian #NuRD Alert!
"the NuRD complex may drive differentiation into somatic lineages in planarians"
Yeah it does. #NuRDIsTheWormyWord
#Chromatin #Transcription
doi.org/10.3389/frag...
"the NuRD complex may drive differentiation into somatic lineages in planarians"
Yeah it does. #NuRDIsTheWormyWord
#Chromatin #Transcription
doi.org/10.3389/frag...
Frontiers | Systemic identification and characterization of the conserved core NuRD complex in planarian
The nucleosome remodeling and deacetylase (NuRD) complex, well known for its ATP-dependent chromatin remodeling and histone deacetylation activities combined...
doi.org
October 17, 2025 at 9:06 AM
Planarian #NuRD Alert!
"the NuRD complex may drive differentiation into somatic lineages in planarians"
Yeah it does. #NuRDIsTheWormyWord
#Chromatin #Transcription
doi.org/10.3389/frag...
"the NuRD complex may drive differentiation into somatic lineages in planarians"
Yeah it does. #NuRDIsTheWormyWord
#Chromatin #Transcription
doi.org/10.3389/frag...
Reposted by Surfin' NuRD
By me this week - the happiest thing I've got to report of late, with a glorious trip over the summer to Montreal
"Forget EVs. Cycling is revolutionising transport."
www.economist.com/internationa...
"Forget EVs. Cycling is revolutionising transport."
www.economist.com/internationa...
Forget EVs. Cycling is revolutionising transport
Pedal power is booming, spinning up a new culture war
www.economist.com
October 9, 2025 at 3:20 PM
By me this week - the happiest thing I've got to report of late, with a glorious trip over the summer to Montreal
"Forget EVs. Cycling is revolutionising transport."
www.economist.com/internationa...
"Forget EVs. Cycling is revolutionising transport."
www.economist.com/internationa...
Reposted by Surfin' NuRD
Are you enthusiastic about stem cell biology and developmental biology and looking to start a PhD in 2026? Funded opportunites now available. Contact for more infomation. Links below! @lovegrovelab.bsky.social @veronicabiga.bsky.social @manchester.ac.uk @ukri.org
October 9, 2025 at 4:21 PM
Are you enthusiastic about stem cell biology and developmental biology and looking to start a PhD in 2026? Funded opportunites now available. Contact for more infomation. Links below! @lovegrovelab.bsky.social @veronicabiga.bsky.social @manchester.ac.uk @ukri.org
Reposted by Surfin' NuRD
These images are separated by one day
October 8, 2025 at 2:27 PM
These images are separated by one day
Reposted by Surfin' NuRD
On National Poetry Day, the greatest poem I have ever read
October 2, 2025 at 8:41 AM
On National Poetry Day, the greatest poem I have ever read
Reposted by Surfin' NuRD
I have an MRC-funded PhD project available (www.exeter.ac.uk/study/fundin...) on how warming will change the problem of AMR. Join a small and friendly group (padpadpadpad.netlify.app/about) in (sometimes) sunny Cornwall. 🧪🦠 #microsky
Please share the ad below with anyone who may be interested.
Please share the ad below with anyone who may be interested.
September 16, 2025 at 8:08 AM
I have an MRC-funded PhD project available (www.exeter.ac.uk/study/fundin...) on how warming will change the problem of AMR. Join a small and friendly group (padpadpadpad.netlify.app/about) in (sometimes) sunny Cornwall. 🧪🦠 #microsky
Please share the ad below with anyone who may be interested.
Please share the ad below with anyone who may be interested.
Reposted by Surfin' NuRD
Truth to ReformUK is like daylight to a vampire…… and
It’s our job to let the light in. 🔦
yorkshirebylines.co.uk/society/inco...
It’s our job to let the light in. 🔦
yorkshirebylines.co.uk/society/inco...
Incomers: the myth vs reality of refugees in the UK
Britain hosts just 1% of the world’s refugees – far fewer than many nations – yet myths of handouts and 'overwhelm' still dominate debate
yorkshirebylines.co.uk
October 1, 2025 at 5:59 AM
Truth to ReformUK is like daylight to a vampire…… and
It’s our job to let the light in. 🔦
yorkshirebylines.co.uk/society/inco...
It’s our job to let the light in. 🔦
yorkshirebylines.co.uk/society/inco...
Reposted by Surfin' NuRD
If you want to know why we should care about protein expression dynamics have a read of the perspective piece I wrote for @dev-journal.bsky.social. While you're there check out my fellow Pathway to Independence fellows' interesting pieces!
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
Pathway to Independence: a forecast for the future of developmental biology
ABSTRACT. In 2022, Development launched its Pathway to Independence (PI) programme, aimed at supporting postdocs as they transition to their first independent position. In 2025, we welcome our third c...
journals.biologists.com
September 30, 2025 at 2:04 PM
If you want to know why we should care about protein expression dynamics have a read of the perspective piece I wrote for @dev-journal.bsky.social. While you're there check out my fellow Pathway to Independence fellows' interesting pieces!
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
Reposted by Surfin' NuRD
Handmade by the artist. Comes in gift box with numbered and signed card of authenticity. Available for preorder for short time only👇👇👇👇
coldwarsteve.bigcartel.com/product/patr...
coldwarsteve.bigcartel.com/product/patr...
September 24, 2025 at 3:10 PM
Handmade by the artist. Comes in gift box with numbered and signed card of authenticity. Available for preorder for short time only👇👇👇👇
coldwarsteve.bigcartel.com/product/patr...
coldwarsteve.bigcartel.com/product/patr...
Reposted by Surfin' NuRD
NOT TO BE MISSED. My awesome colleague Rob Brewster may have COMPLETELY upended our understanding of how TFs work ... a must-read for anyone who cares in the slightest about gene regulation
E. coli transcription factors regulate promoter activity by a universal, homeostatic mechanism | Science www.science.org/doi/10.1126/...
E. coli transcription factors regulate promoter activity by a universal, homeostatic mechanism
Transcription factors (TFs) may activate or repress gene expression through an interplay of different mechanisms, including RNA polymerase (RNAP) recruitment, exclusion, and initiation. However, depen...
www.science.org
September 11, 2025 at 7:21 PM
NOT TO BE MISSED. My awesome colleague Rob Brewster may have COMPLETELY upended our understanding of how TFs work ... a must-read for anyone who cares in the slightest about gene regulation
Reposted by Surfin' NuRD
Please share!
PhD projects available through @gw4biomeddtp.bsky.social
Please get in touch if you are interested in studying chromatin biology in stem cell models
gw4biomed.ac.uk/architects-o...
gw4biomed.ac.uk/risk-vs-prot...
gw4biomed.ac.uk/rna-dependen...
gw4biomed.ac.uk/investigatin...
PhD projects available through @gw4biomeddtp.bsky.social
Please get in touch if you are interested in studying chromatin biology in stem cell models
gw4biomed.ac.uk/architects-o...
gw4biomed.ac.uk/risk-vs-prot...
gw4biomed.ac.uk/rna-dependen...
gw4biomed.ac.uk/investigatin...
Architects of the Genome: Using genomic technologies to elucidate the role of CTCF in neurodevelopmental disorders - GW4 BioMed MRC DTP
Project Code MRCNMH26Ex Flynn Project Type The project is primarily wet-lab based, with a dry-lab component in Years 2 and 3. Research Theme Neuroscience and Mental Health Project Summary Download Sum...
gw4biomed.ac.uk
September 2, 2025 at 12:22 PM
Please share!
PhD projects available through @gw4biomeddtp.bsky.social
Please get in touch if you are interested in studying chromatin biology in stem cell models
gw4biomed.ac.uk/architects-o...
gw4biomed.ac.uk/risk-vs-prot...
gw4biomed.ac.uk/rna-dependen...
gw4biomed.ac.uk/investigatin...
PhD projects available through @gw4biomeddtp.bsky.social
Please get in touch if you are interested in studying chromatin biology in stem cell models
gw4biomed.ac.uk/architects-o...
gw4biomed.ac.uk/risk-vs-prot...
gw4biomed.ac.uk/rna-dependen...
gw4biomed.ac.uk/investigatin...
What a job done by the @fnucleosome.bsky.social organisers. Awesome autumn lineup of speakers!
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!
register here for the entire series: us06web.zoom.us/webinar/regi...
register here for the entire series: us06web.zoom.us/webinar/regi...
September 1, 2025 at 4:05 PM
What a job done by the @fnucleosome.bsky.social organisers. Awesome autumn lineup of speakers!
Check it out, Chromatin Kids!
Chromatin remodeller does stuff to Transcription Factors!
Functions where it is seldom seen!
Both decreases and increases chromatin accessibility!
How cool is that?
Chromatin remodeller does stuff to Transcription Factors!
Functions where it is seldom seen!
Both decreases and increases chromatin accessibility!
How cool is that?
The chromatin remodeller CHD4 controls both nucleosome integrity and transcription factor binding to promote activity of active regulatory elements and to prevent activation of silent enhancers https://www.biorxiv.org/content/10.1101/2025.08.29.672645v1
August 30, 2025 at 4:18 PM
Check it out, Chromatin Kids!
Chromatin remodeller does stuff to Transcription Factors!
Functions where it is seldom seen!
Both decreases and increases chromatin accessibility!
How cool is that?
Chromatin remodeller does stuff to Transcription Factors!
Functions where it is seldom seen!
Both decreases and increases chromatin accessibility!
How cool is that?
Reposted by Surfin' NuRD
HP1β and densely packed chromatin form separate microdomains in mouse ES cells, which are reconfigured upon exit from naive pluripotency https://www.biorxiv.org/content/10.1101/2025.08.25.671447v1
August 28, 2025 at 5:18 AM
HP1β and densely packed chromatin form separate microdomains in mouse ES cells, which are reconfigured upon exit from naive pluripotency https://www.biorxiv.org/content/10.1101/2025.08.25.671447v1